Mechanical properties of human trabecular bone lamellae quantified by nanoindentation

Zysset, P. K.; Guo, X. E.; Hoffler, C. E.; Moore, K. E.; Goldstein, S. A.

Affiliations

¹Orthopaedic Research Laboratories, University of Michigan, USA

Abstract and keywords

The elastic modulus and hardness of embedded and rewet trabecular bone lamellae of the proximal femur have been quantified in four males and four females by nanoindentation. The average elastic moduli ranged from 6.9 to 15.9 GPa and were found to be significantly different among individuals. Hardness correlated with elastic modulus and followed similar trends.

Keywords: Elastic properties; femur; hardness; lamella; trabecular bone

Links

PubMed: 10100945

Cited Works (6)

Year	Entry
1993	Katz JL, Meunier A. Scanning acoustic microscope studies of the elastic properties of osteons and osteon lamellae. J Biomech Eng. November 1993;115(4B):543-548.
1992	Oliver WC, Pharr GM. An improved technique for determining hardness and elastic modulus using load and displacement sensing indentation experiments. J Mater Res. 1992;7(6):1564-1583.
1958	Amprino R. Investigations on some physical properties of bone tissue. Acta Anat. 1958;34(3):161-186.
1997	Rho J-Y, Tsui TY, Pharr GM. Elastic properties of human cortical and trabecular lamellar bone measured by nanoindentation. Biomaterials. 1997;18(20):1325-1330.
1984	Currey JD. Mechanical Adaptations of Bone. Princeton, NJ: Princeton University Press; 1984.
1994	Ascenzi A, Baschieri P, Benvenuti A. The torsional properties of single selected osteons. J Biomech. July 1994;27(7):875-884.

Cited By (32)

