Cell shape, cytoskeletal tension, and RhoA regulate stem cell lineage commitment

McBeath, Rowena; Pirone, Dana M.; Nelson, Celeste M.; Bhadriraju, Kiran; Chen, Christopher S.

Year	Entry
2013	Taiani JT, Krawetz RJ, Yamashita A, Pauchard Y, Buie HR, Ponjevic D, Boyd SK, Rancourt DE, Matyas JR. Embryonic stem cells incorporate into newly formed bone and do not form tumors in an immunocompetent mouse fracture model. Cell Transplant. 2013;22(8):1453-1462.
2008	Gurkan UA, Akkus O. The mechanical environment of bone marrow: a review. Ann Biomed Eng. December 2008;36(12):1978-1991.
2010	Nichol JW, Koshy ST, Bae H, Hwang CM, Yamanlar S, Khademhosseini A. Cell-laden microengineered gelatin methacrylate hydrogels. Biomaterials. July 2010;31(21):5536-5544.
2021	Hensley AP, McAlinden A. The role of microRNAs in bone development. Bone. February 2021;143:115760.
2021	Birks S, Uzer G. At the nuclear envelope of bone mechanobiology. Bone. October 2021;151:116023.
2006	Engler AJ, Sen S, Sweeney HL, Discher DE. Matrix elasticity directs stem cell lineage specification. Cell. August 25, 2006;126(4):P677-P689.
2006	Zhao C, Irie N, Takada Y, Shimoda K, Miyamoto T, Nishiwaki T, Suda T, Matsuo K. Bidirectional ephrinB2-EphB4 signaling controls bone homeostasis. Cell Metab. August 2006;4(2):111-121.
2009	Guilak F, Cohen DM, Estes BT, Gimble JM, Liedtke W, Chen CS. Control of stem cell fate by physical interactions with the extracellular matrix. Cell Stem Cell. July 2, 2009;5(1):17-26.
2007	David V, Martin A, Lafage-Proust M-H, Malaval L, Peyroche S, Jones DB, Vico L, Guignandon A. Mechanical loading down-regulates peroxisome proliferator-activated receptor γ in bone marrow stromal cells and favors osteoblastogenesis at the expense of adipogenesis. Endocrinology. May 2007;148(5):2553-2562.
2006	Ingber DE. Cellular mechanotransduction: putting all the pieces together again. FASEB J. May 2006;20(7):811-827.
2012	Thompson WR, Rubin CT, Rubin J. Mechanical regulation of signaling pathways in bone. Gene. July 25, 2012;503(2):179-193.
2005	Woods A, Wang G, Beier F. RhoA/ROCK signaling regulates Sox9 expression and actin organization during chondrogenesis. J Biol Chem. March 25, 2005;280(12):11626-11634.
2020	Sen B, Paradise CR, Xie Z, Sankaran J, Uzer G, Styner M, Meyer M, Dudakovic A, van Wijnen AJ, Rubin J. Β‐catenin preserves the stem state of murine bone marrow stromal cells through activation of EZH2. J Bone Miner Res. June 2020;35(6):1149-1162.
2017	Labriola NR. The Role of Mechanical Properties in Stem Cell Adipogenesis [PhD thesis]. Brown University; May 2017.
2018	Shah MK. Role of Mechanophenotype in Cell-Substrate Interactions [PhD thesis]. Brown University; May 2018.
2013	Miller GJ. Mechanoregulation and Mechanotransduction in Skeletal Tissue Differentiation [Master's thesis]. Boston University; 2013.
2008	McBride SH. Elucidating Biophysical Cues Conducive to Targeted Multipotent Cell Differentiation [Master's thesis]. Cleveland, OH: Case Western Reserve University; January 2008.
2011	McBride SH. Multiscale Mechanobiology of Periosteal Bone Generation: Cell Scale Studies to Translational Models [PhD thesis]. Cleveland, OH: Case Western Reserve University; January 2011.
2011	Zimmermann JA. Controlling Mesenchymal Stem Cell Shape and Fate Through Prescribed Seeding Conditions [Master's thesis]. Cleveland, OH: Case Western Reserve University; August 2011.
