A hypothetical mechanism for the stimulation of osteonal remodelling by fatigue damage

Martin, R. Bruce; Burr, David B.

Year	Entry
1996	Egerer AK, Saha S, McMillan PJ, Rivera J. Morphology of the cement line in human bone and its relationship to bone strength. In: Proceedings of the 15th Southern Biomedical Engineering Conference. March 29-31, 1996; Dayton, OH.7-10.
2002	Currey JD. Bones: Structure and Mechanics. Princeton, NJ: Princeton University Press; 2002.
1988	Parfitt AM. Bone remodeling: relationship to the amount and structure of bone, and the pathogenesis and prevention of fractures. In: Riggs BL, Melton LJ III, eds. Osteoporosis: Etiology, Diagnosis, and Management. New York, NY: Raven Press; 1988:45-93.
1998	Martin RB, Burr DB, Sharkey NA. Skeletal Tissue Mechanics. New York, NY: Springer-Verlag; 1998.
2002	Banse X. When density fails to predict bone strength. Acta Orthop Scand. 2002;73(2)(suppl 303):2-57.
1995	Turner CH, Owan I, Takano Y. Mechanotransduction in bone: role of strain rate. Am J Physiol Endocrinol Metab. September 1995;269(3):E438-E442.
1987	Schaffler MB, Burr DB, Frederickson RG. Morphology of the osteonal cement line in human bone. Anat Rec. March 1987;217(3):223-228.
2005	Skedros JG, Holmes JL, Vajda EG, Bloebaum AD. Cement lines of secondary osteons in human bone are not mineral‐deficient: new data in a historical perspective. Anat Rec. September 2005;286A(1):781-803.
2004	Wang X, Puram S. The toughness of cortical bone and its relationship with age. Ann Biomed Eng. January 2004;32(1):123-135.
1989	Schaffler MB, Radin EL, Burr DB. Mechanical and morphological effects of strain rate on fatigue of compact bone. Bone. 1989;10(3):207-214.
1990	Schaffler MB, Radin EL, Burr DB. Long-term fatigue behavior of compact bone at low strain magnitude and rate. Bone. 1990;11(5):321-326.
1993	Mori S, Burr DB. Increased intracortical remodeling following fatigue damage. Bone. March–April 1993;14(2):103-109.
1994	Crofts RD, Boyce TM, Bloebaum RD. Aging changes in osteon mineralization in the human femoral neck. Bone. March–April 1994;15(2):147-152.
1994	Schaffler MB, Pitchford WC, Choi K, Riddle JM. Examination of compact bone microdamage using back-scattered electron microscopy. Bone. September–October 1994;15(5):483-488.
1995	Schaffler MB, Choi K, Milgrom C. Aging and matrix microdamage accumulation in human compact bone. Bone. December 1995;17(6):521-525.
1997	Norman TL, Wang Z. Microdamage of human cortical bone: incidence and morphology in long bones. Bone. April 1997;20(4):375-379.
1997	Mori S, Harruff R, Ambrosius W, Burr DB. Trabecular bone volume and microdamage accumulation in the femoral heads of women with and without femoral neck fractures. Bone. December 1997;21(6):521-526.
1998	Fazzalari NL, Forwood MR, Smith K, Manthey BA, Herreen P. Assessment of cancellous bone quality in severe osteoarthrosis: bone mineral density, mechanics, and microdamage. Bone. 1998;22(4):381-388.
1998	Bentolila V, Boyce TM, Fyhrie DP, Drumb R, Skerry TM, Schaffler MB. Intracortical remodeling in adult rat long bones after fatigue loading. Bone. September 1998;23(3):275-281.
2010	Shi X, Liu XS, Wang X, Guo XE, Niebur GL. Effects of trabecular type and orientation on microdamage susceptibility in trabecular bone. Bone. May 2010;46(5):1260-1266.
2019	Burr DB. Stress concentrations and bone microdamage: John Currey's contributions to understanding the initiation and arrest of cracks in bone. Bone. October 2019;127:517-525.
1984	Parfitt AM. The cellular basis of bone remodeling: the quantum concept reexamined in light of recent advances in the cell biology of bone. Calcif Tiss Int. March 1984;36(suppl 1):S37-S45.
1993	Burr DB. Remodeling and the repair of fatigue damage. Calcif Tiss Int. February 1993;53(suppl 1):S75-S81.
1993	Lanyon LE. Osteocytes, strain detection, bone modeling and remodeling. Calcif Tiss Int. February 1993;53(suppl 1):S102-S107.