Year	Entry
2001	Guo XE. Mechanical properties of cortical and cancellous bone tissue. In: Cowin SC, ed. Bone Mechanics Handbook. 2nd ed. Boca Raton, FL: CRC Press; 2001:10-1–10-23.
2007	Mulder L, Koolstra JH, den Toonder JMJ, van Eijden TMGJ. Intratrabecular distribution of tissue stiffness and mineralization in developing trabecular bone. Bone. August 2007;41(2):256-265.
2008	Wang X, Allen MR, Burr DB, Lavernia EJ, Jeremić B, Fyhrie DP. Identification of material parameters based on ohr–Coulomb failure criterion for bisphosphonate treated canine vertebral cancellous bone. Bone. October 2008;43(4):775-780.
2009	Ciarelli TE, Tjhia C, Rao S, Qiu S, Parfitt M, Fyhrie DP. Trabecular packet-level lamellar density patterns differ by fracture status and bone formation rate in white females. Bone. November 2009;45(5):903-908.
2011	Tjhia CK, Odvina CV, Rao DS, Stover SM, Wang X, Fyhrie DP. Mechanical property and tissue mineral density differences among severely suppressed bone turnover (SSBT) patients, osteoporotic patients, and normal subjects. Bone. December 2011;49(6):1279-1289.
2019	Liu P, Liang X, Li Z, Zhu X, Zhang Z, Cai L. Decoupled effects of bone mass, microarchitecture and tissue property on the mechanical deterioration of osteoporotic bones. Compos Pt B-Eng. November 15, 2019;177:107436.
2003	Ferguson VL, Bushby AJ, Boyde A. Nanomechanical properties and mineral concentration in articular calcified cartilage and subchondral bone. J Anat. August 2003;203(2):191-202.
2002	Arthur Moore TL, Gibson LJ. Microdamage accumulation in bovine trabecular bone in uniaxial compression. J Biomech Eng. February 2002;124(1):63-71.
2015	Oftadeh R, Perez-Viloria M, Villa-Camacho JC, Vaziri A, Nazarian A. Biomechanics and mechanobiology of trabecular bone: a review. J Biomech Eng. January 2015;137(1):010802.
2003	Fan Z, Rho J-Y. Effects of viscoelasticity and time-dependent plasticity on nanoindentation measurements of human cortical bone. J Biomed Mater Res. October 1, 2003;A67(1):208-214.
2008	Mulder L, Koolstra JH, den Toonder JMJ, van Eijden TMGJ. Relationship between tissue stiffness and degree of mineralization of developing trabecular bone. J Biomed Mater Res. February 2008;A84(2):508-515.
2013	Carretta R, Stüssi E, Müller R, Lorenzetti S. Within subject heterogeneity in tissue-level post-yield mechanical and material properties in human trabecular bone. J Mech Behav Biomed Mater. August 2013;24:64-73.
2005	Gupta HS, Schratter S, Tesch W, Roschger P, Berzlanovich A, Schoeberl T, Klaushofer K, Fratzl P. Two different correlations between nanoindentation modulus and mineral content in the bone–cartilage interface. J Struct Biol. February 2005;149(2):138-148.
2008	Ruppel ME, Miller LM, Burr DB. The effect of the microscopic and nanoscale structure on bone fragility. Osteoporos Int. September 2008;19(9):1251-1265.
2001	Birnbaum K, Sindelar R, Gärtner JR, Wirtz DC. Material properties of trabecular bone structures. Surg Radiol Anat. 2001;23(6):399-407.
2016	Guang Y. Characterization of Bone and Bone Marrow Lesions in the Osteoarthritic Hip [Master's thesis]. Boston University; 2016.
2010	Campbell SE. Nanoindentation of Bio- and Geo-Mineralized Composites: Contribution of Microstructure and Composition [PhD thesis]. University of Colorado; 2010.
2016	Wang J. Plate-Rod Microstructural Modeling for Accurate and Fast Assessment of Bone Strength [PhD thesis]. Columbia University; 2016.
2005	Yoon YJ. Estimates of Bone Elastic Constants At Sequential Hierarchical Levels [PhD thesis]. New York, NY: The City University of New York; 2005.
2006	Garcia D. Elastic Plastic Damage Laws for Cortical Bone [PhD thesis]. Lausanne, Switzerland: École Polytechnique Fédérale de Lausanne; 2006.
2014	Carretta R. Post-Yield Mechanics and Material Composition of Single Trabeculae: A Combined Experimental and Modelling Approach [PhD thesis]. Swiss Federal Institute of Technology Zürich; 2014.
2006	Nagaraja S. Microstructural Stresses and Strains Associated With Trabecular Bone Microdamage [PhD thesis]. Atlanta, GA: Georgia Institute of Technology; December 2006.
2012	Hamed E. Multiscale Modeling of Elastic Moduli and Strength of Bone [PhD thesis]. University of Illinois at Urbana-Champaign; 2012.
2001	Arthur Moore TL. Microdamage Accumulation in Bovine Trabecular Bone [PhD thesis]. Cambridge, MA: Massachusetts Institute of Technology; June 2001.
2015	Oftadeh R. Hierarchical Analysis and Multiscale Modelling of Cellular Structures: From Meta Materials to Bone Structure [PhD thesis]. Northeastern University; December 2015.
2007	Zhang J. Mechanical Property Determination of Bone Through Nano- and Microindentation Testing and Finite Element Simulation [PhD thesis]. University of Notre Dame; July 2007.
2010	Shi X. Effects of Architecture on Microdamage Susceptibility in Trabecular Bone [PhD thesis]. University of Notre Dame; April 2010.
2013	Toal VR. The Mechanics of Microdamage and Microfracture in Trabecular Bone [PhD thesis]. Brisbane, Australia: Queensland University of Technology; September 2013.
2011	Yao H. Microstructure-Based Characterization and Modeling of Trabecular Bone Deformation and Failure [PhD thesis]. Southern Methodist University; August 3, 2011.
2000	Niebur GL. A Computational Investigation of Multiaxial Failure in Trabecular Bone [PhD thesis]. Berkeley, CA: Berkeley, University of California; 2000.
2012	Tjhia CKH. Bone Quality of Patients With Atypical Fractures and Severely Suppressed Bone Turnover [PhD thesis]. Davis, University of California; 2012.
2020	Hamandi FMRA. Hierarchical Structure, Properties and Bone Mechanics At Macro, Micro, and Nano Levels [PhD thesis]. Dayton, OH: Wright State University; 2020.