Schaffler, Mitchell B.

Links

AcademicTree: 381009

Academic genealogy

Doctoral Descendants

Affiliations (7)

Name	Count	Oldest	Newest
Henry Ford Health System	4	1994	1998
Mount Sinai School of Medicine	23	1998	2010
The City College of New York	15	2005	2022
Henry Ford Hospital	6	1990	1997
West Virginia University	6	1985	1989
The City University of New York	3	2005	2015
University of California, San Diego (UCSD)	2	1989	1989

Papers (53)

Year	Article	Times Cited	Times Cited (no self-citations)
1987	Schaffler MB, Burr DB, Frederickson RG. Morphology of the osteonal cement line in human bone. Anat Rec. March 1987;217(3):223-228.	57	52
2009	McNamara LM, Majeska RJ, Weinbaum S, Friedrich V, Schaffler MB. Attachment of osteocyte cell processes to the bone matrix. Anat Rec. March 2009;292(3):355-363.	42	31
2004	You L, Weinbaum S, Cowin SC, Schaffler MB. Ultrastructure of the osteocyte process and its pericellular matrix. Anat Rec. June 2004;278A(2):505-513.	78	59
1989	Schaffler MB, Radin EL, Burr DB. Mechanical and morphological effects of strain rate on fatigue of compact bone. Bone. 1989;10(3):207-214.	121	108
1989	Burr DB, Schaffler MB, Yang KH, Wu DD, Lukoschek M, Kandzari D, Sivaneri N, Blaha JD, Radin EL. The effects of altered strain environments on bone tissue kinetics. Bone. 1989;10(3):215-221.	28	26
1989	Burr DB, Schaffler MB, Yang KH, Lukoschek M, Sivaneri N, Blaha JD, Radin EL. Skeletal change in response to altered strain environments: is woven bone a response to elevated strain? Bone. 1989;10(3):223-233.	44	42
1990	Schaffler MB, Radin EL, Burr DB. Long-term fatigue behavior of compact bone at low strain magnitude and rate. Bone. 1990;11(5):321-326.	86	68
1994	Fyhrie DP, Schaffler MB. Failure mechanisms in human vertebral cancellous bone. Bone. 1994;15(1):105-109.	138	125
1994	Schaffler MB, Pitchford WC, Choi K, Riddle JM. Examination of compact bone microdamage using back-scattered electron microscopy. Bone. September–October 1994;15(5):483-488.	89	83
1995	Schaffler MB, Choi K, Milgrom C. Aging and matrix microdamage accumulation in human compact bone. Bone. December 1995;17(6):521-525.	224	210
1996	Wenzel TE, Schaffler MB, Fyhrie DP. In vivo trabecular microcracks in human vertebral bone. Bone. August 1996;19(2):89-95.	92	78
1998	Bentolila V, Boyce TM, Fyhrie DP, Drumb R, Skerry TM, Schaffler MB. Intracortical remodeling in adult rat long bones after fatigue loading. Bone. September 1998;23(3):275-281.	129	102
2000	Vashishth D, Koontz J, Qiu SJ, Lundin-Cannon D, Yeni YN, Schaffler MB, Fyhrie DP. In vivo diffuse damage in human vertebral trabecular bone. Bone. February 2000;26(2):147-152.	108	80
2000	Vashishth D, Verborgt O, Divine G, Schaffler MB, Fyhrie DP. Decline in osteocyte lacunar density in human cortical bone is associated with accumulation of microcracks with age. Bone. April 2000;26(4):375-380.	62	55
2001	Vashishth D, Gibson GJ, Khoury JI, Schaffler MB, Kimura J, Fyhrie DP. Influence of nonenzymatic glycation on biomechanical properties of cortical bone. Bone. February 2001;28(2):195-201.	147	108
2001	Hausman MR, Schaffler MB, Majeska RJ. Prevention of fracture healing in rats by an inhibitor of angiogenesis. Bone. December 2001;29(6):560-564.	30	30
2004	Akkus O, Adar F, Schaffler MB. Age-related changes in physicochemical properties of mineral crystals are related to impaired mechanical function of cortical bone. Bone. March 2004;34(4):443-453.	107	101
2004	Hernandez CJ, Majeska RJ, Schaffler MB. Osteocyte density in woven bone. Bone. November 2004;35(5):1095-1099.	13	12
