Multilineage potential of adult human mesenchymal stem cells

Pittenger, Mark F.; Mackay, Alastair M.; Beck, Stephen C.; Jaiswal, Rama K.; Douglas, Robin; Mosca, Joseph D.; Moorman, Mark A.; Simonetti, Donald W.; Craig, Stewart; Marshak, Daniel R.

Year	Entry
2016	Krell ES, Montemurro NJ, Pacific KP, Emele L, Lin SS. Orthobiologics in foot & ankle. In: Valderrabano V, Easley M, eds. Foot and Ankle Sports Orthopaedics. Cham, Switzerland: Springer International Publishing; 2016:119-125.
2008	Gurkan UA, Akkus O. The mechanical environment of bone marrow: a review. Ann Biomed Eng. December 2008;36(12):1978-1991.
2006	Estes BT, Wu AW, Guilak F. Potent induction of chondrocytic differentiation of human adipose-derived adult stem cells by bone morphogenetic protein 6. Arthritis Rheum. April 2006;54(4):1222-1232.
2006	Pelttari K, Winter A, Steck E, Goetzke K, Hennig T, Ochs BG, Aigner T, Richter W. Premature induction of hypertrophy during in vitro chondrogenesis of human mesenchymal stem cells correlates with calcification and vascular invasion after ectopic transplantation in SCID mice. Arthritis Rheum. October 2006;54(10):3254-3266.
2001	Justesen J, Stenderup K, Ebbesen EN, Mosekilde L, Steiniche T, Kassem M. Adipocyte tissue volume in bone marrow is increased with aging and in patients with osteoporosis. Biogerontology. September 2001;2(3):165-171.
2000	Temenoff JS, Mikos AG. Review: tissue engineering for regeneration of articular cartilage. Biomaterials. March 1, 2000;21(5):431-440.
2003	Yoshimoto H, Shin YM, Terai H, Vacanti JP. A biodegradable nanofiber scaffold by electrospinning and its potential for bone tissue engineering. Biomaterials. May 2003;24(12):2077-2082.
2004	Awad HA, Wickham MQ, Leddy HA, Gimble JM, Guilak F. Chondrogenic differentiation of adipose-derived adult stem cells in agarose, alginate, and gelatin scaffolds. Biomaterials. July 2004;25(16):3211-3222.
2005	Li W-J, Tuli R, Okafor C, Derfoul A, Danielson KG, Hall DJ, Tuan RS. A three-dimensional nanofibrous scaffold for cartilage tissue engineering using human mesenchymal stem cells. Biomaterials. February 2005;26(6):599-609.
2005	Li W-J, Tuli R, Huang X, Laquerriere P, Tuan RS. Multilineage differentiation of human mesenchymal stem cells in a three-dimensional nanofibrous scaffold. Biomaterials. September 2005;26(25):5158-5166.
2007	Baker BM, Mauck RL. The effect of nanofiber alignment on the maturation of engineered meniscus constructs. Biomaterials. April 2007;28(11):1967-1977.
2007	Mauck RL, Byers BA, Yuan X, Tuan RS. Regulation of cartilaginous ECM gene transcription by chondrocytes and MSCs in 3D culture in response to dynamic loading. Biomech Model Mechanobiol. January 2007;6(1-2):113-125.
2020	Ali D, Chen L, Kowal JM, Okla M, Manikandan M, AlShehri M, AlMana Y, AlObaidan R, AlOtaibi N, Hamam R, Alajez NM, Aldahmash A, Kassem M, Alfayez M. Resveratrol inhibits adipocyte differentiation and cellular senescence of human bone marrow stromal stem cells. Bone. April 2020;133:115252.
2020	Yianni V, Sharpe PT. Epigenetic mechanisms driving lineage commitment in mesenchymal stem cells. Bone. May 2020;134:115309.
2020	Louvet L, Leterme D, Delplace S, Miellot F, Marchandise P, Gauthier V, Hardouin P, Chauveau C, Ghali Mhenni O. Sirtuin 1 deficiency decreases bone mass and increases bone marrow adiposity in a mouse model of chronic energy deficiency. Bone. July 2020;136:115361.
2020	Cakouros D, Gronthos S. The changing epigenetic landscape of mesenchymal stem/stromal cells during aging. Bone. August 2020;137:115440.
2021	Moussa FM, Cook BP, Sondag GR, DeSanto M, Obri MS, McDermott SE, Safadi FF. The role of miR-150 regulates bone cell differentiation and function. Bone. April 2021;145:115470.
2024	Cao Y, Bolam SM, Boss AL, Murray HC, Munro JT, Poulsen RC, Dalbeth N, Brooks AE, Matthews BG. Characterization of adult human skeletal cells in different tissues reveals a CD90⁺CD34⁺ periosteal stem/progenitor population. Bone. January 2024;178:116926.
2021	Wallimann A, Hildebrand M, Groeger D, Stanic B, Akdis CA, Zeiter S, Richards RG, Moriarty TF, O’Mahony L, Thompson K. An exopolysaccharide produced by Bifidobacterium longum 35624® inhibits osteoclast formation via a tlr2-dependent mechanism. Calcif Tiss Int. May 2021;108(5):654-666.
