This paper describes the injury patterns of pedestrians involved in collisions with cars, compares them with other road casualties and estimates the possible effect of car front profile on injury location. Injury patterns were identified using the Rhône Road Trauma Registry which covers all the casualties resulting from crashes in the Rhône Département (1.6 million inhabitants) who seek medical care in health facilities. Fatality rates were estimated from national police reports for the same years (1996-2007), and the two data sources were linked to obtain information on the front profile of the striking car. As with all groups of road users, most of the pedestrians involved in car crashes were young. However elderly people were overrepresented when the size of the exposed population was taken into account. The most frequently injured body regions were the lower extremities (50% of victims), the head/face/neck (38%) and the upper extremities (27%). Pelvic injuries were much more common for women. The most severe injuries (AIS4+) were mostly to the head and thorax, for all groups of road users. However, pedestrians sustained twice as many head injuries as thoracic injuries. When the front profiles were grouped together according to the most common car types in Europe, the risk of being killed was higher for MPVs. More specifically, the risk of sustaining an AIS2+ thoracic injury was higher in a collision with an MPV. Our study confirms that it is quite justified for the tests based on European Enhanced Vehicle-Safety Committee guidelines to be focused on the head and the lower extremities. However, no test procedure exists for thoracic injuries, which is the body region with the second highest number of severe or fatal injuries.