Large Scale Elasto-Plastic Modelling for in Vivo Assessment of Bone Strength from High Resolution Peripheral Quantitative Computed Tomography

Osteoporosis is a “silent epidemic” of weakening bones, often leading to fracture. To predict fracture, the finite element method based on micro-computed tomography can be used, modelling bone behaviour under load. Elasto-plastic finite element modelling is able to directly calculate bone strength, but until recently it has been computationally expensive. Advancements in GPU technology have exponentially increased the computational power available in consumer-grade hardware and enabled the implementation of a custom elasto-plastic finite element solver for large-scale models. Both analytical and mechanical validation of the elasto-plastic solver was performed. Elasto-plastic finite element models based on tomography data were able to predict failure load with a correlation coefficient of 0.81. These new developments in elasto-plastic finite element modelling have enabled the direct estimation of patient-specific yield properties on consumer-grade hardware.

Year	Entry
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Year

Entry

2006

Khosla S, Riggs BL, Atkinson EJ, Oberg AL, McDaniel LJ, Holets M, .Peterson JM, Melton LJ III. Effects of sex and age on bone microstructure at the ultradistal radius: a population-based noninvasive in vivo assessment. J Bone Miner Res. January 2006;21(1):124-131.

2007

MacNeil JA, Boyd SK. Accuracy of high-resolution peripheral quantitative computed tomography for measurement of bone quality. Med Eng Phys. December 2007;29(10):1096-1105.

2008

MacNeil JA, Boyd SK. Bone strength at the distal radius can be estimated from high-resolution peripheral quantitative computed tomography and the finite element method. Bone. June 2008;42(6):1203-1213.

1996

Rüegsegger P, Koller B, Müller R. A microtomographic system for the nondestructive evaluation of bone architecture. Calcif Tiss Int. 1996;58(1):24-29.

2002

Pistoia W, van Rietbergen B, Lochmüller E-M, Lill CA, Eckstein F, Rüegsegger P. Estimation of distal radius failure load with micro-finite element analysis models based on three-dimensional peripheral quantitative computed tomography images. Bone. June 2002;30(6):842-848.