Systematic and random errors in compression testing of trabecular bone

Keaveny, Tony M.; Pinilla, Tania P.; Crawford, R. Paul; Kopperdahl, David L.; Lou, Albert

Year	Entry
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2007	Perilli E, Baleani M, Öhman C, Baruffaldi F, Viceconti M. Structural parameters and mechanical strength of cancellous bone in the femoral head in osteoarthritis do not depend on age. Bone. November 2007;41(5):760-768.
2009	Bevill G, Eswaran SK, Farahmand F, Keaveny TM. The influence of boundary conditions and loading mode on high-resolution finite element-computed trabecular tissue properties. Bone. April 2009;44(4):573-578.
2009	Garrison JG, Slaboch CL, Niebur GL. Density and architecture have greater effects on the toughness of trabecular bone than damage. Bone. May 2009;44(5):924-929.
2011	Öhman C, Baleani M, Pani C, Taddei F, Alberghini M, Viceconti M, Manfrini M. Compressive behaviour of child and adult cortical bone. Bone. October 2011;49(4):769-776.
2014	Hernandez CJ, Lambers FM, Widjaja J, Chapa C, Rimnac CM. Quantitative relationships between microdamage and cancellous bone strength and stiffness. Bone. September 2014;66:205-213.
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2019	vom Scheidt A, Hemmatian H, Püschel K, Krause M, Amling M, Busse B. Bisphosphonate treatment changes regional distribution of trabecular microstructure in human lumbar vertebrae. Bone. October 2019;127:482-487.
2018	Zhao S, Arnold M, Ma S, Abel RL, Cobb JP, Hansen U, Boughton O. Standardizing compression testing for measuring the stiffness of human bone. Bone Joint Res. August 2018;7(8):524-538.
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2005	Morgan EF, Yeh OC, Keaveny TM. Damage in trabecular bone at small strains. Euro J Morphol. February–April 2005;42(1-2):13-21.
2005	Wang X, Guyette J, Liu X, Roeder RK, Niebur GL. Axial-shear interaction effects on microdamage in bovine tibial trabecular bone. Euro J Morphol. February–April 2005;42(1-2):61-70.
2018	Levrero-Florencio F, Pankaj P. Using non-linear homogenization to improve the performance of macroscopic damage models of trabecular bone. Front Physiol. May 2018;9:545.
2016	Palanca M, Tozzi G, Cristofolini L. The use of digital image correlation in the biomechanical area: a review. Int Biomech. 2016;3(1):1-21.
2020	Belda R, Palomar M, Peris-Serra JL, Vercher-Martínez A, Giner E. Compression failure characterization of cancellous bone combining experimental testing, digital image correlation and finite element modeling. Int J Mech Sci. January 2020;165:105213.
2016	Schwiedrzik J, Gross T, Bina M, Pretterklieber M, Zysset P, Pahr D. Experimental validation of a nonlinear μFE model based on cohesive-frictional plasticity for trabecular bone. Int J Num Meth Biomed Eng. April 2016;32(4):e02739.
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2020	Blondel M, Abidine Y, Assemat P, Palierne S, Swider P. Identification of effective elastic modulus using modal analysis: application to canine cancellous bone. J Biomech. September 18, 2020;110:109972.
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2004	İnceoğlu S. Failure of Pedicle Screw-Bone Interface: Biomechanics of Pedicle Screw Insertion and Pullout [PhD thesis]. Cleveland State University; December 2004.
1999	Yang G. Averaging and Bounding of Anisotropic Elastic Constants [PhD thesis]. New York, NY: The City University of New York; 1999.
2016	Florencio FL. Multiscale Modelling of Trabecular Bone: From Micro to Macroscale [PhD thesis]. Edinburgh, Scotland: University of Edinburgh; 2016.
2018	Xie S. Characterisation of Time-Dependent Mechanical Behaviour of Trabecular Bone and Its Constituents [PhD thesis]. Edinburgh, Scotland: University of Edinburgh; 2018.
2005	Day JS. Bone Quality: The Mechanical Effects of Microarchitecture and Matrix Properties [PhD thesis]. Erasmus University Rotterdam; 2005.