2012	Song MJ. Elucidating the Mechanical Milieu of Stem Cells in Situ and Delivering Mechanical Signals to Direct Cell Fate in Tissue Engineering Scaffolds [PhD thesis]. Cleveland, OH: Case Western Reserve University; August 2012.
2013	Chang H. Toward Clinical Stem Cell Sourcing and Definition of Prescriptive Biophysical Protocols to Guide Stem Cell Fate During Healing [PhD thesis]. Cleveland, OH: Case Western Reserve University; August 2013.
2017	Bogdanowicz DR. Designing the Stem Cell Microenvironment for Guided Connective Tissue Regeneration [PhD thesis]. Columbia University; 2017.
2017	Silverstein AM. Development of Biofidelic Culture Models of Osteoarthritis [PhD thesis]. Columbia University; 2017.
2012	Diekman BO. Stem Cell-Based Strategies to Study, Prevent, and Treat Cartilage Injury and Osteoarthritis [PhD thesis]. Duke University; 2012.
2019	Bjergaard SS. The Roles of Focal Adhesion Assembly in Membrane Localization of Ion Channels and Action Potential Shape [PhD thesis]. Duke University; 2019.
2014	Studer D. Engineering Phenotypically Stable Cartilage [PhD thesis]. Swiss Federal Institute of Technology Zürich; 2014.
2016	Loebel C. Engineering Hyaluronan-Tyramine Hydrogels to Modulate Mesenchymal Stem Cell Behavior [PhD thesis]. Swiss Federal Institute of Technology Zürich; 2016.
2018	Formica FA. From Electrospinning to Protein Engineering: Novel Approaches for Cartilage Repair [PhD thesis]. Swiss Federal Institute of Technology Zürich; 2018.
2006	Michael KE. FAK Modulates Cell Adhesion Strengthening Via Two Distinct Mechanisms: Integrin Binding and Vinculin Localization [PhD thesis]. Atlanta, GA: Georgia Institute of Technology; December 2006.
2007	Connelly JT. Regulatory Mechanisms in the Chondrogenesis of Mesenchymal Progenitors: The Roles of Cyclic Tensile Loading and Cell-Matrix Interactions [PhD thesis]. Atlanta, GA: Georgia Institute of Technology; August 2007.
2011	Dumbauld DW. The Role of Vinculin in the Cell Adhesion Strengthening Process [PhD thesis]. Atlanta, GA: Georgia Institute of Technology; May 2011.
2013	Lee T. Triggerable Ligand Presentation Using Caged-RGD [PhD thesis]. Atlanta, GA: Georgia Institute of Technology; December 2013.
2018	Garcia J. Hydrogel Engineering for Enhancing Vascularization and Augmenting Immunomodulation of Encapsulated Mesenchymal Stem Cells [PhD thesis]. Atlanta, GA: Georgia Institute of Technology; August 2018.
2019	Klosterhoff BS. Mechanobiological Regulation of Early Stage Bone Repair [PhD thesis]. Atlanta, GA: Georgia Institute of Technology; August 2019.
2017	Darnell MC. Mechanotransduction Across Time and Length Scales [PhD thesis]. Cambridge, MA: Harvard University; May 2017.
2014	Steward AJ. The Mechanotransduction of Hydrostatic Pressure by Mesenchymal Stem Cells [PhD thesis]. University of Notre Dame; April 2014.
2019	McDermott AM. Mechanical Regulation of Progenitor Cell Differentiation During Endochondral Ossification [PhD thesis]. University of Notre Dame; July 2019.
2012	Ma X. Finite Element Modeling of Collagen Fibers in the Mechanical Interaction Between Cells and the Extracellular Matrix [PhD thesis]. The Ohio State University; 2012.
2010	Gurkan UA. Engineering of Bone Marrow in Vitro for Investigating the Role of Growth Factors and Their Mechanoresponsiveness in Osteogenesis [PhD thesis]. Purdue University; May 2010.
2018	Yang F. The Synergistic Effect of Bone Graft Substitute Architecture and Mechanical Environment on HMSCs Responses in Vitro [PhD thesis]. Queen Mary University of London; December 2018.
2011	Zhao Y. The Characterization of Bovine Adipose-Derived Stem Cells in Conventional and Co-Culture Environments for Tissue Engineering [Master's thesis]. Queen's University; February 2011.