2006	Engler AJ, Sen S, Sweeney HL, Discher DE. Matrix elasticity directs stem cell lineage specification. Cell. August 25, 2006;126(4):P677-P689.
2014	Zhou BO, Yue R, Murphy MM, Peyer JG, Morrison SJ. Leptin-receptor-expressing mesenchymal stromal cells represent the main source of bone formed by adult bone marrow. Cell Stem Cell. August 7, 2014;15(2):154-168.
2004	McBeath R, Pirone DM, Nelson CM, Bhadriraju K, Chen CS. Cell shape, cytoskeletal tension, and RhoA regulate stem cell lineage commitment. Dev Cell. April 2004;6(4):483-495.
2003	Winkler DG, Sutherland MK, Geoghegan JC, Yu C, Hayes T, Skonier JE, Shpektor D, Jonas M, Kovacevich BR, Staehling-Hampton K, Appleby M, Brunkow ME, Latham JA. Osteocyte control of bone formation via sclerostin, a novel BMP antagonist. EMBO J. January 2003;22(23):6267-6276.
2007	David V, Martin A, Lafage-Proust M-H, Malaval L, Peyroche S, Jones DB, Vico L, Guignandon A. Mechanical loading down-regulates peroxisome proliferator-activated receptor γ in bone marrow stromal cells and favors osteoblastogenesis at the expense of adipogenesis. Endocrinology. May 2007;148(5):2553-2562.
2000	Manolagas SC. Birth and death of bone cells: basic regulatory mechanisms and implications for the pathogenesis and treatment of osteoporosis. Endocr Rev. April 2000;21(2):115-137.
2001	Barry F, Boynton RE, Liu B, Murphy JM. Chondrogenic differentiation of mesenchymal stem cells from bone marrow: differentiation-dependent gene expression of matrix components. Exp Cell Res. August 15, 2001;268(2):189-200.
2003	Simmons CA, Matlis S, Thornton AJ, Chen S, Wang C-Y, Mooney DJ. Cyclic strain enhances matrix mineralization by adult human mesenchymal stem cells via the extracellular signal-regulated kinase (ERK1/2) signaling pathway. J Biomech. August 2003;36(8):1087-1096.
2002	Kalajzic I, Kalajzic Z, Kaliterna M, Gronowicz G, Clark SH, Lichtler AC, Rowe D. Use of type I collagen green fluorescent protein transgenes to identify subpopulations of cells at different stages of the osteoblast lineage. J Bone Miner Res. January 2002;17(1):15-25.
2009	Colnot C. Skeletal cell fate decisions within periosteum and bone marrow during bone regeneration. J Bone Miner Res. February 2009;24(2):274-282.
2019	Chen Y, Aiken A, Saw S, Weiss A, Fang H, Khokha R. TIMP loss activates metalloproteinase‐TNFΑ‐DKK1 axis to compromise Wnt signaling and bone mass. J Bone Miner Res. January 2019;34(1):182-194.
2020	Zhu H, Swami S, Yang P, Shapiro F, Wu JY. Direct reprogramming of mouse fibroblasts into functional osteoblasts. J Bone Miner Res. April 2020;35(4):698-713.
2020	Schepper JD, Collins F, Rios‐Arce ND, Kang HJ, Schaefer L, Gardinier JD, Raghuvanshi R, Quinn RA, Britton R, Parameswaran N, McCabe LR. Involvement of the gut microbiota and barrier function in glucocorticoid‐induced osteoporosis. J Bone Miner Res. April 2020;35(4):801-820.
2022	De Kinderen P, Meester J, Loeys B, Peeters S, Gouze E, Woods S, Mortier G, Verstraeten A. Differentiation of induced pluripotent stem cells into chondrocytes: methods and applications for disease modeling and drug discovery. J Bone Miner Res. March 2022;37(3):397-410.
2007	Caplan AI. Adult mesenchymal stem cells for tissue engineering versus regenerative medicine. J Cell Physiol. November 2007;213(2):341-347.
2004	Li YJ, Batra NN, You L, Meier SC, Coe IA, Yellowley CE, Jacobs CR. Oscillatory fluid flow affects human marrow stromal cell proliferation and differentiation. J Orthop Res. November 2004;22(6):1283-1289.
2009	Riddle RC, Donahue HJ. From streaming-potentials to shear stress: 25 years of bone cell mechanotransduction. J Orthop Res. February 2009;27(2):143-149.
2022	Ebert R, Weissenberger M, Braun C, Wagenbrenner M, Herrmann M, Müller-Deubert S, Krug M, Jakob F, Rudert M. Impaired regenerative capacity and senescence-associated secretory phenotype in mesenchymal stromal cells from samples of patients with aseptic joint arthroplasty loosening. J Orthop Res. February 2022;40(2):513-523.
2004	Salgado AJ, Coutinho OP, Reis RL. Bone tissue engineering: state of the art and future trends. Macromol Biosci. August 9, 2004;4(8):743-765.
