Age-related changes in the collagen network and toughness of bone

Wang, X.; Shen, X.; Li, X.; Agrawal, C. Mauli

Year	Entry
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2021	Schubert A, Erlinger N, Leo C, Iraeus J, John J, Klug C. Development of a 50th percentile female femur model. In: Proceedings of the 2021 International IRCOBI Conference on the Biomechanics of Injury. September 8-10, 2021; Online.308-332.
2019	Zhai X, Guo Z, Gao J, Kedir N, Nie Y, Claus B, Sun T, Xiao X, Fezzaa K, Chen WW. High-speed X-ray visualization of dynamic crack initiation and propagation in bone. Acta Biomater. May 2019;90:278-286.
2004	Wang X, Puram S. The toughness of cortical bone and its relationship with age. Ann Biomed Eng. January 2004;32(1):123-135.
2018	Xie S, Wallace RJ, Callanan A, Pankaj P. From tension to compression: asymmetric mechanical behaviour of trabecular bone’s organic phase. Ann Biomed Eng. June 2018;46(6):801-809.
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2003	Nalla RK, Kinney JH, Ritchie RO. Effect of orientation on the in vitro fracture toughness of dentin: the role of toughening mechanisms. Biomaterials. October 2003;24(22):3955-3968.
2005	Nalla RK, Kruzic JJ, Kinney JH, Ritchie RO. Mechanistic aspects of fracture and R-curve behavior in human cortical bone. Biomaterials. January 2005;26(2):217-231.
2011	Barth HD, Zimmermann EA, Schaible E, Tang SY, Alliston T, Ritchie RO. Characterization of the effects of x-ray irradiation on the hierarchical structure and mechanical properties of human cortical bone. Biomaterials. December 2011;32(34):8892-8904.
2002	Burr DB. The contribution of the organic matrix to bone's material properties. Bone. July 2002;31(1):8-11.
2003	Ferguson VL, Ayers RA, Bateman TA, Simske SJ. Bone development and age-related bone loss in male C57BL/6J mice. Bone. March 2003;32(3):387-398.
2004	Akkus O, Adar F, Schaffler MB. Age-related changes in physicochemical properties of mineral crystals are related to impaired mechanical function of cortical bone. Bone. March 2004;34(4):443-453.
2004	Loveridge N, Power J, Reeve J, Boyde A. Bone mineralization density and femoral neck fragility. Bone. October 2004;35(4):929-941.
2004	Nalla RK, Kruzic JJ, Kinney JH, Ritchie RO. Effect of aging on the toughness of human cortical bone: evaluation by R-curves. Bone. December 2004;35(6):1240-1246.
2005	Hernandez CJ, Tang SY, Baumbach BM, Hwu PB, Sakkee AN, van der Ham F, DeGroot J, Bank RA, Keaveny TM. Trabecular microfracture and the influence of pyridinium and non-enzymatic glycation-mediated collagen cross-links. Bone. December 2005;37(6):825-832.
2006	Garnero P, Borel O, Gineyts E, Duboeuf F, Solberg H, Bouxsein ML, Christiansen C, Delmas PD. Extracellular post-translational modifications of collagen are major determinants of biomechanical properties of fetal bovine cortical bone. Bone. March 2006;38(3):300-309.
2006	Ruppel ME, Burr DB, Miller LM. Chemical makeup of microdamaged bone differs from undamaged bone. Bone. August 2006;39(2):318-324.
2006	Viguet-Carrin S, Roux JP, Arlot ME, Merabet Z, Leeming DJ, Byrjalsen I, Delmas PD, Bouxsein ML. Contribution of the advanced glycation end product pentosidine and of maturation of type I collagen to compressive biomechanical properties of human lumbar vertebrae. Bone. November 2006;39(5):1073-1079.
2006	Allen MR, Iwata K, Sato M, Burr DB. Raloxifene enhances vertebral mechanical properties independent of bone density. Bone. November 2006;39(5):1130-1135.
2006	Nyman JS, Roy A, Acuna RL, Gayle HJ, Reyes MJ, Tyler JH, Dean DD, Wang X. Age-related effect on the concentration of collagen crosslinks in human osteonal and interstitial bone tissue. Bone. December 2006;39(6):1210-1217.
2007	Yan J, Mecholsky JJ Jr, Clifton KB. How tough is bone? application of elastic–plastic fracture mechanics to bone. Bone. February 2007;40(2):479-484.
2007	Nagaraja S, Lin ASP, Guldberg RE. Age-related changes in trabecular bone microdamage initiation. Bone. April 2007;40(4):973-980.
2007	Wallace JM, Rajachar RM, Allen MR, Bloomfield SA, Robey PG, Young MF, Kohn DH. Exercise-induced changes in the cortical bone of growing mice are bone- and gender-specific. Bone. April 2007;40(4):1120-1127.
2007	Tang SY, Zeenath U, Vashishth D. Effects of non-enzymatic glycation on cancellous bone fragility. Bone. April 2007;40(4):1144-1151.
2007	Tang SY, Vashishth D. A non-invasive in vitro technique for the three-dimensional quantification of microdamage in trabecular bone. Bone. May 2007;40(5):1259-1264.