2009	Ofek G. Biomechanics of the Single Chondrocyte and Its Developing Extracellular Matrix [PhD thesis]. Houston, TX: Rice University; May 2009.
2011	Willard VP. Characterization of the Temporomandibular Joint Disc and Fibrocartilage Engineering Using Human Embryonic Stem Cells [PhD thesis]. Houston, TX: Rice University; May 2011.
2006	Tacy NJ. Mechano-Biological Regulation of Human Mesenchymal Stem Cell Osteogenic Differentiation [PhD thesis]. Troy, NY: Rensselaer Polytechnic Institute; May 2006.
2010	Viswanathan P. Emulsion Templated Porous Scaffolds for Bone Tissue Engineering [Master's thesis]. University of Sheffield; December 2010.
2013	Delaine-Smith RM. Mechanical and Physical Guidance of Osteogenic Differentiation and Matrix Production [PhD thesis]. University of Sheffield; January 2013.
2007	Malone AMD. Mechanotransduction Mechanisms in Bone Cells [PhD thesis]. Stanford University; August 2007.
2008	Arnsdorf EJ. Guiding Osteogenic Lineage Commitment: The Role of Mesenchymal Stem Cell Biology and the Mechanical Microenvironment [PhD thesis]. Stanford University; September 2008.
2010	Chen JC. Mechanical Factors in Initial Long Bone Ossification and Later Functional Adaptation [PhD thesis]. Stanford University; May 2010.
2012	Uzer G. Role of Fluid Shear Modulation on Bone Cell Metabolism During High-Frequency Oscillatory Vibrations [PhD thesis]. Stony Brook, NY: Stony Brook University; December 2012.
2015	Pongkitwitoon S. Mechanotransduction of Low Intensity Vibration in Human Bone Marrow Mesenchymal Stem Cells and Macrophages [PhD thesis]. Stony Brook, NY: Stony Brook University; May 2015.
2018	Patel VS. Harnessing Cell Mechanosensitivity to Combat Obesity-Induced Systemic Metabolic Disruptions and to Promote Protein Production for Bioprocessing [PhD thesis]. Stony Brook, NY: Stony Brook University; December 2018.
2015	Tseng L-F. Shape Memory Electrospun Scaffolds for Cell Mechanobiology and Bone Regenerative Applications [PhD thesis]. University of Syracuse; December 2015.
2016	Wang J. Studies of Cell Motility and Differentiation in Complex 3D in Vitro Microenvironment [PhD thesis]. University of Syracuse; December 2016.
2020	Hoang PK. Cardiac Organoid Technology and Computational Processing of Cardiac Physiology for Advanced Drug Screening Applications [PhD thesis]. University of Syracuse; December 2020.
2017	Gonzalez Fernandez T. Integrating Non-Viral Gene Therapy and 3D Bioprinting for Bone, Cartilage and Osteochondral Tissue Engineering [PhD thesis]. Trinity College Dublin; December 2017.
2017	Irvine AD. Modulating Mechanical Cues and Oxygen Availability to Regulate Chondrogenesis Within MSC Laden Hydrogels [PhD thesis]. Trinity College Dublin; June 2017.
2018	Olvera Ramos DP. Spatial Presentation of Tissue Specific Extracellular Matrix Components and Growth Factors on Porous Electrospun Fibre Scaffolds for Bone-Ligament Interface Tissue Engineering [PhD thesis]. Trinity College Dublin; 2018.
2013	Pineda Fortin ET. The Role of the Cytoskeleton in Pluripotent Stem Cell Differentiation [PhD thesis]. Tulane University; 2013.
2006	Ho JE. Strategies for Improving Osseointegration of Titanium Implants [PhD thesis]. Berkeley, CA: Berkeley, University of California; 2006.
2009	Pollock JF. Engineering Thermoreversible, Biomimetic Sol-Gels for Three-Dimensional Cell Culture and Tissue Generation [PhD thesis]. Berkeley, CA: Berkeley, University of California; 2009.
2010	Schmidt RC. Femtosecond Laser Nanomachining as a Technique for Probing the Role of Adhesion Geometry and Density on Cell Behavior [PhD thesis]. Berkeley, CA: Berkeley, University of California; 2010.
