Time-dependent behaviour of demineralised trabecular bone:​ experimental investigation and development of a constitutive model

Xie, Shuqiao; Wallace, Robert J.; Pankaj, Pankaj

Affiliations

¹School of Engineering, Institute for Bioengineering, The University of Edinburgh, Alrick Building, The King’s Buildings, Edinburgh, EH9 3BF, UK

²Department of Orthopaedics, The University of Edinburgh, Chancellor’s Building, Edinburgh, EH16 4SB, UK

Abstract and keywords

Trabecular bone is a cellular composite material comprising primarily of mineral and organic phases and its mechanical response to loads is time-dependent. The contribution of the organic phase to the time-dependent behaviour of bone is not yet understood. We investigated the time-dependent response of demineralised trabecular bone through tensile multiple-load-creep-unload-recovery experiments. We found that demineralised trabecular bone's time-dependent response is nonlinearly related to the applied stress levels - it stiffens with increased stress levels. Our results also indicated that the time-dependent behaviour is associated with the original bone volume ratio (BV/TV). Irrecoverable strain exists, even at the low strain levels, but are not associated with BV/TV. Furthermore, we found that the nonlinear viscoelastic model can accurately predict the time-dependent behaviour of the trabecular bone's organic phase, which can be incorporated together with the properties of mineral to generate a composite model of bone. This study will help to provide a better understanding of this natural composite material.

Keywords: Bone volume ratio; Recoverable and irrecoverable strain; Nonlinear viscoelasticity; Collagen; Creep compliance

Links

DOI: 10.1016/j.jmbbm.2020.103751

PubMed: 32347212

WoS: 000563527900002

History

Received: 2019-09-30

Revised: 2020-03-20

Accepted: 2020-03-23

Online: 2020-04-11

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Cited By (1)

Year	Entry
2022	Kunath BA. Design and Validation of an Open-Source 3D Printable Bioreactor System for Ex Vivo Bone Culture [Master's thesis]. Queen's University; June 2022.