2008	Nyman JS, Ni Q, Nicolella DP, Wang X. Measurements of mobile and bound water by nuclear magnetic resonance correlate with mechanical properties of bone. Bone. January 2008;42(1):193-199.
2010	Tang SY, Vashishth D. Non-enzymatic glycation alters microdamage formation in human cancellous bone. Bone. January 2010;46(1):148-154.
2010	Viguet-Carrin S, Follet H, Gineyts E, Roux JP, Munoz F, Chapurlat R, Delmas PD, Bouxsein ML. Association between collagen cross-links and trabecular microarchitecture properties of human vertebral bone. Bone. February 2010;46(2):342-347.
2010	Wolfram U, Wilke H-J, Zysset PK. Rehydration of vertebral trabecular bone: influences on its anisotropy, its stiffness and the indentation work with a view to age, gender and vertebral level. Bone. February 2010;46(2):348-354.
2010	Barth HD, Launey ME, MacDowell AA, Ager JW III, Ritchie RO. On the effect of X-ray irradiation on the deformation and fracture behavior of human cortical bone. Bone. June 2010;46(6):1475-1485.
2010	Isaksson H, Malkiewicz M, Nowak R, Helminen HJ, Jurvelin JS. Rabbit cortical bone tissue increases its elastic stiffness but becomes less viscoelastic with age. Bone. December 2010;47(6):1030-1038.
2013	Willett TL, Sutty S, Gaspar A, Avery N, Grynpas M. In vitro non-enzymatic ribation reduces post-yield strain accommodation in cortical bone. Bone. February 2013;52(2):611-622.
2014	Gallant MA, Brown DM, Hammond M, Wallace JM, Du J, Deymier-Black AC, Almer JD, Stock SR, Allen MR, Burr DB. Bone cell-independent benefits of raloxifene on the skeleton: a novel mechanism for improving bone material properties. Bone. April 2014;61:191-200.
2018	Karim L, Moulton J, Van Vliet M, Velie K, Robbins A, Malekipour F, Abdeen A, Ayres D, Bouxsein ML. Bone microarchitecture, biomechanical properties, and advanced glycation end-products in the proximal femur of adults with type 2 diabetes. Bone. September 2018;114:32-39.
2020	Creecy A, Uppuganti S, Girard MR, Schlunk SG, Amah C, Granke M, Unal M, Does MD, Nyman JS. The age-related decrease in material properties of BALB/c mouse long bones involves alterations to the extracellular matrix. Bone. January 2020;130:115126.
2020	Burr DB. Fifty years of bisphosphonates: what are their mechanical effects on bone? Bone. September 2020;138:115518.
2021	Surowiec RK, Ram S, Idiyatullin D, Goulet R, Schlecht SH, Galban CJ, Kozloff KM. In vivo quantitative imaging biomarkers of bone quality and mineral density using multi-band-SWIFT magnetic resonance imaging. Bone. February 2021;143:115615.
2021	Creecy A, Brown KL, Rose KL, Voziyan P, Nyman JS. Post-translational modifications in collagen type I of bone in a mouse model of aging. Bone. February 2021;143:115763.
2021	Singleton RC, Pharr GM, Nyman JS. Increased tissue-level storage modulus and hardness with age in male cortical bone and its association with decreased fracture toughness. Bone. July 2021;148:115949.
2021	Frank M, Grabos A, Reisinger AG, Burr DB, Pahr DH, Allen MR, Thurner PJ. Effects of anti-resorptive treatment on the material properties of individual canine trabeculae in cyclic tensile tests. Bone. September 2021;150:115995.
2022	Willett TL, Voziyan P, Nyman JS. Causative or associative: a critical review of the role of advanced glycation end-products in bone fragility. Bone. October 2022;163:116485.
2023	Heath S, Han Y, Hua R, Roy A, Jiang J, Nyman JS, Wang X. Assessment of glycosaminoglycan content in bone using Raman spectroscopy. Bone. June 2023;171:116751.
2023	Wang B, Vashishth D. Advanced glycation and glycoxidation end products in bone. Bone. November 2023;176:116880.
2024	Rubin MR, Dhaliwal R. Role of advanced glycation endproducts in bone fragility in type 1 diabetes. Bone. January 2024;178:116928.
2007	Allen MR, Burr DB. Mineralization, microdamage, and matrix: how bisphosphonates influence material properties of bone. BoneKEy Osteovision. February 2007;4(2):49-60.
2015	Zimmermann EA, Busse B, Ritchie RO. The fracture mechanics of human bone: influence of disease and treatment. BoneKEy Rep. September 2015;4:743.
2006	Saito M, Fujii K, Marumo K. Degree of mineralization-related collagen crosslinking in the femoral neck cancellous bone in cases of hip fracture and controls. Calcif Tiss Int. September 2006;79(3):160-168.
2010	Willinghamm MD, Brodt MD, Lee KL, Stephens AL, Ye J, Silva MJ. Age-related changes in bone structure and strength in female and male BALB/c mice. Calcif Tiss Int. June 2010;86(6):470-483.