1999	Ferguson C, Alpern E, Miclau T, Helms JA. Does adult fracture repair recapitulate embryonic skeletal formation? Mech Dev. September 1999;87(1-2):57-66.
2002	Zuk PA, Zhu M, Ashjian P, De Ugarte DA, Huang JI, Mizuno H, Alfonso ZC, Fraser JK, Benhaim P, Hedrick MH. Human adipose tissue is a source of multipotent stem cells. Mol Biol Cell. December 2002;13(12):4279-4295.
2010	Estes BT, Diekman BO, Gimble JM, Guilak F. Isolation of adipose-derived stem cells and their induction to a chondrogenic phenotype. Nat Protoc. July 2010;5(7):1294-1311.
2012	Long F. Building strong bones: molecular regulation of the osteoblast lineage. Nat Rev Mol Cell Biol. January 2012;13(1):27-38.
2002	Hunziker EB. Articular cartilage repair: basic science and clinical progress. a review of the current status and prospects. Osteoarthritis Cartilage. June 2002;10(6):432-463.
2006	Mauck RL, Yuan X, Tuan RS. Chondrogenic differentiation and functional maturation of bovine mesenchymal stem cells in long-term agarose culture. Osteoarthritis Cartilage. February 2006;14(2):179-189.
2002	Sekiya I, Vuoristo JT, Larson BL, Prockop DJ. In vitro cartilage formation by human adult stem cells from bone marrow stroma defines the sequence of cellular and molecular events during chondrogenesis. Proc Natl Acad Sci USA. April 2, 2002;99(7):4397-4402.
2004	Huang CC, Hagar KL, Frost LE, Sun Y, Cheung HS. Effects of cyclic compressive loading on chondrogenesis of rabbit bone-marrow derived mesenchymal stem cells. Stem Cells. May 2004;22(3):313-323.
2001	Zuk PA, Zhu M, Mizuno H, Huang J, Futrell JW, Katz AJ, Benhaim P, Lorenz HP, Hedrick MH. Multilineage cells from human adipose tissue: implications for cell-based therapies. Tissue Eng. April 2001;7(2):211-228.
2006	Miyanishi K, Trindade MCD, Lindsey DP, Beaupré GS, Carter DR, Goodman SB, Schurman DJ, Smith RL. Effects of hydrostatic pressure and transforming growth factor-β3 on adult human mesenchymal stem cell chondrogenesis in vitro. Tissue Eng. June 2006;12(6):1419-1428.
2016	Beane OS. The Effects of Aging and Chemotherapeutics on Mesenchymal Stem Cell Regenerative Properties [PhD thesis]. Brown University; May 2016.
2017	Marble HD. Gene Expression-Based Identification and Isolation of Cellular Subpopulations [PhD thesis]. Brown University; May 2017.
2019	Sutermaster BA. Investigations in Cell Sorting Techniques [PhD thesis]. Brown University; May 2019.
2021	Dempsey M. Molecular Recognition Tools for Live-Cell Labeling and Enrichment [PhD thesis]. Brown University; October 2021.
2004	Pennington DE. Integrin Expression and Fibronectin Matrix Assembly During in Vitro Chondrogenesis [PhD thesis]. Cleveland, OH: Case Western Reserve University; May 2004.
2011	McBride SH. Multiscale Mechanobiology of Periosteal Bone Generation: Cell Scale Studies to Translational Models [PhD thesis]. Cleveland, OH: Case Western Reserve University; January 2011.
2013	Chang H. Toward Clinical Stem Cell Sourcing and Definition of Prescriptive Biophysical Protocols to Guide Stem Cell Fate During Healing [PhD thesis]. Cleveland, OH: Case Western Reserve University; August 2013.
2017	Tangtrongsup S. Effects of Dexamethasone and Oxidative Environment on Chondrogenesis of Bone Marrow-Derived Mesenchymal Stem Cells [PhD thesis]. Colorado State University; 2017.
2003	Mauck RL. Functional Tissue Engineering of Articular Cartilage: The Effect of Physical Forces on the in Vitro Growth of Engineered Constructs [PhD thesis]. Columbia University; 2003.
2009	Wang I-N. Role of Heterotypic Cellular Interactions in the Regeneration of the Anterior Cruciate Ligament-to-Bone Interface [PhD thesis]. Columbia University; 2009.
2011	Moffat KL. Biomimetic Nanofiber Scaffold Design for Tendon-to-Bone Interface Tissue Engineering [PhD thesis]. Columbia University; 2011.
2014	Sampat SR. Optimization of Culture Conditions for Cartilage Tissue Engineering Using Synovium-Derived Stem Cells [PhD thesis]. Columbia University; 2014.
2014	Subramony SD. Nanofiber-Based Scaffold for Integrative Anterior Cruciate Ligament Reconstruction [PhD thesis]. Columbia University; 2014.
2015	Chuang PJ. Development and Characterization of Ion Encapsulated Liposomes for Vesicle-Mediated Biomineralization [PhD thesis]. Columbia University; 2015.
