A biomimetic surface engineering strategy was developed to increase osseointegration surrounding titanium implants. Enzymatically degradable interpenetrating polymer networks (edIPNs) of poly(acrylamide-co-ethylene glycol/acrylic acid) (p(AAm-co-EG/AAc) were functionalized with a 15 amino acid sequence from bone sialoprotein containing the adhesive and mitogenic ligand - Arg-Gly-Asp (-RGD-) (bsp(15)-RGD) to differentially improve the peri-implant bone formation and fixation strength in a rat femoral ablation implant model as compared to control and nondegradable IPNs previously characterized. Efficient production of the peptide-based crosslinker was demonstrated and its ability to create edIPNs and conjugate bsp(15)-RGD to reintroduce cellular attachment was verified. In vitro and surface characterization data on the effect of roughness demonstrated that dual acid etch treatment resulted in surfaces with defined topography and levels of alkaline phosphatase (ALP) activity, a marker for osteobladst differentiation, elevated above control. In vivo results were mixed, as implants grafted with edIPN and bsp(15)-RGD showed no improvement in peri-implant bone formation or fixation strength when controlling for surface topography, yet edIPN surfaces without bsp(15)-RGD featured significantly higher peri-implant bone formation compared to nondegradable IPN historical data. Roughened surfaces displayed significantly higher implant fixation strength compared to historical controls, and equivalent roughness-normalized fixation strength compared to historical data on hydroxyapatite/tricalcium phosphate (HA/TCP) -coated surfaces. Mechanical performance was found to be related to not only implant topography, but also implant positioning. In order to validate the biomimetic approach towards increasing osseointegration, more powerful bioconjugated signaling molecules were considered as a strategy to outweigh the influence of signaling ligands natively present in vivo. To this end, the signaling domain of Sonic hedgehog, a known potent upstream regulator of cell fate and implicated in osteoblast transformation from undifferentiated cells, was successfully conjugated at a surface density r = 2.42 pmol/cm2. Subsequent in vitro experiments found that such surfaces were able to sustain elevated ALP activity compared to controls when using a rat bone marrow stem cell model. Future experiments will be geared towards further exploration of the biomimetic surface engineering concept in vitro to optimize surface chemistry factors, and subsequently in vivo to demonstrate improvement in osseointegration.