Biomechanics of fracture:​ is bone mineral density sufficient to assess risk?

McCreadie, Barbara R.; Goldstein, Steven A.

Affiliations

¹Orthopedic Research Laboratories, University of Michigan, Ann Arbor, Michigan, USA

Links

DOI: 10.1359/jbmr.2000.15.12.2305

PubMed: 11127195

WoS: 000165463300003

Cited Works (38)

Year	Entry
1993	Goldstein SA, Goulet R, McCubbrey D. Measurement and significance of three-dimensional architecture to the mechanical integrity of trabecular bone. Calcif Tiss Int. February 1993;53(suppl 1):S127-S133.
1989	Mosekilde L. Sex differences in age-related loss of vertebral trabecular bone mass and structure—biomechanical consequences. Bone. 1989;10(6):425-432.
1989	Eriksson SAV, Isberg BO, Lindgren JU. Prediction of vertebral strength by dual photon absorptiometry and quantitative computed tomography. Calcif Tiss Int. April 1989;44(4):243-250.
2000	Ciarelli TE, Fyhrie DP, Schaffler MB, Goldstein SA. Variations in three‐dimensional cancellous bone architecture of the proximal femur in female hip fractures and in controls. J Bone Miner Res. 2000;15(1):32-40.
1993	Grynpas M. Age and disease-related changes in the mineral of bone. Calcif Tiss Int. February 1993;53(suppl 1):S57-S64.
1985	Cummings SR. Are patients with hip fractures more osteoporotic? review of the evidence. Am J Med. March 1985;78(3):487-494.
1994	Goulet RW, Goldstein SA, Ciarelli MJ, Kuhn JL, Brown MB, Feldkamp LA. The relationship between the structural and orthogonal compressive properties of trabecular bone. J Biomech. April 1994;27(4):375-389.
1994	Greenspan SL, Myers ER, Maitland LA, Resnick NM, Hayes WC. Fall severity and bone mineral density as risk factors for hip fracture in ambulatory elderly. JAMA. January 12, 1994;271(2):128-133.
1989	Mosekilde L, Bentzen SM, Ørtoft G, Jørgensen J. The predictive value of quantitative computed tomography for vertebral body compressive strength and ash density. Bone. 1989;10(6):465-470.
1998	Martin RB, Burr DB, Sharkey NA. Skeletal Tissue Mechanics. New York, NY: Springer-Verlag; 1998.
1994	Crofts RD, Boyce TM, Bloebaum RD. Aging changes in osteon mineralization in the human femoral neck. Bone. March–April 1994;15(2):147-152.
1986	Mosekilde L, Mosekilde L. Normal vertebral body size and compressive strength: relations to age and to vertebral and iliac trabecular bone compressive strength. Bone. 1986;7(3):207-212.
1988	Lang SM, Moyle DD, Berg EW, Detorie N, Gilpin AT, Pappas NJ Jr, Reynolds JC, Tkacik M, Waldron RL II. Correlation of mechanical properties of vertebral trabecular bone with equivalent mineral density as measured by computed tomography. J Bone Joint Surg. December 1988;70A(10):1531-1538.
2000	Beck TJ, Looker AC, Ruff CB, Sievanen H, Wahner HW. Structural trends in the aging femoral neck and proximal shaft: analysis of the third national health and nutrition examination survey dual‐energy x‐ray absorptiometry data. J Bone Miner Res. December 2000;15(12):2297-2304.
1993	Faulkner KG, Cummings SR, Black D, Palermo L, Glüer C, Genant HK. Simple measurement of femoral geometry predicts hip fracture: the study of osteoporotic fractures. J Bone Miner Res. September 1993;8(10):1211-1217.
1990	Lotz JC, Hayes WC. The use of quantitative computed tomography to estimate risk of fracture of the hip from falls. J Bone Joint Surg. June 1990;72A(5):689-700.
1996	Hayes WC, Myers ER, Robinovitch SN, Van Den Kroonenberg A, Courtney AC, McMahon TA. Etiology and prevention of age-related hip fractures. Bone. January 1996;18(1)(suppl):77S-86S.
