Behavior of in vivo bone under cyclic loading

Seireg, A.; Kempke, W.

Affiliations

¹Department of Mechanical Engineering, University of Wisconsin, Madison, Wk. 53706, U.S.A.

²Department of Engineering, I.B.M. Co., Rochester, Minnesota U.S.A.

Abstract

The paper deals with the design of a test arrangement capable of applying different combinations of static and fluctuating loads to the tibia of live rats. The Cyclic Loads are applied to the right tibia while the left tibia is constrained without subjection to external loads for comparison. Long duration tests at relatively low loads were performed to investigate the influence of cyclic stress on the physical characteristics and mineral content. Destructive, fatigue-type tests were also performed. Highly reproducible fracture data, and endurance limit are obtained.

Links

DOI: 10.1016/0021-9290(69)90020-7

PubMed: 16335144

WoS: A1969E332500008

History

Received: 1969-01-03

Cited Works (2)

Year	Entry
1957	Evans FG. Stress and Strain in Bones: Their Relation to Fractures and Osteogenesis. Springfield, IL: Charles C. Thomas; 1957.
1964	Currey JD. Three analogies to explain the mechanical properties of bone. Biorheology. 1964;2(1):1-10.

Cited By (24)

Year	Entry
1973	Evans FG. Mechanical Properties of Bone. Springfield, IL: Charles C. Thomas; 1973.
1990	Goldstein SA, Hollister SJ, Kuhn JL, Kikuchi N. The mechanical and remodeling properties of trabecular bone. In: Mow VC, Ratcliffe A, Woo SL-Y, eds. Biomechanics of Diarthrodial Joints. Vol 2. New York, NY: Springer-Verlag; 1990:61-81.
1979	Wall JC, Chatterji SK, Jeffery JW. Age-related changes in the density and tensile strength of human femoral cortical bone. Calcif Tiss Int. December 1979;27(1):105-108.
1989	Forwood MR, Parker AW. Microdamage in response to repetitive torsional loading in the rat tibia. Calcif Tiss Int. July 1989;45(1):47-53.
1998	Akhter MP, Cullen DM, Pedersen EA, Kimmel DB, Recker RR. Bone response to in vivo mechanical loading in two breeds of mice. Calcif Tiss Int. November 1998;63(5):442-449.
1971	Heřt J, Lišková M, Landa J. Reaction of bone to mechanical stimuli, I: continuous and intermittent loading of tibia in rabbit. Folia Morphol (Praha). August 1971;19(3):290-300.
1974	Barnes GRG, Pinder DN. In vivo tendon tension and bone strain measurement and correlation. J Biomech. January 1974;7(1):35-42.
1974	Gray RJ, Korbacher GK. Compressive fatigue behaviour of bovine compact bone. J Biomech. May 1974;7(3):287-292.
1991	Goldstein SA, Matthews LS, Kuhn JL, Hollister SJ. Trabecular bone remodeling: an experimental model. J Biomech. 1991;24(suppl 1):135-150.
1992	Akhter MP, Raab DM, Turner CH, Kimmel DB, Recker RR. Characterization of in vivo strain in the rat tibia during external application of a four-point bending load. J Biomech. October 1992;25(10):1241-1246.
1993	Michel MC, Guo X-DE, Gibson LJ, McMahon TA, Hayes WC. Compressive fatigue behavior of bovine trabecular bone. J Biomech. April–May 1993;26(4-5):453-463.
2005	George WT, Vashishth D. Influence of phase angle between axial and torsional loadings on fatigue fractures of bone. J Biomech. April 2005;38(4):819-825.
2003	Moore TLA, Gibson LJ. Fatigue of bovine trabecular bone. J Biomech Eng. December 2003;125(6):761-768.
2003	Moore TLA, Gibson LJ. Fatigue microdamage in bovine trabecular bone. J Biomech Eng. December 2003;125(6):769-776.
1970	Evans FG, Riolo ML. Relations between the fatigue life and histology of adult human cortical bone. J Bone Joint Surg. December 1970;52A(8):1579-1586.
1974	Reilly DT, Burstein AH. The mechanical properties of cortical bone. J Bone Joint Surg. 1974;56A(5):1001-1022.
1979	Goodship AE, Lanyon LE, McFie H. Functional adaptation of bone to increased stress: an experimental study. J Bone Joint Surg. June 1979;61A(4):539-546.
1990	Nunamaker DM, Butterweck DM, Provost MT. Fatigue fractures in thoroughbred racehorses: relationships with age, peak bone strain, and training. J Orthop Res. July 1990;8(4):604-611.
1971	Swanson SAV, Freeman MAR, Day WH. The fatigue properties of human cortical bone. Med Biol Eng. January 1971;9(1):23-32.
1993	Guo X-DE. Fatigue of Trabecular Bone [PhD thesis]. Cambridge, MA: Harvard University; 1993.
2001	Arthur Moore TL. Microdamage Accumulation in Bovine Trabecular Bone [PhD thesis]. Cambridge, MA: Massachusetts Institute of Technology; June 2001.
2005	George WT. Multiaxial Fracture Characteristics of Aging Human Bone [PhD thesis]. Troy, NY: Rensselaer Polytechnic Institute; April 2005.
1991	Pattin CAG. Cyclic Mechanical Property Degradation in Bone During Fatigue Loading [PhD thesis]. Stanford University; March 1991.
1985	Schaffler MB. Stiffness and Fatigue of Compact Bone At Physiological Strains and Strain Rates [PhD thesis]. West Virginia University; 1985.