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Hayes, Wilson C.
1,2
;
Piazza, Stephen J.
2
;
Zysset, Philippe K.
2
Biomechanics of fracture risk prediction of the hip and spine by quantitative computed tomography
Radiol Clin North Am
. 1991;29(1):1-18
Affiliations
1
Harvard Medical School
2
Orthopaedic Biomechanics Laboratory, Beth Israel Hospital, Boston, Massachusetts
Links
PubMed:
1985322
WoS:
A1991ET79400002
Cited Works (43)
Year
Entry
1990
Snyder BD, Hayes WC. Multiaxial structure-property relations in trabecular bone. In: Mow VC, Ratcliffe A, Woo SL-Y, eds.
Biomechanics of Diarthrodial Joints
. Vol 2. New York, NY: Springer-Verlag; 1990:31-59.
1985
Cann CE, Genant HK, Kolb FO, Ettinger B. Quantitative computed tomography for prediction of vertebral fracture risk.
Bone
. 1985;6(1):1-7.
1978
Crowninshield RD, Johnston RC, Andrews JG, Brand RA. A biomechanical investigation of the human hip.
J Biomech
. 1978;11(1-2):75-85.
1985
Gibson LJ. The mechanical behaviour of cancellous bone.
J Biomech
. 1985;18(5):317-328.
1985
Cummings SR. Are patients with hip fractures more osteoporotic? review of the evidence.
Am J Med
. March 1985;78(3):487-494.
1982
Schultz A, Andersson G, Örtengren R, Haderspeck K, Nachemson A. Loads on the lumbar spine: validation of a biomechanical analysis by measurements of intradiscal pressures and myoelectric signals.
J Bone Joint Surg
. June 1982;64A(5):713-720.
1984
Yang KH, King AI. Mechanism of facet load transmission as a hypothesis for low-back pain.
Spine
. September 1984;9(6):557-565.
1989
Magaziner J, Simonsick EM, Kashner TM, Hebel JR, Kenzora JE. Survival experience of aged hip fracture patients.
Am J Public Health
. March 1989;79(3):274-278.
1989
Mosekilde L, Bentzen SM, Ørtoft G, Jørgensen J. The predictive value of quantitative computed tomography for vertebral body compressive strength and ash density.
Bone
. 1989;10(6):465-470.
1986
Riggs BL, Melton LJ III. Involutional osteoporosis.
NEJM
. June 26, 1986;314(26):1676-1686.
1982
Leichter I, Margulies JY, Weinreb A, Mizrahi J, Robin GC, Conforty B, Makin M, Bloch B. The relationship between bone density, mineral content, and mechanical strength in the femoral neck.
Clin Orthop Relat Res
. March 1982;163:272-281.
1988
Lang SM, Moyle DD, Berg EW, Detorie N, Gilpin AT, Pappas NJ Jr, Reynolds JC, Tkacik M, Waldron RL II. Correlation of mechanical properties of vertebral trabecular bone with equivalent mineral density as measured by computed tomography.
J Bone Joint Surg
. December 1988;70A(10):1531-1538.
1984
Röhrle H, Scholten R, Sigolotto C, Sollbach W, Kellner H. Joint forces in the human pelvis-leg skeleton during walking.
J Biomech
. 1984;17(6):409-424.
1990
Lotz JC, Hayes WC. The use of quantitative computed tomography to estimate risk of fracture of the hip from falls.
J Bone Joint Surg
. June 1990;72A(5):689-700.
1990
Melton LJ III, Eddy DM, Johnston C Jr. Screening for osteoporosis.
Ann Intern Med
. April 1, 1990;112(7):516-528.
1976
Carter DR, Hayes WC. Bone compressive strength: the influence of density and strain rate.
Science
. September 10, 1976;194(4270):1174-1176.
1977
Carter DR, Hayes WC. The compressive behavior of bone as a two-phase porous structure.
J Bone Joint Surg
. 1977;59A(7):954-962.
1988
Melton LJ III, Chao EYS, Lane J. Biomechanical aspects of fractures. In: Riggs BL, Melton LJ III, eds.
