Indentation of bone tissue:​ a short review

Zysset, P. K.

Affiliations

¹Institute of Lightweight Design and Structural Biomechanics, Vienna University of Technology (TU-Wien), Gußhausstraße 27-29, A-1040 Wien, Austria

Links

DOI: 10.1007/s00198-009-0854-9

PubMed: 19340511

WoS: 000265941900026

Cited Works (28)

Year	Entry
1998	Roschger P, Fratzl P, Eschberger J, Klaushofer K. Validation of quantitative backscattered electron imaging for the measurement of mineral density distribution in human bone biopsies. Bone. October 1998;23(4):319-326.
1999	Zysset PK, Guo XE, Hoffler CE, Moore KE, Goldstein SA. Elastic modulus and hardness of cortical and trabecular bone lamellae measured by nanoindentation in the human femur. J Biomech. October 1999;32(10):1005-1012.
1992	Blackburn J, Hodgskinson R, Currey JD, Mason JE. Mechanical properties of microcallus in human cancellous bone. J Orthop Res. March 1992;10(2):237-246.
1951	Evans FG, Lebow M. Regional differences in some of the physical properties of the human femur. J Appl Physiol. 1951;3(9):563-572.
1958	Amprino R. Investigations on some physical properties of bone tissue. Acta Anat. 1958;34(3):161-186.
2001	Swadener JG, Pharr GM. Indentation of elastically anisotropic half-spaces by cones and parabolae of revolution. Philos Mag. February 2001;81A(2):447-466.
2005	Hoffler CE, Guo XE, Zysset PK, Goldstein SA. An application of nanoindentation technique to measure bone tissue lamellae properties. J Biomech Eng. January 2005;127(7):1046-1053.
1989	Hodgskinson R, Currey JD, Evans GP. Hardness, an indicator of the mechanical competence of cancellous bone. J Orthop Res. September 1989;7(5):754-758.
2000	Hoffler CE, Moore KE, Kozloff K, Zysset PK, Brown MB, Goldstein SA. Heterogeneity of bone lamellar-level elastic moduli. Bone. June 2000;26(6):603-609.
1999	Rho JY, Zioupos P, Currey JD, Pharr GM. Variations in the individual thick lamellar properties within osteons by nanoindentation. Bone. September 1999;25(3):295-300.
1999	Rho J-Y, Pharr GM. Effects of drying on the mechanical properties of bovine femur measured by nanoindentation. J Mater Sci Mater Med. 1999;10(8):485-488.
1999	Turner CH, Rho J, Takano Y, Tsui TY, Pharr GM. The elastic properties of trabecular and cortical bone tissues are similar: results from two microscopic measurement techniques. J Biomech. April 1999;32(4):437-441.
2006	Bembey AK, Oyen ML, Bushby AJ, Boyde A. Viscoelastic properties of bone as a function of hydration state determined by nanoindentation. Philos Mag. November 21–December 11, 2006;86(33-35):5691-5703.
1992	Oliver WC, Pharr GM. An improved technique for determining hardness and elastic modulus using load and displacement sensing indentation experiments. J Mater Res. 1992;7(6):1564-1583.
2000	Hoffler CE, Moore KE, Kozloff K, Zysset PK, Goldstein SA. Age, gender, and bone lamellae elastic moduli. J Orthop Res. May 2000;18(3):432-437.
1996	Ziv V, Wagner HD, Weiner S. Microstructure-microhardness relations in parallel-fibered and lamellar bone. Bone. May 1996;18(5):417-428.
2001	Hengsberger S, Kulik A, Zysset P. A combined atomic force microscopy and nanoindentation technique to investigate the elastic properties of bone structural units. Eur Cell Mater. January–June 2001;1:12-17.
2003	Hengsberger S, Enstroem J, Peyrin F, Zysset P. How is the indentation modulus of bone tissue related to its macroscopic elastic response? a validation study. J Biomech. October 2003;36(10):1503-1509.
2002	Hengsberger S, Kulik A, Zysset P. Nanoindentation discriminates the elastic properties of individual human bone lamellae under dry and physiological conditions. Bone. 2002;30(1):178-184.
1990	Evans GP, Behiri JC, Currey JD, Bonfield W. Microhardness and Young's modulus in cortical bone exhibiting a wide range of mineral volume fractions, and in a bone analogue. J Mater Sci Mater Med. June 1990;1(1):38-43.
2006	Donnelly E, Baker SP, Boskey AL, van der Meulen MC. Effects of surface roughness and maximum load on the mechanical properties of cancellous bone measured by nanoindentation. J Biomed Mater Res. May 2006;A77(2):426-435.
2004	Bushby AJ, Ferguson VL, Boyde A. Nanoindentation of bone: comparison of specimens tested in liquid and embedded in polymethylmethacrylate. J Bone Miner Res. January 2004;19(1):249-259.
1997	Rho J-Y, Tsui TY, Pharr GM. Elastic properties of human cortical and trabecular lamellar bone measured by nanoindentation. Biomaterials. 1997;18(20):1325-1330.
2004	Oliver WC, Pharr GM. Measurement of hardness and elastic modulus by instrumented indentation: advances in understanding and refinements to methodology. J Mater Res. January 2004;19(1):3-20.
2003	Xu J, Rho JY, Mishra SR, Fan Z. Atomic force microscopy and nanoindentation characterization of human lamellar bone prepared by microtome sectioning and mechanical polishing technique. J Biomed Mater Res. December 1, 2003;A67(3):719-726.
2007	Chevalier Y, Pahr D, Allmer H, Charlebois M, Zysset P. Validation of a voxel-based FE method for prediction of the uniaxial apparent modulus of human trabecular bone using macroscopic mechanical tests and nanoindentation. J Biomech. 2007;40(15):3333-3340.
1966	Weaver JK. The microscopic hardness of bone. J Bone Joint Surg. March 1966;48A(2):273-288.
1997	Guo XE, Goldstein SA. Is trabecular bone tissue different from cortical bone tissue? Forma. 1997;12(3-4):185-196.

