Bone microdamage and skeletal fragility in osteoporotic and stress fractures

Burr, David B.; Forwood, Mark R.; Fyhrie, David P.; Martin, R. Bruce; Schaffler, Mitchell B.; Turner, Charles H.

Year	Entry
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2022	Yan C, Bice RJ, Frame JW, Warden SJ, Kersh ME. Multidirectional basketball activities load different regions of the tibia: a subject-specific muscle-driven finite element study. Bone. June 2022;159:116392.
2007	Allen MR, Burr DB. Mineralization, microdamage, and matrix: how bisphosphonates influence material properties of bone. BoneKEy Osteovision. February 2007;4(2):49-60.
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2018	Yan C. Effect of Fatigue Loading on Impact Response of Rat Ulna [Master's thesis]. University of Illinois at Urbana-Champaign; 2018.
2002	Hudson JA. The Ontogeny of Transverse Femoral Geometry and Bone Modeling in the Ward Skeletal Population [PhD thesis]. Kent State University; August 2002.
2020	Jazinizadeh F. Assessment of Hip Fracture Risk in Older Adults by Considering the Effect of Geometry and Bone Mineral Density Distribution in the Femur Using Single Dual-Energy X-Ray Absorptiometry Scans [PhD thesis]. Hamilton, ON: McMaster University; August 2020.
2001	Arthur Moore TL. Microdamage Accumulation in Bovine Trabecular Bone [PhD thesis]. Cambridge, MA: Massachusetts Institute of Technology; June 2001.
2007	Tai K. Nanomechanics and Ultrastructural Studies of Cortical Bone: Fundamental Insights Regarding Structure-Function, Mineral-Organic Force Mechanics Interactions, and Heterogeneity [PhD thesis]. Cambridge, MA: Massachusetts Institute of Technology; June 2007.
2008	Courtland H-W. Intra-Species Variation in Skeletal Mechanical Function is Achieved Through Genetic Regulation of Both the Quality and Morphology of Bone [PhD thesis]. Mount Sinai School of Medicine; 2008.
2008	Herman BC. Osteocytes and Activation of Bone Remodeling [PhD thesis]. Mount Sinai School of Medicine; 2008.
2007	Smith IO. The Effect of Grain Size, Microcracking and Grain Boundary Grooving on Osteoblast Attachment in Hydroxyapatite [PhD thesis]. East Lansing, MI: Michigan State University; 2007.
2015	Oftadeh R. Hierarchical Analysis and Multiscale Modelling of Cellular Structures: From Meta Materials to Bone Structure [PhD thesis]. Northeastern University; December 2015.
2019	Ghiasi MS. Mechanobiological Modeling on Bone Fracture Healing [PhD thesis]. Northeastern University; December 2019.
2004	Tovar A. Bone Remodeling as a Hybrid Cellular Automaton Optimization Process [PhD thesis]. University of Notre Dame; December 2004.
2004	Wang X. Measurement and Analysis of Microdamage in Bone [PhD thesis]. University of Notre Dame; December 2004.
2006	Leng H. Micro-Computed Tomography of Microdamage in Cortical Bone [PhD thesis]. University of Notre Dame; May 2006.
2010	Shi X. Effects of Architecture on Microdamage Susceptibility in Trabecular Bone [PhD thesis]. University of Notre Dame; April 2010.
2011	Garrison JG. The Relative Importance of Stress State, Microarchitecture, and Damage Burden in the Failure Behavior of Trabecular Bone [PhD thesis]. University of Notre Dame; April 2011.
2011	Ross RD. Functionalized Gold Nanoparticles as Damage-Specific X-Ray Computed Tomography Contrast Agents in Bone Tissue [PhD thesis]. University of Notre Dame; November 2011.
2011	Wu Z. Measures of Bone Quality and Their Relationship to Bone Mechanical Properties [PhD thesis]. University of Notre Dame; December 2011.
2013	Turnbull TL. The Spatial Distribution of Fatigue Microdamage Accumulation in Cortical Bone and Factors Influencing Fracture Risk [PhD thesis]. University of Notre Dame; July 2013.
2015	Gargac J. Evaluation of Bone Healing, Damage, and Adaptation Using Computational Modeling and Image Processing Techniques [PhD thesis]. University of Notre Dame; July 2015.
2017	Kreipke TC. Structural, Mechanical, and Biological Relationships of Trabecular Bone in Osteoporosis [PhD thesis]. University of Notre Dame; April 2017.