2016	Zhang X. Nanofiber-Based Scaffold for Integrative Rotator Cuff Repair [PhD thesis]. Columbia University; 2016.
2017	Bogdanowicz DR. Designing the Stem Cell Microenvironment for Guided Connective Tissue Regeneration [PhD thesis]. Columbia University; 2017.
2017	Roach BL. Modulation of the in Vitro Mechanical and Chemical Environment for the Optimization of Tissue-Engineered Articular Cartilage [PhD thesis]. Columbia University; 2017.
2019	Qu D. Tissue Engineering Strategies for Fibrocartilage Interface Regeneration [PhD thesis]. Columbia University; 2019.
2010	Babalola OM. Effects of Physical Stimuli on Extracellular Matrix Assembly by Chondrocytes and Mesenchymal Stem Cells: Experimental and Finite Element Analyses [PhD thesis]. Ithaca, NY: Cornell University; May 2010.
2017	McCorry MC. Tissue Engineering the Meniscus for Clinical Translation: Stem Cells, Fibers, and Attachments [PhD thesis]. Ithaca, NY: Cornell University; August 2017.
2018	Cohen BP. Overcoming Clinical Challenges to Tissue Engineering the Human Auricle [PhD thesis]. Ithaca, NY: Cornell University; December 2018.
2020	Sloan SR Jr. Tissue-Engineered Annulus Fibrosus Repair and Nucleus Pulposus Augmentation in Pre-Clinical Models of Intervertebral Disc Degeneration [PhD thesis]. Ithaca, NY: Cornell University; May 2020.
2021	Lintz M. Tissue Engineering Strategies for Total Disc Replacement: Structure and Mechanical Function of the Intervertebral Disc [PhD thesis]. Ithaca, NY: Cornell University; August 2021.
2005	Androjna C. Natural Extracellular Matrices for Tendon Tissue Engineering [PhD thesis]. Cleveland State University; May 2005.
2020	Yu T. Chondroitin Sulfate Conjugated Nanofiber Shish Kebabs as Biomimetic Bone Templates [PhD thesis]. Drexel University; January 2020.
2008	Estes BT. Functional Tissue Engineering of Cartilage Using Adipose-Derived Stem Cells [PhD thesis]. Duke University; 2008.
2012	Diekman BO. Stem Cell-Based Strategies to Study, Prevent, and Treat Cartilage Injury and Osteoarthritis [PhD thesis]. Duke University; 2012.
2012	Lee EJ. Direct Differentiation of Mouse Induced Pluripotent Stem Cells Into Nucleus Pulposus-Like Cells [Master's thesis]. Duke University; 2012.
2015	Wu C-L. The Effects of Obesity on Stem Cell Function and the Development of Osteoarthritis [PhD thesis]. Duke University; 2015.
2016	Glass KA. Combined Gene Therapy and Functional Tissue Engineering for the Treatment of Osteoarthritis [PhD thesis]. Duke University; 2016.
2016	Juhas ME. Engineering Highly-Functional, Self-Regenerative Skeletal Muscle Tissues With Enhanced Vascularization and Survival in Vivo [PhD thesis]. Duke University; 2016.
2018	Huynh NPT. Bioinformatics and Molecular Approaches for the Development of Biological Artificial Cartilage [PhD thesis]. Duke University; 2018.
2008	Stok K. Biological Quantification of Murine Osteoarticular Joints Following Treatment Using Stem Cell-Based Gene Therapy [PhD thesis]. Swiss Federal Institute of Technology Zürich; 2008.
2014	Bruderer MS. Transcription Factor-Specific Reporter Constructs: Basis for the Functional Identification and Isolation of Subpopulations of Human Mesenchymal Stem Cells and Tool for Live Cell Approaches [PhD thesis]. Swiss Federal Institute of Technology Zürich; 2014.
2014	Studer D. Engineering Phenotypically Stable Cartilage [PhD thesis]. Swiss Federal Institute of Technology Zürich; 2014.
2014	Wüst S. 3D Bioprinting of Multicellular Skeletal Tissues [PhD thesis]. Swiss Federal Institute of Technology Zürich; 2014.
2015	Millan CA. Formation of Engineered Microtissues by Schiff Base Crosslinking [PhD thesis]. Swiss Federal Institute of Technology Zürich; 2015.
2015	Nimeskern LG. Functional Characterization of Auricular Cartilage in Tissue Engineering and Regenerative Medicine [PhD thesis]. Swiss Federal Institute of Technology Zürich; 2015.
2015	Vetsch JR. Perfusion Bioreactors for Bone Tissue Engineering: A Combined Experimental and Computational Approach [PhD thesis]. Swiss Federal Institute of Technology Zürich; 2015.
2016	Loebel C. Engineering Hyaluronan-Tyramine Hydrogels to Modulate Mesenchymal Stem Cell Behavior [PhD thesis]. Swiss Federal Institute of Technology Zürich; 2016.
2020	Kessel B. Advanced Biofabrication Methods for Cartilage Tissue Engineering [PhD thesis]. Swiss Federal Institute of Technology Zürich; 2020.
