Effects of Age -Related Ultra-Structural Level Changes in Bone on Microdamage Mechanisms

Year	Entry
1998	Zioupos P, Casinos A. Cumulative damage and the response of human bone in two-step loading fatigue. J Biomech. September 1998;31(9):825-833.
1998	Yeni YN, Brown CU, Norman TL. Influence of bone composition and apparent density on fracture toughness of the human femur and tibia. Bone. January 1998;22(1):79-84.
1993	Parfitt AM. Bone age, mineral density, and fatigue damage. Calcif Tiss Int. February 1993;53(suppl 1):S82-S86.
1999	Timlin JA, Carden A, Morris MD. Chemical microstructure of cortical bone probed by Raman transects. Appl Spectrosc. November 1999;53(11):1429-1435.
1993	Heaney RP. Is there a role for bone quality in fragility fractures? Calcif Tiss Int. February 1993;53(suppl 1):S3-S6.
1999	Timlin JA, Carden A, Morris MD, Bonadio JF, Hoffler CE II, Kozloff K, Goldstein SA. Spatial distribution of phosphate species in mature and newly generated mammalian bone by hyperspectral Raman imaging. J Biomed Opt. January 1999;4(1):28-34.
1991	Rey C, Renugopalakrishman V, Collins B, Glimcher MJ. Fourier transform infrared spectroscopic study of the carbonate ions in bone mineral during aging. Calcif Tiss Int. October 1991;49(4):251-258.
2000	Timlin JA, Carden A, Morris MD, Rajachar RM, Kohn DH. Raman spectroscopic imaging markers for fatigue-related microdamage in bovine bone. Anal Chem. May 15, 2000;72(10):2229-2236.
1993	Turner CH, Burr DB. Basic biomechanical measurements of bone: a tutorial. Bone. 1993;14(4):595-608.
1970	Chamay A. Mechanical and morphological aspect of experimental overload and fatigue in bone. J Biomech. May 1970;3(3):263-270.
1995	Landis WJ. The strength of a calcified tissue depends in part on the molecular structure and organization of its constituent mineral crystals in their organic matrix. Bone. May 1995;16(5):533-544.
1993	Grynpas M. Age and disease-related changes in the mineral of bone. Calcif Tiss Int. February 1993;53(suppl 1):S57-S64.
1997	Jepsen KJ, Davy DT. Comparison of damage accumulation measures in human cortical bone. J Biomech. September 1997;30(9):891-894.
1960	Frost HM. Presence of microscopic cracks in vivo in bone. Henry Ford Hosp Med Bull. 1960;8(1):25-35.
1977	Carter DR, Hayes WC. Compact bone fatigue damage: a microscopic examination. Clin Orthop Relat Res. September 1977;127:265-274.
1993	Mori S, Burr DB. Increased intracortical remodeling following fatigue damage. Bone. March–April 1993;14(2):103-109.
1999	Muir P, Johnson KA, Ruaux-Mason CP. In vivo matrix microdamage in a naturally occurring canine fatigue fracture. Bone. November 1999;25(5):571-576.
2002	Tarnowski CP, Ignelzi MA Jr, Morris MD. Mineralization of developing mouse calvaria as revealed by Raman microspectroscopy. J Bone Miner Res. June 2002;17(6):1118-1126.
1992	Akhter MP, Raab DM, Turner CH, Kimmel DB, Recker RR. Characterization of in vivo strain in the rat tibia during external application of a four-point bending load. J Biomech. October 1992;25(10):1241-1246.
1993	Ott SM. When bone mass fails to predict bone failure. Calcif Tiss Int. February 1993;53(suppl 1):S7-S13.
1999	Zysset PK, Guo XE, Hoffler CE, Moore KE, Goldstein SA. Elastic modulus and hardness of cortical and trabecular bone lamellae measured by nanoindentation in the human femur. J Biomech. October 1999;32(10):1005-1012.
2001	Ou‐Yang H, Paschalis EP, Mayo WE, Boskey AL, Mendelsohn R. Infrared microscopic imaging of bone: spatial distribution of CO₃²⁻. J Bone Miner Res. May 2001;16(5):893-900.
