Trabecular bone modulus and strength can depend on specimen geometry

Keaveny, Tony M.; Borchers, Robert E.; Gibson, Lorna; Hayes, Wilson C.

Year	Entry
2009	Rhee Y, Hur J-H, Won Y-Y, Lim S-K, Beak M-H, Cui W-Q, Kim K-G, Kim YE. Assessment of bone quality using finite element analysis based upon micro-CT images. Clin Orthop Surg. March 2009;1(1):40-47.
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2021	Peña Fernández M, Kao AP, Bonithon R, Howells D, link="bodey-andrew-j"Bodey AJ, Wanelik K, Witte F, Johnston R, Arora H, Tozzi G. Time-resolved in situ synchrotron-microct: 4D deformation of bone and bone analogues using digital volume correlation. Acta Biomater. September 1, 2021;131:424.
2004	Hung CT, Mauck RL, Wang CC-B, Lima EG, Ateshian GA. A paradigm for functional tissue engineering of articular cartilage via applied physiologic deformational loading. Ann Biomed Eng. January 2004;32(1):35-49.
2001	Keaveny TM, Morgan EF, Niebur GL, Yeh OC. Biomechanics of trabecular bone. Annu Rev Biomed Eng. 2001;3:307-333.
2008	Matsuura M, Eckstein F, Lochmüller E-M, Zysset PK. The role of fabric in the quasi-static compressive mechanical properties of human trabecular bone from various anatomical locations. Biomech Model Mechanobiol. February 2008;7(1):27-42.
2010	Harrison NM, McHugh PE. Comparison of trabecular bone behavior in core and whole bone samples using high-resolution modeling of a vertebral body. Biomech Model Mechanobiol. 2010;9(4):469-480.
1997	Odgaard A. Three-dimensional methods for quantification of cancellous bone architecture. Bone. 1997;20(4):315-328.
1998	Majumdar S, Kothari M, Augat P, Newitt DC, Link TM, Lin JC, Lang T, Lu Y, Genant HK. High-resolution magnetic resonance imaging: three-dimensional trabecular bone architecture and biomechanical properties. Bone. May 1998;22(5):445-454.
2000	Gadeleta SJ, Boskey AL, Paschalis E, Carlson C, Menschik F, Baldini T, Peterson M, Rimnac CM. A physical, chemical, and mechanical study of lumbar vertebrae from normal, ovariectomized, and nandrolone decanoate-treated cynomolgus monkeys (macaca fascicularis). Bone. October 2000;27(4):541-550.
2006	Nazarian A, Stauber M, Zurakowski D, Snyder BD, Müller R. The interaction of microstructure and volume fraction in predicting failure in cancellous bone. Bone. December 2006;39(6):1196-1202.
2007	Perilli E, Baleani M, Öhman C, Baruffaldi F, Viceconti M. Structural parameters and mechanical strength of cancellous bone in the femoral head in osteoarthritis do not depend on age. Bone. November 2007;41(5):760-768.
2018	Zhao S, Arnold M, Ma S, Abel RL, Cobb JP, Hansen U, Boughton O. Standardizing compression testing for measuring the stiffness of human bone. Bone Joint Res. August 2018;7(8):524-538.
2008	Nazarian A, von Stechow D, Zurakowski D, Müller R, Snyder BD. Bone volume fraction explains the variation in strength and stiffness of cancellous bone affected by metastatic cancer and osteoporosis. Calcif Tiss Int. December 2008;83(6):368-379.
2008	Helgason B, Perilli E, Schileo E, Taddei F, Brynjólfsson S, Viceconti M. Mathematical relationships between bone density and mechanical properties: a literature review. Clin Biomech (Bristol, Avon). 2008;23(2):135-146.
1993	Keaveny TM, Borchers RE, Gibson LJ, Hayes WC. Theoretical analysis of the experimental artifact in trabecular bone compressive modulus [published correction appears in J Biomech. 1993;26(9):1143]. J Biomech. April–May 1993;26(4-5):599-607.
1994	Keaveny TM, Guo XE, Wachtel EF, McMahon TA, Hayes WC. Trabecular bone exhibits fully linear elastic behavior and yields at low strains. J Biomech. 1994;27(9):1127-1136.
1994	Keaveny TM, Wachtel EF, Ford CM, Hayes WC. Differences between the tensile and compressive strengths of bovine tibial trabecular bone depend on modulus. J Biomech. 1994;27(9):1137-1146.
