Advanced glycation end-products and bone fractures

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Vashishth, Deepak¹

Advanced glycation end-products and bone fractures

IBMS Bonekey. August 2009;6(8):268-278

©2009 International Bone & Mineral Society

Affiliations

¹Department of Biomedical Engineering, Center of Biotechnology & Interdisciplinary Studies, Rensselaer Polytechnic Institute, Troy, New York, USA
Abstract and keywords

Bone does not turn over uniformly, and becomes susceptible to post-translational modification by nonenzymatic glycation (NEG). NEG of bone causes the formation of advanced glycation end-products (AGEs) and this process is accelerated with aging, diabetes and antiresorptive postmenopausal osteoporosis therapy. Due to the elevated incidence of fracture associated with aging and diabetes, several studies have attempted to measure and evaluate AGEs as biomarkers for fracture risk. Here current methods of estimating AGEs in bone by liquid chromatography and fluorometric assay are summarized and the relationships between AGEs and fracture properties at whole bone, apparent tissue and matrix levels are discussed

Keywords: Advanced glycation end-products (AGEs); Bone; Mechanical properties; Non-enzymatic glycation; Pentosidine; Toughness
Links

DOI: 10.1138/20090390

PubMed: 27158323

PubMedCentral: PMC4856156

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