Experiments on cell mechanosensitivity:​ bone cells as mechanical engineers

Burger, Elisabeth H.

Year	Entry
1990	Palumbo C, Palazzini S, Marotti G. Morphological study of intercellular junctions during osteocyte differentiation. Bone. 1990;11(6):401-406.
1987	Salzstein RA, Pollack SR. Electromechanical potentials in cortical bone, II: experimental analysis. J Biomech. 1987;20(3):271-280.
1991	Ingber D. Integrins as mechanochemical transducers. Curr Opin Cell Biol. October 1991;3(5):841-848.
1985	Burr DB, Martin RB, Schaffler MB, Radin EL. Bone remodeling in response to in vivo fatigue microdamage. J Biomech. 1985;18(3):189-200.
1992	van der Plas A, Nijweide PJ. Isolation and purification of osteocytes. J Bone Miner Res. April 1992;7(4):389-396.
1994	Chow JW, Chambers TJ. Indomethacin has distinct early and late actions on bone formation induced by mechanical stimulation. Am J Physiol Endocrinol Metab. August 1994;267(2):E287-E292.
1990	Reich KM, Gay CV, Frangos JA. Fluid shear stress as a mediator of osteoblast cyclic adenosine monophosphate production. J Cell Physiol. April 1990;143(1):100-103.
1990	Palumbo C, Palazzini S, Zaffe D, Marotti G. Osteocyte differentiation in the tibia of newborn rabbit: an ultrastructural study of the formation of cytoplasmic processes. Acta Anat. 1990;137(4):350-358.
2000	Smit TH, Burger EH. Is BMU-coupling a strain-regulated phenomenon? a finite element analysis. J Bone Miner Res. February 2000;12(2):301-307.
1995	Pitsillides AA, Rawlinson SCF, Suswillo RFL, Bourrin S, Zaman G, Lanyon LE. Mechanical strain‐induced NO production by bone cells: a possible role in adaptive bone (re)modeling? FASEB J. December 1995;9(15):1614-1622.
1996	Rawlinson SCF, Pitsillides AA, Lanyon LE. Involvement of different ion channels in osteoblasts' and osteocytes' early responses to mechanical strain. Bone. December 1996;19(6):609-614.
1995	Klein-Nulend J, Semeins CM, Ajubi NE, Nijweide P, Burger EH. Pulsating fluid flow increases nitric oxide (NO) synthesis by osteocytes but not periosteal fibroblasts - correlation with prostaglandin upregulation. Biochem Biophys Res Commun. December 14, 1995;217(2):640-648.
1990	Nijweide PJ, Burger EH. Mechanisms of bone formation in vitro. In: Hall BK, ed. Bone. Volume 1: The Osteoblast and Osteocyte. Caldwell, NJ: Inc., The Telford Press; 1990:303-326.
1995	Turner CH, Owan I, Takano Y. Mechanotransduction in bone: role of strain rate. Am J Physiol Endocrinol Metab. September 1995;269(3):E438-E442.
1999	Burger EH, Klein-Nulend J. Mechanotransduction in bone: role of the lacunocanalicular network. FASEB J. May 1999;12(9001):S101-S112.
1991	Cowin SC, Moss-Salentijn L, Moss ML. Candidates for the mechanosensory system in bone. J Biomech Eng. May 1991;113(2):191-197.
1998	Jacobs CR, Yellowley CE, Davis BR, Zhou Z, Cimbala JM, Donahue HJ. Differential effect of steady versus oscillating flow on bone cells. J Biomech. November 1998;31(11):969-976.
1995	Hung T Clark, Pollack R Solomon, Reilly TM, Brighton T Carl. Real-time calcium response of cultured bone cells to fluid flow. Clin Orthop Relat Res. April 1995;313:256-269.
1995	Cowin SC, Weinbaum S, Zeng Y. A case for bone canaliculi as the anatomical site of strain generated potentials. J Biomech. November 1995;28(11):1281-1297.
1977	Piekarski K, Munro M. Transport mechanism operating between blood supply and osteocytes in long bones. Nature. September 1, 1977;270(5623):80-82.
1996	Hung CT, Allen FD, Pollack SR, Brighton CT. Intracellular Ca²⁺ stores and extracellular Ca²⁺ are required in the real-time Ca²⁺ response of bone cells experiencing fluid flow. J Biomech. November 1996;29(11):1411-1417.
