The regional acceleratory phenomenon: a review

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Frost, Harold M.¹

The regional acceleratory phenomenon: a review

Henry Ford Hosp Med J. 1983;31(1):3-9

Affiliations

¹Southern Colorado Clinic, 2002 Lake Avenue, Pueblo, CO 81004
Abstract

Tbe regional acceleratory phenomenon (RAP) is a complex reaction of mammaUan tissues to diverse noxious stimuli. The phenomenon occurs regionally in the anatomical sense, involves both soft and hard tissues, and is characterized by an acceleration and domination of most ongoing normal vital tissue processes. It may represent an "SOS" mechanism which evolved to potentiate tissue heaUng and local tissue defensive reactions. When a RAP is obtunded, retarded healing and lowered resistance to infection and mechanical abuse may ensue.

When ignored in experimental design, the phenomenon can seriously perturb studies of metabolic bone disease and of the effects of mechanical, endocrinologic, and biochemical factors on skeletal physiology.
Links

URL: https://scholarlycommons.henryford.com/hfhmedjournal/vol31/iss1/2

PubMed: 6345475
History

Received: 1982-11-24

Accepted: 1983-01-24

Cited Works (6)

Year	Entry
1978	Uhthoff HK, Jaworski ZF. Bone loss in response to long-term immobilisation. J Bone Joint Surg. August 1978;60B(3):420-429.
1974	Minaire P, Meunier P, Edouard C, Bernard J, Courpron P, Bourret J. Quantitative histological data on disuse osteoporosis: comparison with biological data. Calcif Tiss Res. December 1974;17(1):57-73.
1979	Goodship AE, Lanyon LE, McFie H. Functional adaptation of bone to increased stress: an experimental study. J Bone Joint Surg. June 1979;61A(4):539-546.
1892	Wolff J. Das Gesetz der Transformation der Knochen. Berlin: Hirschwald; 1892.
1980	Jaworski ZFG, Liskova-Kiar M, Uhthoff HK. Effect of long-term immobilisation on the pattern of bone loss in older dogs. J Bone Joint Surg. February 1980;62B(1):104-110.
1964	Frost HM. Mathematical Elements of Lamellar Bone Remodelling. Springfield, IL: Charles C. Thomas; 1964.

Cited By (28)

Year	Entry
1986	Frost HM. Intermediary Organization of the Skeleton. Vols. 1-2. Boca Raton, FL: CRC Press; 1986.
2001	Jee WSS. Integrated bone tissue physiology: anatomy and physiology. In: Cowin SC, ed. Bone Mechanics Handbook. 2nd ed. Boca Raton, FL: CRC Press; 2001:1-1–1-68.
1990	Frost HM. Skeletal structural adaptations to mechanical usage (SATMU), III: the hyaline cartilage modeling problem. Anat Rec. April 1990;226(4):423-432.
1990	Li XJ, Jee WSS, Chow S-Y, Woodbury DM. Adaptation of cancellous bone to aging and immobilization in the rat: a single photon absorptiometry and histomorphometry study. Anat Rec. May 1990;227B(1):12-24.
2020	Wilkinson JM. The use of bisphosphonates to meet orthopaedic challenges. Bone. August 2020;137:115443.
2021	Ghasem-Zadeh A, Galea MP, Nunn A, Panisset M, Wang X-F, Iuliano S, Boyd SK, Forwood MR, Seeman E. Heterogeneity in microstructural deterioration following spinal cord injury. Bone. January 2021;142:115778.
1985	Frost HM. The pathomechanics of osteoporoses. Clin Orthop Relat Res. November 1985;200:198-225.
2000	Lee TC, Staines A, Taylor D. Bone adaptation to load: microdamage as a stimulus for bone remodelling. J Anat. December 2000;201(6):437-446.
1991	Goldstein SA, Matthews LS, Kuhn JL, Hollister SJ. Trabecular bone remodeling: an experimental model. J Biomech. 1991;24(suppl 1):135-150.
1995	Hillam RA, Skerry TM. Inhibition of bone resorption and stimulation of formation by mechanical loading of the modeling rat ulna in vivo. J Bone Miner Res. June 1995;10(5):683-689.
2019	Emami AJ, Toupadakis CA, Telek SM, Fyhrie DP, Yellowley CE, Christiansen BA. Age dependence of systemic bone loss and recovery following femur fracture in mice. J Bone Miner Res. January 2019;34(1):157-170.
2001	Jee WSS, Yao W. Overview: animal models of osteopenia and osteoporosis. J Musculoskel Neuron Interact. March 2001;1(3):193-207.
1996	Hillam RA. Response of Bone to Mechanical Load and Alterations in Circulating Hormones [PhD thesis]. Bristol, UK: University of Bristol; October 1996.
2016	Li Z. Time-Lapsed in Vivo Bone Response to Implantation in a Mouse Model of Disease and Treatment [PhD thesis]. Swiss Federal Institute of Technology Zürich; 2016.
1998	Robling AG. Histomorphometric Assessment of Mechanical Loading History from Human Skeletal Remains: The Relation Between Micromorphology and Macromorphology At the Femoral Midshaft [PhD thesis]. University of Missouri; December 1998.
1992	Bloomfield SA. Site-Specific Changes in Bone Mass and Alterations in Calciotropic Hormones With Electrical Stimulation Exercise in Individuals With Chronic Spinal Cord Injury [PhD thesis]. The Ohio State University; 1992.
2015	Noble GJ. Evaluation of a Press Fit, Percutaneous, Skeletally Anchored Endoprosthesis for Prosthetic Limb Attachment: Bone Response and the Effect of Low Intensity Vibration [PhD thesis]. The Ohio State University; 2015.
2001	Kim DG. Micromechanical Analysis of Bone At a Bone-Implant Interface [PhD thesis]. Troy, NY: Rensselaer Polytechnic Institute; April 2001.
2013	Irish JM. Peri-Implant Bone Turnover in a Rat Model [Master's thesis]. Rush University; 2013.
2004	Roberts MD. Adaptation of Bone to Mechanical and Nonmechanical Stimuli: An Integrated Experimental and Computational Study [PhD thesis]. Tulane University; 2004.
2014	Kaipatur NR. Impact of Bisphosphonate Bone Burden on Orthodontic Tooth Movement [PhD thesis]. Edmonton, AB: University of Alberta; 2014.
2003	Verborgt O. Osteocyte Apoptosis and Bone Remodeling [PhD thesis]. University of Antwerp; 2003.
2020	Spanswick P. Using HR-PQCT and Finite Element Analysis to Inform Clinical Assessment of Distal Radius Fractures [Master's thesis]. Calgary, AB: University of Calgary; August 2020.
2019	Emami AJ. Systemic Bone Loss After Femoral Fracture in Mice: Potential Mechanisms and Age-Related Effects [PhD thesis]. Davis, University of California; 2019.
1996	Adams DJ. Mechanical Factors Initiating Appositional Bone Formation [PhD thesis]. University of Iowa; May 1996.
1996	Rouleau JP. The Influence of Cyclic Strain Amplitude and Timing of Mechanical Stimulation on Secondary Fracture Healing [PhD thesis]. University of Michigan; 1996.
2008	Waldorff EI. Effects of Aging and Disuse on Bone Remodeling in Response to Microdamage [PhD thesis]. University of Michigan; 2008.
2006	Blouin S. Modèles animaux de perte osseuse bénigne et maligne utilisable pour l'évaluation de biomatériaux [Animal Models of Benign and Malignant Bone Loss Usable in Biomaterial Studies] [PhD thesis]. Université d'Angers; 2006.