1995	Duncan RL, Turner CH. Mechanotransduction and the functional response of bone to mechanical strain. Calcif Tiss Int. December 1995;57(5):344-358.
1990	Burr DB, Stafford T. Validity of the bulk-staining technique to separate artifactual from in vivo bone microdamage. Clin Orthop Relat Res. November 1990;260:305-308.
2004	Doblaré M, García JM, Gomez MJ. Modelling bone tissue fracture and healing: a review. Eng Fract Mech. September 2004;71(13-14):1809-1840.
2005	Ritchie RO, Kinney JH, Kruzic JJ, Nalla RK. A fracture mechanics and mechanistic approach to the failure of cortical bone. Fatigue Fract Eng Mater Struct. April 2005;28(4):345-371.
2000	Lee TC, O'Brien FJ, Taylor D. The nature of fatigue damage in bone. Int J Fract. November 2000;22(10):847-853.
2000	O’Brien FJ, Taylor D, Dickson GR, Lee TC. Visualisation of three‐dimensional microcracks in compact bone. J Anat. October 2000;197(3):413-420.
2000	Lee TC, Staines A, Taylor D. Bone adaptation to load: microdamage as a stimulus for bone remodelling. J Anat. December 2000;201(6):437-446.
1984	Lipson SF, Katz JL. The relationship between elastic properties and microstructure of bovine cortical bone. J Biomech. 1984;17(4):231-240.
1985	Burr DB, Martin RB, Schaffler MB, Radin EL. Bone remodeling in response to in vivo fatigue microdamage. J Biomech. 1985;18(3):189-200.
1987	Currey JD. The evolution of the mechanical properties of amniote bone. J Biomech. 1987;20(11-12):1035-1044.
1987	Carter DR. Mechanical loading history and skeletal biology. J Biomech. 1987;20(11-12):1095-1109.
1988	Burr DB, Schaffler MB, Frederickson RG. Composition of the cement line and its possible mechanical role as a local interface in human compact bone. J Biomech. 1988;21(11):939-945.
1991	Goldstein SA, Matthews LS, Kuhn JL, Hollister SJ. Trabecular bone remodeling: an experimental model. J Biomech. 1991;24(suppl 1):135-150.
1992	Choi K, Goldstein SA. A comparison of the fatigue behavior of human trabecular and cortical bone tissue. J Biomech. 1992;25(12):1371-1381.
1993	Burr DB, Martin RB. Calculating the probability that microcracks initiate resorption spaces. J Biomech. April–May 1993;26(4-5):613-616.
1996	Pattin CA, Caler WE, Carter DR. Cyclic mechanical property degradation during fatigue loading of cortical bone. J Biomech. January 1996;29(1):69-79.
1996	Zysset PK, Curnier A. A 3D damage model for trabecular bone based on fabric tensors. J Biomech. December 1996;29(12):1549-1558.
1997	Braidotti P, Branca FP, Stagni L. Scanning electron microscopy of human cortical bone failure surfaces. J Biomech. February 1997;30(2):155-162.
1997	Vashishth D, Behiri JC, Bonfield W. Crack growth resistance in cortical bone: concept of microcrack toughening. J Biomech. August 1997;30(8):763-769.
1998	Taylor D. Microcrack growth parameters for compact bone deduced from stiffness variations. J Biomech. July 1998;31(7):587-592.
1999	Taylor D, O'Brien F, Prina-Mello A, Ryan C, O'Reilly P, Lee TC. Compression data on bovine bone confirms that a “stressed volume” principle explains the variability of fatigue strength results. J Biomech. November 1999;32(11):1199-1203.
2001	Nicolella DP, Nicholls AE, Lankford J, Davy DT. Machine vision photogrammetry: a technique for measurement of microstructural strain in cortical bone. J Biomech. January 2001;34(1):135-139.
2001	Niebur GL, Yuen JC, Burghardt AJ, Keaveny TM. Sensitivity of damage predictions to tissue level yield properties and apparent loading conditions. J Biomech. May 2001;34(5):699-706.
2002	O’Brien FJ, Taylor D, Lee TC. An improved labelling technique for monitoring microcrack growth in compact bone. J Biomech. April 2002;35(4):523-526.
2003	O’Brien FJ, Taylor D, Lee TC. Microcrack accumulation at different intervals during fatigue testing of compact bone. J Biomech. July 2003;36(7):973-980.
1995	Luo G, Cowin SC, Sadegh AM, Arramon YP. Implementation of strain rate as a bone remodeling stimulus. J Biomech Eng. August 1995;117(3):329-338.