1994	Keaveny TM, Wachtel EF, Guo XE, Hayes WC. Mechanical behavior of damaged trabecular bone. J Biomech. November 1994;27(11):1309-1318.
1998	Hou FJ, Lang SM, Hoshaw SJ, Reimann DA, Fyhrie DP. Human vertebral body apparent and hard tissue stiffness. J Biomech. November 1998;31(11):1009-1015.
1999	Jacobs CR, Davis BR, Rieger CJ, Francis JJ, Saad M, Fyhrie DP. The impact of boundary conditions and mesh size on the accuracy of cancellous bone tissue modulus determination using large-scale finite-element modeling. J Biomech. November 1999;32(11):1159-1164.
2004	Nazarian A, Müller R. Time-lapsed microstructural imaging of bone failure behavior. J Biomech. 2004;37(1):55-65.
2006	Guedes RM, Simões JA, Morais JL. Viscoelastic behaviour and failure of bovine cancellous bone under constant strain rate. J Biomech. 2006;39(1):49-60.
2007	Öhman C, Baleani M, Perilli E, Dall’Ara E, Tassani S, Baruffaldi F, Viceconti M. Mechanical testing of cancellous bone from the femoral head: experimental errors due to off-axis measurements. J Biomech. 2007;40(11):2426-2433.
2007	Nazarian A, Muller J, Zurakowski D, Müller R, Snyder BD. Densitometric, morphometric and mechanical distributions in the human proximal femur. J Biomech. 2007;40(11):2573-2579.
2008	Perilli E, Baleani M, Öhman C, Fognani R, Baruffaldi F, Viceconti M. Dependence of mechanical compressive strength on local variations in microarchitecture in cancellous bone of proximal human femur. J Biomech. 2008;41(2):438-446.
2008	Harrison NM, McDonnell PF, O’Mahoney DC, Kennedy OD, O’Brien FJ, McHugh PE. Heterogeneous linear elastic trabecular bone modelling using micro-CT attenuation data and experimentally measured heterogeneous tissue properties. J Biomech. August 7, 2008;41(11):2589-2596.
1993	Keaveny TM, Hayes WC. A 20-year perspective on the mechanical properties of trabecular bone. J Biomech Eng. November 1993;115(4B):534-542.
1998	Bowman SM, Guo XE, Cheng DW, Keaveny TM, Gibson LJ, Hayes WC, McMahon TA. Creep contributes to the fatigue behavior of bovine trabecular bone. J Biomech Eng. October 1998;120(5):647-654.
2001	Yamashita J, Furman BR, Rawls HR, Wang X, Agrawal CM. The use of dynamic mechanical analysis to assess the viscoelastic properties of human cortical bone. J Biomed Mater Res. 2001;B58(1):47-53.
1994	Keyak JH, Lee IY, Skinner HB. Correlations between orthogonal mechanical properties and density of trabecular bone: use of different densitometric measures. J Biomed Mater Res. November 1994;A28(11):1329-1336.
2005	Nazarian A, Stauber M, Müller R. Design and implementation of a novel mechanical testing system for cellular solids. J Biomed Mater Res. 2005;B73(2):400-411.
2002	Rubin C, Turner AS, Müller R, Mittra E, McLeod K, Lin W, Qin Y. Quantity and quality of trabecular bone in the femur are enhanced by a strongly anabolic, noninvasive mechanical intervention. J Bone Miner Res. February 2002;17(2):349-357.
2006	Stauber M, Rapillard L, van Lenthe GH, Zysset P, Müller R. Importance of individual rods and plates in the assessment of bone quality and their contribution to bone stiffness. J Bone Miner Res. April 2006;21(4):586-595.
1998	Swartz SM, Parker A, Huo C. Theoretical and empirical scaling patterns and topological homology in bone trabeculae. J Exp Biol. February 1998;201(4):573-590.
2011	Chen P-Y, McKittrick J. Compressive mechanical properties of demineralized and deproteinized cancellous bone. J Mech Behav Biomed Mater. October 2011;4(7):961-973.
2012	Kelly N, McGarry JP. Experimental and numerical characterisation of the elasto-plastic properties of bovine trabecular bone and a trabecular bone analogue. J Mech Behav Biomed Mater. May 2012;9:184-197.
