Elastic properties of human cortical and trabecular lamellar bone measured by nanoindentation

Rho, Jae-Young; Tsui, Ting Y.; Pharr, George M.

Year	Entry
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2014	Carretta R. Post-Yield Mechanics and Material Composition of Single Trabeculae: A Combined Experimental and Modelling Approach [PhD thesis]. Swiss Federal Institute of Technology Zürich; 2014.
2022	Peruzzi CRP. Nanoscale Deformation Mechanisms and Yield Prediction of Lamellar Bone [PhD thesis]. Swiss Federal Institute of Technology Zürich; 2022.
2006	Nagaraja S. Microstructural Stresses and Strains Associated With Trabecular Bone Microdamage [PhD thesis]. Atlanta, GA: Georgia Institute of Technology; December 2006.
2010	Feng L. Multi-Scale Characterization of Swine Femoral Cortical Bone and Long Bone Defect Repair by Regeneration [PhD thesis]. University of Illinois at Urbana-Champaign; 2010.
2012	Hamed E. Multiscale Modeling of Elastic Moduli and Strength of Bone [PhD thesis]. University of Illinois at Urbana-Champaign; 2012.
2017	Bakalova LP. Relating Cortical Bone Mechanics to Intracortical Pore Morphology, Distribution and Remodeling History Within the Fibula Diaphysis [Master's thesis]. University of Illinois at Urbana-Champaign; 2017.
2019	Livingston E. Morphological and Mechanical Analysis of the Porous Structure of Cortical Bone [Master's thesis]. University of Illinois at Urbana-Champaign; 2019.
2015	Rodriguez-Florez N. Mechanics of Cortical Bone: Exploring the Micro- and Nano-Scale [PhD thesis]. Imperial College London; January 2015.
2002	Follet H. Caractérisation Biomécanique Et Modélisation 3D Par Imagerie X Et IRM Haute Résolution De L’os Spongieux Humain: Evaluation Du Risque Fracturaire [PhD thesis]. Institut national des sciences appliquées de Lyon (INSA Lyon); 2002.
2020	Bennison MBL. The Role of Cancellous Bone Architecture in Misalignment and Side Effect Errors [Master's thesis]. Sudbury, ON: Laurentian University; 2020.
2022	Rahovich P. Effects of Bone Structural Unit (BSU) Geometry and Material Properties on Crack Growth Through Idealized Trabecular Microstructures [Master's thesis]. Sudbury, ON: Laurentian University; 2022.
2011	Abdel-Wahab AA-GM. Experimental and Numerical Analysis of Deformation and Fracture of Cortical Bone Tissue [PhD thesis]. Loughborough University; August 2011.
2013	Li S. Cutting of Cortical Bone Tissue: Analysis of Deformation and Fracture Process [PhD thesis]. Loughborough University; June 2013.
28	Wang M. Effect of Osteonal Microstructure on Crack Propagation: A Computational Study [PhD thesis]. Loughborough University; October 28.
2014	Holub O. Biomechanics of Spinal Metastases [PhD thesis]. University of Leeds; April 2014.
2007	Akhtar R. Micromechanical Behaviour of Bone [PhD thesis]. University of Manchester; 2007.
2001	Arthur Moore TL. Microdamage Accumulation in Bovine Trabecular Bone [PhD thesis]. Cambridge, MA: Massachusetts Institute of Technology; June 2001.
2007	Tai K. Nanomechanics and Ultrastructural Studies of Cortical Bone: Fundamental Insights Regarding Structure-Function, Mineral-Organic Force Mechanics Interactions, and Heterogeneity [PhD thesis]. Cambridge, MA: Massachusetts Institute of Technology; June 2007.
2012	Rennick JA. Bone Fracture Prediction Using Computed Tomography Based Rigidity Analysis and the Finite Element Method [Master's thesis]. Northeastern University; April 2012.
2015	Oftadeh R. Hierarchical Analysis and Multiscale Modelling of Cellular Structures: From Meta Materials to Bone Structure [PhD thesis]. Northeastern University; December 2015.
2012	Deymier-Black AC. Study of the Elasto-Plastic Properties of Mineralized Biomaterials Via Synchrotron High-Energy X-Ray Diffraction [PhD thesis]. Evanston, IL: Northwestern University; June 2012.