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Year	Entry
2018	Wu D, Isaksson P, Ferguson SJ, Persson C. Young’s modulus of trabecular bone at the tissue level: a review. Acta Biomater. September 15, 2018;78:1.
2016	Mirzaali MJ, Schwiedrzik JJ, Thaiwichai S, Best JP, Michler J, Zysset PK, Wolfram U. Mechanical properties of cortical bone and their relationships with age, gender, composition and microindentation properties in the elderly. Bone. December 2016;93:196-211.
2013	Zysset PK, Dall'Ara E, Varga P, Pahr DH. Finite element analysis for prediction of bone strength. BoneKEy Rep. August 2013;2:386.
2022	Farlay D, Falgayrac G, Ponçon C, Rizzo S, Cortet B, Chapurlat R, Penel G, Badoud I, Ammann P, Boivin G. Material and nanomechanical properties of bone structural units of cortical and trabecular iliac bone tissues from untreated postmenopausal osteoporotic women. Bone Rep. December 2022;17:101623.
2011	Donnelly E. Methods for assessing bone quality: a review. Clin Orthop Relat Res. August 2011;469:2128-2138.
2016	Hunt HB, Donnelly E. Bone quality assessment techniques: geometric, compositional, and mechanical characterization from macroscale to nanoscale. Clin Rev Bone Miner Metab. September 2016;14(3):133-149.
2012	Gross T, Pahr DH, Peyrin F, Zysset PK. Mineral heterogeneity has a minor influence on the apparent elastic properties of human cancellous bone: SRμCT-based finite element study. Comput Methods Biomech Biomed Eng. November 2012;15(11):1137-1144.
2020	Pepe V, Oliviero S, Cristofolini L, Dall’Ara E. Regional nanoindentation properties in different locations on the mouse tibia from C57BL/6 and Balb/C female mice. Front Bioeng Biotechnol. May 15, 2020;8:478.
2011	Dall'Ara E, Öhman C, Baleani M, Viceconti M. Reduced tissue hardness of trabecular bone is associated with severe osteoarthritis. J Biomech. May 17, 2011;44(8):1593-1598.
2020	Hongo H, Hasegawa T, Saito M, Tsuboi K, Yamamoto T, Sasaki M, Abe M, de Freitas PHL, Yurimoto H, Udagawa N, Li M, Amizuka N. Osteocytic osteolysis in PTH-treated wild-type and Rankl^−/− mice examined by transmission electron microscopy, atomic force microscopy, and isotope microscopy. J Histochem Cytochem. October 2020;68(10):651-668.
2011	Reisinger AG, Pahr DH, Zysset PK. Principal stiffness orientation and degree of anisotropy of human osteons based on nanoindentation in three distinct planes. J Mech Behav Biomed Mater. November 2011;4(8):2113-2127.
2020	Jin Y, Zhang T, Lui YF, Sze KY, Lu WW. The measured mechanical properties of osteoporotic trabecular bone decline with the increment of deformation volume during micro-indentation. J Mech Behav Biomed Mater. March 2020;103:103546.
2018	Guss JD. The Role of the Gut Microbiome in Bone and Joint [PhD thesis]. Ithaca, NY: Cornell University; December 2018.
2018	Hunt HB. Characterization of Material Properties, Microarchitecture, and Mechanics of Bone from Subjects With Type 2 Diabetes Mellitus [PhD thesis]. Ithaca, NY: Cornell University; December 2018.