2006	McNamara LM, Ederveen AGH, Lyons CG, Price C, Schaffler MB, Weinans H, Prendergast PJ. Strength of cancellous bone trabecular tissue from normal, ovariectomized and drug-treated rats over the course of ageing. Bone. August 2006;39(2):392-400.	38	27
2010	Emerton K, Hu B, Woo A, Sinofsky A, Hernandez C, Majeska R, Jepsen K, Schaffler M. Osteocyte apoptosis and control of bone resorption following ovariectomy in mice. Bone. March 2010;46(3):577-583.	18	12
2010	Herman BC, Cardoso L, Majeska RJ, Jepsen KJ, Schaffler MB. Activation of bone remodeling after fatigue: differential response to linear microcracks and diffuse damage. Bone. October 2010;47(4):766-772.	26	22
2011	Lynch ME, Main RP, Xu Q, Schmicker TL, Schaffler MB, Wright TM, van der Meulen MCH. Tibial compression is anabolic in the adult mouse skeleton despite reduced responsiveness with aging. Bone. September 2011;49(3):439-446.	39	26
2012	Kennedy OD, Herman BC, Laudier DM, Majeska RJ, Sun HB, Schaffler MB. Activation of resorption in fatigue-loaded bone involves both apoptosis and active pro-osteoclastogenic signaling by distinct osteocyte populations. Bone. May 2012;50(5):1115-1122.	33	22
2014	Kennedy OD, Laudier DM, Majeska RJ, Sun HB, Schaffler MB. Osteocyte apoptosis is required for production of osteoclastogenic signals following bone fatigue in vivo. Bone. July 2014;64:132-137.	20	14
2005	Seref-Ferlengez Z, Kennedy OD, Schaffler MB. Bone microdamage, remodeling and bone fragility: how much damage is too much damage? BoneKEy Rep. March 18, 2005;4:644.	0	0
2015	Seref-Ferlengez Z, Kennedy OD, Schaffler MB. Bone microdamage, remodeling and bone fragility: how much damage is too much damage? BoneKEy Rep. March 2015;4:644.	34	32
2014	Schaffler MB, Cheung W-Y, Majeska R, Kennedy O. Osteocytes: master orchestrators of bone. Calcif Tiss Int. January 2014;94(1):5-24.	58	52
2010	Lynch ME, Main RP, Xu Q, Walsh DJ, Schaffler MB, Wright TM, van der Meulen MCH. Cancellous bone adaptation to tibial compression is not sex dependent in growing mice. J Appl Physiol. September 2010;109(3):685-691.	43	26
1985	Burr DB, Martin RB, Schaffler MB, Radin EL. Bone remodeling in response to in vivo fatigue microdamage. J Biomech. 1985;18(3):189-200.	274	215
1988	Schaffler MB, Burr DB. Stiffness of compact bone: effects of porosity and density. J Biomech. 1988;21(1):13-16.	194	182
1988	Burr DB, Schaffler MB, Frederickson RG. Composition of the cement line and its possible mechanical role as a local interface in human compact bone. J Biomech. 1988;21(11):939-945.	137	126
1997	Jepsen KJ, Schaffler MB, Kuhn JL, Goulet RW, Bonadio J, Goldstein SA. Type I collagen mutation alters the strength and fatigue behavior of Mov13 cortical tissue. J Biomech. November–December 1997;30(11-12):1141-1147.	54	46
2001	You L, Cowin SC, Schaffler MB, Weinbaum S. A model for strain amplification in the actin cytoskeleton of osteocytes due to fluid drag on pericellular matrix. J Biomech. November 2001;34(11):1375-1386.	101	75
2004	McCreadie BR, Hollister SJ, Schaffler MB, Goldstein SA. Osteocyte lacuna size and shape in women with and without osteoporotic fracture. J Biomech. April 2004;37(4):563-572.	36	32
2010	Fung DT, Wang VM, Andarawis-Puri N, Basta-Pljakic J, Li Y, Laudier DM, Sun HB, Jepsen KJ, Schaffler MB, Flatow EL. Early response to tendon fatigue damage accumulation in a novel in vivo model. J Biomech. January 19, 2010;43(2):274-279.	24	20
1997	Burr DB, Forwood MR, Fyhrie DP, Martin RB, Schaffler MB, Turner CH. Bone microdamage and skeletal fragility in osteoporotic and stress fractures. J Bone Miner Res. January 1997;12(1):6-15.	214	177