2005	Case ND. Oscillatory Compressive Loading Effects on Mesenchymal Progenitor Cells Undergoing Chondrogenic Differentiation in Hydrogel Suspension [PhD thesis]. Atlanta, GA: Georgia Institute of Technology; May 2005.
2005	Mouw JK. Mechanoregulation of Chondrocytes and Chondroprogenitors: The Role of TGF-Β and SMAD Signaling [PhD thesis]. Atlanta, GA: Georgia Institute of Technology; December 2005.
2005	Porter BD. Development and Application of a 3-D Perfusion Bioreactor Cell Culture System for Bone Tissue Engineering [PhD thesis]. Atlanta, GA: Georgia Institute of Technology; December 2005.
2006	Gemmiti CV. Effect of Fluid Flow on Tissue-Engineered Cartilage in a Novel Bioreactor [PhD thesis]. Atlanta, GA: Georgia Institute of Technology; December 2006.
2007	Connelly JT. Regulatory Mechanisms in the Chondrogenesis of Mesenchymal Progenitors: The Roles of Cyclic Tensile Loading and Cell-Matrix Interactions [PhD thesis]. Atlanta, GA: Georgia Institute of Technology; August 2007.
2007	Phillips JE. Runx2-Genetically Engineered Dermal Fibroblasts for Orthopaedic Tissue Repair [PhD thesis]. Atlanta, GA: Georgia Institute of Technology; December 2007.
2009	Wojtowicz AM. Genetically-Engineered Bone Marrow Stromal Cells and Collagen Mimetic Scaffold Modification for Healing Critically-Sized Bone Defects [PhD thesis]. Atlanta, GA: Georgia Institute of Technology; August 2009.
2010	Dupont KM. Human Stem Cell Delivery and Programming for Functional Regeneration of Large Segmental Bone Defects [PhD thesis]. Atlanta, GA: Georgia Institute of Technology; May 2010.
2013	Dosier CR. Bone Tissue Engineering Utilizing Adult Stem Cells in Biologically Functionalized Hydrogels [PhD thesis]. Atlanta, GA: Georgia Institute of Technology; May 2013.
2015	Allen AB. Modulation of Stem Cell Delivery Strategy by Platelet Lysate Utilization and Cell Aggregation for Enhanced Bone Regeneration [PhD thesis]. Atlanta, GA: Georgia Institute of Technology; August 2015.
2018	Garcia J. Hydrogel Engineering for Enhancing Vascularization and Augmenting Immunomodulation of Encapsulated Mesenchymal Stem Cells [PhD thesis]. Atlanta, GA: Georgia Institute of Technology; August 2018.
2008	Wang L. Tissue Engineering the TMJ Condyle Using Human Umbilical Cord Mesenchymal Stromal Cells [PhD thesis]. Lawrence, KS: University of Kansas; 2008.
2007	Geris L. Mathematical Modelling of Bone Regeneration During Fracture Healing and Implant Osseointegration [PhD thesis]. Katholieke Universiteit Leuven; May 2007.
2019	Ilas DC. The Role of Mesenchymal Stem Cells and Osteocytes in Subchondral Bone Changes in Hip Osteoarthritis [PhD thesis]. University of Leeds; May 2019.
2003	Chan GK. Delineation of Regulatory Factors and Mechanisms That Govern the Differentiation of Mesenchymal Cells to the Osteoblastic Lineage [PhD thesis]. McGill University; June 2003.
2003	Duque G. Molecular Changes in the Aging Osteoblast [PhD thesis]. McGill University; March 2003.
2013	Khayat G. Low Frequency Stimulation of Stem Cells in Dynamic Culture Modulates Differentiation Pathways [PhD thesis]. McGill University; July 2013.
2013	Vernon LL. Articular Cartilage Response Following Impact Injury [PhD thesis]. University of Miami; August 2013.
2009	Kopesky PW. Self-Assembling Peptide Hydrogels Promote in Vitro Chondrogenesis of Bone Marrow-Derived Stromal Cells: Effects of Peptide Sequence, Cell Donor Age, and Method of Growth Factor Delivery [PhD thesis]. Cambridge, MA: Massachusetts Institute of Technology; June 2009.
2010	Lee H-Y. Ultrastructure and Nanomechanical Properties of Aggrecan from Native Cartilage and Engineered Tissue [PhD thesis]. Cambridge, MA: Massachusetts Institute of Technology; June 2010.
2012	Florine EM. Optimizing Chondrogenic Factors and Protein Delivery Methods for Cartilage Repair [PhD thesis]. Cambridge, MA: Massachusetts Institute of Technology; June 2012.
2016	Liebesny PH. Single-Dose Growth Factor Treatments to Enhance Cell Recruitment and Neotissue Integration in an Augmented Microfracture Cartilage Repair Model [PhD thesis]. Cambridge, MA: Massachusetts Institute of Technology; June 2016.
2009	McCullen SD. Assessment of Nanofibrous Scaffold Chemistry, Design, and Use of Extracellular Stimuli for Bone Tissue Engineering [PhD thesis]. North Carolina State University; 2009.
