Biomechanical properties of metastatically involved osteolytic bone

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Whyne, Cari M.^1,2,3; Ferguson, Dallis^1,3; Clement, Allison¹; Rangrez, Mohammedayaz¹; Hardisty, Michael^1,2

Biomechanical properties of metastatically involved osteolytic bone

Curr Osteoporos Rep. December 2020;18(6):705-715

©2020 Springer Science+Business Media, LLC, part of Springer Nature

Affiliations

¹Orthopaedic Biomechanics Lab, Sunnybrook Research Institute, University of Toronto, Toronto, Canada

²Department of Surgery, University of Toronto, Toronto, Canada

³Biomedical Engineering, University of Toronto, Toronto, Canada
Abstract and keywords

Purpose of Review: Skeletal metastasis involves the uncoupling of physiologic bone remodeling resulting in abnormal bone turnover and radical changes in bony architecture, density, and quality. Bone strength assessment and fracture risk prediction are critical in clinical treatment decision-making. This review focuses on bone tissue and structural mechanisms altered by osteolytic metastasis and the resulting changes to its material and mechanical behavior.

Recent Findings: Both organic and mineral phases of bone tissue are altered by osteolytic metastatic disease, with diminished bone quality evident at multiple length-scales. The mechanical performance of bone with osteolytic lesions is influenced by a combination of tissue-level and structural changes.

Summary: This review considers the effects of osteolytic metastasis on bone biomechanics demonstrating its negative impact at tissue and structural levels. Future studies need to assess the cumulative impact of cancer treatments on metastatically involved bone quality, and its utility in directing multimodal treatment planning.

Keywords: Osteolytic metastases; Biomechanical properties; Bone quality; Multiscale; Cancer treatment effects
Links

DOI: 10.1007/s11914-020-00633-z
History

Accepted: 2020-09-29

Online: 2020-10-19

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