Quantum concept of bone remodeling and turnover:​ implications for the pathogenesis of osteoporosis

Parfitt, A. M.

Year	Entry
1983	Parfitt AM. The physiologic and clinical significance of bone histomorphometric data. In: Recker RR, ed. Bone Histomorphometry: Techniques and Interpretation. Boca Raton, FL: Inc., CRC Press; 1983:143-223.
1986	Frost HM. Intermediary Organization of the Skeleton. Vols. 1-2. Boca Raton, FL: CRC Press; 1986.
2025	Cole ME, Crowder C, Stout SD. Bone remodeling and its histomorphological products. In: Stout SD, Crowder C, eds. Bone Histology: A Biological Anthropological Perspective. 2nd ed. Boca Raton, FL: CRC Press; 2025:1-46.
1988	Parfitt AM. Bone remodeling: relationship to the amount and structure of bone, and the pathogenesis and prevention of fractures. In: Riggs BL, Melton LJ III, eds. Osteoporosis: Etiology, Diagnosis, and Management. New York, NY: Raven Press; 1988:45-93.
1988	Lindsay R. Sex steroids in the pathogenesis and prevention of osteoporosis. In: Riggs BL, Melton LJ III, eds. Osteoporosis: Etiology, Diagnosis, and Management. New York, NY: Raven Press; 1988:333-358.
1988	Eastell R, Heath H III, Kumar R, Riggs BL. Hormonal factors: PTH, vitamin D, and calcitonin. In: Riggs BL, Melton LJ III, eds. Osteoporosis: Etiology, Diagnosis, and Management. New York, NY: Raven Press; 1988:373-388.
1990	Goldstein SA, Hollister SJ, Kuhn JL, Kikuchi N. The mechanical and remodeling properties of trabecular bone. In: Mow VC, Ratcliffe A, Woo SL-Y, eds. Biomechanics of Diarthrodial Joints. Vol 2. New York, NY: Springer-Verlag; 1990:61-81.
2010	Busse B, Djonic D, Milovanovic P, Hahn M, Püschel K, Ritchie RO, Djuric M, Amling M. Decrease in the osteocyte lacunar density accompanied by hypermineralized lacunar occlusion reveals failure and delay of remodeling in aged human bone. Aging Cell. December 2010;9(6):1065-1075.
1987	Parfitt AM. Trabecular bone architecture in the pathogenesis and prevention of fracture. Am J Med. January 26, 1987;82(suppl 1B):68-72.
1996	Forwood MR, Owan I, Takano Y, Turner CH. Increased bone formation in rat tibiae after a single short period of dynamic loading in vivo. Am J Physiol Endocrinol Metab. March 1996;270(3):E419-E423.
1982	Genant HK, Cann CE, Ettinger B, Gordan GS. Quantitative computed tomography of vertebral spongiosa: a sensitive method for detecting early bone loss after oophorectomy. Ann Intern Med. 1982;97(5):699-705.
2006	Robling AG, Castillo AB, Turner CH. Biomechanical and molecular regulation of bone remodeling. Annu Rev Biomed Eng. 2006;8:455-498.
1996	Amling M, Pösl M, Ritzel H, Hahn M, Vogel M, Wening VJ, Delling G. Architecture and distribution of cancellous bone yield vertebral fracture clues: a histomorphometric analysis of the complete spinal column from 40 autopsy specimens. Arch Orthop Trauma Surg. July 1996;115(5):262-269.
1994	Forwood MR, Turner CH. The response of rat tibiae to incremental bouts of mechanical loading: a quantum concept for bone formation. Bone. November–December 1994;15(6):603.
1995	Forwood MR, Turner CH. Skeletal adaptations to mechanical usage: results from tibial loading studies in rats. Bone. October 1995;17(4)(suppl):197S-205S.
1983	Dempster DW, Arlot MA, Meunier PJ. Mean wall thickness and formation periods of trabecular bone packets in corticosteroid-induced osteoporosis. Calcif Tiss Int. December 1983;35(1):410-417.