2012	Samberg M. Biological Interactions of Silver Nanoparticles [PhD thesis]. North Carolina State University; 2012.
2013	Charoenpanich A. Analyses of Human Adipose Derived Stem Cells and Human Mesenchymal Stem Cells for Functional Tissue Engineering Using Biomimetic Physical Stimuli [PhD thesis]. North Carolina State University; 2013.
2015	Damaraju SM. Piezoelectric Scaffolds for Osteochondral Defect Repair [PhD thesis]. New Jersey Institute of Technology; May 2015.
2013	Weiss HE. Engineering a Replacement Bone Tissue With Adult Adipose-Derived Stem Cells [PhD thesis]. University of Notre Dame; April 2013.
2015	Coughlin TR. Mechanobiological Signals in Trabecular Bone and Marrow [PhD thesis]. University of Notre Dame; July 2015.
2017	Kreipke TC. Structural, Mechanical, and Biological Relationships of Trabecular Bone in Osteoporosis [PhD thesis]. University of Notre Dame; April 2017.
2010	Bahney CS. Cartilage Engineering: Designing an Improved System for Effecting Repair of Articular Cartilage Defects [PhD thesis]. Portland, OR: Oregon Health & Science University; August 2010.
2021	Chen T. Improving Transport and Storage of Mesenchymal Stem Cells Through Investigations Into Their Energy Metabolism [PhD thesis]. University of Oxford; 2021.
2017	Dwivedi G. Identification of in Situ Progenitor Cell Features Contributing to Cartilage Repair and Strategies for Cartilage Repair Augmentation [PhD thesis]. École polytechnique de Montréal; April 2017.
2010	Gurkan UA. Engineering of Bone Marrow in Vitro for Investigating the Role of Growth Factors and Their Mechanoresponsiveness in Osteogenesis [PhD thesis]. Purdue University; May 2010.
2018	Cai L. Magnetic Resonance Imaging for the Functional Analysis of Tissues and Biomaterials [PhD thesis]. Purdue University; May 2018.
2011	Zhao Y. The Characterization of Bovine Adipose-Derived Stem Cells in Conventional and Co-Culture Environments for Tissue Engineering [Master's thesis]. Queen's University; February 2011.
2010	Schrobback K. In Vitro Cultivation of Adult Human Chondrocytes: Importance of Culture System, Oxygen and Zonal Differences [PhD thesis]. Queensland University of Technology; 2010.
2015	Babur BK. Utilizing Micropellets as Building Blocks in Cartilage Tissue Engineering [PhD thesis]. Queensland University of Technology; February 2015.
2015	Kuaha K. Environments for Zonal Cartilage Tissue Engineering [PhD thesis]. Queensland University of Technology; 2015.
2016	Levett PA. Photocrosslinkable Hydrogels for Cartilage Tissue Engineering [PhD thesis]. Queensland University of Technology; 2016.
2020	Music E. Optimisation of Methods for Driving Chondrogenesis of Human and Ovine Bone Marrow–derived Stromal Cells [PhD thesis]. Queensland University of Technology; 2020.
2007	Hoben GMB. Self Assembly of Fibrochondrocytes and Human Embryonic Stem Cells for Tissue Engineering of Fibrocartilage [PhD thesis]. Houston, TX: Rice University; December 2007.
2007	Koay EJ. Chondrocyte Biomechanics and Chondrogenesis [PhD thesis]. Houston, TX: Rice University; December 2007.
2006	Tacy NJ. Mechano-Biological Regulation of Human Mesenchymal Stem Cell Osteogenic Differentiation [PhD thesis]. Troy, NY: Rensselaer Polytechnic Institute; May 2006.
2010	Janeiro C. The Effect of Bone Quality on Osteoclastic Bone Resorption [PhD thesis]. Troy, NY: Rensselaer Polytechnic Institute; May 2010.
2010	Liu S. Development and Initial Testing of a Rat Model for Particle-Induced Impaired Implant Fixation [PhD thesis]. Rush University; 2010.
2022	van Dijk Christiansen P. The Relevance of Reversal Cells and Intermittent Parathyroid Hormone on the Duration of the Reversal-Resorption Phase in Intracortical Bone Remodeling Events [PhD thesis]. University of Southern Denmark (SDU); November 2022.
2010	Viswanathan P. Emulsion Templated Porous Scaffolds for Bone Tissue Engineering [Master's thesis]. University of Sheffield; December 2010.
2013	Delaine-Smith RM. Mechanical and Physical Guidance of Osteogenic Differentiation and Matrix Production [PhD thesis]. University of Sheffield; January 2013.
2013	Viswanathan P. In Situ Surface Functionalisation of Scaffolds Using Block Copolymer Self-Assembly [PhD thesis]. University of Sheffield; 2013.
2013	Walker NG. The Role of Mesenchymal Stem Cells from Adult Human Bone Marrow in in Vitro Wound Models [PhD thesis]. University of Sheffield; June 2013.
2007	Malone AMD. Mechanotransduction Mechanisms in Bone Cells [PhD thesis]. Stanford University; August 2007.
2008	Arnsdorf EJ. Guiding Osteogenic Lineage Commitment: The Role of Mesenchymal Stem Cell Biology and the Mechanical Microenvironment [PhD thesis]. Stanford University; September 2008.