2020	O’Sullivan LM. Time-Sequence of Biomechanical Adaption in Trabecular Tissue During Estrogen Deficiency [PhD thesis]. National University of Ireland Galway; March 2020.
2011	Agnew AM. Histomorphometry of the Elderly Rib: A Methodological Approach With Implications for Biomechanics, Function, and Fracture Risk [PhD thesis]. The Ohio State University; 2011.
2018	Dominguez VM. Defining Bone Quality: Cortical Microdamage and Its Contribution to Fracture Risk in the Human Rib [PhD thesis]. The Ohio State University; 2018.
2004	Sasimontonkul S. Do Running and Fatigued Running Relate to Tibial Stress Fractures? [PhD thesis]. Oregon State University; 2004.
2013	Gaddini GW. Effects of 12 Months of Voluntary Alcohol Self-Administration on Intracortical Bone Remodeling in a Rhesus Macaque Model [Master's thesis]. Oregon State University; 2013.
2023	Ning B. In Vivo Experimental Platform Evaluating Synchronously 3D Bone Growth, (re)modeling, Microdamage and Mechanical Properties [PhD thesis]. École polytechnique de Montréal; August 2023.
2012	Sun X. Mechanically Induced Calcium Efflux from Bone Matrix Stimulates Osteoblasts [PhD thesis]. Purdue University; May 2012.
2015	Clauser CA. In Vivo Tibial Loading of Healthy and Osteolathrytic Mice [Master's thesis]. Indianapolis, IN: Purdue University; May 2015.
2012	Jimenez Palomar I. Mechanical Properties of Bone At the Sub-lamellar Level [PhD thesis]. London, England: Queen Mary University of London; September 2012.
2021	Zojaji M. Quantifying the Accuracy of Euler-Bernoulli and Timoshenko Beam Theories for Long Bones in Three- and Four-Point Bend Tests With Finite Element Analysis [Master's thesis]. Queen's University; September 2021.
2013	Toal VR. The Mechanics of Microdamage and Microfracture in Trabecular Bone [PhD thesis]. Brisbane, Australia: Queensland University of Technology; September 2013.
2009	Lancianese SL. Modeling the Effect of Obesity and Related Biomechanical Risk Factors on the Onset of Knee Osteoarthritis [PhD thesis]. University of Rochester; 2009.
2001	Kim DG. Micromechanical Analysis of Bone At a Bone-Implant Interface [PhD thesis]. Troy, NY: Rensselaer Polytechnic Institute; April 2001.
2005	George WT. Multiaxial Fracture Characteristics of Aging Human Bone [PhD thesis]. Troy, NY: Rensselaer Polytechnic Institute; April 2005.
2006	Diab T. The Role of Damage Morphology in Age-Related Increase in Bone Fragility [PhD thesis]. Troy, NY: Rensselaer Polytechnic Institute; 2006.
2010	Janeiro C. The Effect of Bone Quality on Osteoclastic Bone Resorption [PhD thesis]. Troy, NY: Rensselaer Polytechnic Institute; May 2010.
2011	Karim L. The Biomolecular Basis of Bone Fracture [PhD thesis]. Troy, NY: Rensselaer Polytechnic Institute; November 2011.
2014	Bradke BS. The Role of Cortical and Cancellous Bone Quality on Vertebral Fragility [PhD thesis]. Troy, NY: Rensselaer Polytechnic Institute; April 2014.
2009	Ruppel ME. Alterations in the Mineral and Collagen Matrix of Bisphosphonate-Treated Bone and Osteoblasts [PhD thesis]. Stony Brook, NY: Stony Brook University; May 2009.
2011	Lin L. Simulation and in Vitro Studies of Transverse Ultrasound Attenuation in Cortical Bone [Master's thesis]. Stony Brook, NY: Stony Brook University; May 2011.
2008	Kennedy OD. The Effect of Bone Turnover on Bone Quality and Material Properties [PhD thesis]. Trinity College Dublin; 2008.
2021	Frank M. Mechanical Characterization of Individual Trabeculae [PhD thesis]. Vienna University of Technology; February 2021.
2005	Ashe MC. Upper Limb Bone Health: Cadaveric, Imaging and Clinical Studies With Special Emphasis on Peripheral Quantitative Computed Tomography [PhD thesis]. Vancouver, BC: University of British Columbia; April 2005.