Osteoporosis: Etiology, Diagnosis, and Management
. New York, NY: Raven Press; 1988:111-131.
1985
Melton LJ, Riggs BL. Risk factors for injury after a fall.
Clin Geriatr Med
. August 1985;1(3):525-539.
1976
Dalén N, Hellström L-G, Jacobson B. Bone mineral content and mechanical strength of the femoral neck.
Acta Orthop Scand
. 1976;47(5):503-508.
1988
Genant HK, Ettinger B, Harris ST, Block JE, Steiger P. Quantitative computed tomography in assessment of osteoporosis. In: Riggs BL, Melton LJ III, eds.
Osteoporosis: Etiology, Diagnosis, and Management
. New York, NY: Raven Press; 1988:221-249.
1989
Melton LJ III, Kan SH, Frye MA, Wahner HW, O'Fallon WM, Riggs BL. Epidemiology of vertebral fractures in women.
Am J Epidemiol
. May 1989;129(5):1000-1011.
1988
Melton LJ III, Kan SH, Wahner HW, Riggs BL. Lifetime fracture risk: an approach to hip fracture risk assessment based on bone mineral density and age.
J Clin Epidemiol
. 1988;41(10):985-994.
1988
Rice JC, Cowin SC, Bowman JA. On the dependence of the elasticity and strength of cancellous bone on apparent density.
J Biomech
. 1988;21(2):155-168.
1988
Hui SL, Slemenda CW, Johnston CC Jr. Age and bone mass as predictors of fracture in a prospective study.
J Clin Invest
. June 1988;81(6):1804-1809.
1982
Riggs BL, Wahner HW, Seeman E, Offord KP, Dunn WL, Mazess RB, Johnson KA, Melton LJ III. Changes in bone mineral density of the proximal femur and spine with aging: differences between the postmenopausal and senile osteoporosis syndromes.
J Clin Invest
. October 1982;70(4):716-723.
1988
Alho A, Husby R, Høiseth A. Bone mineral content and mechanical strength: an ex vivo study on human femora at autopsy.
Clin Orthop Relat Res
. February 1988;227:292-297.
1987
Goldstein SA. The mechanical properties of trabecular bone: dependence on anatomic location and function.
J Biomech
. 1987;20(11-12):1055-1061.
1990
Lotz JC, Gerhart TN, Hayes WC. Mechanical properties of trabecular bone from the proximal femur: a quantitative CT study.
J Comput Assist Tomogr
. January–February 1990;14(1):107-114.
1980
Hansson T, Roos B, Nachemson A. The bone mineral content and ultimate compressive strength of lumbar vertebrae.
Spine
. January–February 1980;5(1):46-55.
1986
Melton LJ III, Wahner HW, Richelson LS, O'Fallon WM, Riggs BL. Osteoporosis and the risk of hip fracture.
Am J Epidemiol
. August 1986;124(2):254-261.
1981
Nachemson AL. Disc pressure measurements.
Spine
. January–February 1981;6(1):93-97.
1989
Esses SI, Lotz JC, Hayes WC. Biomechanical properties of the proximal femur determined in vitro by single‐energy quantitative computed tomography.
J Bone Miner Res
. October 1989;4(5):715-722.
1988
Davy DT, Kotzar GM, Brown RH, Heiple KG, Goldberg VM, Heiple KG Jr, Berilla J, Burstein AH. Telemetric force measurements across the hip after total arthroplasty.
J Bone Joint Surg
. January 1988;70A(1):45-50.
1978
Hardt DE. Determining muscle forces in the leg during normal human walking: an application and evaluation of optimization methods.
J Biomech Eng
. May 1978;100(2):72-78.
1988
Phillips S, Fox N, Jacobs J, Wright WE. The direct medical costs of osteoporosis for american women aged 45 and older, 1986.
Bone
. 1988;9(5):271-279.
1967
Paul JP. Forces transmitted by joints in the human body.
Proc Inst Mech Eng
. 1967;181(pt 3J):8-15.