2009	Alwood JS. Radiation and Mechanical Unloading Effects on Mouse Vertebral Bone: Ground-Based Models of the Spaceflight Environment [PhD thesis]. Stanford University; September 2009.
2013	Zheng Ch. Effects of Biochemical Factors and Mechanical Loading on Chondrogenesis of Human Adipose-Derived Stem Cells [PhD thesis]. Stanford University; December 2013.
2005	Squire ME. Bone’s Response to Unloading, as Defined by Altered Gene Expression, Cellular Activity, and Architecture, is Modulated by Genetics and Gender [PhD thesis]. Stony Brook, NY: Stony Brook University; August 2005.
2009	Ozcivici E. Recovery of Trabecular Bone from Disuse Induced Deterioration in Cellular, Morphological and Biomechanical Properties [PhD thesis]. Stony Brook, NY: Stony Brook University; May 2009.
2010	Jatkar A. Whole Body Vibration as a Treatment to Counter Bone Detriment and Obesity Caused by Poor Nutritional Intake [Master's thesis]. Stony Brook, NY: Stony Brook University; May 2010.
2014	Pagnotti GM. Low Intensity Vibrations Mitigate Cancer-Induced Bone Loss With Indications of Reduced Tumor Progression [PhD thesis]. Stony Brook, NY: Stony Brook University; August 2014.
2007	McMahon LA. The Effect of Cyclic Tensile Loading and Growth Factors on the Chondrogenic Differentiation of Bone-Marrow Derived Mesenchymal Stem Cells in a Collagen-Glycosaminoglycan Scaffold [PhD thesis]. Trinity College Dublin; September 2007.
2010	Roddy KA. Mechanoregulation of Joint Morphogenesis: Investigating the Role of Muscle Induced Mechanical Forces in the Regulation of Differentiation and Growth in the Avian Knee Joint [PhD thesis]. Trinity College Dublin; 2010.
2014	Xue F. Computational Investigations of Mesenchymal Stem Cell Ageing in Mechanobiological Simulations of Tissue Differentiation [PhD thesis]. Trinity College Dublin; 2014.
2016	Vazão de Almeida HM. Cartilage Extracellular Matrix-Derived Scaffolds for Joint Regeneration [PhD thesis]. Trinity College Dublin; January 2016.
2017	Critchley SE. Towards 3D Bioprinting of Anatomically Accurate, Mechanically Reinforced Cartilage Templates for Biological Joint Resurfacing [PhD thesis]. Trinity College Dublin; 2017.
2017	Irvine AD. Modulating Mechanical Cues and Oxygen Availability to Regulate Chondrogenesis Within MSC Laden Hydrogels [PhD thesis]. Trinity College Dublin; June 2017.
2018	Daly A. 3D Bioprinting of Developmentally Inspired Templates for Bone and Joint Regeneration [PhD thesis]. Trinity College Dublin; March 2018.
2018	Olvera Ramos DP. Spatial Presentation of Tissue Specific Extracellular Matrix Components and Growth Factors on Porous Electrospun Fibre Scaffolds for Bone-Ligament Interface Tissue Engineering [PhD thesis]. Trinity College Dublin; 2018.
2015	Li H. Neural Stem/progenitor Cell 3-D Differentiation for Repair of Central Nervous System Injuries [PhD thesis]. University of Akron; May 2015.
1999	Awad HA. Mesenchymal Stem Cell Seeded Collagen Scaffolds for Tendon Repair [PhD thesis]. University of Cincinnati; 1999.
2013	Soicher MA. Fabrication and Characterization of Remineralized Bone Matrices (RBM) for Use as Bone Tissue Engineering Substrates [PhD thesis]. Davis, University of California; 2013.
2017	Brown WEHP. Engineering Osteochondral Constructs to Treat Articular Cartilage Defects [PhD thesis]. Davis, University of California; 2017.
2005	Klein TJ. Cartilage Tissue Engineering: Biophysical Modulation of Functional Depth-Dependent Properties [PhD thesis]. San Diego (UCSD), University of California; 2005.
2011	Cheng KK-W. Diminished Matrix in Pathologic Intervertebral Discs and Tissue Engineered Solutions [PhD thesis]. San Francisco, University of California; 2011.
2012	Statman LY. Mechanosensitive Β-Catenin Signaling Modulates Mesenchymal Stem Cell Chondrogenesis [PhD thesis]. San Francisco, University of California; 2012.
2001	Smith-Adaline EA. Influence of Mechanical Stimulation on Strain Environment and Patterns of Gene Expression During Fracture Healing [PhD thesis]. University of Michigan; 2001.
2004	Taboas JM. Mechanobiologic Regulation of Skeletal Progenitor Cell Differentiation [PhD thesis]. University of Michigan; 2004.
2007	Liao EE. Enhancement of Chondrogenesis by Directing Cellular Condensation Through Chondroinductive Microenvironments, And, Designed Solid Freeform Fabricated Scaffolds [PhD thesis]. University of Michigan; 2007.