1984	Parfitt AM. The cellular basis of bone remodeling: the quantum concept reexamined in light of recent advances in the cell biology of bone. Calcif Tiss Int. March 1984;36(suppl 1):S37-S45.
1984	Parfitt AM. Age-related structural changes in trabecular and cortical bone: cellular mechanisms and biomechanical consequences. Calcif Tiss Int. 1984;36(suppl 1):S123-S128.
1995	Duncan RL, Turner CH. Mechanotransduction and the functional response of bone to mechanical strain. Calcif Tiss Int. December 1995;57(5):344-358.
1987	Aaron JE, Makins NB, Sagreiya K. The microanatomy of trabecular bone loss in normal aging men and women. Clin Orthop Relat Res. February 1987;215:260-271.
1986	Eriksen EF. Normal and pathological remodeling of human trabecular bone: three dimensional reconstruction of the remodeling sequence in normals and in metabolic bone disease. Endocr Rev. November 1986;7(4):379-408.
2012	Skedros JG, Knight AN, Farnsworth RW, Bloebaum RD. Do regional modifications in tissue mineral content and microscopic mineralization heterogeneity adapt trabecular bone tracts for habitual bending? analysis in the context of trabecular architecture of deer calcanei. J Anat. March 2012;220(3):242-255.
1991	Goldstein SA, Matthews LS, Kuhn JL, Hollister SJ. Trabecular bone remodeling: an experimental model. J Biomech. 1991;24(suppl 1):135-150.
1990	Eriksen EF, Hodgson SF, Eastell R, Cedel SL, O'Fallon WM, Riggs BL. Cancellous bone remodeling in type I (postmenopausal) osteoporosis: quantitative assessment of rates of formation, resorption, and bone loss at tissue and cellular levels. J Bone Miner Res. April 1990;5(4):311-319.
2001	Duan Y, Turner CH, Kim B-T, Seeman E. Sexual dimorphism in vertebral fragility is more the result of gender differences in age-related bone gain than bone loss. J Bone Miner Res. December 2001;16(12):2267-2275.
1983	Parfitt AM, Mathews CH, Villanueva AR, Kleerekoper M, Frame B, Rao DS. Relationships between surface, volume, and thickness of iliac trabecular bone in aging and in osteoporosis: implications for the microanatomic and cellular mechanisms of bone loss. J Clin Invest. October 1983;72(4):1396-1409.
2011	Hartmann MA, Dunlop JWC, Bréchet YJM, Fratzl P, Weinkamer R. Trabecular bone remodelling simulated by a stochastic exchange of discrete bone packets from the surface. J Mech Behav Biomed Mater. August 2011;4(6):879-887.
1983	Kragstrup J, Melsen F, Mosekilde L. Thickness of bone formed at remodeling sites in normal human iliac trabecular bone: variations with age and sex. Metab Bone Dis Rel Res. 1983–1984;5(1):17-21.
1986	Riggs BL, Melton LJ III. Involutional osteoporosis. NEJM. June 26, 1986;314(26):1676-1686.
1994	Sims NA. The Pathogenesis of Post-Menopausal Osteopaenia Using the Oophorectomised Rat Model [PhD thesis]. Adelaide, Australia: The University of Adelaide; July 1994.
2005	Takai E. Modulation of Bone Cell Mechanotransduction [PhD thesis]. Columbia University; 2005.
2007	Liu XS. High-Resolution Image Based Micro-Mechanical Modeling of Trabecular Bone [PhD thesis]. Columbia University; 2007.
2009	Chan M. Mechanobiology of 3D Co-Culture Trabecular Explant Model [PhD thesis]. Columbia University; 2009.
2020	Robinson ST. Bone Mechanobiology of Modeling and Remodeling and the Effect of Hematopoietic Lineage Cells [PhD thesis]. Columbia University; 2020.
2019	Bakr M. Parathyroid Hormone Effect on Facilitating Stress Fracture Repair [PhD thesis]. Brisbane, Australia: Griffith University; July 2019.
