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Fox, Alice J. Sophia
1
; Bedi, Asheesh
2
;
Rodeo, Scott A.
2
The basic science of articular cartilage: structure, composition, and function
Sports Health
. November–December 2009;1(6):461-468
©2009 The Author(s)
Affiliations
1
Laboratory of Soft Tissue Research,
Hospital for Special Surgery
, New York, New York
2
Sports Medicine and Shoulder Service,
Hospital for Special Surgery
, New York, New York
Keywords
Keywords:
articular cartilage; basic science; extracellular matrix; collagen; proteoglycan; chondrocyte
Links
DOI:
10.1177/1941738109350438
PubMed:
23015907
PubMedCentral:
PMC3445147
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Finnilä MAJ, Gupta SD, Turunen MJ, Hellberg I, Turkiewicz A, Lutz-Bueno V, Jonsson E, Holler M, Ali N, Hughes V, Isaksson H, Tjörnstrand J, Önnerfjord P, Guizar-Sicairos M, Saarakkala S, Englund M. Mineral crystal thickness in calcified cartilage and subchondral bone in healthy and osteoarthritic human knees.
J Bone Miner Res
. September 2022;37(9):1700-1710.
2022
Liu H, Witzigreuter L, Sathiaseelan R, Agbaga M-P, Brush RS, Stout MB, Zhu S. Obesity promotes lipid accumulation in mouse cartilage: a potential role of acetyl-CoA carboxylase (ACC) mediated chondrocyte de novo lipogenesis.
J Orthop Res
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2020
Aggleton J.
First-Hand Experience: A Methodology for Exploring Bone Architecture
[PhD thesis]. Bristol, UK: University of Bristol; January 2020.
2015
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Synthesis and Characterization of Cationic Contrast Agents & Imaging of Articular Cartilage Using X-Ray Computed Tomography and Magnetic Resonance
[PhD thesis]. Boston University; 2015.
2018
Wallace C.
Effects of Glucocorticoids on Chondrocytes and Cartilage
[Master's thesis]. Boston University; 2018.
2018
Wang Y.
Transport of GAG Digesting Enzymes in Engineered Cartilage Tissues
[Master's thesis]. Boston University; 2018.
2018
Wang T.
Optimization of Delivery of TGF-Beta for Improving Quality of Engineered Articular Cartilage
[Master's thesis]. Boston University; 2018.
2021
Lawson TB.
Nanoparticle Sensors and Lubricants for Degenerative Articular Cartilage
[PhD thesis]. Boston University; 2021.
2021
Lyu Y.
Optimization of Culture Media Replenishment Regimens for Cartilage Tissue Engineering
[Master's thesis]. Boston University; 2021.
2018
Butcher AL.
Deformation and Fracture of Soft Materials for Cartilage Tissue Engineering
[PhD thesis]. Cambridge, UK: University of Cambridge; May 2018.
2019
Shegaf A.
Cartilage Biomechanical and Mechanobiological Response to Sliding Contact
[PhD thesis]. Carleton University; August 2019.
2022
de Angelis N.
Finite Element Analysis of Full Range of Motion Walking and Sitting Down in Patient-Specific Models With Cam Deformities
[Master's thesis]. Carleton University; 2022.
2019
Cash HL.
The Mechanical and Functional Effects of Ionizing Radiation on Articular Cartilage
[PhD thesis]. Clemson, SC: Clemson University; May 2019.
2020
Wilson RL.
Next Generation Biometrics for the Modeling and Detection of Early Soft Tissue Degeneration in Vivo
[PhD thesis]. University of Colorado; 2020.
2020
Barthold JE.
Development of Extracellular Matrix Based Biomaterials for Articular Cartilage Repair
[PhD thesis]. University of Colorado; 2020.
2022
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Designing Architected Materials to Mimic Native Tissue Mechanics and Improve Cartilage-Regenerative Implants
[PhD thesis]. University of Colorado; 2022.