1998	Guo XE, Liang LC, Goldstein SA. Micromechanics of osteonal cortical bone fracture. J Biomech Eng. February 1998;120(1):112-117.
1996	Gustafson MB, Martin RB, Gibson V, Storms DH, Stover SM, Gibeling J, Griffin L. Calcium buffering is required to maintain bone stiffness in saline solution. J Biomech. September 1996;29(9):1191-1194.
1991	Pleshko N, Boskey A, Mendelsohn R. Novel infrared spectroscopic method for the determination of crystallinity of hydroxyapatite minerals. Biophys J. October 1991;60(4):786-793.
2000	Carden A, Morris MD. Application of vibrational spectroscopy to the study of mineralized tissues (review). J Biomed Opt. July 2000;5(3):259-268.
1985	Burr DB, Martin RB, Schaffler MB, Radin EL. Bone remodeling in response to in vivo fatigue microdamage. J Biomech. 1985;18(3):189-200.
2000	Gadeleta SJ, Boskey AL, Paschalis E, Carlson C, Menschik F, Baldini T, Peterson M, Rimnac CM. A physical, chemical, and mechanical study of lumbar vertebrae from normal, ovariectomized, and nandrolone decanoate-treated cynomolgus monkeys (macaca fascicularis). Bone. October 2000;27(4):541-550.
1996	Fratzl P, Schreiber S, Klaushofer K. Bone mineralization as studied by small-angle x-ray scattering. Connect Tissue Res. 1996;34(4):247-254.
1997	Jepsen KJ, Schaffler MB, Kuhn JL, Goulet RW, Bonadio J, Goldstein SA. Type I collagen mutation alters the strength and fatigue behavior of Mov13 cortical tissue. J Biomech. November–December 1997;30(11-12):1141-1147.
1996	Zioupos P, Wang XT, Currey JD. Experimental and theoretical quantification of the development of damage in fatigue tests of bone and antler. J Biomech. August 1996;29(8):989-1002.
1992	Boskey AL, Pleshko N, Doty SB, Mendelsohn R. Applications of fourier transform infrared (FT-IR) microscopy to the study of mineralization in bone and cartilage. Cell Mater. 1992;2(3):209-220.
1999	Baig AA, Fox JL, Young RA, Wang Z, Hsu J, Higuchi WI, Chhettry A, Zhuang H, Otsuka M. Relationships among carbonated apatite solubility, crystallite size, and microstrain parameters. Calcif Tiss Int. May 1999;64(5):437-449.
1996	Pattin CA, Caler WE, Carter DR. Cyclic mechanical property degradation during fatigue loading of cortical bone. J Biomech. January 1996;29(1):69-79.
1996	Prendergast PJ, Huiskes R. Microdamage and osteocyte-lacuna strain in bone: a microstructural finite element analysis. J Biomech Eng. May 1996;118(2):240-246.
1998	Boyce TM, Fyhrie DP, Glotkowski MC, Radin EL, Schaffler MB. Damage type and strain mode associations in human compact bone bending fatigue. J Orthop Res. May 1998;16(3):322-329.
1988	Hui SL, Slemenda CW, Johnston CC Jr. Age and bone mass as predictors of fracture in a prospective study. J Clin Invest. June 1988;81(6):1804-1809.
1994	Schaffler MB, Pitchford WC, Choi K, Riddle JM. Examination of compact bone microdamage using back-scattered electron microscopy. Bone. September–October 1994;15(5):483-488.
1995	Schaffler MB, Choi K, Milgrom C. Aging and matrix microdamage accumulation in human compact bone. Bone. December 1995;17(6):521-525.
2000	Sevostianov I, Kachanov M. Impact of the porous microstructure on the overall elastic properties of the osteonal cortical bone. J Biomech. July 2000;33(7):881-888.
1982	Lanyon LE, Goodship AE, Pye CJ, MacFie JH. Mechanically adaptive bone remodelling. J Biomech. 1982;15(3):141-154.
1993	Boyde A, Elliott JC, Jones SJ. Stereology and histogram analysis of backscattered electron images: age changes in bone. Bone. May–June 1993;14(3):205-210.