1998	Bowman SM, Guo XE, Cheng DW, Keaveny TM, Gibson LJ, Hayes WC, McMahon TA. Creep contributes to the fatigue behavior of bovine trabecular bone. J Biomech Eng. October 1998;120(5):647-654.
2003	Lieberman DE, Pearson OM, Polk JD, Demes B, Crompton AW. Optimization of bone growth and remodeling in response to loading in tapered mammalian limbs. J Exp Biol. September 15, 2003;206(18):3125-3138.
2010	Zhang J, Michalenko MM, Kuhl E, Ovaert TC. Characterization of indentation response and stiffness reduction of bone using a continuum damage model. J Mech Behav Biomed Mater. February 2010;3(2):189-202.
1992	Martin B. A theory of fatigue damage accumulation and repair in cortical bone. J Orthop Res. November 1992;10(6):818-825.
1995	Martin B. Mathematical model for repair of fatigue damage and stress fracture in osteonal bone. J Orthop Res. May 1995;13(3):309-316.
1998	Taylor D. Fatigue of bone and bones: an analysis based on stressed volume. J Orthop Res. March 1998;16(2):163-169.
1998	Boyce TM, Fyhrie DP, Glotkowski MC, Radin EL, Schaffler MB. Damage type and strain mode associations in human compact bone bending fatigue. J Orthop Res. May 1998;16(3):322-329.
2005	O'Brien FJ, Taylor D, Lee TC. The effect of bone microstructure on the initiation and growth of microcracks. J Orthop Res. March 2005;23(2):475-480.
2008	Kosmopoulos V, Keller TS. Predicting trabecular bone microdamage initiation and accumulation using a non-linear perfect damage model. Med Eng Phys. July 2008;30(6):725-732.
1996	McKee MD, Nanci A. Osteopontin at mineralized tissue interfaces in bone, teeth, and osseointegrated implants: ultrastructural distribution and implications for mineralized tissue formation, turnover, and repair. Microsc Res Tech. February 1996;33(2):141-164.
2007	Taylor D, Hazenberg JG, Lee TC. Living with cracks: damage and repair in human bone. Nat Mater. April 2007;6(4):263-268.
2011	Zimmermann EA, Schaible E, Bale H, Barth HD, Tang SY, Reichert P, Busse B, Alliston T, Ager JW III, Ritchie RO. Age-related changes in the plasticity and toughness of human cortical bone at multiple length scales. Proc Natl Acad Sci USA. August 30, 2011;108(35):14416-14421.
1989	Miller SC, de Saint-Georges L, Bowman BM, Jee WSS. Bone lining cells: structure and function. Scanning Microsc. 1989;3(3):953-961.
2004	Pearson OM, Lieberman DE. The aging of Wolff's “law”: ontogeny and responses to mechanical loading in cortical bone. Yearb Phys Anthropol. 2004;47:63-99.
1999	Taylor WR. A Computer Based Technique for Predicting Changes in Bone Properties With Applications in Pre-Clinical Testing of Hip Implants [PhD thesis]. University of Bath; 1999.
2007	Clark EM. An Investigation Into the Role of Bone Mass and Other Factors in Determining Fracture Risk in Children [PhD thesis]. Bristol, UK: University of Bristol; 2007.
1989	Fondrk MT. An Experimental and Analytical Investigation Into the Nonlinear Constitutive Equations of Cortical Bone [PhD thesis]. Cleveland, OH: Case Western Reserve University; May 1989.
2011	Kummari SR. Experimental and Computational Evaluation of Microscopic Tissue Damage and Remodeling Cavities in Trabecular Bone [PhD thesis]. Cleveland, OH: Case Western Reserve University; May 2011.
1998	Bateman TA. Cytokine Therapies for Short-Term Disuse Osteopenia Models in Murines [PhD thesis]. University of Colorado; 1998.
2003	Winwood K. An Experimental Investigation Into the Effects of Cyclic Fatigue on Ageing Human Cortical Bone [PhD thesis]. Cranfield University; September 2003.
2004	Mi LY. Analysis of Avian Bone Response to Mechanical Loading Using a Computational Connected Network [PhD thesis]. New York, NY: The City College of New York; 2004.
1994	Zysset P. A Constitutive Law for Trabecular Bone [PhD thesis]. Lausanne, Switzerland: École Polytechnique Fédérale de Lausanne; 1994.
2006	Garcia D. Elastic Plastic Damage Laws for Cortical Bone [PhD thesis]. Lausanne, Switzerland: École Polytechnique Fédérale de Lausanne; 2006.
