Control of stem cell fate by physical interactions with the extracellular matrix

Guilak, Farshid; Cohen, Daniel M.; Estes, Bradley T.; Gimble, Jeffrey M.; Liedtke, Wolfgang; Chen, Christopher S.

Affiliations

¹Department of Surgery, Duke University Medical Center, Durham, NC 27710, USA

²Department of Biomedical Engineering, Duke University Medical Center, Durham, NC 27710, USA

³Department of Bioengineering University of Pennsylvania, Philadelphia, PA 19104, USA

⁴Stem Cell Laboratory, Pennington Biomedical Research Center, Louisiana State University System, Baton Rouge, LA 70808, USA

⁵Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA

Abstract

A diverse array of environmental factors contributes to the overall control of stem cell activity. In particular, new data continue to mount on the influence of the extracellular matrix (ECM) on stem cell fate through physical interactions with cells, such as the control of cell geometry, ECM geometry/topography at the nanoscale, ECM mechanical properties, and the transmission of mechanical or other biophysical factors to the cell. Here, we review some of the physical processes by which cues from the ECM can influence stem cell fate, with particular relevance to the use of stem cells in tissue engineering and regenerative medicine.

Links

DOI: 10.1016/j.stem.2009.06.016

PubMed: 19570510

PubMedCentral: PMC2768283

WoS: 000267879200007

History

Revised: 2009-07-2

Online: 2009-07-2

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2011	Garrigues NW II. Electrospun Scaffolds for Cartilage Tissue Engineering: Methods to Affect Anisotropy, Material, and Cellular Infiltration [PhD thesis]. Duke University; 2011.
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2013	Soicher MA. Fabrication and Characterization of Remineralized Bone Matrices (RBM) for Use as Bone Tissue Engineering Substrates [PhD thesis]. Davis, University of California; 2013.
2017	Brown WEHP. Engineering Osteochondral Constructs to Treat Articular Cartilage Defects [PhD thesis]. Davis, University of California; 2017.
2012	Allen J. Modeling Cartilage Extracellular Matrix Stiffness: A Potent Regulator of TGFbeta-Inducible Chondrocyte Differentiation [PhD thesis]. San Francisco, University of California; 2012.
2020	Monteiro DA. Physical Cues Regulate the Localization and Activation of TGFβ Receptors to Control the Quantity and Quality of Signaling Pathway Activity [PhD thesis]. San Francisco, University of California; 2020.
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2022	Davidson CD. Biomaterial Control of Cell Forces to Enable Intercellular Communication During Vasculogenic Assembly [PhD thesis]. University of Michigan; 2022.
2011	Lozoya Iniquez OA. Mechanics in Biology of Progenitors: Spheroid Growth Modeling in Silico and Mechanical Induction of Human Hepatic Stem Cell Phenotype in Vitro [PhD thesis]. University of North Carolina at Chapel Hill; May 2011.
2010	Baker BM. Meniscus Tissue Engineering With Nanofibrous Scaffolds [PhD thesis]. Philadelphia, PA: University of Pennsylvania; 2010.
2015	Heo SC. Differentiation Induces Dynamic Alterations in Mesenchymal Stem Cell Nuclear Architecture and Mechanotransduction [PhD thesis]. Philadelphia, PA: University of Pennsylvania; 2015.