2001	Paschalis EP, Verdelis K, Doty SB, Boskey AL, Mendelsohn R, Yamauchi M. Spectroscopic characterization of collagen cross‐links in bone. J Bone Miner Res. October 2001;16(10):1821-1828.
1987	Legros R, Balmain N, Bonel G. Age-related changes in mineral of rat and bovine cortical bone. Calcif Tiss Int. September 1987;41(3):137-144.
1993	Burr DB. Remodeling and the repair of fatigue damage. Calcif Tiss Int. February 1993;53(suppl 1):S75-S81.
1999	Camacho NP, Rinnerthaler S, Paschalis EP, Mendelsohn R, Boskey AL, Fratzl P. Complementary information on bone ultrastructure from scanning small angle X-ray scattering and Fourier-transform infrared microspectroscopy. Bone. September 1999;25(3):287-293.
1994	Zioupos P, Currey JD, Sedman AJ. An examination of the micromechanics of failure of bone and antler by acoustic emission tests and laser scanning confocal microscopy. Med Eng Phys. May 1994;16(3):203-212.
1999	Boskey AL, Wright TM, Blank RD. Collagen and bone strength. J Bone Miner Res. March 1999;14(3):330-335.
1997	Vashishth D, Behiri JC, Bonfield W. Crack growth resistance in cortical bone: concept of microcrack toughening. J Biomech. August 1997;30(8):763-769.
1996	Paschalis EP, DiCarlo E, Betts F, Sherman P, Mendelsohn R, Boskey AL. FTIR microspectroscopic analysis of human osteonal bone. Calcif Tiss Int. December 1996;59(6):480-487.
1997	Paschalis EP, Betts F, DiCarlo E, Mendelsohn R, Boskey AL. FTIR microspectroscopic analysis of normal human cortical and trabecular bone. Calcif Tiss Int. December 1997;61(6):480-486.
1996	Wenzel TE, Schaffler MB, Fyhrie DP. In vivo trabecular microcracks in human vertebral bone. Bone. August 1996;19(2):89-95.
1998	Fazzalari NL, Forwood MR, Manthey BA, Smith K, Kolesik P. Three-dimensional confocal images of microdamage in cancellous bone. Bone. October 1998;23(4):373-378.
1991	Sasaki N, Ikawa T, Fukuda A. Orientation of mineral in bovine bone and the anisotropic mechanical properties of plexiform bone. J Biomech. 1991;24(1):57-61.
1976	Ascenzi A, Bonucci E. Mechanical similarities between alternate osteons and cross-ply laminates. J Biomech. 1976;9(2):65-71.
1998	Zioupos P, Currey JD. Changes in the stiffness, strength, and toughness of human cortical bone with age. Bone. January 1998;22(1):57-66.
1989	Martin RB, Ishida J. The relative effects of collagen fiber orientation, porosity, density, and mineralization on bone strength. J Biomech. 1989;22(5):419-426.
1999	Reilly GC, Currey JD. The development of microcracking and failure in bone depends on the loading mode to which it is adapted. J Exp Biol. 1999;202(5):543-552.
1996	Norman TL, Nivargikar SV, Burr DB. Resistance to crack growth in human cortical bone is greater in shear than in tension. J Biomech. August 1996;29(8):1023-1031.
1997	Paschalis EP, Betts F, DiCarlo E, Mendelsohn R, Boskey AL. FTIR microspectroscopic analysis of human iliac crest biopsies from untreated osteoporotic bone. Calcif Tiss Int. December 1997;61(6):487-492.
1991	Rey C, Shimizu M, Collins B, Glimcher MJ. Resolution-enhanced fourier transform infrared spectroscopy study of the environment of phosphate ion in the early deposits of a solid phase of calcium phosphate in bone and enamel and their evolution with age, II: investigations in the v₃ PO₄ domain. Calcif Tiss Int. December 1991;49(6):383-388.