2019	Bakr M. Parathyroid Hormone Effect on Facilitating Stress Fracture Repair [PhD thesis]. Brisbane, Australia: Griffith University; July 2019.
1993	Guo X-DE. Fatigue of Trabecular Bone [PhD thesis]. Cambridge, MA: Harvard University; 1993.
1997	Bowman SM. Creep of Trabecular Bone [PhD thesis]. Cambridge, MA: Harvard University; May 1997.
2002	Hudson JA. The Ontogeny of Transverse Femoral Geometry and Bone Modeling in the Ward Skeletal Population [PhD thesis]. Kent State University; August 2002.
2002	Egerer AK. The Relationship Between the Osteonal Cement Line and Bone Strength [PhD thesis]. Loma Linda University; June 2002.
1998	Robling AG. Histomorphometric Assessment of Mechanical Loading History from Human Skeletal Remains: The Relation Between Micromorphology and Macromorphology At the Femoral Midshaft [PhD thesis]. University of Missouri; December 1998.
2008	Herman BC. Osteocytes and Activation of Bone Remodeling [PhD thesis]. Mount Sinai School of Medicine; 2008.
2004	Tovar A. Bone Remodeling as a Hybrid Cellular Automaton Optimization Process [PhD thesis]. Notre Dame, IN: University of Notre Dame; December 2004.
2006	Leng H. Micro-Computed Tomography of Microdamage in Cortical Bone [PhD thesis]. University of Notre Dame; May 2006.
2007	Zhang J. Mechanical Property Determination of Bone Through Nano- and Microindentation Testing and Finite Element Simulation [PhD thesis]. University of Notre Dame; July 2007.
2010	Shi X. Effects of Architecture on Microdamage Susceptibility in Trabecular Bone [PhD thesis]. University of Notre Dame; April 2010.
2013	Turnbull TL. The Spatial Distribution of Fatigue Microdamage Accumulation in Cortical Bone and Factors Influencing Fracture Risk [PhD thesis]. University of Notre Dame; July 2013.
2011	Wagnac É. Expérimentation et modélisation détaillée de la colonne vertébrale pour étudier le rôle de facteurs anatomiques et biomécaniques sur les traumatismes rachidiens [PhD thesis]. École polytechnique de Montréal; November 2011.
2002	Wang X. Simulation for Bone Adaptive Remodeling: A Stochastic Approach With Application on Spine Fusion [PhD thesis]. Queen's University; May 2002.
2010	Janeiro C. The Effect of Bone Quality on Osteoclastic Bone Resorption [PhD thesis]. Troy, NY: Rensselaer Polytechnic Institute; May 2010.
1991	Pattin CAG. Cyclic Mechanical Property Degradation in Bone During Fatigue Loading [PhD thesis]. Stanford University; March 1991.
1994	Levenston ME. Simulation of Functional Adaptation in Trabecular and Cortical Bone [PhD thesis]. Stanford University; September 1994.
1997	Qin Y-X. Fluid Flow, Matrix Strain and Loading Frequency as Interdependent Control Parameters in Skeletal Adaptation [PhD thesis]. Stony Brook, NY: State University of New York at Stony Brook; May 1997.
2000	O’Brien FJ. Microcracks and the Fatigue Behaviour of Compact Bone [PhD thesis]. Trinity College Dublin; October 2000.
2008	Kennedy OD. The Effect of Bone Turnover on Bone Quality and Material Properties [PhD thesis]. Trinity College Dublin; 2008.
1994	Oden ZM. Computational Prediction of Functional Adaptation in Canine Radii [PhD thesis]. Tulane University; 1994.
2003	Verborgt O. Osteocyte Apoptosis and Bone Remodeling [PhD thesis]. University of Antwerp; 2003.
2011	Ebacher V. Experimental Study of Deformation and Microcracking in Human Cortical Bone [PhD thesis]. Vancouver, BC: University of British Columbia; May 2011.
2006	Rouhi G. Theoretical Aspects of Bone Remodeling and Resorption Processes [PhD thesis]. Calgary, AB: University of Calgary; March 2006.
2000	Niebur GL. A Computational Investigation of Multiaxial Failure in Trabecular Bone [PhD thesis]. Berkeley, CA: University of California; 2000.
1987	Stover SM. Dorsal Metacarpal Disease in Thoroughbred Horses: Relationship to the Development of the Third Metacarpal Bone [PhD thesis]. Davis, University of California; 1987.
2001	Shelton DR. Fatigue Crack Growth Behavior in Equine Cortical Bone [PhD thesis]. Davis, University of California; 2001.