2005	Felsenberg D, Boonen S. The bone quality framework: determinants of bone strength and their interrelationships, and implications for osteoporosis management. Clin Ther. January 2005;27(1):1-11.
2020	Maghsoudi-Ganjeh M, Wang X, Zeng X. Nanomechanics and ultrastructure of bone: a review. Comput Model Eng Sci. 2020;125(1):1-32.
2007	Vashishth D. The role of the collagen matrix in skeletal fragility. Curr Osteoporos Rep. June 2007;5(2):62-66.
2020	Whyne CM, Ferguson D, Clement A, Rangrez M, Hardisty M. Biomechanical properties of metastatically involved osteolytic bone. Curr Osteoporos Rep. December 2020;18(6):705-715.
2005	Ritchie RO, Kinney JH, Kruzic JJ, Nalla RK. A fracture mechanics and mechanistic approach to the failure of cortical bone. Fatigue Fract Eng Mater Struct. April 2005;28(4):345-371.
2009	Vashishth D. Advanced glycation end-products and bone fractures. IBMS Bonekey. August 2009;6(8):268-278.
2011	Mischinski S, Ural A. Finite element modeling of microcrack growth in cortical bone. J Appl Mech. July 2011;78(4):041016.
2007	Valcourt U, Merle B, Gineyts E, Viguet-Carrin S, Delmas PD, Garnero P. Non-enzymatic glycation of bone collagen modifies osteoclastic activity and differentiation. J Biol Chem. February 23, 2007;282(8):5691-5703.
2003	Kotha SP, Guzelsu N. Tensile damage and its effects on cortical bone. J Biomech. November 2003;36(11):1683-1689.
2005	Nalla RK, Stölken JS, Kinney JH, Ritchie RO. Fracture in human cortical bone: local fracture criteria and toughening mechanisms. J Biomech. July 2005;38(7):1517-1525.
2006	Nyman JS, Roy A, Shen X, Acuna RL, Tyler JH, Wang X. The influence of water removal on the strength and toughness of cortical bone. J Biomech. 2006;39(5):931-938.
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2008	Siegmund T, Allen MR, Burr DB. Failure of mineralized collagen fibrils: modeling the role of collagen cross-linking. J Biomech. 2008;41(7):1427-1435.
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2007	Ural A, Vashishth D. Effects of intracortical porosity on fracture toughness in aging human bone: a μCT-based cohesive finite element study. J Biomech Eng. October 2007;129(5):625-631.
2019	Shitole P, Gupta A, Ghosh R. Fracture mechanism and fracture toughness at the interface between cortical and cancellous bone. J Biomech Eng. November 2019;141(11):114502.
2005	Ager JW III, Nalla RK, Breeden KL, Ritchie RO. Deep-ultraviolet Raman spectroscopy study of the effect of aging on human cortical bone. J Biomed Opt. May–June 2005;10(3):034012.
2003	Paschalis EP, Burr DB, Mendelsohn R, Hock JM, Boskey AL. Bone mineral and collagen quality in humeri of ovariectomized cynomolgus monkeys given rhPTH(1–34) for 18 months. J Bone Miner Res. April 2003;18(4):769-775.
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2007	Miller LM, Little W, Schirmer A, Sheik F, Busa B, Judex S. Accretion of bone quantity and quality in the developing mouse skeleton. J Bone Miner Res. July 2007;22(7):1037-1045.
2010	Shane E, Burr D, Ebeling PR, Abrahamsen B, Adler RA, Brown TD, Cheung AM, Cosman F, Curtis JR, Dell R, Dempster D, Einhorn TA, Genant HK, Geusens P, Klaushofer K, Koval K, Lane JM, McKiernan F, McKinney R, Ng A, Nieves J, O'Keefe R, Papapoulos S, Sen HT, van der Meulen MCH, Weinstein RS, Whyte M. Atypical subtrochanteric and diaphyseal femoral fractures: report of a task force of the American Society for Bone and Mineral Research. J Bone Miner Res. November 2010;25(11):2267-2294.
2012	Tang SY, Herber R-P, Ho SP, Alliston T. Matrix metalloproteinase–13 is required for osteocytic perilacunar remodeling and maintains bone fracture resistance. J Bone Miner Res. September 2012;27(9):1936-1950.
2013	Christen D, Melton LJ III, Zwahlen A, Amin S, Khosla S, Müller R. Improved fracture risk assessment based on nonlinear micro-finite element simulations from HRpQCT images at the distal radius. J Bone Miner Res. December 2013;28(12):2601-2608.
2014	Carriero A, Zimmermann EA, Paluszny A, Tang SY, Bale H, Busse B, Alliston T, Kazakia G, Ritchie RO, Shefelbine SJ. How tough is brittle bone? investigating osteogenesis imperfecta in mouse bone. J Bone Miner Res. June 2014;29(6):1392-1401.
2015	McNerny EMB, Gong B, Morris MD, Kohn DH. Bone fracture toughness and strength correlate with collagen cross-link maturity in a dose-controlled lathyrism mouse model. J Bone Miner Res. March 2015;30(3):455-464.
2015	Granke M, Makowski AJ, Uppuganti S, Does MD, Nyman JS. Identifying novel clinical surrogates to assess human bone fracture toughness. J Bone Miner Res. July 2015;30(7):1290-1300.