2020	Acciaioli A, Falco L, Balean M. Measurement of apparent mechanical properties of trabecular bone tissue: accuracy and limitation of digital image correlation technique. J Mech Behav Biomed Mater. March 2020;103:103542.
2020	Koria L, Mengoni M, Brockett C. Estimating tissue-level properties of porcine talar subchondral bone. J Mech Behav Biomed Mater. October 2020;110:103931.
2007	Beaupied H, Lespessailles E, Benhamou C-L. Evaluation of macrostructural bone biomechanics. Joint Bone Spine. May 2007;74(3):233-239.
1994	Les CM, Keyak JH, Stover SM, Taylor KT, Kaneps AJ. Estimation of material properties in the equine metacarpus with use of quantitative computed tomography. J Orthop Res. November 1994;12(6):822-833.
1997	Keaveny TM, Pinilla TP, Crawford RP, Kopperdahl DL, Lou A. Systematic and random errors in compression testing of trabecular bone [published correction appears in J Orthop Res. 1995;17(1):151]. J Orthop Res. 1997;15(1):101-110.
1998	Ladd AJC, Kinney JH, Haupt DL, Goldstein SA. Finite‐element modeling of trabecular bone: comparison with mechanical testing and determination of tissue modulus. J Orthop Res. September 1998;16(5):622-628.
2009	Fritsch A, Hellmich C, Dormieux L. Ductile sliding between mineral crystals followed by rupture of collagen crosslinks: experimentally supported micromechanical explanation of bone strength. J Theo Biol. September 21, 2009;260(2):230-252.
2005	Cook RB. Non-Invasively Assessed Skeletal Bone Status and Its Relationship to the Biomechanical Properties and Condition of Cancellous Bone [PhD thesis]. Cranfield, UK: Cranfield University; December 18, 2005.
2019	Bin Rosli AH. Characterisation of Trabecular Bone Behaviour Under Impact [PhD thesis]. Edinburgh, Scotland: University of Edinburgh; 2019.
1994	Zysset P. A Constitutive Law for Trabecular Bone [PhD thesis]. Lausanne, Switzerland: École Polytechnique Fédérale de Lausanne; 1994.
2005	Stauber M. Volumetric Spatial Decomposition of Porous Microstructures: A Framework for Element Based Analysis of Trabecular Bone [PhD thesis]. Swiss Federal Institute of Technology Zürich; 2005.
2008	Nazarian A. Relative Interaction of Material and Structure in Normal and Pathologic Bone [PhD thesis]. Swiss Federal Institute of Technology Zürich; 2008.
2001	Arthur Moore TL. Microdamage Accumulation in Bovine Trabecular Bone [PhD thesis]. Cambridge, MA: Massachusetts Institute of Technology; June 2001.
2015	Gargac J. Evaluation of Bone Healing, Damage, and Adaptation Using Computational Modeling and Image Processing Techniques [PhD thesis]. University of Notre Dame; July 2015.
2012	Kelly N. An Experimental and Computational Investigation of the Inelastic Behaviour of Trabecular Bone [PhD thesis]. Galway, Ireland: National University of Ireland Galway; September 2012.
2020	O’Sullivan LM. Time-Sequence of Biomechanical Adaption in Trabecular Tissue During Estrogen Deficiency [PhD thesis]. National University of Ireland Galway; March 2020.
2012	Tozzi G. In Vitro Studies of Bone-Cement Interface and Related Work on Cemented Acetabular Replacement [PhD thesis]. Portsmouth, England: University of Portsmouth; May 29, 2012.
2018	Peña Fernández M. X-Ray Biomechanical Imaging and Digital Volume Correlation of Bone: From Regeneration to Structure [PhD thesis]. Portsmouth, England: University of Portsmouth; December 2018.
2005	Buie HR. Use of Finite Element Method Modelling and Rapid Prototyping to Study the Effect of Trabecular Bone Architecture on Apparent Mechanical Properties [Master's thesis]. Queen's University; November 2005.
2013	Morton JJ. An Investigation of Rat Vertebra Failure Behaviour Under Uniaxial Compression Through Time-Lapsed Micro-CT Imaging [Master's thesis]. Queen's University; 2013.
2022	Kunath BA. Design and Validation of an Open-Source 3D Printable Bioreactor System for Ex Vivo Bone Culture [Master's thesis]. Queen's University; June 2022.