2006	Rao SH. The Genetics of Osteogenesis Imperfecta and Potential Therapeutics in a Murine Model [PhD thesis]. Davis, University of California; 2006.
1996	Adams DJ. Mechanical Factors Initiating Appositional Bone Formation [PhD thesis]. University of Iowa; May 1996.
1991	Choi K. The Micro Mechanical Properties of Bone Tissue [PhD thesis]. University of Michigan; 1991.
1994	Jepsen KJ. Characterization of the Hierarchical Composite Properties of Cortical Bone: A Transgenic Approach [PhD thesis]. University of Michigan; 1994.
1995	Guldberg RE. Mechanical Adaptation of Trabecular Bone Formation in Vivo [PhD thesis]. University of Michigan; 1995.
1996	Beck BR. The Relationship of Streaming Potential Magnitude to Strain and Periosteal Modeling [PhD thesis]. Eugene, OR: University of Oregon; December 1996.
1993	Boyce TM. Aging Changes Within the Human Femoral Neck Cortex [PhD thesis]. University of Utah; August 1993.
2013	Eleazer CD. The Interaction of Mechanical Loading and Metabolic Stress on Human Cortical Bone: Testing Anthropological Assumptions Using Cross-Sectional Geometry and Histomorphology [PhD thesis]. Knoxville, University of Tennessee; August 2013.
1985	Schaffler MB. Stiffness and Fatigue of Compact Bone At Physiological Strains and Strain Rates [PhD thesis]. Morgantown, WV: West Virginia University; 1985.
1998	Yeni YN. Fracture Mechanics of Human Cortical Bone: The Relationship of Geometry, Microstructure and Composition With the Fracture of the Tibia, Femoral Shaft and the Femoral Neck [PhD thesis]. Morgantown, WV: West Virginia University; 1998.
2001	Parsamian GP. Damage Mechanics of Human Cortical Bone [PhD thesis]. West Virginia University; 2001.

Year	Entry
1972	Pope MH, Outwater JO. The fracture characteristics of bone substance. J Biomech. September 1972;5(5):457-465.
1977	Saha S. Longitudinal shear properties of human compact bone and its constituents, and the associated failure mechanisms. J Mater Sci. 1977;12(9):1798-1806.
1973	Cooke FW, Zeidman H, Scheifele SJ. The fracture mechanics of bone: another look at composite modeling. J Biomed Mater Res. May 1973;7(3):383-399.
1979	Alto A, Pope MH. On the fracture toughness of equine metacarpi. J Biomech. 1979;12(6):415-421.
1976	Carter DR, Hayes WC. Fatigue life of compact bone, I: effects of stress amplitude, temperature and density. J Biomech. 1976;9(1):27-34.
1974	Simkin A, Robin G. Fracture formation in differing collagen fiber pattern of compact bone. J Biomech. 1974;7(2):183-188.
1970	Chamay A. Mechanical and morphological aspect of experimental overload and fatigue in bone. J Biomech. May 1970;3(3):263-270.
1973	Margel-Robertson DR. Studies of Fracture in Bone [PhD thesis]. Stanford University; March 1973.
1972	Chamay A, Tschantz P. Mechanical influences in bone remodeling: experimental research on Wolff's law. J Biomech. March 1972;5(2):173-180.
1977	Saha S, Hayes WC. Relations between tensile impact properties and microstructure of compact bone. Calcif Tiss Res. December 1977;24(1):65-72.
1976	Wright TM, Hayes WC. The fracture mechanics of fatigue crack propagation in compact bone. J Biomed Mater Res. July 1976;10(4):637-648.
1960	Frost HM. Presence of microscopic cracks in vivo in bone. Henry Ford Hosp Med Bull. 1960;8(1):25-35.
1977	Tappen NC. Three‐dimensional studies of resorption spaces and developing osteons. Am J Anat. July 1977;149(3):301-331.
1977	Carter DR, Hayes WC. Compact bone fatigue damage: a microscopic examination. Clin Orthop Relat Res. September 1977;127:265-274.
1971	Swanson SAV, Freeman MAR, Day WH. The fatigue properties of human cortical bone. Med Biol Eng. January 1971;9(1):23-32.
1962	Currey JD. Stress concentrations in bone. Q J Microsc Sci. March 1962;103(1):111-133.
1972	Jaworski ZF, Meunier P, Frost HM. Observations on two types of resorption cavities in human lamellar cortical bone. Clin Orthop Relat Res. March–April 1972;83:279-285.
1974	Pope MH, Murphy MC. Fracture energy of bone in a shear mode. Med Biol Eng. November 1974;12(6):763-767.