2007	Zhang J. Mechanical Property Determination of Bone Through Nano- and Microindentation Testing and Finite Element Simulation [PhD thesis]. University of Notre Dame; July 2007.
2010	Shi X. Effects of Architecture on Microdamage Susceptibility in Trabecular Bone [PhD thesis]. University of Notre Dame; April 2010.
2011	Wu Z. Measures of Bone Quality and Their Relationship to Bone Mechanical Properties [PhD thesis]. University of Notre Dame; December 2011.
2017	Kreipke TC. Structural, Mechanical, and Biological Relationships of Trabecular Bone in Osteoporosis [PhD thesis]. University of Notre Dame; April 2017.
2020	O’Sullivan LM. Time-Sequence of Biomechanical Adaption in Trabecular Tissue During Estrogen Deficiency [PhD thesis]. National University of Ireland Galway; March 2020.
2012	Tozzi G. In Vitro Studies of Bone-Cement Interface and Related Work on Cemented Acetabular Replacement [PhD thesis]. Portsmouth, England: University of Portsmouth; May 29, 2012.
2019	Curto M. Multi-Material 3D Printing of Bioinspired Mechanical Structures [PhD thesis]. Portsmouth, England: University of Portsmouth; March 2019.
2012	Sun X. Mechanically Induced Calcium Efflux from Bone Matrix Stimulates Osteoblasts [PhD thesis]. Purdue University; May 2012.
2012	Jimenez Palomar I. Mechanical Properties of Bone At the Sub-lamellar Level [PhD thesis]. London, England: Queen Mary University of London; September 2012.
2005	Buie HR. Use of Finite Element Method Modelling and Rapid Prototyping to Study the Effect of Trabecular Bone Architecture on Apparent Mechanical Properties [Master's thesis]. Queen's University; November 2005.
2009	Lievers WB. Effects of Geometric and Material Property Changes on the Apparent Elastic Properties of Cancellous Bone [PhD thesis]. Queen's University; April 2009.
2010	Engbretson AC. Determining the Modulus of Intact Bovine Vertebral Cancellous Bone Tissue: Development and Validation of a Protocol [Master's thesis]. Queen's University; August 25, 2010.
2013	Morton JJ. An Investigation of Rat Vertebra Failure Behaviour Under Uniaxial Compression Through Time-Lapsed Micro-CT Imaging [Master's thesis]. Queen's University; 2013.
2022	Beloglowka K. Ex Vivo Mechanical Testing and FEA Modelling of Bovine Trabecular Bone [Master's thesis]. Queen's University; September 2022.
2001	Kim DG. Micromechanical Analysis of Bone At a Bone-Implant Interface [PhD thesis]. Troy, NY: Rensselaer Polytechnic Institute; April 2001.
2006	Diab T. The Role of Damage Morphology in Age-Related Increase in Bone Fragility [PhD thesis]. Troy, NY: Rensselaer Polytechnic Institute; 2006.
2011	Yao H. Microstructure-Based Characterization and Modeling of Trabecular Bone Deformation and Failure [PhD thesis]. Southern Methodist University; August 3, 2011.
2004	Mittra ES. Assessment of Trabecular Bone Quality Using Microstructure, Micro-Mechanics and Micro-Finite Element Modeling [PhD thesis]. Stony Brook, NY: Stony Brook University; May 2004.
2009	Ozcivici E. Recovery of Trabecular Bone from Disuse Induced Deterioration in Cellular, Morphological and Biomechanical Properties [PhD thesis]. Stony Brook, NY: Stony Brook University; May 2009.
2009	Ruppel ME. Alterations in the Mineral and Collagen Matrix of Bisphosphonate-Treated Bone and Osteoblasts [PhD thesis]. Stony Brook, NY: Stony Brook University; May 2009.
2011	Vijayaraghavan S. Duration of Reambulation Phases as a Modulator of the Detrimental Impact of Multiple Disuse Exposures on the Skeleton [Master's thesis]. Stony Brook, NY: Stony Brook University; August 2011.