1983
Bohr H, Schaadt O. Bone mineral content of femoral bone and the lumbar spine measured in women with fracture of the femoral neck by dual photon absorptiometry.
Clin Orthop Relat Res
. October 1983;179:240-245.
1983
Mazess RB. Errors in measuring trabecular bone by computed tomography due to marrow and bone composition.
Calcif Tiss Int
. December 1983;35(2):148-152.
1982
Mazess RB. On aging bone loss.
Clin Orthop Relat Res
. May 1982;165:239-252.
1985
McBroom RJ, Hayes WC, Edwards WT, Goldberg RP, White AA III. Prediction of vertebral body compressive fracture using quantitative computed tomography.
J Bone Joint Surg
. 1985;67A(8):1206-1214.
1982
Wicks M, Garrett R, Vernon-Roberts B, Fazzalari N. Absence of metabolic bone disease in the proximal femur in patients with fracture of the femoral neck.
J Bone Joint Surg
. 1982;64B(3):319-322.
1970
McLeish R, Charnley J. Abduction forces in the one-legged stance.
J Biomech
. March 1970;3(2):191-209.
Cited By (67)
Year
Entry
2002
Müller R. The Zürich experience: one decade of three-dimensional high-resolution computed tomography.
Top Magn Reson Imaging
. 2002;13(5):307-322.
2001
Villarraga ML, Ford CM. Applications of bone mechanics. In: Cowin SC, ed.
Bone Mechanics Handbook
. 2nd ed. Boca Raton, FL: CRC Press; 2001:33-1–33-33.
2010
Keaveny TM. Biomechanical computed tomography: noninvasive bone strength analysis using clinical computed tomography scans.
Annals NY Acad Sci
. 2010;1192(1):57-65.
1996
Melton LJ III. Epidemiology of hip fractures: implications of the exponential increase with age.
Bone
. March 1996;18(3)(suppl 1):S121-S125.
1998
Majumdar S, Kothari M, Augat P, Newitt DC, Link TM, Lin JC, Lang T, Lu Y, Genant HK. High-resolution magnetic resonance imaging: three-dimensional trabecular bone architecture and biomechanical properties.
Bone
. May 1998;22(5):445-454.
1998
Ebbesen EN, Thomsen JS, Beck-Nielsen H, Nepper-Rasmussen HJ, Mosekilde L. Vertebral bone density evaluated by dual-energy X-ray absorptiometry and quantitative computed tomography in vitro.
Bone
. September 1998;23(3):283-290.
1999
Ebbesen EN, Thomsen JS, Beck-Nielsen H, Nepper-Rasmussen HJ, Mosekilde L. Lumbar vertebral body compressive strength evaluated by dual-energy X-ray absorptiometry, quantitative computed tomography, and ashing.
Bone
. December 1999;25(6):713-724.
2009
Keyak JH, Koyama AK, LeBlanc A, Lu Y, Lang TF. Reduction in proximal femoral strength due to long-duration spaceflight.
Bone
. March 2009;44(3):449-453.
2013
Zysset PK, Dall'Ara E, Varga P, Pahr DH. Finite element analysis for prediction of bone strength.
BoneKEy Rep
. August 2013;2:386.
1993
Cooper C. The epidemiology of fragility fractures: is there a role for bone quality?
Calcif Tiss Int
. February 1993;53(suppl 1):S23-S26.
1996
Pinilla TP, Boardman KC, Bouxsein ML, Myers ER, Hayes WC. Impact direction from a fall influences the failure load of the proximal femur as much as age-related bone loss.
Calcif Tiss Int
. April 1996;58(4):231-235.
1993
Nevitt MC, Cummings SR; Study of Osteoporofic Fractures Research Group. Type of fall and risk of hip and wrist fractures: the study of osteoporotic fractures.
J Am Geriatr Soc
. November 1993;41(11):1226-1234.
1994
Zysset PK, Sonny M, Hayes WC. Morphology-mechanical property relations in trabecular bone of the osteoarthritic proximal tibia.