2020	Waqas K, Chen J, Koromani F, Trajanoska K, van der Eerden BCJ, Uitterlinden AG, Rivadeneira F, Zillikens MC. Skin autofluorescence, a noninvasive biomarker for advanced glycation end‐products, is associated with prevalent vertebral and major osteoporotic fractures: the Rotterdam Study. J Bone Miner Res. October 2020;35(10):1904-1913.
2022	Bailey S, Stadelmann MA, Zysset PK, Vashishth D, Alkalay RN. Influence of metastatic bone lesion type and tumor origin on human vertebral bone architecture, matrix quality, and mechanical properties. J Bone Miner Res. May 2022;37(5):896-907.
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2009	Schwartz AV, Garnero P, Hillier TA, Sellmeyer DE, Strotmeyer ES, Feingold KR, Resnick HE, Tylavsky FA, Black DM, Cummings SR, Harris TB, Bauer DC; Health, Aging, and Body Composition Study. Pentosidine and increased fracture risk in older adults with type 2 diabetes. J Clin Endocrinol Metab. July 2009;94(7):2380-2386.
2004	Fratzl P, Gupta HS, Paschalis EP, Roschger P. Structure and mechanical quality of the collagen–mineral nano-composite in bone. J Mater Chem. 2004;14(14):2115-2123.
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2011	Kulin RM, Jiang F, Vecchio KS. Effects of age and loading rate on equine cortical bone failure. J Mech Behav Biomed Mater. January 2011;4(1):57-75.
2011	Koester KJ, Barth HD, Ritchie RO. Effect of aging on the transverse toughness of human cortical bone: evaluation by R-curves. J Mech Behav Biomed Mater. October 2011;4(7):1504-1513.
2013	Nyman JS, Gorochow LE, Horch RA, Uppuganti S, Zein-Sabatto A, Manhard MK, Does MD. Partial removal of pore and loosely bound water by low-energy drying decreases cortical bone toughness in young and old donors. J Mech Behav Biomed Mater. June 2013;22:136-145.
2015	Poundarik AA, Wu P-C, Evis Z, Sroga GE, Ural A, Rubin M, Vashishth D. A direct role of collagen glycation in bone fracture. J Mech Behav Biomed Mater. December 2015;52:120-130.
2020	Maghsoudi-Ganjeh M, Wang X, Zeng X. Computational investigation of the effect of water on the nanomechanical behavior of bone. J Mech Behav Biomed Mater. January 2020;101:103454.
2020	Fleps I, Bahaloo H, Zysset PK, Ferguson SJ, Pálsson H, Helgason B. Empirical relationships between bone density and ultimate strength: a literature review. J Mech Behav Biomed Mater. October 2020;110:103866.
2021	Jia S, Gong H, Cen H, Shi P, Zhang R, Li Z, Bi X. Influence of non-enzymatic glycation on the mechanical properties of cortical bone. J Mech Behav Biomed Mater. July 1, 2021;119:104553.
2022	Shin M, Zhang M, vom Scheidt A, Pelletier MH, Walsh WR, Martens PJ, Kruzic JJ, Busse B, Gludovatz B. Impact of test environment on the fracture resistance of cortical bone. J Mech Behav Biomed Mater. May 2022;129:105155.
2019	Zhai X, Gao J, Nie Y, Guo Z, Kedir N, Claus B, Sun T, Fezzaa K, Xiao X, Chen WW. Real-time visualization of dynamic fractures in porcine bones and the loading-rate effect on their fracture toughness. J Mech Phys Solids. October 2019;(131):358-371.
2007	Nyman JS, Roy A, Tyler JH, Acuna RL, Gayle HJ, Wang X. Age‐related factors affecting the postyield energy dissipation of human cortical bone. J Orthop Res. May 2007;25(7):646-655.
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2005	Nyman JS, Reyes M, Wang X. Effect of ultrastructural changes on the toughness of bone. Micron. October–December 2005;36(7-8):566-582.
2003	Nalla RK, Kinney JH, Ritchie RO. Mechanistic fracture criteria for the failure of human cortical bone. Nat Mater. 2003;2(3):164-168.
2008	Koester KJ, Ager JW III, Ritchie RO. The true toughness of human cortical bone measured with realistically short cracks. Nat Mater. August 2008;7(8):672-677.
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2006	Viguet-Carrin S, Garnero P, Delmas PD. The role of collagen in bone strength. Osteoporos Int. March 2006;17(3):319-336.
2006	Saito M, Fujii K, Soshi S, Tanaka T. Reductions in degree of mineralization and enzymatic collagen cross-links and increases in glycation-induced pentosidine in the femoral neck cortex in cases of femoral neck fracture. Osteoporos Int. July 2006;17(7):986-995.
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2018	Torres AM. Fatigue Behavior of Cancellous Bone, Microdamage Accumulation, and Biologically Inspired Cellular Solids [PhD thesis]. Ithaca, NY: Cornell University; August 2018.
2005	Cook RB. Non-Invasively Assessed Skeletal Bone Status and Its Relationship to the Biomechanical Properties and Condition of Cancellous Bone [PhD thesis]. Cranfield, UK: Cranfield University; December 18, 2005.