1998	Robling AG. Histomorphometric Assessment of Mechanical Loading History from Human Skeletal Remains: The Relation Between Micromorphology and Macromorphology At the Femoral Midshaft [PhD thesis]. University of Missouri; December 1998.
1988	Lotz JC. Hip Fracture Risk Predictions by X-Ray Computed Tomography [PhD thesis]. Cambridge, MA: Massachusetts Institute of Technology; August 1988.
2017	Kreipke TC. Structural, Mechanical, and Biological Relationships of Trabecular Bone in Osteoporosis [PhD thesis]. University of Notre Dame; April 2017.
2005	Buie HR. Use of Finite Element Method Modelling and Rapid Prototyping to Study the Effect of Trabecular Bone Architecture on Apparent Mechanical Properties [Master's thesis]. Queen's University; November 2005.
2014	Gangadharan V. Delineating the Cellular Mechanism of Osteoblast Desensitization to Mechanical Stimulation [PhD thesis]. University of Delaware; 2014.
2023	Tits A. Attaching Soft to Hard: A Multimodal Correlative Investigation of the Tendon-Bone Interface [PhD thesis]. Liège, Belgique: Université de Liège; 2023.
1991	Choi K. The Micro Mechanical Properties of Bone Tissue [PhD thesis]. University of Michigan; 1991.
1993	McCubbrey DA. The Macroscopic Architectural Properties of Vertebral Trabecular Bone and Their Relation to Whole Vertebral Failure Loads [PhD thesis]. University of Michigan; 1993.
1998	Ciarelli TE. Architectural and Material Contributions to Fracture of the Spine and Proximal Femur [PhD thesis]. University of Michigan; 1998.
2001	Smith-Adaline EA. Influence of Mechanical Stimulation on Strain Environment and Patterns of Gene Expression During Fracture Healing [PhD thesis]. University of Michigan; 2001.

Year	Entry
1978	Heaney RP, Recker RR, Saville PD. Menopausal changes in bone remodeling. J Lab Clin Med. December 1978;92(6):964-970.
1976	Parfitt AM. The actions of parathyroid hormone on bone: relation to bone remodeling and turnover, calcium homeostasis, and metabolic bone diseases: part II of IV parts: PTH and bone cells: bone turnover and plasma calcium regulation. Metabolism. August 1976;25(8):909-955.
1976	Parfitt AM. The actions of parathyroid hormone on bone: relation to bone remodeling and turnover, calcium homeostasis, and metabolic bone disease: part III of IV parts: PTH and osteoblasts, the relationship between bone turnover and bone loss, and the state of the bones in primary hyperparathyroidism. Metabolism. September 1976;25(9):1033-1069.
1976	Parfitt AM. The actions of parathyroid hormone on bone: relation to bone remodeling and turnover, calcium homeostasis, and metabolic bone disease: part I of IV parts: mechanisms of calcium transfer between blood and bone and their cellular basis: morphological and kinetic approaches to bone turnover. Metabolism. July 1976;25(7):809-844.
1970	Merz WA, Schenk RK. Quantitative structural analysis of human cancellous bone. Acta Anat. 1970;75(1):54-66.
1969	Schenk RK, Merz WA, Müller J. A quantitative histological study on bone resorption in human cancellous bone. Acta Anat. 1969;76(1):44-53.
1978	Lips P, Courpron P, Meunier PJ. Mean wall thickness of trabecular bone packets in the human iliac crest: changes with age. Calcif Tiss Res. 1978;26(1):13-17.
1969	Frost HM. Tetracycline-based histological analysis of bone remodeling. Calcif Tiss Res. 1969;3(1):211-237.
1960	Jowsey J. Age changes in human bone. Clin Orthop. 1960;17:210-218.
1972	Jaworski ZF, Meunier P, Frost HM. Observations on two types of resorption cavities in human lamellar cortical bone. Clin Orthop Relat Res. March–April 1972;83:279-285.