2008	Weaver AS. The Effect of Mechanical Stimulation on Bone Fracture Healing: Changes in Callus Morphology and Mesenchymal Stem Cell Homing [PhD thesis]. University of Michigan; 2008.
2018	Wu B. Development of Self-Regulatory Gene Circuits for Cartilage Tissue Engineering [PhD thesis]. University of Michigan; 2018.
2007	Wu Y-L. Interaction of Bone Cells With Biomimetic Hydroxyapatite Gelatin Nanocomposites Towards Developing Bone Tissue Engineering [PhD thesis]. University of Minnesota; December 2007.
2014	O’Conor CJ. TRPV4-Mediated Mechanotransduction in Articular Cartilage Function and Disease [PhD thesis]. University of North Carolina at Chapel Hill; 2014.
2011	Thaler R. The Effect of the Lathyrogens Beta-Aminopropionitril and Homocysteine on Osteoblastic Differentiation in Regard to Collagen Matrix Formation and Epigenetic Regulation of Gene Expression [PhD thesis]. University of Vienna; June 2011.
2013	Blaber EA. Stem Cell-Based Tissue Regeneration in Space [PhD thesis]. University of New South Wales; November 2013.
2010	Baker BM. Meniscus Tissue Engineering With Nanofibrous Scaffolds [PhD thesis]. Philadelphia, PA: University of Pennsylvania; 2010.
2010	Huang AH. Enhancing Mesenchymal Stem Cell Chondrogenesis for Cartilage Tissue Engineering [PhD thesis]. Philadelphia, PA: University of Pennsylvania; 2010.
2010	Nerurkar NL. Integrating Theoretical and Experimental Methods for Multi-Scale Tissue Engineering of the Annulus Fibrosus of the Intervertebral Dis [PhD thesis]. Philadelphia, PA: University of Pennsylvania; 2010.
2011	Erickson IE. Optimization and Translation of MSC-Based Hyaluronic Acid Hydrogels for Cartilage Repair [PhD thesis]. Philadelphia, PA: University of Pennsylvania; 2011.
2011	Silverman LI. Enhancing Meniscus Repair Through Biomaterial Design [PhD thesis]. Philadelphia, PA: University of Pennsylvania; 2011.
2013	Farrell MJ. Cartilage Tissue Engineering With Heterogeneous and Clonal Mesenchymal Stem Cell Populations: Multi-Scale Analysis of Maturation, Stability, and Response to Environmental Stressors [PhD thesis]. Philadelphia, PA: University of Pennsylvania; 2013.
2015	Driscoll TP. Nuclear Connectivity in Mesenchymal Stem Cell Differentiation and Its Role in Mechanotransduction [PhD thesis]. Philadelphia, PA: University of Pennsylvania; 2015.
2015	Heo SC. Differentiation Induces Dynamic Alterations in Mesenchymal Stem Cell Nuclear Architecture and Mechanotransduction [PhD thesis]. Philadelphia, PA: University of Pennsylvania; 2015.
2017	Kim M. Multi-Cellular and Multi-Scale Approaches for Cartilage Repair [PhD thesis]. Philadelphia, PA: University of Pennsylvania; 2017.
2017	McLeod CM. Single Cell Molecular Heterogeneity in Musculoskeletal Differentiation [PhD thesis]. Philadelphia, PA: University of Pennsylvania; 2017.
2017	Mohanraj B. High Throughput and Mechano-Active Platforms to Promote Cartilage Regeneration and Repair [PhD thesis]. Philadelphia, PA: University of Pennsylvania; 2017.
2008	Moss IL. Modified-Hyaluronan and Elastin-Like Polypeptide Composite Material for Tissue Engineering of the Nucleus Pulposus [Master's thesis]. University of Toronto; 2008.
2013	Liu CC. Effects of a New Conjugate Drug in a Rat Model of Postmenopausal Osteoporosis [Master's thesis]. University of Toronto; 2013.
2018	Zhang L. Effects of Osteoblast-Specific Gα_S Overexpression on Skeletal Development and Response to Catabolic and Anabolic Stimuli Using a Transgenic Mouse Model [PhD thesis]. University of Toronto; 2018.
2013	Manning CN. Anti-Inflammatory Effect of Adipose-Derived Mesenchymal Stem Cells for Flexor Tendon Healing [PhD thesis]. St. Louis, MO: Washington University in St. Louis; August 2013.
2020	Ross A. Tissue Engineering of Induced Pluripotent Stem Cells for the Development of Novel Treatment Strategies for Osteoarthritis [PhD thesis]. St. Louis, MO: Washington University in St. Louis; May 2020.

Year	Entry
1998	Johnstone B, Hering TM, Caplan AI, Goldberg VM, Yoo JU. In vitro chondrogenesis of bone marrow-derived mesenchymal progenitor cells. Exp Cell Res. January 10, 1998;238(1):265-272.
1998	Mackay AM, Beck SC, Murphy JM, Barry FP, Chichester CO, Pittenger MF. Chondrogenic differentiation of cultured human mesenchymal stem cells from marrow. Tissue Eng. Winter 1998;4(4):415-428.