2012	Kwaczala AT. Alendronate and PTH Differentially Modulate Bone Quality and Reduce Adiposity in an OVX Rat Model [PhD thesis]. Stony Brook, NY: Stony Brook University; December 2012.
2004	McNamara LM. Biomechanical Origins of Osteoporosis [PhD thesis]. Trinity College Dublin; March 2004.
2006	Gleeson JP. Composition and Mechanical Properties of Osteoarthritic Subchondral Trabecular Tibial Bone [PhD thesis]. Trinity College Dublin; November 2006.
2004	Shimko DA. Design and Optimization of a Tissue-Engineered Bone Graft Substitute [PhD thesis]. Tulane University; 2004.
2011	Reisinger AG. Modeling and Validation of Multiscale Lamellar Bone Elasticity [PhD thesis]. Vienna University of Technology; November 2011.
2014	Gross T. Development and Application of 3d CT Image-Based Micro and Macro Finite Element Models for Human Bones and Orthopedic Implant Systems [PhD thesis]. Vienna University of Technology; 2014.
2021	Frank M. Mechanical Characterization of Individual Trabeculae [PhD thesis]. Vienna University of Technology; February 2021.
2006	Soares Silva LDM. Nanoindentation Study and Quantitative Backscattered Electron Imaging of Human Cortical Bone [Master's thesis]. Vancouver, BC: University of British Columbia; 2006.
2008	Tang A. Nanoindentation of Peri-Implant Bone and Dentin [Master's thesis]. Vancouver, BC: University of British Columbia; March 2008.
2013	Owoc JS. Large Scale Elasto-Plastic Modelling for in Vivo Assessment of Bone Strength from High Resolution Peripheral Quantitative Computed Tomography [Master's thesis]. Calgary, AB: University of Calgary; August 2013.
2000	Nauman EA. The Analytical Design of a Hybrid Bone Substitute [PhD thesis]. Berkeley, CA: Berkeley, University of California; Spring 2000.
2000	Niebur GL. A Computational Investigation of Multiaxial Failure in Trabecular Bone [PhD thesis]. Berkeley, CA: Berkeley, University of California; 2000.
2002	Morgan EF-i. The Dependence on Anatomic Site of Trabecular Bone Structure-Function Relationships [PhD thesis]. Berkeley, CA: Berkeley, University of California; 2002.
2003	Bayraktar HH. Multiaxial Strength and Micromechanics of Human Bone [PhD thesis]. Berkeley, CA: Berkeley, University of California; 2003.
2004	Kazakia GJ. Development, Analysis, and Imaging of a Tissue Engineered Trabecular Bone Substitute [PhD thesis]. Berkeley, CA: Berkeley, University of California; 2004.
2019	Sadoughi S. Micromechanics of Human Bone: Role of Architecture and Tissue Material Properties [PhD thesis]. Berkeley, CA: Berkeley, University of California; 2019.
2012	Tjhia CKH. Bone Quality of Patients With Atypical Fractures and Severely Suppressed Bone Turnover [PhD thesis]. Davis, University of California; 2012.
2018	Patel RR. Does Patient-Specific Implant Design Reduce Subsidence Risk in Lumbar Interbody Fusion? A Bottom Up Analysis of Methods to Reduce Vertebral Endplate Stress [PhD thesis]. University of Colorado Denver; 2018.
2013	Wang Y-K. Multi-Level Micromechanical Modeling of Bone Tissues [PhD thesis]. Los Angeles, CA: Los Angeles, University of California; 2013.
2019	Jung J-Y. Learning from Nature: An Investigation of an Impact-Resistant System on the Woodpecker Head as a Non-Traumatic Brain Injury Animal Model [PhD thesis]. San Siego, CA: University of California San Diego; 2019.
2011	Chen CG. TGF-Β/Smad3 Regulation of Bone, Cartilage, and Tendon Matrix Composition and Material Properties [PhD thesis]. San Francisco, University of California; 2011.
2016	Jones DA. Reference Point Indentation of Human Trabecular Bone Treated With Bisphosphonates for Varying Durations [Master's thesis]. University of Kentucky; 2016.
2024	Qalaj P. Finite Element Analysis of Nanoindentation Across Bone Interfaces and Effects on the Measured Mechanical Properties [Master's thesis]. Liège, Belgique: Université de Liège; 2024.