2008	Tommasini SM. Phenotypic Integration Contributes to Skeletal Functionality and Fragility [PhD thesis]. New York, NY: The City University of New York; 2008.
2023	Maghami E. Fracture Micromechanics Analyses of Hard Tissues: Study of Increased Glycation Through Diabetes and Age-Related Changes [PhD thesis]. Drexel University; January 2023.
2018	Xie S. Characterisation of Time-Dependent Mechanical Behaviour of Trabecular Bone and Its Constituents [PhD thesis]. Edinburgh, Scotland: University of Edinburgh; 2018.
2016	Oei L. Epidemiological, Radiological and Genetic Aspects of Endocrine Bone Diseases [PhD thesis]. Erasmus University Rotterdam; December 14, 2016.
2007	Voide R. Functional Phenotyping of Bone: A Hierarchical Assessment of Bone Failure Characteristics [PhD thesis]. Swiss Federal Institute of Technology Zürich; 2007.
2019	Fleps I. Assessing the Risk of Hip Fracture: Subject-Specific Dynamic Models for the Simulation of Sideways Fall Impact [PhD thesis]. Swiss Federal Institute of Technology Zürich; 2019.
2006	Nagaraja S. Microstructural Stresses and Strains Associated With Trabecular Bone Microdamage [PhD thesis]. Atlanta, GA: Georgia Institute of Technology; December 2006.
2010	Wang JL. Effects of Aging and Remodeling on Bone Microdamage Formation [Master's thesis]. Atlanta, GA: Georgia Institute of Technology; December 2010.
2011	O'Neal JM. The Effects of Aging and Remodeling on Bone Quality and Microdamage [PhD thesis]. Atlanta, GA: Georgia Institute of Technology; August 2011.
2020	Lamarche BA. Morphometric Changes With Age in Human Trabecular Bone Structural Units (BSU) of the Lumbar Spine [Master's thesis]. Sudbury, ON: Laurentian University; 2020.
2022	Rahovich P. Effects of Bone Structural Unit (BSU) Geometry and Material Properties on Crack Growth Through Idealized Trabecular Microstructures [Master's thesis]. Sudbury, ON: Laurentian University; 2022.
2011	Abdel-Wahab AA-GM. Experimental and Numerical Analysis of Deformation and Fracture of Cortical Bone Tissue [PhD thesis]. Loughborough University; August 2011.
28	Wang M. Effect of Osteonal Microstructure on Crack Propagation: A Computational Study [PhD thesis]. Loughborough University; October 28.
2014	Jameson JR. Characterization of Bone Material Properties and Microstructure in Osteogenesis Imperfecta/brittle Bone Disease [PhD thesis]. Marquette University; December 2014.
2019	Nobakhti S. Multiscale Characteristics of Bone Toughness [PhD thesis]. Northeastern University; July 2019.
2011	Agnew AM. Histomorphometry of the Elderly Rib: A Methodological Approach With Implications for Biomechanics, Function, and Fracture Risk [PhD thesis]. The Ohio State University; 2011.
2019	Mustafy T. The Short and Long Term Effects of in Vivo Cyclic Axial Compression Applied During Puberty on Bone Growth, Morphometry and Biomechanics [PhD thesis]. École polytechnique de Montréal; July 2019.
2012	Tozzi G. In Vitro Studies of Bone-Cement Interface and Related Work on Cemented Acetabular Replacement [PhD thesis]. Portsmouth, England: University of Portsmouth; May 29, 2012.
2016	Hammond MA. The Influence of Collagen Crosslinking and Treadmill Exercise on the Mechanics, Composition, and Morphology of Bone At Multiple Length Scales [PhD thesis]. Purdue University; May 2016.
2008	Crookshank MCM. Optimizing Fracture Management: Correlating the Physical and Mechanical Properties of Bone to Computed Tomography to Generate an Estimate of Bone Quality [Master's thesis]. Queen's University; January 2008.
2019	Beltejar M-JG. Understanding the Genetic Basis for Bone-Matrix Quality [PhD thesis]. University of Rochester; 2019.
2005	George WT. Multiaxial Fracture Characteristics of Aging Human Bone [PhD thesis]. Troy, NY: Rensselaer Polytechnic Institute; April 2005.
2006	Diab T. The Role of Damage Morphology in Age-Related Increase in Bone Fragility [PhD thesis]. Troy, NY: Rensselaer Polytechnic Institute; 2006.
2007	Tang SY-C. Effects of Non-Enzymatic Glycation on the Biomechanical Behavior of Bone [PhD thesis]. Troy, NY: Rensselaer Polytechnic Institute; 2007.
2010	Janeiro C. The Effect of Bone Quality on Osteoclastic Bone Resorption [PhD thesis]. Troy, NY: Rensselaer Polytechnic Institute; May 2010.
2011	Karim L. The Biomolecular Basis of Bone Fracture [PhD thesis]. Troy, NY: Rensselaer Polytechnic Institute; November 2011.
2014	Bradke BS. The Role of Cortical and Cancellous Bone Quality on Vertebral Fragility [PhD thesis]. Troy, NY: Rensselaer Polytechnic Institute; April 2014.