2012	Kohen N. Designing Synthetic Culture Systems for Human Stem Cell Culture [PhD thesis]. Berkeley, CA: Berkeley, University of California; 2012.
2014	Rode NA. Design of Electrospun Hydrogel Fibers Containing Multivalent Peptide Conjugates for Cardiac Tissue Engineering [PhD thesis]. Berkeley, CA: Berkeley, University of California; 2014.
2017	Ramasubramanian AM. Engineering Novel Peptide and Polymer Systems for Human Pluripotent Stem Cell Self-Renewal and Differentiation [PhD thesis]. Berkeley, CA: Berkeley, University of California; 2017.
2012	Allen J. Modeling Cartilage Extracellular Matrix Stiffness: A Potent Regulator of TGFbeta-Inducible Chondrocyte Differentiation [PhD thesis]. San Francisco, University of California; 2012.
2015	Rys JP. Mechanobiology of TGFΒ Receptor Dynamics and Signaling in Chondrocytes [PhD thesis]. San Francisco, University of California; 2015.
2020	Monteiro DA. Physical Cues Regulate the Localization and Activation of TGFβ Receptors to Control the Quantity and Quality of Signaling Pathway Activity [PhD thesis]. San Francisco, University of California; 2020.
2021	McDonough RC. Controlled Calcium Activation Via Chemogenetic Signaling Platforms for Tissue Engineering of Articular Cartilage [PhD thesis]. University of Delaware; 2021.
2013	Yew AG. Clinorotation Time-Lapse Microscopy for Live-Cell Assays in Simulated Microgravity [PhD thesis]. University of Maryland; 2013.
2017	Sharma P. The Influence of Vimentin Intermediate Filaments on Human Mesenchymal Stem Cell Response to Physical Stimuli [PhD thesis]. University of Maryland; 2017.
2009	Krizan SJ. The Role of Adhesion Strength in Human Mesenchymal Stem Cell Osteoblastic Differentiation on Biodegradable Polymers [PhD thesis]. University of Michigan; 2009.
2023	Madsen E. Cell and Material Specific Dual-Functional Peptides for Enhancing Mesenchymal Stem Cell Migration for Bone Tissue Engineering [PhD thesis]. University of Michigan; 2023.
2024	Mededovic M. Development of Gene Delivery Coating for Orthopedic Implants: Enhanced Gap Junction Communication in MSCs Accelerates Ischemic Bone Fracture Healing [PhD thesis]. University of Michigan; 2024.
2022	Blank MA. Defining Mechanisms by Which EphrinB2 in Osteocytes Controls Bone Strength and Material Quality [PhD thesis]. University of Melbourne; September 2022.
2010	Baker BM. Meniscus Tissue Engineering With Nanofibrous Scaffolds [PhD thesis]. Philadelphia, PA: University of Pennsylvania; 2010.
2015	Driscoll TP. Nuclear Connectivity in Mesenchymal Stem Cell Differentiation and Its Role in Mechanotransduction [PhD thesis]. Philadelphia, PA: University of Pennsylvania; 2015.
2015	Heo SC. Differentiation Induces Dynamic Alterations in Mesenchymal Stem Cell Nuclear Architecture and Mechanotransduction [PhD thesis]. Philadelphia, PA: University of Pennsylvania; 2015.
2015	Smith JR. Defining the Role of Blood-Spinal Cord Barrier Breakdown and Spinal Thrombin Signaling in the Development of Pain Following Neural Trauma [PhD thesis]. Philadelphia, PA: University of Pennsylvania; 2015.
2017	Cosgrove BD. Engineering Complex Microenvironments to Manipulate and Study Cellular Mechanobiology [PhD thesis]. Philadelphia, PA: University of Pennsylvania; 2017.
2021	Pham T. A Novel Role of HUWE1 in PDGF D Regulation of Bone Marrow Mesenchymal Stem Cell Differentiation [PhD thesis]. Detroit, MI: Wayne State University; 2021.
2021	Speer JE. Engineering Nucleus Pulposus Cell-Matrix Interactions With Laminin Ligands for Tissue Regeneration [PhD thesis]. St. Louis, MO: Washington University in St. Louis; May 2021.

Year	Entry
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