2011	Yao H. Microstructure-Based Characterization and Modeling of Trabecular Bone Deformation and Failure [PhD thesis]. Southern Methodist University; August 3, 2011.
2004	McNamara LM. Biomechanical Origins of Osteoporosis [PhD thesis]. Trinity College Dublin; March 2004.
2006	Gleeson JP. Composition and Mechanical Properties of Osteoarthritic Subchondral Trabecular Tibial Bone [PhD thesis]. Trinity College Dublin; November 2006.
2001	Boyd SK. Microstructural Bone Adaptation in an Experimental Model of Osteoarthritis [PhD thesis]. Calgary, AB: University of Calgary; January 2001.
2002	Wohl GR. Bone Mechanics in Transplanted Osteochondral Grafts [PhD thesis]. Calgary, AB: University of Calgary; September 2002.
2003	Pardy CK. The Effects of Doxycycline on the Mechanical and Morphometric Properties of Early and Established Osteoarthritic Bone in a Canine Model Following Anterior Cruciate Ligament Injury [Master's thesis]. Calgary, AB: University of Calgary; October 2003.
2007	MacNeil JAM. Clinical Assessment of Bone Quality [PhD thesis]. Calgary, AB: University of Calgary; June 2007.
2013	Enns-Bray WS. Mapping Anisotropy of the Proximal Femur for Improved Image-Based Finite Element Analysis [Master's thesis]. Calgary, AB: University of Calgary; August 2013.
2004	Kazakia GJ. Development, Analysis, and Imaging of a Tissue Engineered Trabecular Bone Substitute [PhD thesis]. Berkeley, CA: Berkeley, University of California; 2004.
2016	Chen C. Mechanical and Micro-Structural Modeling of Trabecular Bone by in Vivo Imaging [PhD thesis]. University of Iowa; December 2016.
2012	Wilkerson LT. Finite Element Analysis of Cancellous Bone [Master's thesis]. University of Kentucky; 2012.
2020	Amromanoh OA. An Experimental Study of the Effect of Bone Inorganic-Organic Composition on the Mechanical Properties [Master's thesis]. Winnipeg, MB: University of Manitoba; April 2020.
1993	Goulet RW. The Quantification of the Structure and Mechanical Properties of Trabecular Bone [PhD thesis]. University of Michigan; 1993.
2019	Martig S. Compressive Fatigue Life and Micromorphology of Equine Metacarpal Subchondral Bone [PhD thesis]. University of Melbourne; June 2019.
2009	García-Rodríguez S. Mechanical Behavior of Trabecular Bone [PhD thesis]. University of Wisconsin – Madison; 2009.

Year	Entry
1989	Ashman RB, Rho JY, Turner CH. Anatomical variation of orthotropic elastic moduli of the proximal human tibia. J Biomech. 1989;22(8-9):895-900.
1989	Linde F, Hvid I. The effect of constraint on the mechanical behaviour of trabecular bone specimens. J Biomech. 1989;22(5):485-490.
1991	Odgaard A, Linde F. The underestimation of Young's modulus in compressive testing of cancellous bone specimens. J Biomech. 1991;24(8):691-698.
1988	Harrigan TP, Jasty M, Mann RW, Harris WH. Limitations of the continuum assumption in cancellous bone. J Biomech. 1988;21(4):269-275.
1989	Turner CH. Yield behavior of bovine cancellous bone [published correction appears in J Biomech Eng. 1989;111(4):335]. J Biomech Eng. August 1989;111(3):256-260.
1993	Keaveny TM, Borchers RE, Gibson LJ, Hayes WC. Theoretical analysis of the experimental artifact in trabecular bone compressive modulus [published correction appears in J Biomech. 1993;26(9):1143]. J Biomech. April–May 1993;26(4-5):599-607.
1977	Carter DR, Hayes WC. The compressive behavior of bone as a two-phase porous structure. J Bone Joint Surg. 1977;59A(7):954-962.
1987	Linde F, Hvid I. Stiffness behaviour of trabecular bone specimens. J Biomech. 1987;20(1):83-89.
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1980	Brown TD, Ferguson AB Jr. Mechanical property distributions in the cancellous bone of the human proximal femur. Acta Orthop Scand. 1980;51(1):429-437.
1989	Odgaard A, Hvid I, Linde F. Compressive axial strain distributions in cancellous bone specimens. J Biomech. 1989;22(8-9):829-835.