2016	Bailey SM. The Role of Extra-Cellular Matrix Proteins and Post-Translational Modifications on Bone Fracture [PhD thesis]. Troy, NY: Rensselaer Polytechnic Institute; September 2016.
2018	Samvelyan H. The Effect of Timing of Feeding on Bone's Adaptive Response to Mechanical Loading [PhD thesis]. University of Sheffield; March 2018.
2009	Ruppel ME. Alterations in the Mineral and Collagen Matrix of Bisphosphonate-Treated Bone and Osteoblasts [PhD thesis]. Stony Brook, NY: Stony Brook University; May 2009.
2012	Kwaczala AT. Alendronate and PTH Differentially Modulate Bone Quality and Reduce Adiposity in an OVX Rat Model [PhD thesis]. Stony Brook, NY: Stony Brook University; December 2012.
2021	Frank M. Mechanical Characterization of Individual Trabeculae [PhD thesis]. Vienna University of Technology; February 2021.
2011	Ebacher V. Experimental Study of Deformation and Microcracking in Human Cortical Bone [PhD thesis]. Vancouver, BC: University of British Columbia; May 2011.
2018	Tang T. Fracture Mechanisms and Structural Fragility of Human Femoral Cortical Bone [PhD thesis]. Vancouver, BC: University of British Columbia; April 2018.
2017	Fung A. Experimental Validation of Finite Element Predicted Bone Strain in the Human Metatarsal [Master's thesis]. Calgary, AB: University of Calgary; April 2017.
2011	Barth HD. A Hierarchical Approach to Characterizing the Fracture Behavior of Bone Utilizing Synchrotron Radiation [PhD thesis]. Berkeley, CA: Berkeley, University of California; F 2011.
2011	Zimmermann EA. Deformation and Fracture of Human Cortical Bone Across Multiple Length-Scales [PhD thesis]. Berkeley, CA: Berkeley, University of California; F 2011.
2014	Nawathe S. Micromechanics of the Human Proximal Femur: Role of Microstructure and Tissue-Level Ductility on Femoral Strength [PhD thesis]. Berkeley, CA: Berkeley, University of California; 2014.
2018	Pendleton MM. Effects of Spaceflight- and Clinically-Relevant Ionizing Radiation Exposure on Bone Biomechanics [PhD thesis]. Berkeley, CA: Berkeley, University of California; 2018.
2012	Hardisty MR. Not Tough Enough: Why Bone Turns Pale When it Feels Stressed [PhD thesis]. Davis, CA: Davis, University of California; 2012.
2023	Bermudez B. Effects of Unsaturated Fatty Acids on Bone Strength, Accrual, and Nutrient Trafficking [PhD thesis]. University of Colorado Denver; 2023.
2013	Wang Y-K. Multi-Level Micromechanical Modeling of Bone Tissues [PhD thesis]. Los Angeles, CA: Los Angeles, University of California; 2013.
2010	Kulin RM. On the Dynamic Behavior of Mineralized Tissues [PhD thesis]. San Diego (UCSD), University of California; 2010.
2012	Evdokimenko E. Investigation Into Mechanical Properties of Bone and Its Main Constituents [PhD thesis]. San Diego (UCSD), University of California; 2012.
2019	Jung J-Y. Learning from Nature: An Investigation of an Impact-Resistant System on the Woodpecker Head as a Non-Traumatic Brain Injury Animal Model [PhD thesis]. San Siego, CA: University of California San Diego; 2019.
2005	Yan J. Elastic-Plastic Fracture Mechanics of Compact Bone [PhD thesis]. University of Florida; 2005.
2019	Aaronson JD. Effects of Hyperglycemia and Advanced Glycation End Products on Novel Ocy454 Osteocytes [Master's thesis]. University of Massachusetts at Dartmouth; May 2019.
2021	Vaidya RS. Diabetes Associated Alterations in Osteocytic Regulation of Bone Remodelling [PhD thesis]. University of Massachusetts at Dartmouth; August 2021.
2007	Wallace JM III. Investigating the Inbred Strain-Specific Response to Biglycan-Deficiency and Exercise: A Study in Genetically-Mediated Skeletal Adaptation [PhD thesis]. University of Michigan; 2007.
2009	Sahar ND. Investigating the Effects of Age and Exercise on Bone Composition and the Impact of Composition on Mechanical Integrity. [PhD thesis]. University of Michigan; 2009.
2013	Davis MS. Microdamage: Its Role in the Mechanical Integrity of Low Bone Mass Diseases and Its Treatment Implications [PhD thesis]. University of Michigan; 2013.
2014	Sinder BP. Sclerostin Antibody as a Treatment for Osteogenesis Imperfecta [PhD thesis]. University of Michigan; 2014.
2015	Begun DL. Age-Related Changes in Bone: Variation and Factors Influencing Bone Fragility [PhD thesis]. University of Michigan; 2015.
2019	Surowiec R. Novel Models to Image and Quantify Bone Drug Efficacy and Disease Progression in Vivo: Addressing the Fragility Phenotype [PhD thesis]. University of Michigan; 2019.
