Mechanical properties of porcine femoral cortical bone measured by nanoindentation

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Feng, Liang¹; Chittenden, Michael¹; Schirer, Jeffrey³; Dickinson, Michelle⁴; Jasiuk, Iwona^1,2

Mechanical properties of porcine femoral cortical bone measured by nanoindentation

J Biomech. June 26, 2012;45(10):1775-1782

©2012 Elsevier Ltd. All rights reserved.

Affiliations

¹Department of Mechanical Science and Engineering, University of Illinois Urbana-Champaign, Urbana, IL 61801, USA

²Department of Bioengineering, University of Illinois Urbana-Champaign, Urbana, IL 61801, USA

³Hysitron Inc., 9625 West 76th Street, Minneapolis, MN 55344, USA

⁴Department of Chemical and Materials Engineering, University of Auckland, 92019 Auckland, New Zealand
Abstract and keywords

This study uses a nanoindentation technique to examine variations in the local mechanical properties of porcine femoral cortical bone under hydrated conditions. Bone specimens from three age groups (6, 12 and 42 months), representing developing bone, ranging from young to mature animals, were tested on the longitudinal and transverse cross-sectional surfaces. Elastic modulus and hardness of individual lamellae within bone's microstructure: laminar bone, interstitial bone, and osteons, were measured. Both the elastic modulus and hardness increased with age. However, the magnitudes of these increases were different for each microstructural component. The longitudinal moduli were higher than the transverse moduli. Dehydrated samples were also tested to allow a comparison with hydrated samples and these resulted in higher moduli and hardness than the hydrated samples. Ag+++ MAain, the degree of variation was different for each microstructural component. These results indicate that the developmental changes in bone have different rates of mechanical change within each microstructural component.

Keywords: Nanoindentation; Cortical bone; Elastic moduli; Hardness; Age; Laminar bone; Interstitial lamellae; Osteons
Links

DOI: 10.1016/j.jbiomech.2012.05.001

PubMed: 22648144

WoS: 000306451800004
History

Accepted: 2012-05-1

Online: 2012-05-28

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