2022	Rezaee T. Effect of Clinically Relevant Alterations of Mineral and Protein on Bone Biomechanics [PhD thesis]. University of Massachusetts at Dartmouth; May 2022.
1998	Ciarelli TE. Architectural and Material Contributions to Fracture of the Spine and Proximal Femur [PhD thesis]. University of Michigan; 1998.
2005	Oyen ML. Ultrastructural Characterization of Time-Dependent, Inhomogeneous Materials and Tissues [PhD thesis]. Minneapolis, MN: University of Minnesota; June 2005.
2006	Seong W-J. Relationships Between the Physical Properties of Human Jawbone and the Initial Stability of Dental Implant, and Their Dependency on Anatomical Regions of Jawbone [PhD thesis]. University of Minnesota; April 2006.
2010	Schwen LO. Composite Finite Elements for Trabecular Bone Microstructures [PhD thesis]. Bonn, Germany: Rheinische Friedrich-Wilhelms-Universität Bonn; July 2010.
2011	Wolfram U. Mechanical Multiscale Characterisation of Vertebral Trabecular Bone for the Prediction of Vertebral Fracture Risk [PhD thesis]. University of Ulm; 2011.
2011	Rieger R. Modélisation mécano-biologique par éléments finis de l'os trabéculaire: Des activités cellulaires au remodelage osseux [Mechano-Biological Modeling of Trabecular Bone by Finite Elements: From Cells’ Activities to Bone Remodeling] [PhD thesis]. University of Orleans; 2011.
2022	Delelio DM. Evaluation of Bone’s Response to Force: Fracture Type, Fracture Location, and Fracture Severity Across the Female Lifespan [Master's thesis]. Reno, University of Nevada; December 2022.
2021	Atthapreyangkul A. Multi-Scale Finite Element Modelling of Human Cortical Bone: An Analysis of the Mechanical Properties and Microdamage Onset of Cortical Bone [PhD thesis]. University of New South Wales; April 2021.
2016	Arango Villegas C. Study of the Mechanical Behavior of Cortical Bone Microstructure by the Finite Element Method [PhD thesis]. Universität Politècnica de València; May 2016.
2020	Belda González R. Mechanical and Morphometric Characterization of Cancellous Bone [PhD thesis]. Universität Politècnica de València; March 2020.
2015	Lin C-L. A Study of Human and Bovine Trabecular Bones Using Nanoindentation and Quantitative Backscattered Electron Imaging [PhD thesis]. Brisbane, Australia: University of Queensland; 2015.
2016	Lin C-l. A Study of Human and Bovine Trabecular Bones Using Nanoindentation and Quantitative Backscattered Electron Imaging [PhD thesis]. Brisbane, Australia: University of Queensland; 2016.
2020	Singleton RC. A Study of Aging in Male Cortical Bone Using Nanoindentation [PhD thesis]. Knoxville, University of Tennessee; August 2020.
2009	Potter RS. Age Effects on the Material and Mechanical Properties of Bone At the Osteocyte Lacuna [Master's thesis]. San Antionio, TX: University of Texas at San Antonio; December 2009.
2010	Reyes MJ. Age-Related Influence of Bone Remodeling on Local Tissue Properties of Human Cortical Bone [PhD thesis]. San Antionio, TX: University of Texas at San Antonio; December 2010.
2016	Boruah S. A Viscoelastic Model for High Strain Rate Loading of the Human Calvarium [PhD thesis]. Charlottesville, VA: University of Virginia; May 2016.
2018	Khor F. Computational Modeling of Hard Tissue Response and Fracture in the Lower Cervical Spine Under Compression Including Age Effects [Master's thesis]. University of Waterloo; 2018.
2019	Demirtas A. Assessment of the Influence of Possible Side Effects of Long-Term Bisphosphonate Treatment on Cortical Bone Fracture Resistance Using Finite Element Modeling [PhD thesis]. Villanova, PA: Villanova University; July 2019.
2013	Faingold A. Bone Elementary Units: Mechanical Properties and Structure [PhD thesis]. Weizmann Institute of Science; February 2013.