2005	Stauber M. Volumetric Spatial Decomposition of Porous Microstructures: A Framework for Element Based Analysis of Trabecular Bone [PhD thesis]. Swiss Federal Institute of Technology Zürich; 2005.
2007	Voide R. Functional Phenotyping of Bone: A Hierarchical Assessment of Bone Failure Characteristics [PhD thesis]. Swiss Federal Institute of Technology Zürich; 2007.
2008	Nazarian A. Relative Interaction of Material and Structure in Normal and Pathologic Bone [PhD thesis]. Swiss Federal Institute of Technology Zürich; 2008.
2006	Nagaraja S. Microstructural Stresses and Strains Associated With Trabecular Bone Microdamage [PhD thesis]. Atlanta, GA: Georgia Institute of Technology; December 2006.
2010	Wang JL. Effects of Aging and Remodeling on Bone Microdamage Formation [Master's thesis]. Atlanta, GA: Georgia Institute of Technology; December 2010.
2011	O'Neal JM. The Effects of Aging and Remodeling on Bone Quality and Microdamage [PhD thesis]. Atlanta, GA: Georgia Institute of Technology; August 2011.
2012	Hamed E. Multiscale Modeling of Elastic Moduli and Strength of Bone [PhD thesis]. University of Illinois at Urbana-Champaign; 2012.
2016	Currier EJ. Predicting Peak Load of the Femoral Neck Using Structural Parameters [Master's thesis]. University of Illinois at Urbana-Champaign; 2016.
2020	Song H. The Effect of Mechanical Loading on Bone During Growth [PhD thesis]. University of Illinois at Urbana-Champaign; 2020.
2020	Bennison MBL. The Role of Cancellous Bone Architecture in Misalignment and Side Effect Errors [Master's thesis]. Sudbury, ON: Laurentian University; 2020.
2014	Holub O. Biomechanics of Spinal Metastases [PhD thesis]. University of Leeds; April 2014.
2001	Arthur Moore TL. Microdamage Accumulation in Bovine Trabecular Bone [PhD thesis]. Cambridge, MA: Massachusetts Institute of Technology; June 2001.
2015	Oftadeh R. Hierarchical Analysis and Multiscale Modelling of Cellular Structures: From Meta Materials to Bone Structure [PhD thesis]. Northeastern University; December 2015.
2004	Wang X. Measurement and Analysis of Microdamage in Bone [PhD thesis]. University of Notre Dame; December 2004.
2011	Garrison JG. The Relative Importance of Stress State, Microarchitecture, and Damage Burden in the Failure Behavior of Trabecular Bone [PhD thesis]. University of Notre Dame; April 2011.
2012	Kelly N. An Experimental and Computational Investigation of the Inelastic Behaviour of Trabecular Bone [PhD thesis]. Galway, Ireland: National University of Ireland Galway; September 2012.
2020	O’Sullivan LM. Time-Sequence of Biomechanical Adaption in Trabecular Tissue During Estrogen Deficiency [PhD thesis]. National University of Ireland Galway; March 2020.
2011	Wagnac É. Expérimentation et modélisation détaillée de la colonne vertébrale pour étudier le rôle de facteurs anatomiques et biomécaniques sur les traumatismes rachidiens [PhD thesis]. École polytechnique de Montréal; November 2011.
2012	Tozzi G. In Vitro Studies of Bone-Cement Interface and Related Work on Cemented Acetabular Replacement [PhD thesis]. Portsmouth, England: University of Portsmouth; May 29, 2012.
2020	Karali A. Multi-Scale Evaluation of Bone Combining Indentation, in Situ XCT Mechanics and Digital Volume Correlation [PhD thesis]. Portsmouth, England: University of Portsmouth; 2020.
2005	Buie HR. Use of Finite Element Method Modelling and Rapid Prototyping to Study the Effect of Trabecular Bone Architecture on Apparent Mechanical Properties [Master's thesis]. Queen's University; November 2005.
2009	Lievers WB. Effects of Geometric and Material Property Changes on the Apparent Elastic Properties of Cancellous Bone [PhD thesis]. Queen's University; April 2009.