2018	Alousaimi H. A Study of Bone Quality in Femoral Neck of Osteoarthritis [Master's thesis]. Vancouver, BC: University of British Columbia; August 2018.
2017	Fung A. Experimental Validation of Finite Element Predicted Bone Strain in the Human Metatarsal [Master's thesis]. Calgary, AB: University of Calgary; April 2017.
2023	Bruce OL. Tibial-Fibular Morphology: Variation, Sexual Dimorphism, and Mechanical Implications [PhD thesis]. Calgary, AB: University of Calgary; May 2023.
2002	Morgan EF-i. The Dependence on Anatomic Site of Trabecular Bone Structure-Function Relationships [PhD thesis]. Berkeley, CA: Berkeley, University of California; 2002.
2003	Bayraktar HH. Multiaxial Strength and Micromechanics of Human Bone [PhD thesis]. Berkeley, CA: Berkeley, University of California; 2003.
1999	Donahue SW. Bone Strain and Microdamage At Stress Fracture Sites in Human Metatarsals [PhD thesis]. Davis, University of California; 1999.
2003	Nyman JS. Simulations of Bone Adaptation to Total Knee Arthroplasty and Bisphosphonates Through Remodeling Stimulated by Microdamage and Disuse [PhD thesis]. Davis, University of California; 2003.
2004	Castillo AB. The Female Ferret (Mustela Putorius Furo) as an in Vivo Model for Skeletal Research [PhD thesis]. Davis, University of California; 2004.
2012	Hardisty MR. Not Tough Enough: Why Bone Turns Pale When it Feels Stressed [PhD thesis]. Davis, CA: Davis, University of California; 2012.
2012	Tjhia CKH. Bone Quality of Patients With Atypical Fractures and Severely Suppressed Bone Turnover [PhD thesis]. Davis, University of California; 2012.
2013	Wang Y-K. Multi-Level Micromechanical Modeling of Bone Tissues [PhD thesis]. Los Angeles, CA: Los Angeles, University of California; 2013.
2016	Jones DA. Reference Point Indentation of Human Trabecular Bone Treated With Bisphosphonates for Varying Durations [Master's thesis]. University of Kentucky; 2016.
1998	Ciarelli TE. Architectural and Material Contributions to Fracture of the Spine and Proximal Femur [PhD thesis]. University of Michigan; 1998.
2003	Rajachar RM. Effects of Age -Related Ultra-Structural Level Changes in Bone on Microdamage Mechanisms [PhD thesis]. University of Michigan; 2003.
2007	Wallace JM III. Investigating the Inbred Strain-Specific Response to Biglycan-Deficiency and Exercise: A Study in Genetically-Mediated Skeletal Adaptation [PhD thesis]. University of Michigan; 2007.
2008	Waldorff EI. Effects of Aging and Disuse on Bone Remodeling in Response to Microdamage [PhD thesis]. University of Michigan; 2008.
2009	Sahar ND. Investigating the Effects of Age and Exercise on Bone Composition and the Impact of Composition on Mechanical Integrity. [PhD thesis]. University of Michigan; 2009.
2023	Zweifler L. The Role of Turnover and Inflammation in Bone [PhD thesis]. University of Michigan; 2023.
2019	Martig S. Compressive Fatigue Life and Micromorphology of Equine Metacarpal Subchondral Bone [PhD thesis]. University of Melbourne; June 2019.
2011	Wolfram U. Mechanical Multiscale Characterisation of Vertebral Trabecular Bone for the Prediction of Vertebral Fracture Risk [PhD thesis]. University of Ulm; 2011.
2014	Carter Y. Quantitative Imaging of Sex and Age Differences in Human Cortical Bone Osteocyte Lacunae [PhD thesis]. University of Saskatchewan; July 2014.
2018	Burnett WD. Relationships Between Image-Based and Mechanical Bone Properties With Pain in Knee Osteoarthritis [PhD thesis]. University of Saskatchewan; July 2018.
2021	Harrison KD. A Novel in Vivo Synchrotron Radiation Micro-CT Imaging Platform for the Direct Tracking of Remodeling Events in Cortical Bone [PhD thesis]. University of Saskatchewan; December 2021.
2013	Eleazer CD. The Interaction of Mechanical Loading and Metabolic Stress on Human Cortical Bone: Testing Anthropological Assumptions Using Cross-Sectional Geometry and Histomorphology [PhD thesis]. Knoxville, University of Tennessee; August 2013.