1996	Ajubi NE, Klein-Nulend J, Nijweide PJ, Vrijheid-Lammers T, Alblas MJ, Burger EH. Pulsating fluid flow increases prostaglandin production by cultured chicken osteocytes: a cytoskeleton-dependent process. Biochem Biophys Res Commun. August 5, 1996;225(1):62-68.
1981	Doty SB. Morphological evidence of gap junctions between bone cells. Calcif Tiss Int. 1981;33(5):509-512.
1997	Owan I, Burr DB, Turner CH, Qiu J, Tu Y, Onyia JE, Duncan RL. Mechanotransduction in bone: osteoblasts are more responsive to fluid forces than mechanical strain. Am J Physiol Cell Physiol. September 1997;273(3):C810-C815.
1996	Prendergast PJ, Huiskes R. Microdamage and osteocyte-lacuna strain in bone: a microstructural finite element analysis. J Biomech Eng. May 1996;118(2):240-246.
1987	Frost HM. Bone “mass” and the “mechanostat”: a proposal. Anat Rec. September 1987;219(1):1-9.
1994	Schaffler MB, Pitchford WC, Choi K, Riddle JM. Examination of compact bone microdamage using back-scattered electron microscopy. Bone. September–October 1994;15(5):483-488.
1997	Mak AFT, Huang DT, Zhang JD, Tong P. Deformation-induced hierarchical flows and drag forces in bone canaliculi and matrix microporosity. J Biomech. January 1997;30(1):11-18.
1996	Forwood MR, Owan I, Takano Y, Turner CH. Increased bone formation in rat tibiae after a single short period of dynamic loading in vivo. Am J Physiol Endocrinol Metab. March 1996;270(3):E419-E423.
1990	Murray DW, Rushton N. The effect of strain on bone cell prostaglandin E₂ release: a new experimental method. Calcif Tiss Int. July 1990;47(1):35-39.
1995	Hillam RA, Skerry TM. Inhibition of bone resorption and stimulation of formation by mechanical loading of the modeling rat ulna in vivo. J Bone Miner Res. June 1995;10(5):683-689.
1996	Turner CH, Takano Y, Owan I, Murrell GA. Nitric oxide inhibitor L-NAME suppresses mechanically induced bone formation in rats. Am J Physiol Endocrinol Metab. April 1996;270(4):E634-E639.
1994	Turner CH, Forwood MR, Rho J, Yoshikawa T. Mechanical loading thresholds for lamellar and woven bone formation. J Bone Miner Res. January 1994;9(1):87-97.
1986	Palumbo C. A three-dimensional ultrastructural study of osteoid-osteocytes in the tibia of chick embryos. Cell Tissue Res. October 1986;246(1):125-131.
1995	Klein-Nulend J, van der Plas A, Semeins CM, Ajubi NE, Frangos JA, Nijweide PJ, Burger EH. Sensitivity of osteocytes to biomechanical stress in vitro. FASEB J. March 1995;9(5):441-445.
1993	Burr DB, Martin RB. Calculating the probability that microcracks initiate resorption spaces. J Biomech. April–May 1993;26(4-5):613-616.
1998	Tanaka-Kamioka K, Kamioka H, Ris H, Lim S-S. Osteocyte shape is dependent on actin filaments and osteocyte processes are unique actin-rich projections. J Bone Miner Res. October 1998;13(10):1555-1568.
1998	Bentolila V, Boyce TM, Fyhrie DP, Drumb R, Skerry TM, Schaffler MB. Intracortical remodeling in adult rat long bones after fatigue loading. Bone. September 1998;23(3):275-281.
1994	Turner CH, Forwood MR, Otter MW. Mechanotransduction in bone: do bone cells act as sensors of fluid flow? FASEB J. August 1994;8(11):875-878.
1997	Klein‐Nulend J, Burger EH, Semeins CM, Raisz LG, Pilbeam CC. Pulsating fluid flow stimulates prostaglandin release and inducible prostaglandin g/h synthase mrna expression in primary mouse bone cells. J Bone Miner Res. January 1997;12(1):45-51.
