Bone, cartilage, and tendon healing are clinically challenging processes. In order to address these concerns, orthobiologic research aims to enhance key steps involved in these processes using autologous and recombinant compounds, with the goal of achieving maximal clinical results. The potential for a quicker return to sport is appealing for athletes at all levels, and many high profile cases have driven continued orthobiologic research. In this chapter, we review the current clinical evidence regarding the use of biologic agents and scaffolds to improve healing following injury to the foot and ankle.