2013	Morton JJ. An Investigation of Rat Vertebra Failure Behaviour Under Uniaxial Compression Through Time-Lapsed Micro-CT Imaging [Master's thesis]. Queen's University; 2013.
2013	Schumacher Y. Comparison of Two Loading Surface Preparation Methods on Rat Vertebral Bodies for Compression Testing [Master's thesis]. Queen's University; September 2013.
2019	Heney AP. Effect of Fatigue-Induced Microdamage on the Compressive Properties of Bovine Trabecular Bone [Master's thesis]. Queen's University; September 2019.
2022	Beloglowka K. Ex Vivo Mechanical Testing and FEA Modelling of Bovine Trabecular Bone [Master's thesis]. Queen's University; September 2022.
2022	Kunath BA. Design and Validation of an Open-Source 3D Printable Bioreactor System for Ex Vivo Bone Culture [Master's thesis]. Queen's University; June 2022.
2023	Branni MG. Constitutive Models of Bone: The Human Femur [PhD thesis]. Queensland University of Technology; 2023.
2018	Groenen KHJ. Spinal (in)stability in Metastatic Bone Disease: Experimental, Computational, and Clinical Perspectives [PhD thesis]. Radboud University; 2018.
2011	Karim L. The Biomolecular Basis of Bone Fracture [PhD thesis]. Troy, NY: Rensselaer Polytechnic Institute; November 2011.
2011	Yao H. Microstructure-Based Characterization and Modeling of Trabecular Bone Deformation and Failure [PhD thesis]. Southern Methodist University; August 3, 2011.
2004	McNamara LM. Biomechanical Origins of Osteoporosis [PhD thesis]. Trinity College Dublin; March 2004.
2006	Verhulp E. Analyses of Trabecular Bone Failure [PhD thesis]. Eindhoven, The Netherlands: Eindhoven University of Technology; 2006.
2014	Gross T. Development and Application of 3d CT Image-Based Micro and Macro Finite Element Models for Human Bones and Orthopedic Implant Systems [PhD thesis]. Vienna University of Technology; 2014.
2022	Davis RA. Investigating the Effects of Aging and Prolonged Opioid Use on Bone Histomorphometry, Quality, and Biomechanics [PhD thesis]. University of Akron; August 2022.
2001	Speirs AD. Calcium Phosphate Cement Composites in Revision Hip Replacement [Master's thesis]. Vancouver, BC: University of British Columbia; February 2001.
2016	Gustafson HM. Quantifying the Response of Vertebral Bodies to Compressive Loading Using Digital Image Correlation [PhD thesis]. Vancouver, BC: University of British Columbia; October 2016.
2001	Boyd SK. Microstructural Bone Adaptation in an Experimental Model of Osteoarthritis [PhD thesis]. Calgary, AB: University of Calgary; January 2001.
2002	Wohl GR. Bone Mechanics in Transplanted Osteochondral Grafts [PhD thesis]. Calgary, AB: University of Calgary; September 2002.
2007	MacNeil JAM. Clinical Assessment of Bone Quality [PhD thesis]. Calgary, AB: University of Calgary; June 2007.
2012	Nishiyama KKS. In Vivo Assessment of Bone Microarchitecture and Estimated Bone Strength [PhD thesis]. Calgary, AB: University of Calgary; October 2012.
2013	Enns-Bray WS. Mapping Anisotropy of the Proximal Femur for Improved Image-Based Finite Element Analysis [Master's thesis]. Calgary, AB: University of Calgary; August 2013.
2017	Fung A. Experimental Validation of Finite Element Predicted Bone Strain in the Human Metatarsal [Master's thesis]. Calgary, AB: University of Calgary; April 2017.
1998	Kopperdahl DL. Structural Consequences of Damage on the Mechanical Behavior of the Human Vertebral Body [PhD thesis]. Berkeley, CA: Berkeley, University of California; 1998.
2000	Niebur GL. A Computational Investigation of Multiaxial Failure in Trabecular Bone [PhD thesis]. Berkeley, CA: University of California; 2000.