2019	Knowles NK. Improving Material Mapping in Glenohumeral Finite Element Models: A Multi-Level Evaluation [PhD thesis]. University of Western Ontario; 2019.
2022	Luo TD. The Effects of Ascorbic Acid in the Treatment of Radiation-Induced Bone Damage [PhD thesis]. Winston-Salem, NC: Wake Forest University; September 2022.
2009	García-Rodríguez S. Mechanical Behavior of Trabecular Bone [PhD thesis]. University of Wisconsin – Madison; 2009.
2020	Hamandi FMRA. Hierarchical Structure, Properties and Bone Mechanics At Macro, Micro, and Nano Levels [PhD thesis]. Dayton, OH: Wright State University; 2020.

Year	Entry
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1975	Runkle JC, Pugh J. The micro-mechanics of cancellous bone, II: determination of the elastic modulus of individual trabeculae by a buckling analysis. Bull Hosp Joint Dis. April 1975;36(1):2-10.
1992	Hogan HA. Micromechanics modeling of Haversian cortical bone properties. J Biomech. May 1992;25(5):549-556.
1984	Brown TD, Vrahas MS. The apparent elastic modulus of the juxtarticular subchondral bone of the femoral head. J Orthop Res. 1984;2(1):32-38.
1967	Ascenzi A, Bonucci E. The tensile properties of single osteons. Acta Anat. 1967;158(4):375-386.
1975	Townsend PR, Rose RM, Radin EL. Buckling studies of single human trabeculae. J Biomech. July 1975;8(3-4):199-200.
1968	Ascenzi A, Bonucci E. The compressive properties of single osteons. Anat Rec. July 1968;161(3):377-392.
1989	Kuhn JL, Goldstein SA, Choi K, London M, Feldkamp LA, Matthews LS. Comparison of the trabecular and cortical tissue moduli from human iliac crests. J Orthop Res. November 1989;7(6):876-884.
1974	Evans FG, Vincentelli R. Relations of the compressive properties of human cortical bone to histological structure and calcification. J Biomech. January 1974;7(1):1-10.
1989	Hodgskinson R, Currey JD, Evans GP. Hardness, an indicator of the mechanical competence of cancellous bone. J Orthop Res. September 1989;7(5):754-758.
1990	Choi K, Kuhn JL, Ciarelli MJ, Goldstein SA. The elastic moduli of human subchondral, trabecular, and cortical bone tissue and the size-dependency of cortical bone modulus. J Biomech. 1990;23(11):1103-1113.
1992	Oliver WC, Pharr GM. An improved technique for determining hardness and elastic modulus using load and displacement sensing indentation experiments. J Mater Res. 1992;7(6):1564-1583.
1989	Mente PL, Lewis JL. Experimental method for the measurement of the elastic modulus of trabecular bone tissue. J Orthop Res. 1989;7(3):456-461.
1993	Katz JL, Meunier A. Scanning acoustic microscope studies of the elastic properties of osteons and osteon lamellae. J Biomech Eng. November 1993;115(4B):543-548.
1990	Evans GP, Behiri JC, Currey JD, Bonfield W. Microhardness and Young's modulus in cortical bone exhibiting a wide range of mineral volume fractions, and in a bone analogue. J Mater Sci Mater Med. June 1990;1(1):38-43.
1974	Reilly DT, Burstein AH, Frankel VH. The elastic modulus for bone. J Biomech. May 1974;7(3):271-275.
1991	Lotz JC, Gerhart TN, Hayes WC. Mechanical properties of metaphyseal bone in the proximal femur. J Biomech. 1991;24(5):317-329.
1993	Rho JY, Ashman RB, Turner CH. Young's modulus of trabecular and cortical bone material: ultrasonic and microtensile measurements. J Biomech. February 1993;26(2):111-119.
1990	Ascenzi A, Baschieri P, Benvenuti A. The bending properties of single osteons. J Biomech. 1990;23(8):763-771.
1989	Ryan SD, Williams JL. Tensile testing of rodlike trabeculae excised from bovine femoral bone. J Biomech. 1989;22(4):351-355.
1992	Pharr GM, Oliver WC. Measurement of thin film mechanical properties using nanoindentation. MRS Bull. July 1992;17(7):28-33.