2011	Wolfram U. Mechanical Multiscale Characterisation of Vertebral Trabecular Bone for the Prediction of Vertebral Fracture Risk [PhD thesis]. University of Ulm; 2011.
2022	Snow TJ. An Investigation of the Role of Collagen Network on the Dynamic Fracture Initiation Toughness of Bovine Cortical Bone [Master's thesis]. University of Utah; December 2022.
2020	Singleton RC. A Study of Aging in Male Cortical Bone Using Nanoindentation [PhD thesis]. Knoxville, University of Tennessee; August 2020.
2010	Kyle KA. Differential Effects of PPAR-Γ Activation Vs. Chemical or Genetic Reduction of DPP-4 Activity on Murine Bone Quality [Master's thesis]. University of Toronto; 2010.
2010	Magalhaes JKRS. The Role of Rac1 and Rac2 in Determining Bone Quality in Aged and Osteoporotic Female Mouse Models [Master's thesis]. University of Toronto; 2010.
2010	Wynnyckyj C. The Consequences of Collagen Degradation on Bone Mechanical Properties [PhD thesis]. University of Toronto; 2010.
2018	Burke MV. Quantification of Changes in Vertebral Bone Quality in the Presence of Metastases [PhD thesis]. University of Toronto; 2018.
2009	Potter RS. Age Effects on the Material and Mechanical Properties of Bone At the Osteocyte Lacuna [Master's thesis]. San Antionio, TX: University of Texas at San Antonio; December 2009.
2010	Reyes MJ. Age-Related Influence of Bone Remodeling on Local Tissue Properties of Human Cortical Bone [PhD thesis]. San Antionio, TX: University of Texas at San Antonio; December 2010.
2011	Islam A. Mechanistic Model of Nanoscratch Test to Determine the in Situ Toughness of Bone [Master's thesis]. San Antionio, TX: University of Texas at San Antonio; May 2011.
2014	Gandhi C. Effects of Matrix Advanced Glycation End Products on Human Osteoclast Resorption of Human Cortical Bone [Master's thesis]. San Antionio, TX: University of Texas at San Antonio; May 2014.
2020	Maghsoudi-Ganjeh M. Computational Investigation of Ultrastructural Behavior of Bone and Bone-Inspired Materials [PhD thesis]. San Antionio, TX: University of Texas at San Antonio; May 2020.
2017	Levine IC. The Effects of Body Composition and Body Configuration on Impact Dynamics During Lateral Falls: Insights from in-Vivo, in-Vitro, and in-Silico Approaches [PhD thesis]. University of Waterloo; 2017.
2022	Martel DR. Contributors to Proximal Femur Fracture Force: Multiscale Considerations of Rate, Toughness, and Bone Composition [PhD thesis]. University of Waterloo; 2022.
2011	Horch RA. Studies of ¹H Nuclear Magnetic Resonance Relaxation in Human Cortical Bone: From Ex Vivo Spectroscopy to Clinical Imaging Methods [PhD thesis]. Nashville, TN: Vanderbilt University; December 2011.
2016	Manhard MK. Advancements of MRI Measurements of Bound and Pore Water Concentration of Cortical Bone for Evaluation of Fracture Risk [PhD thesis]. Nashville, TN: Vanderbilt University; August 2016.
2018	Creecy A. Age- and Diabetes-Related Changes in the Matrix and Fracture Resistance of Bone [PhD thesis]. Nashville, TN: Vanderbilt University; August 10, 2018.
2019	Demirtas A. Assessment of the Influence of Possible Side Effects of Long-Term Bisphosphonate Treatment on Cortical Bone Fracture Resistance Using Finite Element Modeling [PhD thesis]. Villanova, PA: Villanova University; July 2019.
2012	Banglmaier RF. Enhancing the Mechanical Properties of a Hydroxyapatite-Collagen Bone Surrogate [PhD thesis]. Detroit, MI: Wayne State University; August 2012.

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1997	Weiner S, Arad T, Sabanay I, Traub. W. Rotated plywood structure of primary lamellar bone in the rat: orientations of the collagen fibril arrays. Bone. June 1997;20(6):509-514.
1996	Aspray TJ, Prentice A, Cole TJ, Sawo Y, Reeve J, Francis RM. Low bone mineral content is common but osteoporotic fractures are rare in elderly rural Gambian women. J Bone Miner Res. July 1996;11(7):1019-1025.
1997	Bank RA, Beekman B, Verzijl N, de Roos JADM, Nico Sakkee A, TeKoppele JM. Sensitive fluorimetric quantitation of pyridinium and pentosidine crosslinks in biological samples in a single high-performance liquid chromatographic run. J Chromatogr B Biomed Sci Appl. December 5, 1997;703:37.
1988	Schaffler MB, Burr DB. Stiffness of compact bone: effects of porosity and density. J Biomech. 1988;21(1):13-16.
1993	Ott SM. When bone mass fails to predict bone failure. Calcif Tiss Int. February 1993;53(suppl 1):S7-S13.
1997	Bank RA, Krikken M, Beekman B, Stoop R, Maroudas A, Lafebers FPJG, Te Koppele JM. A simplified measurement of degraded collagen in tissues: application in healthy, fibrillated and osteoarthritic cartilage. Matrix Biol. November 1997;16(5):233-243.