1990	Nunamaker DM, Butterweck DM, Provost MT. Fatigue fractures in thoroughbred racehorses: relationships with age, peak bone strain, and training. J Orthop Res. July 1990;8(4):604-611.
1984	Rubin CT. Skeletal strain and the functional significance of bone architecture. Calcif Tiss Int. March 1984;36(suppl 1):S11-S18.
1996	Fox SW, Chambers TJ, Chow JW. Nitric oxide is an early mediator of the increase in bone formation by mechanical stimulation. Am J Physiol Endocrinol Metab. June 1996;270(6):E955-E960.
1996	Bronckers ALJJ, Goei W, Luo G, Karsenty G, D'Souza RN, Lyaruu DM, Burger EH. DNA fragmentation during bone formation in neonatal rodents assessed by transferase-mediated end labeling. J Bone Miner Res. September 1996;11(9):1281-1291.
1996	Burr DB, Milgrom C, Fyhrie D, Forwood M, Nyska M, Finestone A, Hoshaw S, Saiag E, Simkin A. In vivo measurement of human tibial strains during vigorous activity. Bone. May 1996;18(5):405-410.
1997	Burr DB, Forwood MR, Fyhrie DP, Martin RB, Schaffler MB, Turner CH. Bone microdamage and skeletal fragility in osteoporotic and stress fractures. J Bone Miner Res. January 1997;12(1):6-15.
1996	Forwood MR. Inducible cyclo‐oxygenase (COX‐2) mediates the induction of bone formation by mechanical loading in vivo. J Bone Miner Res. November 1996;11(11):1688-1693.
1991	Burger EH, Nijweide PJ. Cellular origin and theories of osteoclast differentiation. In: Hall BK, ed. Bone. Volume 2: The Osteoclast. Boca Raton, FL: Inc., CRC Press; 1991:31-59.
1993	Burr DB. Remodeling and the repair of fatigue damage. Calcif Tiss Int. February 1993;53(suppl 1):S75-S81.
1994	Weinbaum S, Cowin SC, Zeng Y. A model for the excitation of osteocytes by mechanical loading-induced bone fluid shear stresses. J Biomech. March 1994;27(3):339-360.
1987	Salzstein RA, Pollack SR, Mak AFT, Petrov N. Electromechanical potentials in cortical bone, I: a continuum approach. J Biomech. 1987;20(3):261-270.
1998	Mosley JR, Lanyon LE. Strain rate as a controlling influence on adaptive modeling in response to dynamic loading of the ulna in growing male rats. Bone. October 1998;23(4):313-318.
1999	Ajubi NE, Klein-Nulend J, Alblas MJ, Burger EH, Nijweide PJ. Signal transduction pathways involved in fluid flow-induced PGE₂ production by cultured osteocytes. Am J Physiol Endocrinol Metab. January 1999;276(1):E171-E178.
1892	Wolff J. Das Gesetz der Transformation der Knochen. Berlin: Hirschwald; 1892.

Year	Entry
2007	Cowin SC, Doty SB. Bone tissue adaptation. In: Tissue Mechanics. Boca Raton, FL: Springer; 2007:385-424.
2004	Doblaré M, García JM, Gomez MJ. Modelling bone tissue fracture and healing: a review. Eng Fract Mech. September 2004;71(13-14):1809-1840.
2007	Fratzl P, Weinkamer R. Nature’s hierarchical materials. Prog Mater Sci. November 2007;52(8):1263-1334.
2012	Druchok C. The Effect of a High-Fat Diet on Bone Strain in Adult Rat Femurs [Master's thesis]. Hamilton, ON: McMaster University; October 2012.
2016	Druchok C. Temporal Influence of NSAIDs on Mechanically Induced Bone Formation and Fluid Flow Stimulated Cellular PGE₂ Production [PhD thesis]. Hamilton, ON: McMaster University; August 2016.
2004	Tovar A. Bone Remodeling as a Hybrid Cellular Automaton Optimization Process [PhD thesis]. University of Notre Dame; December 2004.
2007	Scannell PT. Mechanoregulation Algorithms Predicting Peri-Prosthetic Bone Adaptations [PhD thesis]. Trinity College Dublin; 2007.
2006	Rouhi G. Theoretical Aspects of Bone Remodeling and Resorption Processes [PhD thesis]. Calgary, AB: University of Calgary; March 2006.