1977	Carter DR, Hayes WC. The compressive behavior of bone as a two-phase porous structure. J Bone Joint Surg. 1977;59A(7):954-962.
2000	Dempster DW. The contribution of trabecular architecture to cancellous bone quality. J Bone Miner Res. January 2000;15(1):20-23.
1993	Boyce TM, Bloebaum RD. Cortical aging differences and fracture implications for the human femoral neck. Bone. September–October 1993;14(5):769-778.
1989	Brinckmann P, Biggemann M, Hilweg D. Prediction of the compressive strength of human lumbar vertebrae. Spine. June 1989;14(6):606-610.
1988	Currey JD. The effect of porosity and mineral content on the Young's modulus of elasticity of compact bone. J Biomech. 1988;21(2):131-139.
1983	Riggs BL, Melton LJ III. Evidence for two distinct syndromes of involutional osteoporosis. Am J Med. December 1983;75(6):899-901.
2000	Jordan GR, Loveridge N, Bell KL, Power J, Rushton N, Reeve J. Spatial clustering of remodeling osteons in the femoral neck cortex: a cause of weakness in hip fracture? Bone. March 2000;26(3):305-313.
1980	Hansson T, Roos B, Nachemson A. The bone mineral content and ultimate compressive strength of lumbar vertebrae. Spine. January–February 1980;5(1):46-55.
1997	Burr DB, Forwood MR, Fyhrie DP, Martin RB, Schaffler MB, Turner CH. Bone microdamage and skeletal fragility in osteoporotic and stress fractures. J Bone Miner Res. January 1997;12(1):6-15.
2000	Faulkner KG. Bone matters: are density increases necessary to reduce fracture risk? J Bone Miner Res. February 2000;15(2):183-187.
1988	Ruff CB, Hayes WC. Sex differences in age‐related remodeling of the femur and tibia. J Orthop Res. November 1988;6(6):886-896.
1987	Aaron JE, Makins NB, Sagreiya K. The microanatomy of trabecular bone loss in normal aging men and women. Clin Orthop Relat Res. February 1987;215:260-271.
1996	Pinilla TP, Boardman KC, Bouxsein ML, Myers ER, Hayes WC. Impact direction from a fall influences the failure load of the proximal femur as much as age-related bone loss. Calcif Tiss Int. April 1996;58(4):231-235.
1995	McCubbrey DA, Cody DD, Peterson EL, Kuhn JL, Flynn MJ, Goldstein SA. Static and fatigue failure properties of thoracic and lumbar vertebral bodies and their relation to regional density. J Biomech. August 1995;28(8):891-899.
1991	Cody DD, Goldstein SA, Flynn MJ, Brown EB. Correlations between vertebral regional bone mineral density (rBMD) and whole bone fracture load. Spine. 1991;16(2):146-154.
1993	Melton LJ III, Atkinson EJ, O'Fallon WM, Wahner HW, Riggs BL. Long‐term fracture prediction by bone mineral assessed at different skeletal sites. J Bone Miner Res. September 1993;8(10):1227-1233.
1994	Courtney AC, Wachtel EF, Myers ER, Hayes WC. Effects of loading rate on strength of the proximal femur. Calcif Tiss Int. 1994;55(1):53-58.
2000	Mosekilde L. Age-related changes in bone mass, structure, and strength: effects of loading. Z Rheumatol. February 2000;59(suppl 1):I1-I9.
1993	Beck TJ, Ruff CB, Bissessur K. Age-related changes in female femoral neck geometry: implications for bone strength. Calcif Tiss Int. 1993;53(suppl 1):S41-S46.
1991	Vesterby A, Mosekilde L, Gundersen HJG, Melsen F, Mosekilde L, Holme K, Sørensen S. Biologically meaningful determinants of the in vitro strength of lumbar vertebrae. Bone. 1991;12(3):219-224.
1996	Marshall D, Johnell O, Wedel H. Meta-analysis of how well measures of bone mineral density predict occurrence of osteoporotic fractures. BMJ. May 18, 1996;312(7041):1254-1259.