2001	Vashishth D, Gibson GJ, Khoury JI, Schaffler MB, Kimura J, Fyhrie DP. Influence of nonenzymatic glycation on biomechanical properties of cortical bone. Bone. February 2001;28(2):195-201.
1999	Zioupos P, Currey JD, Hamer AJ. The role of collagen in the declining mechanical properties of aging human cortical bone. J Biomed Mater Res. May 1999;A45(2):108-116.
1993	Nevitt MC, Cummings SR; Study of Osteoporofic Fractures Research Group. Type of fall and risk of hip and wrist fractures: the study of osteoporotic fractures. J Am Geriatr Soc. November 1993;41(11):1226-1234.
1998	Bank RA, Bayliss MT, Lafeber FPJG, Maroudas A, Tekoppele JM. Ageing and zonal variation in post-translational modification of collagen in normal human articular cartilage: the age-related increase in non-enzymatic glycation affects biomechanical properties of cartilage. Biochem J. February 15, 1998;3301(1):345-351.
1996	Jepsen KJ, Goldstein SA, Kuhn JL, Schaffler MB, Bonadio J. Type‐I collagen mutation compromises the post‐yield behavior of Mov13 long bone. J Orthop Res. May 1996;14(3):493-499.
2000	Wang X, Bank RA, TeKoppele JM, Hubbard GB, Althanasiou KA, Agrawal CM. Effect of collagen denaturation on the toughness of bone. Clin Orthop Relat Res. February 2000;371:228-239.
1993	Martin RB, Boardman DL. The effects of collagen fiber orientation, porosity, density, and mineralization on bovine cortical bone bending properties. J Biomech. September 1993;26(9):1047-1054.
1988	Hui SL, Slemenda CW, Johnston CC Jr. Age and bone mass as predictors of fracture in a prospective study. J Clin Invest. June 1988;81(6):1804-1809.
1986	Danielsen CC, Andreassen TT, Mosekilde L. Mechanical properties of collagen from decalcified rat femur in relation to age and in vitro maturation. Calcif Tiss Int. August 1986;39(2):69-73.
1988	Alho A, Husby R, Høiseth A. Bone mineral content and mechanical strength: an ex vivo study on human femora at autopsy. Clin Orthop Relat Res. February 1988;227:292-297.
1997	Currey JD, Foreman J, Laketić I, Mitchell J, Pegg DE, Reilly GC. Effects of ionizing radiation on the mechanical properties of human bone. J Orthop Res. January 1997;15(1):111-117.
1999	Boskey AL, Wright TM, Blank RD. Collagen and bone strength. J Bone Miner Res. March 1999;14(3):330-335.
1997	Vashishth D, Behiri JC, Bonfield W. Crack growth resistance in cortical bone: concept of microcrack toughening. J Biomech. August 1997;30(8):763-769.
1999	Catanese J III, Iverson EP, Ng RK, Keaveny TM. Heterogeneity of the mechanical properties of demineralized bone. J Biomech. December 1999;32(12):1365-1369.
1976	Smith CB, Smith DA. Relations between age, mineral density and mechanical properties of human femoral compacta. Acta Orthop Scand. 1976;47(5):496-502.
1999	Bailey AJ, Sims TJ, Ebbesen EN, Mansell JP, Thomsen JS, Mosekilde L. Age-related changes in the biochemical properties of human cancellous bone collagen: relationship to bone strength. Calcif Tiss Int. September 1999;65(3):203-210.
1996	Martin RB, Lau ST, Mathews PV, Gibson VA, Stover SM. Collagen fiber organization is related to mechanical properties and remodeling in equine bone: a comparsion of two methods. J Biomech. December 1996;29(12):1515-1521.
1995	Singer K, Edmondston S, Day R, Breidahl P, Price R. Prediction of thoracic and lumbar vertebral body compressive strength: correlations with bone mineral density and vertebral region. Bone. August 1995;17(2):167-174.
1993	Bailey AJ, Wotton SF, Sims TJ, Thompson PW. Biochemical changes in the collagen of human osteoporotic bone matrix. Connect Tissue Res. 1993;29(2):119-132.
1971	Katz JL. Hard tissue as a composite material, I: bounds on the elastic behavior. J Biomech. October 1971;4(5):455-473.
1994	Hasegawa K, Turner CH, Burr DB. Contribution of collagen and mineral to the elastic anisotropy of bone. Calcif Tiss Int. November 1994;55(5):381-386.
1975	Burstein AH, Zika JM, Heiple KG, Klein L. Contribution of collagen and mineral to the elastic-plastic properties of bone. J Bone Joint Surg. October 1975;57A(7):956-961.
1998	Knott L, Bailey AJ. Collagen cross-links in mineralizing tissues: a review of their chemistry, function, and clinical relevance. Bone. March 1998;22(3):181-187.
1995	Knott L, Whitehead CC, Fleming RH, Bailey AJ. Biochemical changes in the collagenous matrix of osteoporotic avian bone. Biochem J. September 15, 1995;310(3):1045-1051.