2000	Ciarelli TE, Fyhrie DP, Schaffler MB, Goldstein SA. Variations in three‐dimensional cancellous bone architecture of the proximal femur in female hip fractures and in controls. J Bone Miner Res. 2000;15(1):32-40.	88	81
2000	Verborgt O, Gibson GJ, Schaffler MB. Loss of osteocyte integrity in association with microdamage and bone remodeling after fatigue in vivo. J Bone Miner Res. January 2000;15(1):60-67.	156	134
2002	Verborgt O, Tatton NA, Majeska RJ, Schaffler MB. Spatial distribution of Bax and Bcl-2 in osteocytes after bone fatigue: complementary roles in bone remodeling regulation? J Bone Miner Res. May 2002;17(5):907-914.	38	24
2003	Akkus O, Polyakova‐Akkus A, Adar F, Schaffler MB. Aging of microstructural compartments in human compact bone. J Bone Miner Res. June 2003;18(6):1012-1019.	69	63
2005	Tommasini SM, Nasser P, Schaffler MB, Jepsen KJ. Relationship between bone morphology and bone quality in male tibias: implications for stress fracture risk. J Bone Miner Res. August 2005;20(8):1372-1380.	23	16
2009	Cardoso L, Herman BC, Verborgt O, Laudier D, Majeska RJ, Schaffler MB. Osteocyte apoptosis controls activation of intracortical resorption in response to bone fatigue. J Bone Miner Res. April 2009;24(4):597-605.	51	39
2016	Cabahug-Zuckerman P, Frikha-Benayed D, Majeska RJ, Tuthill A, Yakar S, Judex S, Schaffler MB. Osteocyte apoptosis caused by hindlimb unloading is required to trigger osteocyte RANKL production and subsequent resorption of cortical and trabecular bone in mice femurs. J Bone Miner Res. July 2016;31(7):1356-1365.	28	25
2020	McCutcheon S, Majeska RJ, Spray DC, Schaffler MB, Vazquez M. Apoptotic osteocytes induce RANKL production in bystanders via purinergic signaling and activation of pannexin channels. J Bone Miner Res. May 2020;35(5):966-977.	2	2
2022	Dixit M, Louis LD, Basta-Pljakic J, Yildirim G, Poudel S-B, Kumararaja F, List EO, Duran SO, Kopchick JJ, Ruff RR, Schaffler MB, Yakar S. Lifelong excess in gh elicits sexually dimorphic effects on skeletal morphology and bone mechanical properties. J Bone Miner Res. November 2022;37(11):2201-2214.	0	0
1996	Jepsen KJ, Goldstein SA, Kuhn JL, Schaffler MB, Bonadio J. Type‐I collagen mutation compromises the post‐yield behavior of Mov13 long bone. J Orthop Res. May 1996;14(3):493-499.	60	48
1998	Boyce TM, Fyhrie DP, Glotkowski MC, Radin EL, Schaffler MB. Damage type and strain mode associations in human compact bone bending fatigue. J Orthop Res. May 1998;16(3):322-329.	119	103
1997	Burr DB, Schaffler MB. The involvement of subchondral mineralized tissues in osteoarthrosis: quantitative microscopic evidence. Microsc Res Tech. May 15, 1997;37(4):343-357.	26	24
2003	Schaffler MB. Role of bone turnover in microdamage. Osteoporos Int. September 2003;14(suppl 5):S73-S80.	29	21
2004	Han Y, Cowin SC, Schaffler MB, Weinbaum S. Mechanotransduction and strain amplification in osteocyte cell processes. Proc Natl Acad Sci USA. November 23, 2004;101(47):16689-16694.	103	90
2005	Wang L, Wang Y, Han Y, Henderson SC, Majeska RJ, Weinbaum S, Schaffler MB. In situ measurement of solute transport in the bone lacunar-canalicular system. Proc Natl Acad Sci USA. August 16, 2005;102(46):11911-11916.	48	39
2007	Wang Y, McNamara LM, Schaffler MB, Weinbaum S. A model for the role of integrins in flow induced mechanotransduction in osteocytes. Proc Natl Acad Sci USA. October 2, 2007;104(40):15941-15946.	41	30
2013	Thi MM, Suadicani SO, Schaffler MB, Weinbaum S, Spray DC. Mechanosensory responses of osteocytes to physiological forces occur along processes and not cell body and require αᵥβ₃ integrin. Proc Natl Acad Sci USA. December 24, 2013;110(52):21012-21017.	24	21