J Arthoplast
. 1994;9(2):203-216.
1994
Bowman SM, Keaveny TM, Gibson LJ, Hayes WC, McMahon TA. Compressive creep behavior of bovine trabecular bone.
J Biomech
. March 1994;27(3):301-310.
1992
Cooper C, Atkinson EJ, O'Fallon WM, Melton JL III. Incidence of clinically diagnosed vertebral fractures: a population‐based study in Rochester, Minnesota, 1985‐1989.
J Bone Miner Res
. February 1992;7(2):221-227.
1993
Faulkner KG, Cummings SR, Black D, Palermo L, Glüer C, Genant HK. Simple measurement of femoral geometry predicts hip fracture: the study of osteoporotic fractures.
J Bone Miner Res
. September 1993;8(10):1211-1217.
1994
Myers BS, Arbogast KB, Lobaugh B, Harper KD, Richardson WJ, Drezner MK. Improved assessment of lumbar vertebral body strength using supine lateral dual‐energy X‐ray absorptiometry.
J Bone Miner Res
. May 1994;9(5):687-693.
1995
Melton JL III. How many women have osteoporosis now?
J Bone Miner Res
. February 1995;10(2):175-177.
1996
Haapasalo H, Sievanen H, Kannus P, Heinonen A, Oja P, Vuori I. Dimensions and estimated mechanical characteristics of the humerus after long-term tennis loading.
J Bone Miner Res
. June 1996;11(6):864-872.
1997
Burr DB, Forwood MR, Fyhrie DP, Martin RB, Schaffler MB, Turner CH. Bone microdamage and skeletal fragility in osteoporotic and stress fractures.
J Bone Miner Res
. January 1997;12(1):6-15.
1998
Link TM, Majumdar S, Lin JC, Newitt D, Augat P, Ouyang X, Mathur A, Genant HK. A comparative study of trabecular bone properties in the spine and femur using high resolution mri and ct.
J Bone Miner Res
. January 1998;13(1):122-132.
2004
Eckstein F, Wunderer C, Boehm H, Kuhn V, Priemel M, Link TM, Lochmüller E-M. Reproducibility and side differences of mechanical tests for determining the structural strength of the proximal femur.
J Bone Miner Res
. March 2004;19(3):379-385.
2006
Riggs BL, Melton LJ III, Robb RA, Camp JJ, Atkinson EJ, Oberg AL, Rouleau PA, McCollough CH, Khosla S, Bouxsein ML. Population-based analysis of the relationship of whole bone strength indices and fall-related loads to age- and sex-specific patterns of hip and wrist fractures.
J Bone Miner Res
. February 2006;21(2):315-323.
2006
Bouxsein ML, Melton LJ III, Riggs BL, Muller J, Atkinson EJ, Oberg AL, Robb RA, Camp JJ, Rouleau PA, McCollough CH, Khosla S. Age‐ and sex‐specific differences in the factor of risk for vertebral fracture: a population‐based study using QCT.
J Bone Miner Res
. September 2006;21(9):1475-1482.
2007
Bouxsein ML, Szulc P, Munoz F, Thrall E, Sornay‐Rendu E, Delmas PD. Contribution of trochanteric soft tissues to fall force estimates, the factor of risk, and prediction of hip fracture risk*.
J Bone Miner Res
. June 2007;22(6):825-831.
2008
Boutroy S, Van Rietbergen B, Sornay-Rendu E, Munoz F, Bouxsein ML, Delmas PD. Finite element analysis based on in vivo HR-pQCT images of the distal radius is associated with wrist fracture in postmenopausal women.
J Bone Miner Res
. March 2008;23(3):392-399.
2008
Keaveny TM, Bouxsein ML. Theoretical implications of the biomechanical fracture threshold.
J Bone Miner Res
. October 2008;23(10):1541-1547.
2009
Orwoll ES, Marshall LM, Nielson CM, Cummings SR, Lapidus J, Cauley JA, Ensrud K, Lane N, Hoffmann PR, Kopperdahl DL, Keaveny TM; Osteoporotic Fractures in Men (MrOS) Study Group. Finite element analysis of the proximal femur and hip fracture risk in older men.