1967	Ascenzi A, Bonucci E. The tensile properties of single osteons. Acta Anat. 1967;158(4):375-386.
2000	Reilly GC. Observations of microdamage around osteocyte lacunae in bone. J Biomech. September 2000;33(9):1131-1134.
2002	Halloran BP, Ferguson VL, Simske SJ, Burghardt A, Venton LL, Majumdar S. Changes in bone structure and mass with advancing age in the male C57BL/6J mouse. J Bone Miner Res. June 2002;17(6):1044-1050.
1998	Norman TL, Yeni YN, Brown CU, Wang Z. Influence of microdamage on fracture toughness of the human femur and tibia. Bone. September 1998;23(3):303-306.
2000	Hoffler CE, Moore KE, Kozloff K, Zysset PK, Brown MB, Goldstein SA. Heterogeneity of bone lamellar-level elastic moduli. Bone. June 2000;26(6):603-609.
1996	Courtney AC, Hayes WC, Gibson LJ. Age-related differences in post-yield damage in human cortical bone: experiment and model. J Biomech. November 1996;29(11):1463-1471.
1997	Burr DB, Forwood MR, Fyhrie DP, Martin RB, Schaffler MB, Turner CH. Bone microdamage and skeletal fragility in osteoporotic and stress fractures. J Bone Miner Res. January 1997;12(1):6-15.
1965	Sneddon IN. The relation between load and penetration in the axisymmetric Boussinesq problem for a punch of arbitrary profile. Int J Eng Sci. May 1965;3(1):47-57.
1995	Burr DB, Hooser M. Alterations to the en bloc basic fuchsin staining protocol for the demonstration of microdamage produced in vivo. Bone. October 1995;17(4):431-433.
1993	Martin RB, Boardman DL. The effects of collagen fiber orientation, porosity, density, and mineralization on bovine cortical bone bending properties. J Biomech. September 1993;26(9):1047-1054.
2000	Mashiba T, Hirano T, Turner CH, Forwood MR, Johnston CC, Burr DB. Suppressed bone turnover by bisphosphonates increases microdamage accumulation and reduces some biomechanical properties in dog rib. J Bone Miner Res. April 2000;15(4):613-620.
1990	Burr DB, Stafford T. Validity of the bulk-staining technique to separate artifactual from in vivo bone microdamage. Clin Orthop Relat Res. November 1990;260:305-308.
1996	Currey JD, Brear K, Zioupos P. The effects of ageing and changes in mineral content in degrading the toughness of human femora. J Biomech. February 1996;29(2):257-260.
1995	Mikić B, Carter DR. Bone strain gage data and theoretical models of functional adaptation. J Biomech. April 1995;28(4):465-469.
1999	Jepsen KJ, Davy DT, Krzypow DJ. The role of the lamellar interface during torsional yielding of human cortical bone. J Biomech. March 1999;32(3):303-310.
2000	Lee TC, O'Brien FJ, Taylor D. The nature of fatigue damage in bone. Int J Fract. November 2000;22(10):847-853.
1994	Zioupos P, Currey JD. The extent of microcracking and the morphology of microcracks in damaged bone. J Mater Sci. 1994;29(4):978-986.
1998	Burr DB, Turner CH, Naick P, Forwood MR, Ambrosius W, Hasan MS, Pidaparti R. Does microdamage accumulation affect the mechanical properties of bone? J Biomech. April 1998;31(4):337-345.
1996	Zioupos P, Wang XT, Currey JD. The accumulation of fatigue microdamage in human cortical bone of two different ages in vitro. Clin Biomech (Bristol, Avon). October 1996;11(7):365-375.

Year	Entry
2007	Wallace JM, Rajachar RM, Allen MR, Bloomfield SA, Robey PG, Young MF, Kohn DH. Exercise-induced changes in the cortical bone of growing mice are bone- and gender-specific. Bone. April 2007;40(4):1120-1127.
2007	Wallace JM III. Investigating the Inbred Strain-Specific Response to Biglycan-Deficiency and Exercise: A Study in Genetically-Mediated Skeletal Adaptation [PhD thesis]. University of Michigan; 2007.
2009	Sahar ND. Investigating the Effects of Age and Exercise on Bone Composition and the Impact of Composition on Mechanical Integrity. [PhD thesis]. University of Michigan; 2009.