2017	Gooding AF. Variation in Cortical Bone Distribution in the Aging Adult Appendicular Skeleton [PhD thesis]. Knoxville, University of Tennessee; December 2017.
2010	Wynnyckyj C. The Consequences of Collagen Degradation on Bone Mechanical Properties [PhD thesis]. University of Toronto; 2010.
2009	Nakade R. Influence of Interfacial Properties and Inhomogeneity on Formation of Microdamage in Bone [Master's thesis]. San Antionio, TX: University of Texas at San Antonio; December 2009.
2010	Banka M. Microdamage Induced Collagen Denaturation in Bone [Master's thesis]. San Antionio, TX: University of Texas at San Antonio; December 2010.
2010	Reyes MJ. Age-Related Influence of Bone Remodeling on Local Tissue Properties of Human Cortical Bone [PhD thesis]. San Antionio, TX: University of Texas at San Antonio; December 2010.
2013	Mahmud K. Intrafibrillar Damage Accumulation & the Contribution of Extrafibrillar Mineral to Bone Elastic Modulus [Master's thesis]. San Antionio, TX: University of Texas at San Antonio; August 2013.
2013	Mostafa AJ. The Effect of Advadvanced Glycation Endproducts (AGES) on Bone Formation [Master's thesis]. San Antionio, TX: University of Texas at San Antonio; August 2013.
2017	Kirby ML. Digital Modeling of Trabecular Bones: Structural Analysis and Probabilistic Modeling Techniques [Master's thesis]. San Antionio, TX: University of Texas at San Antonio; August 2017.
1998	Yeni YN. Fracture Mechanics of Human Cortical Bone: The Relationship of Geometry, Microstructure and Composition With the Fracture of the Tibia, Femoral Shaft and the Femoral Neck [PhD thesis]. West Virginia University; 1998.
2001	Parsamian GP. Damage Mechanics of Human Cortical Bone [PhD thesis]. West Virginia University; 2001.

Year	Entry
1990	Schaffler MB, Radin EL, Burr DB. Long-term fatigue behavior of compact bone at low strain magnitude and rate. Bone. 1990;11(5):321-326.
1993	Goldstein SA, Goulet R, McCubbrey D. Measurement and significance of three-dimensional architecture to the mechanical integrity of trabecular bone. Calcif Tiss Int. February 1993;53(suppl 1):S127-S133.
1988	Schaffler MB, Burr DB. Stiffness of compact bone: effects of porosity and density. J Biomech. 1988;21(1):13-16.
1993	Balena R, Toolan BC, Shea M, Markatos A, Myers ER, Lee SC, Opas EE, Seedor JG, Klein H, Frankenfield D, Quartuccio H, Fioravanti C, Clair J, Brown E, Hayes WC, Rodan GA. The effects of 2-year treatment with the aminobisphosphonate alendronate on bone metabolism, bone histomorphometry, and bone strength in ovariectomized nonhuman primates. J Clin Invest. December 1993;92(6):2577-2586.
1985	Burr DB, Martin RB, Schaffler MB, Radin EL. Bone remodeling in response to in vivo fatigue microdamage. J Biomech. 1985;18(3):189-200.
1989	Schaffler MB, Radin EL, Burr DB. Mechanical and morphological effects of strain rate on fatigue of compact bone. Bone. 1989;10(3):207-214.
1987	Fazzalari NL, Vernon-Roberts B, Darracott J. Osteoarthritis of the hip: possible protective and causative roles of trabecular microfractures in the head of the femur. Clin Orthop Relat Res. March 1987;216:224-233.
1960	Frost HM. Presence of microscopic cracks in vivo in bone. Henry Ford Hosp Med Bull. 1960;8(1):25-35.
1977	Carter DR, Hayes WC. Compact bone fatigue damage, I: residual strength and stiffness. J Biomech. 1977;10(5-6):325-337.
1977	Carter DR, Hayes WC. Compact bone fatigue damage: a microscopic examination. Clin Orthop Relat Res. September 1977;127:265-274.
1993	Mori S, Burr DB. Increased intracortical remodeling following fatigue damage. Bone. March–April 1993;14(2):103-109.
1994	Compston JE. Connectivity of cancellous bone: assessment and mechanical implications. Bone. September–October 1994;15(5):463-466.