J Bone Miner Res
. March 2009;24(3):475-483.
2011
Macdonald HM, Nishiyama KK, Kang J, Hanley DA, Boyd SK. Age‐related patterns of trabecular and cortical bone loss differ between sexes and skeletal sites: a population‐based HT‐pQCT study.
J Bone Miner Res
. January 2011;26(1):50-62.
2015
Zysset P, Qin L, Lang T, Khosla S, Leslie WD, Shepherd JA, Schousboe JT, Engelke K. Clinical use of quantitative computed tomography–based finite element analysis of the hip and spine in the management of osteoporosis in adults: the 2015 ISCD official positions—part II.
J Clin Densitom
. July–September 2015;18(3):359-392.
1997
Hwang SN, Wehrli FW, Williams JL. Probability‐based structural parameters from three‐dimensional nuclear magnetic resonance images as predictors of trabecular bone strength.
Med Phys
. August 1997;24(8):1255-1261.
1992
Riggs BL, Melton LJ III. The prevention and treatment of osteoporosis.
NEJM
. August 27, 1992;327(9):620-627.
2003
Muller ME, Webber CE, Bouxsein ML. Predicting the failure load of the distal radius.
Osteoporos Int
. June 2003;14(4):345-352.
2013
Nishiyama KK, Macdonald HM, Hanley DA, Boyd SK. Women with previous fragility fractures can be classified based on bone microarchitecture and finite element analysis measured with HR-pQCT.
Osteoporos Int
. May 2013;24(5):1733-1740.
1993
Mizrahi J, Silva MJ, Keaveny TM, Edwards WT, Hayes WC. Finite-element stress analysis of the normal and osteoporotic lumbar vertebral body.
Spine
. October 15, 1993;18(14):2088-2096.
1997
Myers ER, Wilson SE. Biomechanics of osteoporosis and vertebral fracture.
Spine
. December 15, 1997;22(24)(suppl):25S-31S.
2003
Liebschner MAK, Kopperdahl DL, Rosenberg WS, Keaveny TM. Finite element modeling of the human thoracolumbar spine.
Spine
. March 15, 2003;28(6):559-565.
1998
Majumdar S. A review of magnetic resonance (MR) imaging of trabecular bone micro-architecture: contribution to the prediction of biomechanical properties and fracture prevalence.
Technol Health Care
. 1998;6(5-6):321-327.
1998
Müller R, Gerber SC, Hayes WC. Micro-compression: a novel technique for the nondestructive assessment of local bone failure.
Technol Health Care
. December 1998;6(5-6):433-444.
1994
Zysset P.
A Constitutive Law for Trabecular Bone
[PhD thesis]. Lausanne, Switzerland: École Polytechnique Fédérale de Lausanne; 1994.
2005
Stauber M.
Volumetric Spatial Decomposition of Porous Microstructures: A Framework for Element Based Analysis of Trabecular Bone
[PhD thesis]. Swiss Federal Institute of Technology Zürich; 2005.
2008
Nazarian A.
Relative Interaction of Material and Structure in Normal and Pathologic Bone
[PhD thesis]. Swiss Federal Institute of Technology Zürich; 2008.
2010
Müller T.
Bioimaging and Biomechanics of Bone Competence and Implant Stability
[PhD thesis]. Swiss Federal Institute of Technology Zürich; 2010.
2019
Fleps I.
Assessing the Risk of Hip Fracture: Subject-Specific Dynamic Models for the Simulation of Sideways Fall Impact
[PhD thesis]. Swiss Federal Institute of Technology Zürich; 2019.
1994
Courtney AC.
Mechanical Properties of the Proximal Femur: Changes With Age
[PhD thesis]. Cambridge, MA: Harvard University; May 1994.
1997
Bowman SM.
Creep of Trabecular Bone
[PhD thesis]. Cambridge, MA: Harvard University; May 1997.
2014
Jameson JR.
