Transport mechanism operating between blood supply and osteocytes in long bones

Piekarski, K.; Munro, M.

Year	Entry
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2010	Jacobs CR, Temiyasathit S, Castillo AB. Osteocyte mechanobiology and pericellular mechanics. Annu Rev Biomed Eng. 2010;12:369-400.
2009	Fritton SP, Weinbaum S. Fluid and solute transport in bone: flow-induced mechanotransduction. Annu Rev Fluid Mech. 2009;41:347-374.
1995	Klein-Nulend J, Semeins CM, Ajubi NE, Nijweide P, Burger EH. Pulsating fluid flow increases nitric oxide (NO) synthesis by osteocytes but not periosteal fibroblasts - correlation with prostaglandin upregulation. Biochem Biophys Res Commun. December 14, 1995;217(2):640-648.
1996	Ajubi NE, Klein-Nulend J, Nijweide PJ, Vrijheid-Lammers T, Alblas MJ, Burger EH. Pulsating fluid flow increases prostaglandin production by cultured chicken osteocytes: a cytoskeleton-dependent process. Biochem Biophys Res Commun. August 5, 1996;225(1):62-68.
2004	Bacabac RG, Smit TH, Mullender MG, Dijcks SJ, Van Loon JJWA, Klein-Nulend J. Nitric oxide production by bone cells is fluid shear stress rate dependent. Biochem Biophys Res Commun. March 19, 2004;315(4):823-829.
2006	Vezeridis PS, Semeins CM, Chen Q, Klein-Nulend J. Osteocytes subjected to pulsating fluid flow regulate osteoblast proliferation and differentiation. Biochem Biophys Res Commun. September 29, 2006;348(3):1082-1088.
2021	Smit TH. Closing the osteon: do osteocytes sense strain rate rather than fluid flow? BioEssays. August 2021;43(8):2000327.
2015	Florencio-Silva R, Sasso GRdS, Sasso-Cerri E, Simões MJ, Cerri PS. Biology of bone tissue: structure, function, and factors that influence bone cells. BioMed Res Int. 2015;2015:421746.
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1998	Knothe Tate ML, Niederer P, Knothe U. In vivo tracer transport through the lacunocanalicular system of rat bone in an environment devoid of mechanical loading. Bone. February 1998;22(2):107-117.
2000	Vashishth D, Verborgt O, Divine G, Schaffler MB, Fyhrie DP. Decline in osteocyte lacunar density in human cortical bone is associated with accumulation of microcracks with age. Bone. April 2000;26(4):375-380.
2004	Wang L, Ciani C, Doty SB, Fritton SP. Delineating bone's interstitial fluid pathway in vivo. Bone. March 2004;34(3):499-509.
2008	Vatsa A, Breuls RG, Semeins CM, Salmon PL, Smit TH, Klein-Nulend J. Osteocyte morphology in fibula and calvaria: is there a role for mechanosensing? Bone. September 2008;43(3):452-458.
2012	Lu XL, Huo B, Park M, Guo XE. Calcium response in osteocytic networks under steady and oscillatory fluid flow. Bone. September 2012;51(3):466-473.
2013	Klein-Nulend J, Bakker AD, Bacabac RG, Vatsa A, Weinbaum S. Mechanosensation and transduction in osteocytes. Bone. June 2013;54(2):182-190.
2020	Willie BM, Zimmermann EA, Vitienes I, Main RP, Komarova SV. Bone adaptation: safety factors and load predictability in shaping skeletal form. Bone. February 2020;131:115114.
2020	da Silva Madaleno C, Jatzlau J, Knaus P. BMP signalling in a mechanical context: implications for bone biology. Bone. August 2020;137:115416.
2023	Cunningham HC, Orr S, Murugesh DK, Hsia AW, Osipov B, Go L, Wu PH, Wong A, Loots GG, Kazakia GJ, Christiansen BA. Differential bone adaptation to mechanical unloading and reloading in young, old, and osteocyte deficient mice. Bone. February 2023;167:116646.
2014	Schaffler MB, Cheung W-Y, Majeska R, Kennedy O. Osteocytes: master orchestrators of bone. Calcif Tiss Int. January 2014;94(1):5-24.
1995	Klein-Nulend J, van der Plas A, Semeins CM, Ajubi NE, Frangos JA, Nijweide PJ, Burger EH. Sensitivity of osteocytes to biomechanical stress in vitro. FASEB J. March 1995;9(5):441-445.
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2018	Gatti V, Azoulay EM, Fritton SP. Microstructural changes associated with osteoporosis negatively affect loading-induced fluid flow around osteocytes in cortical bone. J Biomech. January 3, 2018;66:127-136.
1991	Cowin SC, Moss-Salentijn L, Moss ML. Candidates for the mechanosensory system in bone. J Biomech Eng. May 1991;113(2):191-197.
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2011	Thompson WR, Modla S, Grindel BJ, Czymmek KJ, Kirn-Safran CB, Wang L, Duncan RL, Farach-Carson MC. Perlecan/Hspg2 deficiency alters the pericellular space of the lacunocanalicular system surrounding osteocytic processes in cortical bone. J Bone Miner Res. March 2011;26(3):618-629.
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2015	Hesse B, Varga P, Langer M, Pacureanu A, Schrof S, Männicke N, Suhonen H, Maurer P, Cloetens P, Peyrin F, Raum K. Canalicular network morphology is the major determinant of the spatial distribution of mass density in human bone tissue: evidence by means of synchrotron radiation phase-contrast nano-CT. J Bone Miner Res. 2015;30(2):346-356.