2022	Peruzzi CRP. Nanoscale Deformation Mechanisms and Yield Prediction of Lamellar Bone [PhD thesis]. Swiss Federal Institute of Technology Zürich; 2022.
2019	Groetsch A. Micro- and Nanomechanics of Mineralised Collagen Fibre Elasto-Plasticity [PhD thesis]. Ebinburgh, Scotland: Heriot-Watt University; November 2019.
2019	Du J. Mechanical Adaptation of Human Trabecular Bone: Experimental and Computational Study [PhD thesis]. Loughborough University; 2019.
2014	Holub O. Biomechanics of Spinal Metastases [PhD thesis]. University of Leeds; April 2014.
2017	Mathavan N. The Anabolic - Anti-Catabolic Paradigm of Augmenting Skeletal Regeneration: A Bone Quality Perspective [PhD thesis]. Lund, Sweden: Lund University; 2017.
2016	Hunckler MD. Investigation of a Rabbit Ulnar Loading Model for Atypical Fractures in Cortical Bone During Long-Term Bisphosphonate Treatment [Master's thesis]. University of Notre Dame; December 2016.
2023	Ning B. In Vivo Experimental Platform Evaluating Synchronously 3D Bone Growth, (re)modeling, Microdamage and Mechanical Properties [PhD thesis]. École polytechnique de Montréal; August 2023.
2020	Karali A. Multi-Scale Evaluation of Bone Combining Indentation, in Situ XCT Mechanics and Digital Volume Correlation [PhD thesis]. Portsmouth, England: University of Portsmouth; 2020.
2013	Morton JJ. An Investigation of Rat Vertebra Failure Behaviour Under Uniaxial Compression Through Time-Lapsed Micro-CT Imaging [Master's thesis]. Queen's University; 2013.
2016	Chen Y. Verification and Validation of MicroCT-Based Finite Element Models of Bone Tissue Biomechanics [PhD thesis]. Sheffield, UK: University of Sheffield; July 2016.
2018	Costa MC. Prediction of the Risk of Vertebral Fracture in Patients With Metastatic Bone Lesions as a Tool for More Effective Patients’ Management [PhD thesis]. University of Sheffield; November 2018.
2011	Reisinger AG. Modeling and Validation of Multiscale Lamellar Bone Elasticity [PhD thesis]. Vienna University of Technology; November 2011.
2011	Spiesz EM. Experimental and Computational Micromechanics of Mineralized Tendon and Bone [PhD thesis]. Vienna University of Technology; October 2011.
2014	Gross T. Development and Application of 3d CT Image-Based Micro and Macro Finite Element Models for Human Bones and Orthopedic Implant Systems [PhD thesis]. Vienna University of Technology; 2014.
2021	Frank M. Mechanical Characterization of Individual Trabeculae [PhD thesis]. Vienna University of Technology; February 2021.
2012	Evdokimenko E. Investigation Into Mechanical Properties of Bone and Its Main Constituents [PhD thesis]. San Diego (UCSD), University of California; 2012.
2014	Schwiedrzik JJ. Experimental, Theoretical and Numerical Investigation of the Nonlinear Micromechanical Properties of Bone [PhD thesis]. Universität Bern; 2014.