2022
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Multiscale Biophysical Signaling Regulates Tissue Morphogenesis and Degeneration
[PhD thesis]. University of Colorado; 2022.
2022
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Improved Mechanical Characterization of Soft, Hydrated, Heterogeneous Materials for the Design of Tissue Engineering Scaffolds
[PhD thesis]. University of Colorado; 2022.
2018
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Development of a Novel Block Copolymer Hydrogel for Meniscal Replacement
[PhD thesis]. Colorado State University; 2018.
2014
Sampat SR.
Optimization of Culture Conditions for Cartilage Tissue Engineering Using Synovium-Derived Stem Cells
[PhD thesis]. Columbia University; 2014.
2017
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Modulation of the in Vitro Mechanical and Chemical Environment for the Optimization of Tissue-Engineered Articular Cartilage
[PhD thesis]. Columbia University; 2017.
2020
Mosher CZ.
Interface Scaffold Design Principles for Integrative Cartilage Regeneration
[PhD thesis]. Columbia University; 2020.
2021
Hu YJ.
Microstructure and Biomechanics of the Subchondral Bone in the Development of Knee Osteoarthritis
[PhD thesis]. Columbia University; 2021.
2022
Wang C.
Assessment of Crosslink Density in Collagen Models and Ultrafast Laser Crosslinking of Corneal and Cartilage Tissues as Novel Treatment Modalities
[PhD thesis]. Columbia University; 2022.
2017
Adebayo OO.
Biomechanics of Cartilage-Bone Crosstalk in Load-Induced Osteoarthritis
[PhD thesis]. Ithaca, NY: Cornell University; August 2017.
2018
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Evaluating Macromolecular Transport in Articular Cartilage to Better Understand and Predict Transport of Arthritis Therapeutics
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2018
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The Role of the Gut Microbiome in Bone and Joint
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2019
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Development of Collagen Bioinks for Cartilage Bioprinting
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2020
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Imaging the Microscale Mechanical Response of Articular Cartilage in Early Stage Osteoarthritis Treatments
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2020
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The Roles of Subchondral Bone Mass, Stiffness, and Remodeling in Load-Induced Osteoarthritis Development
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2022
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T Cell Immunomodulation in the Lymph Node for Inhibition of Load-Induced Osteoarthritis
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2019
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Biomechanics of the Pericellular Matrix: Roles in Cartilage Development and Osteoarthritis
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2019
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Cartilage Molecular Engineering Using Biomimetic Proteoglycans
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2020
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Decorin Regulates the Structure and Biomechanical Functions of Articular Cartilage Extracellular Matrix in Health and Disease
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2021
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Extracellular Matrix Engineering of Porcine Bioprosthetic Heart Valves
[Master's thesis]. Drexel University; May 2021.
2017
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The Role of Tumor Necrosis Factor-Stimulated Gene 6 Protein (TSG-6) in Osteoarthritis
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2018
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Bioinformatics and Molecular Approaches for the Development of Biological Artificial Cartilage
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In Vivo Mechanical Metrics for the Quantitative Assessment of Cartilage Health
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2016
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2017
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Biomimicking Cartilage: Engineering the Matrix, Molecular Pathways and Oxygen Sensing of Chondrocytes
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2018
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2018
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From Electrospinning to Protein Engineering: Novel Approaches for Cartilage Repair
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From Bedside to Bench and Back: Translatable Approaches for Cartilage Repair
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Engineering an Improved Cartilage Repair Strategy Combining Cells and ECM-Derived Materials
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2016
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Heel Biomechanics Under Blast Conditions
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2023
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The Role of Mechanical Loading, Sex and TRAP/ACP5 on Bone Properties
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2023
Camacho Sierra P.