2002	Morgan EF-i. The Dependence on Anatomic Site of Trabecular Bone Structure-Function Relationships [PhD thesis]. Berkeley, CA: Berkeley, University of California; 2002.
2003	Bayraktar HH. Multiaxial Strength and Micromechanics of Human Bone [PhD thesis]. Berkeley, CA: Berkeley, University of California; 2003.
2004	Kazakia GJ. Development, Analysis, and Imaging of a Tissue Engineered Trabecular Bone Substitute [PhD thesis]. Berkeley, CA: Berkeley, University of California; 2004.
2008	Bevill GR. Micromechanical Modeling of Failure in Trabecular Bone [PhD thesis]. Berkeley, CA: Berkeley, University of California; 2008.
2013	Sanyal A. Bone Strength Multi-Axial Behavior: Volume Fraction, Anisotropy and Microarchitecture [PhD thesis]. Berkeley, CA: Berkeley, University of California; 2013.
2018	Pendleton MM. Effects of Spaceflight- and Clinically-Relevant Ionizing Radiation Exposure on Bone Biomechanics [PhD thesis]. Berkeley, CA: Berkeley, University of California; 2018.
2019	Sadoughi S. Micromechanics of Human Bone: Role of Architecture and Tissue Material Properties [PhD thesis]. Berkeley, CA: Berkeley, University of California; 2019.
2020	Caffrey JP. Experimental Biomechanics of Musculoskeletal Injury Models and Repair Implants [PhD thesis]. San Diego (UCSD), University of California; 2020.
2018	Hilton K. The Effect of Boundary Conditions and Architecture on the Response of Cancellous Bone [Master's thesis]. Cape Town, South Africa: University of Cape Town; October 18, 2018.
2007	Ruffoni D. Modeling of Material and Architectural Quality of Trabecular Bone [PhD thesis]. Liège, Belgique: Université de Liège; September 2007.
2020	Amromanoh OA. An Experimental Study of the Effect of Bone Inorganic-Organic Composition on the Mechanical Properties [Master's thesis]. Winnipeg, MB: University of Manitoba; April 2020.
2013	Iori G. Micro-FEM Models Based on Micro-CT Reconstructions for the in Vitro Characterization of the Elastic Properties of Trabecular Bone Tissue [Master's thesis]. University of Bologna; 2013.
2017	Palanca M. In Vitro Full-Field Methods for the Biomechanical Characterization of Spine Segments [PhD thesis]. University of Bologna; March 2017.
2019	Martig S. Compressive Fatigue Life and Micromorphology of Equine Metacarpal Subchondral Bone [PhD thesis]. University of Melbourne; June 2019.
2011	Wolfram U. Mechanical Multiscale Characterisation of Vertebral Trabecular Bone for the Prediction of Vertebral Fracture Risk [PhD thesis]. University of Ulm; 2011.
2020	Belda González R. Mechanical and Morphometric Characterization of Cancellous Bone [PhD thesis]. Universität Politècnica de València; March 2020.
2018	Burnett WD. Relationships Between Image-Based and Mechanical Bone Properties With Pain in Knee Osteoarthritis [PhD thesis]. University of Saskatchewan; July 2018.
2016	Boruah S. A Viscoelastic Model for High Strain Rate Loading of the Human Calvarium [PhD thesis]. Charlottesville, VA: University of Virginia; May 2016.
2018	Khor F. Computational Modeling of Hard Tissue Response and Fracture in the Lower Cervical Spine Under Compression Including Age Effects [Master's thesis]. University of Waterloo; 2018.
2008	Burgers TA. Press-Fit Fixation and Viscoelastic Response of a Bone-Implant Interface in the Distal Femur [PhD thesis]. University of Wisconsin – Madison; 2008.
2009	García-Rodríguez S. Mechanical Behavior of Trabecular Bone [PhD thesis]. University of Wisconsin – Madison; 2009.
2011	Aiyangar AK. Physical and Computational Modeling of Subsidence of Anterior Interbody Fusion Devices [PhD thesis]. University of Wisconsin – Madison; 2011.
2011	Vivanco Morales JF. Investigation of Fabrication and Environmental Effects on Bioceramic Bone Scaffolds [PhD thesis]. University of Wisconsin – Madison; 2011.
