Building strong bones:​ molecular regulation of the osteoblast lineage

Long, Fanxin

Affiliations

¹Departments of Medicine and Developmental Biology, Washington University School of Medicine, St Louis, Missouri 63110, USA

Abstract

The past 15 years have witnessed tremendous progress in the molecular understanding of osteoblasts, the main bone-forming cells in the vertebrate skeleton. In particular, all of the major developmental signals (including WNT and Notch signalling), along with an increasing number of transcription factors (such as RUNX2 and osterix), have been shown to regulate the differentiation and/or function of osteoblasts. As evidence indicates that osteoblasts may also regulate the behaviour of other cell types, a clear understanding of the molecular identity and regulation of osteoblasts is important beyond the field of bone biology

Links

DOI: 10.1038/nrm3254

PubMed: 22189423

WoS: 000298381700014

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Year	Entry
2020	Hojo H, Ohba S. Gene regulatory landscape in osteoblast differentiation. Bone. August 2020;137:115458.
2020	Kameo Y, Sakano N, Adachi T. Theoretical concept of cortical to cancellous bone transformation. Bone Rep. June 2020;12:100260.
2016	Wu M, Chen G, Li Y-P. TGF-β and BMP signaling in osteoblast, skeletal development, and bone formation, homeostasis and disease. Bone Res. 2016;4:16009.
2013	Baron R, Kneissel M. WNT signaling in bone homeostasis and disease: from human mutations to treatments. Nat Med. February 2013;19(2):179-192.
2014	Alshbool FZ. The Role of Claudins in Bone Metabolism [PhD thesis]. Loma Linda University; December 2014.
2013	Snyder KL. Development of Vapor Deposited Silica Sol-Gel Particles for a Bioactive Materials System to Direct Osteoblast Behavior [PhD thesis]. Houghton, MI: Michigan Technological University; 2013.
2015	Hunter RL. Variation in Cortical Osteocyte Lacunar Density and Distribution: Implications for Bone Quality Assessment [PhD thesis]. The Ohio State University; 2015.
2019	Maynard RD. Establishing the Functional Role of Cped1* in the Genetic Regulation of the Osteoblast* [PhD thesis]. University of Rochester; 2019.
2016	Sankaran JS. Identification of Genes That Modulate Bone Loss During Mechanical Unloading [PhD thesis]. Stony Brook, NY: Stony Brook University; August 2016.
2016	Takyar F. Osteoblastic EphrinB2 in Normal and Parathyroid Hormone (PTH)-Stimulated Bone Formation [PhD thesis]. University of Melbourne; June 2016.
2013	Tomlinson RE. The Role of Angiogenesis in Osteogenic Mechanical Loading [PhD thesis]. St. Louis, MO: Washington University in St. Louis; May 2013.
2021	Harris TL. Mechanisms for Osteoblast and Osteocyte Initiation and Sustainment of Bone Formation in Young-Adult and Aged Mice [PhD thesis]. St. Louis, MO: Washington University in St. Louis; August 2021.