Trabecular bone remodeling: an experimental model

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Goldstein, Steven A.¹; Matthews, Larry S.¹; Kuhn, Janet L.¹; Hollister, Scott J.¹

Trabecular bone remodeling: an experimental model

J Biomech. 1991;24(suppl 1):135-150

Affiliations

¹The Orthopaedic Research Laboratories, The University of Michigan, Section of Orthopaedic Surgey, Department of Surgery, Ann Arbor, MI 48109, U.S.A.
Abstract

An experimental model, capable of inducing controlled stress fields to the distal femoral metaphyses of large dogs, is presented. This model utilized an implantable hydraulic device incorporating five loading cylinders and platens in direct contact with an exposed plane of trabecular bone. A microprocessor controls the loading characteristics, and finite element models were created to calculate the induced stress and strain fields. The trabecular remodeling response is measured using serial in vivo computed tomography, in vitro microcomputed tomography, and histologic analysis. The results of the experiment indicate that significant remodeling can be induced by the activated implant. An increase in trabecular orientation toward the loaded platens was observed, and a statistically significant decrease in connectivity was documented. The greatest effect was associated with a change in the loading rate. A fast rise time (70 ms) loading waveform induced significant bone ingrowth at the implant interface when compared to a slow rise time waveform (700 ms), and demonstrated high correlations with the calculated stress fields as remodeling approached an equilibrium state.
Links

DOI: 10.1016/0021-9290(91)90384-Y

PubMed: 1791174

WoS: A1991HB54500013

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