Multi-Peptide Presentation and Organization in 3D-Printed Scaffolds Drives Osteochondral Tissue Formation
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2013
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Solute Transport in Articular Cartilage: Toward Applications of Diffusion, Partitioning and Adsorption for Tissue Functional Assessment
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2016
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Cartilage Stress Relaxation Induced by Intra-Tissue Transport of Cationic Nanoparticles: Implications for Post-Traumatic Osteoarthritis Drug Delivery
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2019
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Designing Nanocarriers to Penetrate Cartilage and Improve Delivery of Biologic Drugs for Osteoarthritis
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2015
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In Vitro and in Vivo Systems Mechanobiology of Osteoarthritic Chondrocytes
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2017
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Diffusion and Diffusive Exchange Are Sensitive to the Structure of Cartilage as Measured by Nuclear Magnetic Resonance
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2018
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Characterization of Metabolic Changes in Osteoarthritis Using Global Metabolomic Profiling
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2024
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Characterization of Osteoarthritis Metabolism: A Mass Spectrometry Based-Approach
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2016
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Engineered Cartilage on Chitosan Calcium Phosphate Scaffolds for Osteochondral Defects
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2018
Mehta S.
Development of in Vitro Joint Tissue Co-Culture Models for Evaluating Transport and Biological Crosstalk
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2018
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Mapping Cartilage Properties Using Indentation Testing
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2020
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Mechanisms of Cam Morphology of the Proximal Femur
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2021
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Development of Age and Injury Induced Osteoarthritis Models for Evaluation of Therapeutics and Their Delivery Systems
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2021
Valluru PKR.
Mapping Spatial and Temporal Variation in Cartilage Mechanical Properties Using Biphasic Poro-Visco-Elastic Material Model
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2022
Gupta SD.
Mineralized Tissues At the Osteochondral Junction in Healthy and Osteoarthritic Joints: Advanced Microimaging and Mechanical Studies
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2022
Khakpour S.
Multi-Component Finite Element Analysis of Low- Energy Acetabular Fracture: Computational Study of Pelvic Girdle Fracture Mechanism
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2014
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The Development and Application of an Arthrokinematic Biomarker for the Early Detection of Osteoarthritis
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2024
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Using High Resolution X-Ray Computed Tomography and Digital Volume Correlation to Assess Full-Field 3d Strain Distribution Patterns in Osteoarthritic Cartilage
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2023
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Agarose-Collagen Hydrogel Compositions Impact Matrix Mechanics and Extracellular Deposition
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2012
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Simulated Joint Loading Enhances the Expression of of Superficial Zone Markers in Tissue Engineered Cartilage Constructs
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2018
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Methods for Improving Ability to Investigate the Effectiveness of Non-Invasive Treatment Strategies for Medial Knee OA
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2017
Meinert AC.
Hydrogels and Bioreactors for Cartilage Research and Functional Tissue Engineering
[PhD thesis]. Queensland University of Technology; 2017.
2018
Arabshahi Z.
New Mechanical Indentation Framework for Functional Assessment of Articular Cartilage
[PhD thesis]. Queensland University of Technology; 2018.
2019
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Effects of Anti-Angiogenic Factors in Two Different Models of Osteoarthritis
[PhD thesis]. Queensland University of Technology; 2019.
2020
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Optimisation of Methods for Driving Chondrogenesis of Human and Ovine Bone Marrow–derived Stromal Cells
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2021
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Fibre-Reinforced Hydrogels for Functional Cartilage Tissue Engineering
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2018
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The Effects of Cell Cycle Synchronization on the Growth Potential of Primary Articular Chondrocytes
[Master's thesis]. Toronto, ON: Ryerson University; 2018.