1991	Consensus development conference: prophylaxis and treatment of osteoporosis. Am J Med. January 1991;90(1):107-110.
1995	Forwood MR, Burr DB, Takano Y, Eastman DF, Smith PN, Schwardt JD. Risedronate treatment does not increase microdamage in the canine femoral neck. Bone. June 1995;16(6):643-650.
1993	Nevitt MC, Cummings SR; Study of Osteoporofic Fractures Research Group. Type of fall and risk of hip and wrist fractures: the study of osteoporotic fractures. J Am Geriatr Soc. November 1993;41(11):1226-1234.
1976	Wainwright SA, Biggs WD, Currey JD, Gosline JM. Mechanical Design in Organisms. London, UK: Edward Arnold; 1976.
1989	Frost HM. Transient-steady state phenomena in microdamage physiology: a proposed algorithm for lamellar bone. Calcif Tiss Int. June 1989;44(6):367-381.
1977	Carter DR, Hayes WC. The compressive behavior of bone as a two-phase porous structure. J Bone Joint Surg. 1977;59A(7):954-962.
1993	Hayes WC, Myers ER, Morris JN, Gerhart TN, Yett HS, Lipsitz LA. Impact near the hip dominates fracture risk in elderly nursing home residents who fall. Calcif Tiss Int. March 1993;52(3):192-198.
1991	Hayes WC, Piazza SJ, Zysset PK. Biomechanics of fracture risk prediction of the hip and spine by quantitative computed tomography. Radiol Clin North Am. 1991;29(1):1-18.
1996	Pattin CA, Caler WE, Carter DR. Cyclic mechanical property degradation during fatigue loading of cortical bone. J Biomech. January 1996;29(1):69-79.
1988	Rice JC, Cowin SC, Bowman JA. On the dependence of the elasticity and strength of cancellous bone on apparent density. J Biomech. 1988;21(2):155-168.
1989	Forwood MR, Parker AW. Microdamage in response to repetitive torsional loading in the rat tibia. Calcif Tiss Int. July 1989;45(1):47-53.
1988	Hui SL, Slemenda CW, Johnston CC Jr. Age and bone mass as predictors of fracture in a prospective study. J Clin Invest. June 1988;81(6):1804-1809.
1994	Schaffler MB, Pitchford WC, Choi K, Riddle JM. Examination of compact bone microdamage using back-scattered electron microscopy. Bone. September–October 1994;15(5):483-488.
1995	Schaffler MB, Choi K, Milgrom C. Aging and matrix microdamage accumulation in human compact bone. Bone. December 1995;17(6):521-525.
1996	Wenzel TE, Schaffler MB, Fyhrie DP. In vivo trabecular microcracks in human vertebral bone. Bone. August 1996;19(2):89-95.
1993	Burr DB, Martin RB. Calculating the probability that microcracks initiate resorption spaces. J Biomech. April–May 1993;26(4-5):613-616.
1990	Jensen KS, Mosekilde L, Mosekilde L. A model of vertebral trabecular bone architecture and its mechanical properties. Bone. 1990;11(6):417-423.
1994	Fyhrie DP, Schaffler MB. Failure mechanisms in human vertebral cancellous bone. Bone. 1994;15(1):105-109.
1994	Greenspan SL, Myers ER, Maitland LA, Resnick NM, Hayes WC. Fall severity and bone mineral density as risk factors for hip fracture in ambulatory elderly. JAMA. January 12, 1994;271(2):128-133.
1995	Burr DB, Hooser M. Alterations to the en bloc basic fuchsin staining protocol for the demonstration of microdamage produced in vivo. Bone. October 1995;17(4):431-433.
1995	Martin B. Mathematical model for repair of fatigue damage and stress fracture in osteonal bone. J Orthop Res. May 1995;13(3):309-316.
1993	Burr DB. Remodeling and the repair of fatigue damage. Calcif Tiss Int. February 1993;53(suppl 1):S75-S81.
1990	Burr DB, Stafford T. Validity of the bulk-staining technique to separate artifactual from in vivo bone microdamage. Clin Orthop Relat Res. November 1990;260:305-308.
1994	Zioupos P, Currey JD. The extent of microcracking and the morphology of microcracks in damaged bone. J Mater Sci. 1994;29(4):978-986.
1998	Burr DB, Turner CH, Naick P, Forwood MR, Ambrosius W, Hasan MS, Pidaparti R. Does microdamage accumulation affect the mechanical properties of bone? J Biomech. April 1998;31(4):337-345.