Characterization of Bone Material Properties and Microstructure in Osteogenesis Imperfecta/brittle Bone Disease
[PhD thesis]. Marquette University; December 2014.
1995
van den Kroonenberg A.
Dynamic Models of Human Falls for Prediction of Hip Fracture Risk
[PhD thesis]. Cambridge, MA: Massachusetts Institute of Technology; January 1995.
1999
Schaffner G.
Assessment of Hip Fracture Risk in Astronauts Exposed to Long-Term Weightlessness
[PhD thesis]. Cambridge, MA: Massachusetts Institute of Technology; August 1999.
2014
Ellman R.
Skeletal Adaptation to Reduced Mechanical Loading
[PhD thesis]. Cambridge, MA: Massachusetts Institute of Technology; September 2014.
2006
Bauer JJ.
Defining Intensity of Skeletal Loading in Children
[PhD thesis]. Corvalis, OR: Oregon State University; June 2006.
2002
Henley JD.
A Kinematic and Kinetic Analysis of Postural Perturbation
[PhD thesis]. State College, PA: Pennsylvania State University; May 2002.
2008
Laing ACT.
Biomechanical Testing of Hip Protectors and Energy-Absorbing Floors for the Prevention of Fall-Related Hip Fractures
[PhD thesis]. Simon Fraser University; 2008.
2013
Choi WJ.
Biomechanics of Falls and Hip Fractures in Older Adults
[PhD thesis]. Simon Fraser University; F 2013.
2001
Speirs AD.
Calcium Phosphate Cement Composites in Revision Hip Replacement
[Master's thesis]. Vancouver, BC: University of British Columbia; February 2001.
2010
Johnston JD.
Development of a Non-Invasive Imaging Technique for Characterizing Subchondral Bone Density and Stiffness
[PhD thesis]. Vancouver, BC: University of British Columbia; December 2010.
2014
Ariza OR.
A Novel Approach to Finite Element Analysis of Hip Fractures Due to Sideways Falls
[Master's thesis]. Vancouver, BC: University of British Columbia; April 2014.
2012
Nishiyama KKS.
In Vivo Assessment of Bone Microarchitecture and Estimated Bone Strength
[PhD thesis]. Calgary, AB: University of Calgary; October 2012.
1996
Keyak JH.
Prediction of Femoral Strength Using Automated Finite Element Modeling
[PhD thesis]. Berkeley, CA: Berkeley, University of California; 1996.
1999
Whyne CM.
Development of Guidelines for the Prophylactic Treatment of Metastatically Involved Vertebral Bodies
[PhD thesis]. Berkeley, CA: Berkeley, University of California; 1999.
1996
Rossi SA.
The Prediction of Human Cortical Bone Strength Using the Finite-Element Method: A Study of the Flexural and Torsional Behavior of Femoral Shafts With Simulated Metastatic Lesions
[PhD thesis]. San Francisco, University of California; 1996.
2018
Oweis R.
Associations Between Fluoride Intakes, Bone Outcomes and Dental Fluorosis
[PhD thesis]. University of Iowa; May 2018.
1993
Boyce TM.
Aging Changes Within the Human Femoral Neck Cortex
[PhD thesis]. University of Utah; August 1993.
2005
Tschirhart CE.
Biomechanics and Prophylactic Treatment of Spinal Metastases: A Finite Element Based Study
[Master's thesis]. University of Toronto; 2005.
2011
Levine I.
The Effects of Body Mass Index and Gender on Pelvic Stiffness and Peak Impact Force During Lateral Falls
[Master's thesis]. University of Waterloo; 2011.
2017
Levine IC.
The Effects of Body Composition and Body Configuration on Impact Dynamics During Lateral Falls: Insights from in-Vivo, in-Vitro, and in-Silico Approaches
[PhD thesis]. University of Waterloo; 2017.
2022
Martel DR.
Contributors to Proximal Femur Fracture Force: Multiscale Considerations of Rate, Toughness, and Bone Composition
[PhD thesis]. University of Waterloo; 2022.