2016	Cabahug-Zuckerman P, Frikha-Benayed D, Majeska RJ, Tuthill A, Yakar S, Judex S, Schaffler MB. Osteocyte apoptosis caused by hindlimb unloading is required to trigger osteocyte RANKL production and subsequent resorption of cortical and trabecular bone in mice femurs. J Bone Miner Res. July 2016;31(7):1356-1365.
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2011	Miller RM. Mechanobiological Investigation of Periosteum Through Finite Element Modeling and Histology [Master's thesis]. Cleveland, OH: Case Western Reserve University; August 2011.
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2019	Campi AE. Mechanosensitive Ca²⁺ Signaling of Ex Vivo Osteocytes in Aging and Treatment [PhD thesis]. Columbia University; 2019.
2021	Duffy MP. The Osteocyte Primary Cilium is a Mechanoresponsive Organelle That Regulates Cytoskeletal Adaptation and Coordinates Mechanotransduction With Adenylyl Cyclases [PhD thesis]. Columbia University; 2021.
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1997	Zhang D. Electromechanical Mechanisms of Bone Remodeling [PhD thesis]. New York, NY: The City University of New York; 1997.
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2002	You L. A New View of Mechanotransduction in Bone Cells [PhD thesis]. New York, NY: The City University of New York; 2002.
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2005	Beno T. Investigating the Role of Microstructure in Bone Permeability [PhD thesis]. New York, NY: The City University of New York; 2005.
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2008	Ciani C. Characterization of Microporosities and Load-Induced Interstitial Fluid Movement in Normal and Osteopenic Bone [PhD thesis]. New York, NY: The City University of New York; 2008.
2012	Sharma D. Effects of Estrogen Deficiency on the Osteocyte Lacunar-Canalicular Network [PhD thesis]. New York, NY: The City University of New York; 2012.
2013	Souzanchi MF. The Effect of Microarchitecture and Fabric Anisotropy of Trabecular Bone on Its Mechanical Behavior [PhD thesis]. New York, NY: The City University of New York; 2013.
2017	Gatti V. The Effects of Skeletal Unloading on Bone Microstructure and Fluid-Mediated Osteocyte Mechanotransduction [PhD thesis]. New York, NY: The City University of New York; 2017.
2011	Boerckel JD. Mechanical Regulation of Bone Regeneration and Vascular Growth in Vivo [PhD thesis]. Atlanta, GA: Georgia Institute of Technology; August 2011.
2019	Lambert C. A Comparison of the Bone Response to Impact Loading and Resistance Training in Young Adult Women: The OPTIMA-Ex Trial [PhD thesis]. Brisbane, Australia: Griffith University; July 2019.
2014	Ferro Pereira A. Cortical Bone Adaptation: A Finite-Element Study of the Mouse Tibia [PhD thesis]. Imperial College London; January 2014.
2018	Mikolajewicz N. Purinergic Mechanotransduction in Bone [PhD thesis]. McGill University; December 2018.
2014	Ellman R. Skeletal Adaptation to Reduced Mechanical Loading [PhD thesis]. Cambridge, MA: Massachusetts Institute of Technology; September 2014.
2019	Podlisny DR. Effects of Poroelasticity on Mechanoadaptation in Bone [Master's thesis]. Northeastern University; May 2019.
2021	DiMauro NCB. Modeling Fluid Flow in Bone Mechanoadaptation [Master's thesis]. Northeastern University; December 2021.
2011	Ross RD. Functionalized Gold Nanoparticles as Damage-Specific X-Ray Computed Tomography Contrast Agents in Bone Tissue [PhD thesis]. University of Notre Dame; November 2011.
2015	Coughlin TR. Mechanobiological Signals in Trabecular Bone and Marrow [PhD thesis]. University of Notre Dame; July 2015.
2013	Verbruggen SW. Mechanobiological Origins of Osteoporosis [PhD thesis]. National University of Ireland Galway; September 2013.
2020	Simfia I. Estrogen Deficiency Alters the Mechanobiological Responses of Osteoblasts and Osteocytes [PhD thesis]. National University of Ireland Galway; April 2020.
2010	Gurkan UA. Engineering of Bone Marrow in Vitro for Investigating the Role of Growth Factors and Their Mechanoresponsiveness in Osteogenesis [PhD thesis]. Purdue University; May 2010.
2012	Sun X. Mechanically Induced Calcium Efflux from Bone Matrix Stimulates Osteoblasts [PhD thesis]. Purdue University; May 2012.
1983	Rouhana SW. Fluid Flow and Mechanical Damping in Bovine Cortical Bone [PhD thesis]. Troy, NY: Rensselaer Polytechnic Institute; February 1983.
2007	Malone AMD. Mechanotransduction Mechanisms in Bone Cells [PhD thesis]. Stanford University; August 2007.
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1997	Qin Y-X. Fluid Flow, Matrix Strain and Loading Frequency as Interdependent Control Parameters in Skeletal Adaptation [PhD thesis]. Stony Brook, NY: State University of New York at Stony Brook; May 1997.
2003	Verborgt O. Osteocyte Apoptosis and Bone Remodeling [PhD thesis]. University of Antwerp; 2003.
2011	Ebacher V. Experimental Study of Deformation and Microcracking in Human Cortical Bone [PhD thesis]. Vancouver, BC: University of British Columbia; May 2011.
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2021	Cunningham HC. Bone Adaptation to Disuse in Aging Rodents: Age-Related Differences in Response to Mechanical Unloading and Subsequent Reloading [PhD thesis]. Davis, University of California; 2021.
2010	Thompson WR. Perlecan Modulates the Function of the Osteocyte Lacuno-Canalicular System [PhD thesis]. University of Delaware; 2010.
2020	Pei S. Osteocyte Mechanosensing: Interstitial Fluid Flow, Cellular Response, and Turnover of Pericellular Matrix [PhD thesis]. University of Delaware; 2020.
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