2019
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Increasing Collagen Accumulation in 2-D Osteogenic Cell Cultures Through Macromolecular Crowding and Cellular Confinement
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2017
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2018
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Rapid and Durable Integration of Articular Cartilage Via Photochemical Bonding: Benchtop Optimization, in-Vitro Analysis & Preclinical Model
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2018
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Isn’t it Swell? The Effect of Osmotic Swelling on Articular Cartilage and Meniscal Fibrocartilage Mechanics and Diagnostic Approaches
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2019
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Quantitative Imaging of Cartilage and Meniscus for Detection of Early Osteoarthritic Degeneration
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2021
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Contrast Agent Diffusion as a CTa Biomarker for Articular Cartilage Health
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2021
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Development of a Mechanically Versatile Bioreactor System for Cellular Microgravity and Articular Joint Modeling
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2021
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Deep Learning Tools to Accelerate Knee Osteoarthritis Research
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2022
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2017
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The Development and Retention of Articular Cartilage, Disrupted by Metabolic Stressors, is Protected by Low Intensity Vibration
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2017
Irvine AD.
Modulating Mechanical Cues and Oxygen Availability to Regulate Chondrogenesis Within MSC Laden Hydrogels
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2013
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Knee Joint Kinematics and Cartilage Health Using Magnetic Resonance Imaging: Applications to High Tibial Osteotomy
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2014
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The Influence of Maximal and Submaximal Cyclic Concentric and Eccentric Exercise on Chondrocyte Death and Synovial Fluid Proteins in the Rabbit Knee
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2015
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Molecular Basis of Articular Cartilage Boundary Lubrication: Role of PRG4 Structure & Multimerisation
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2017
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Differences in Bone and Cartilage Between Women With Anterior Cruciate Ligament Tears and Healthy Controls
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2018
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Concurrent Assessment of Knee Cartilage Morphology and Bone Microarchitecture Using Contrast-Enhanced HR-PQCT Imaging
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2019
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The Progression of Bone Microarchitecture Changes Following an Acute Knee Injury in Young Adults
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2019
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Longitudinal Assessment of Mechanical Strength of Trabecular Bone Underlying Bone Marrow Lesions Following Acute Anterior Cruciate Ligament Injuries
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2020
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2020
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Proteoglycan-4 in Equine Joint Disease, Exercise, and in Vitro Cartilage Repair
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2014
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2020
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Using Mechanical Stimulation to Improve Tissue-Engineered Articular Cartilage for Implantation in the Knee Joint
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2019
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The Role of Inflammation and Antibiotics in the Development of Post-Traumatic Osteoarthritis in Mice
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2018
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2019
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2021
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Growth and Mechanobiology of the Achilles Enthesis in Mice
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2021
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2021
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Bone, Cartilage and Their Interface: Osteochondral Changes During Very Early Osteoarthritis
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2022
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Multiscale Imaging and Biomechanics of Articular Cartilage in an Animal Model of Osteoarthritis
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2017
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2022
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2017
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The Influence of Vimentin Intermediate Filaments on Human Mesenchymal Stem Cell Response to Physical Stimuli
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2022
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2022
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Chondrocyte Primary Cilia Lengthening and Shortening in Response to Osteoarthritic Sequelae: A Role for Integrin Alpha 1 Beta 1 and Focal Adhesions
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2012
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2017
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Single Cell Molecular Heterogeneity in Musculoskeletal Differentiation
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2018
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Addressing Partial Volume Artifacts With Quantitative Computed Tomography-Based Finite Element Modeling of the Human Proximal Tibia
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2014
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Biomechanical Analysis of Acetabular Dysplasia: Foundations for Improved Clinical Care
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2018
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Characterization of Cam Femoroacetabular Impingement Using Subject-Specific Biomechanics and Population-Based Morphological Measurements
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2020
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Knee Articular Cartilage Material Properties Estimation Through FEA
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2020
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Computational Modelling of Knee Tissue Mechanics During Single-Leg Jump Landing
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2019
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2020
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2020
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Tissue Engineering of Induced Pluripotent Stem Cells for the Development of Novel Treatment Strategies for Osteoarthritis
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2021
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2021
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2021
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Understanding and Improving Adult Stem Cells for Cartilage Tissue Engineering
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Synthetic Gene Circuits for Self-Regulating and Temporal Delivery of Anti-Inflammatory Biologic Drugs in Engineered Tissues
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