Cited By (31)

Year	Entry
2019	Silva AMH, Boyd SK, Manske SL, Alves JM, de Carvalho J. Assessment of the elastic properties of human vertebral trabecular bone using computational mechanical tests and x-ray microtomograph: a subvolume analysis. Biomed Phys Eng Express. July 2019;5(4):045031.
2011	Dragomir-Daescu D, Op Den Buijs J, McEligot S, Dai Y, Entwistle RC, Salas C, Melton LJ III, Bennet KE, Khosla S, Amin S. Robust QCT/FEA models of proximal femur stiffness and fracture load during a sideways fall on the hip. Ann Biomed Eng. February 2011;39(2):742-755.
2001	van der Meulen MCH, Jepsen KJ, Mikić B. Understanding bone strength: size isn’t everything. Bone. July 2001;29(1):101-104.
2004	Akkus O, Adar F, Schaffler MB. Age-related changes in physicochemical properties of mineral crystals are related to impaired mechanical function of cortical bone. Bone. March 2004;34(4):443-453.
2007	Perilli E, Baleani M, Öhman C, Baruffaldi F, Viceconti M. Structural parameters and mechanical strength of cancellous bone in the femoral head in osteoarthritis do not depend on age. Bone. November 2007;41(5):760-768.
2021	Paschalis EP, Dempster DW, Gamsjaeger S, Rokidi S, Hassler N, Brozek W, Chan-Diehl FW, Klaushofer K, Taylor KA. Mineral and organic matrix composition at bone forming surfaces in postmenopausal women with osteoporosis treated with either teriparatide or zoledronic acid. Bone. April 2021;145:115848.
2011	Morris MD, Mandair GS. Raman assessment of bone quality. Clin Orthop Relat Res. August 2011;469:2160-2169.
2008	Perilli E, Baleani M, Öhman C, Fognani R, Baruffaldi F, Viceconti M. Dependence of mechanical compressive strength on local variations in microarchitecture in cancellous bone of proximal human femur. J Biomech. 2008;41(2):438-446.
2011	Kim D-G, Shertok D, Tee BC, Yeni YN. Variability of tissue mineral density can determine physiological creep of human vertebral cancellous bone. J Biomech. June 3, 2011;44(9):1660-1665.
2012	Tassani S, Matsopoulos GK, Baruffaldi F. 3D identification of trabecular bone fracture zone using an automatic image registration scheme: a validation study. J Biomech. July 26, 2012;45(11):2035-2040.
2016	Grassi L, Väänänen SP, Ristinmaa M, Jurvelin JS, Isaksson H. How accurately can subject-specific finite element models predict strains and strength of human femora? investigation using full-field measurements. J Biomech. March 21, 2016;49(5):802-806.
2019	Gustafsson A, Wallin M, Isaksson H. Age-related properties at the microscale affect crack propagation in cortical bone. J Biomech. October 11, 2019;95:109326.
2003	Paschalis EP, Boskey AL, Kassem M, Eriksen EF. Effect of hormone replacement therapy on bone quality in early postmenopausal women. J Bone Miner Res. June 2003;18(6):955-959.
2003	Paschalis E, Recker R, Dicarlo E, Doty S, Atti E, Boskey A. Distribution of collagen cross-links in normal human trabecular bone. J Bone Miner Res. November 2003;18(11):1942-1946.
2004	Paschalis EP, Shane E, Lyritis G, Skarantavos G, Mendelsohn R, Boskey AL. Bone fragility and collagen cross‐links. J Bone Miner Res. December 2004;19(12):2000-2004.
2009	Gourion‐Arsiquaud S, Faibish D, Myers E, Spevak L, Compston J, Hodsman A, Shane E, Recker RR, Boskey ER, Boskey AL. Use of FTIR spectroscopic imaging to identify parameters associated with fragility fracture. J Bone Miner Res. September 2009;24(9):1565-1571.
2013	Gourion-Arsiquaud S, Lukashova L, Power J, Loveridge N, Reeve J, Boskey AL. Fourier transform infrared imaging of femoral neck bone: reduced heterogeneity of mineral-to-matrix and carbonate-to-phosphate and more variable crystallinity in treatment-naive fracture cases compared with fracture-free controls. J Bone Miner Res. January 2013;28(1):150-161.
2020	Chirvi S, Pintar FA, Yoganandan N, Stemper B, Kleinberger M. Trabecular bone mineral density correlations using QCT: central and peripheral human skeleton. J Mech Behav Biomed Mater. December 2020;112:104076.
2017	Paschalis EP, Gamsjaeger S, Klaushofer K. Vibrational spectroscopic techniques to assess bone quality. Osteoporos Int. August 2017;28(8):2275-2291.
2011	O'Neal JM. The Effects of Aging and Remodeling on Bone Quality and Microdamage [PhD thesis]. Atlanta, GA: Georgia Institute of Technology; August 2011.
2013	Deng C. Measuring Femoral Neck Loads in Older Adults During Stair Ascent and Descent [Master's thesis]. Iowa State University; 2013.
2018	Deng C. Femur/femoral Neck Load Estimation During Stair Navigation [PhD thesis]. Iowa State University; 2018.
2016	Currier EJ. Predicting Peak Load of the Femoral Neck Using Structural Parameters [Master's thesis]. University of Illinois at Urbana-Champaign; 2016.
2016	Grassi L. Femoral Strength Prediction Using Finite Element Models: Validation of Models Based on CT and Reconstructed DXA Images Against Full-Field Strain Measurements [PhD thesis]. Lund, Sweden: Lund University; 2016.
2008	Courtland H-W. Intra-Species Variation in Skeletal Mechanical Function is Achieved Through Genetic Regulation of Both the Quality and Morphology of Bone [PhD thesis]. Mount Sinai School of Medicine; 2008.
2016	Bailey SM. The Role of Extra-Cellular Matrix Proteins and Post-Translational Modifications on Bone Fracture [PhD thesis]. Troy, NY: Rensselaer Polytechnic Institute; September 2016.
2012	Ferdous Z. Development of a DXA–based Patient–specific Finite Element Model for Assessing Osteoporotic Fracture Risk [Master's thesis]. Winnipeg, MB: University of Manitoba; 2012.
2000	McCreadie BR. Structural and Material Changes in Osteoporosis: Their Impact on the Mechanical Environment of the Osteocyte [PhD thesis]. University of Michigan; 2000.
2008	Waldorff EI. Effects of Aging and Disuse on Bone Remodeling in Response to Microdamage [PhD thesis]. University of Michigan; 2008.
2009	Sahar ND. Investigating the Effects of Age and Exercise on Bone Composition and the Impact of Composition on Mechanical Integrity. [PhD thesis]. University of Michigan; 2009.
2010	Joiner DM. The Effect of Age on Bone and Its Response to Mechanical Stimulation [PhD thesis]. University of Michigan; 2010.