This paper develops a method for studying pedestrian to car impacts through detailed multi-body modeling of various pedestrian anthropometries and vehicle types. The pedestrian models constitute a multi-body representation of the global joint kinematics and inertia for five representative body sizes. Advanced injury criteria are defined for the pedestrian lower extremities, knee, thorax and head. The vehicle model of a small family car is defined by a facet element mesh for the front-end and windshield of the car. The contact stiffness is variable over the location on the vehicle mesh and has been validated against experimental results and FE simulations of the EEVC impactor tests. The underlying structures of the hood are defined as rigid ellipsoids. The developed model is applied to the reconstruction of two PCDS cases with a small family car. Injury risk data was collected from the simulation model and compared to the injury outcome for the pedestrians involved in these two cases. Results of this study show that the detailed model can distinguish the injury severity for various body parts at impact locations on the vehicle.