2016	Johnson MG. Endothelin-Converting Enzyme-1 Dependent Endothelin 1 Signaling in Osteogenesis [PhD thesis]. University of Wisconsin – Madison; 2016.
2016	Meyer LA. Testing and Modeling Mechanical Properties of Ex Vivo Trabecular Bone [PhD thesis]. University of Wisconsin – Madison; 2016.

Year	Entry
1992	Linde F, Hvid I, Madsen F. The effect of specimen geometry on the mechanical behaviour of trabecular bone specimens. J Biomech. 1992;25(4):359-368.
1991	Odgaard A, Linde F. The underestimation of Young's modulus in compressive testing of cancellous bone specimens. J Biomech. 1991;24(8):691-698.
1993	Keyak JH, Fourkas MG, Meagher JM, Skinner HB. Validation of an automated method of three-dimensional finite element modelling of bone. J Biomed Eng. November 1993;15(6):505-509.
1994	Zhu M, Keller TS, Spengler DM. Effects of specimen load-bearing and free surface layers on the compressive mechanical properties of cellular materials. J Biomech. 1994;27(1):57-66.
1991	Lotz JC, Cheal EJ, Hayes WC. Fracture prediction for the proximal femur using finite element models, II: nonlinear analysis. J Biomech Eng. 1991;113(4):361-364.
1989	Odgaard A, Hvid I, Linde F. Compressive axial strain distributions in cancellous bone specimens. J Biomech. 1989;22(8-9):829-835.
1991	Faulkner KG, Cann CE, Hasegawa BH. Effect of bone distribution on vertebral strength: assessment with patient-specific nonlinear finite element analysis. Radiology. June 1991;179(3):669-674.
1987	Ashman RB, Corin JD, Turner CH. Elastic properties of cancellous bone: measurement by an ultrasonic technique. J Biomech. 1987;20(10):979-986.
1995	van Rietbergen B, Weinans H, Huiskes R, Odgaard A. A new method to determine trabecular bone elastic properties and loading using micromechanical finite-element models. J Biomech. January 1995;28(1):69-81.
1993	Keaveny TM, Borchers RE, Gibson LJ, Hayes WC. Theoretical analysis of the experimental artifact in trabecular bone compressive modulus [published correction appears in J Biomech. 1993;26(9):1143]. J Biomech. April–May 1993;26(4-5):599-607.
1990	Hodgskinson R, Currey JD. The effect of variation in structure on the Young's modulus of cancellous bone: a comparison of human and non-human material. Proc Inst Mech Eng Part H-J Eng Med. 1990;204(2):115-121.
1991	Allard RN, Ashman RB. A comparison between cancellous bone compressive moduli determined from surface strain and total specimen deflection. In: Transacation of the 37th Annual Meeting of the Orthopaedic Research Society. March 4-7, 1991; Anaheim, CA.151.
1994	Keaveny TM, Guo XE, Wachtel EF, McMahon TA, Hayes WC. Trabecular bone exhibits fully linear elastic behavior and yields at low strains. J Biomech. 1994;27(9):1127-1136.
1994	Goulet RW, Goldstein SA, Ciarelli MJ, Kuhn JL, Brown MB, Feldkamp LA. The relationship between the structural and orthogonal compressive properties of trabecular bone. J Biomech. April 1994;27(4):375-389.
1994	Keaveny TM, Wachtel EF, Ford CM, Hayes WC. Differences between the tensile and compressive strengths of bovine tibial trabecular bone depend on modulus. J Biomech. 1994;27(9):1137-1146.
1994	Hollister SJ, Brennan JM, Kikuchi N. A homogenization sampling procedure for calculating trabecular bone effective stiffness and tissue level stres. J Biomech. 1994;27(4):433-444.
1989	Linde F, Hvid I. The effect of constraint on the mechanical behaviour of trabecular bone specimens. J Biomech. 1989;22(5):485-490.
1993	Keaveny TM, Borchers RE, Gibson L, Hayes WC. Trabecular bone modulus and strength can depend on specimen geometry. J Biomech. August 1993;26(8):991-995.