Theses (1)

Year	Article	Times Cited	Times Cited (no self-citations)
1985	Schaffler MB. Stiffness and Fatigue of Compact Bone At Physiological Strains and Strain Rates [PhD thesis]. Morgantown, WV: West Virginia University; 1985.	12	8

Student Theses (11)

Year	Article	Times Cited	Times Cited (no self-citations)
2003	Verborgt O. Osteocyte Apoptosis and Bone Remodeling [PhD thesis]. University of Antwerp; 2003.	0	0
2008	Herman BC. Osteocytes and Activation of Bone Remodeling [PhD thesis]. Mount Sinai School of Medicine; 2008.	1	0
2014	Seref-Ferlengez Z. Diffused Microdamage in Bone Vivo: Structural and Mechanical Bases of Repair [PhD thesis]. New York, NY: The City University of New York; 2014.	1	0
2009	Wang Y. Roles of Integrins in Flow Induced Mechanotransduction in Osteocytes [PhD thesis]. New York, NY: The City University of New York; 2009.	0	0
2009	Emerton KB. Osteocyte Apoptosis Initiation of Targeted Bone Remodeling After Estrogen Withdrawal [PhD thesis]. New York, NY: The City University of New York; 2009.	0	0
2006	Han Y. On the Transmission of Fluid Forces to the Actin Cytoskeleton of Bone and Endothelial Cells [PhD thesis]. New York, NY: The City University of New York; 2006.	0	0
2002	You L. A New View of Mechanotransduction in Bone Cells [PhD thesis]. New York, NY: The City University of New York; 2002.	3	3
2020	Mehraban Alvandi L. Diffuse Damage Repair Mechanism in Bone [PhD thesis]. New York, NY: The City College of New York; 2020.	0	0
2017	Lewis KJ. Osteocyte Calcium Signaling Responses to Mechanical Load in Vivo: A Novel Experimental Approach [PhD thesis]. New York, NY: The City College of New York; 2017.	0	0
2017	Akbas AS. Local Bone Tissue Mechanical Property Changes Without Bone Remodeling: Regulation At the Osteocyte Level [PhD thesis]. New York, NY: The City College of New York; 2017.	0	0
2015	Cabahug-Zuckerman P. A Β₃ Integrin Based Mechanosome in Bone Tissue Osteocytes: Plasticity to Changes in Mechanical Loading [PhD thesis]. New York, NY: The City College of New York; 2015.	0	0

Collaborators (45)

Name	Count	Oldest	Newest
Judex, Stefan	1	2016	2016
McCreadie, Barbara Riemer	1	2004	2004
Milgrom, Charles	1	1995	1995
Andarawis-Puri, Nelly	1	2010	2010
Lynch, Maureen E	2	2010	2011
Martin, R. Bruce	2	1985	1997
Vashishth, Deepak	3	2000	2001
Kimura, James Hiroshi	1	2001	2001
Akkus, Ozan	2	2003	2004
Wang, Vincent M.	1	2010	2010
Prendergast, Patrick J.	1	2006	2006
van der Meulen, Marjolein C. H.	2	2010	2011
Herman, Brad C.	3	2009	2012
Goldstein, Steven A.	4	1996	2004
Jepsen, Karl J.	6	1996	2010
McNamara, Laoise M.	3	2006	2009
Qiu, Shijing	1	2000	2000
Lyons, Christopher Garrett	1	2006	2006
Tommasini, Steven M.	1	2005	2005
Weinans, Harrie	1	2006	2006
Verborgt, Olivier	4	2000	2009
Hernandez, Christopher J.	2	2004	2010
Bonadio, Jeffrey F.	2	1996	1997
Kennedy, Oran D.	5	2005	2015
Cardoso, Luis	2	2009	2010
Weinbaum, Sheldon	7	2001	2013
You, Lidan	2	2001	2004
Cowin, Stephen Corteen	3	2001	2004
Goulet, Robert W.	1	1997	1997
Laudier, Damien M.	4	2009	2014
Radin, Eric L.	6	1985	1998
Hollister, Scott J.	1	2004	2004
Forwood, Mark R.	1	1997	1997
Kuhn, Janet L.	2	1996	1997
Skerry, Timothy M.	1	1998	1998
Wright, Timothy M.	2	2010	2011
Fyhrie, David P.	9	1994	2001
Choi, Kuiwon	1	1994	1994
Main, Russell Paul	2	2010	2011
Majeska, Robert J.	13	2001	2020
Boyce, Todd. M.	2	1998	1998
Ciarelli, Traci E.	2	1996	2000
Yeni, Yener N.	1	2000	2000
Burr, David B.	10	1985	1997
Turner, Charles Hall	1	1997	1997