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Rubin, Clinton
1
;
Turner, A. Simon
2
;
Bain, Steven
3
; Mallinckrodt, Craig
2
;
McLeod, Kenneth
1
Low mechanical signals strengthen long bones
Nature
. August 9, 2001;412(6847):603-604
©2001 Macmillan Magazines Ltd
Affiliations
1
Musculo-Skeletal Research Laboratory, Department of Biomedical Engineering,
State University of New York, Stony Brook
, New York 11794-2580, USA
2
Department of Clinical Sciences,
Colorado State University
, Fort Collins, Colorado 80523, USA
3
Skeletech Inc., Bothell, Washington 98021, USA
Links
DOI:
10.1038/35088122
PubMed:
11493908
WoS:
000170318000028
Cited Works (7)
Year
Entry
1981
Carter DR, Harris WH, Vasu R, Caler WE. The mechanical and biological response of cortical bone to in vivo strain histories. In: Cowin SC, ed.
Mechanical Properties of Bone
. The Joint ASME-ASCE Applied Mechnics, Fluids Engineering and Bioengineering Conference; June 22-24, 1981; Boulder, CO. New York, NY: American Society of Mechical Engineers; 1981:81-92.
1985
Burr DB, Martin RB, Schaffler MB, Radin EL. Bone remodeling in response to in vivo fatigue microdamage.
J Biomech
. 1985;18(3):189-200.
1986
Wolff J.
The Law of Bone Remodelling
. Maquet P, Furlong R, trans. New York, NY: Springer; 1986.
1990
Schaffler MB, Radin EL, Burr DB. Long-term fatigue behavior of compact bone at low strain magnitude and rate.
Bone
. 1990;11(5):321-326.
1995
Rubin CT, Gross TS, McLeod KJ, Bain SD. Morphologie stages in lamellar bone formation stimulated by a potent mechanical stimulus.
J Bone Miner Res
. March 1995;10(3):488-495.
1997
Fritton JC, Rubin CT, Qin Y-X, McLeod KJ. Whole-body vibration in the skeleton: development of a resonance-based testing device.
Ann Biomed Eng
. September–October 1997;25(5):831-839.
2000
Fritton SP, McLeod KJ, Rubin CT. Quantifying the strain history of bone: spatial uniformity and self-similarity of low-magnitude strains.
J Biomech
. March 2000;33(3):317-325.
Cited By (75)
Year
Entry
2001
Rubin C, Xu G, Judex S. The anabolic activity of bone tissue, suppressed by disuse, is normalized by brief exposure to extremely low‐magnitude mechanical stimuli.
FASEB J
. October 2001;15(12):2225-2229.
2002
Currey JD.
Bones: Structure and Mechanics
. Princeton, NJ: Princeton University Press; 2002.
2002
Rubin C, Turner AS, Mallinckrodt C, Jerome C, Mcleod K, Bain S. Mechanical strain, induced noninvasively in the high-frequency domain, is anabolic to cancellous bone, but not cortical bone.
Bone
. March 2002;30(3):445-452.
2002
Judex S, Donahue L, Rubin C. Genetic predisposition to low bone mass is paralleled by an enhanced sensitivity to signals anabolic to the skeleton.
FASEB J
. August 2002;16(10):1280-1282.
2002
Rubin C, Turner AS, Müller R, Mittra E, McLeod K, Lin W, Qin Y. Quantity and quality of trabecular bone in the femur are enhanced by a strongly anabolic, noninvasive mechanical intervention.
J Bone Miner Res
. February 2002;17(2):349-357.
2002
Srinivasan S, Weimer DA, Agans SC, Bain SD, Gross TS. Low‐magnitude mechanical loading becomes osteogenic when rest is inserted between each load cycle.
J Bone Miner Res
. September 2002;17(9):1613-1620.
2002
Ehrlich PJ, Lanyon LE. Mechanical strain and bone cell function: a review.
Osteoporos Int
. September 2002;13(9):688-700.
2002
Wang L.
Investigating the Role of Interstitial Fluid Flow in Bone Adaptation and Metabolism
[PhD thesis]. New York, NY: The City University of New York; 2002.
2003
Cardinale M, Pope MH. The effects of whole body vibration on humans: dangerous or advantageous?
Acta Physiol Hung
. 2003;90(3):195-206.
2003
Judex S, Boyd S, Qin Y-X, Turner S, Ye K, Müller R, Rubin C. Adaptations of trabecular bone to low magnitude vibrations result in more uniform stress and strain under load.
Ann Biomed Eng
. January 2003;31(1):12-20.
2003
Turner CH, Robling AG. Designing exercise regimens to increase bone strength.
Exerc Sport Sci Rev
. January 2003;31(1):45-50.
2003
Rubin CP, Pope M, Fritton C, Magnusson M, Hansson T, McLeod K. Transmissibility of 15-Hertz to 35-Hertz vibrations to the human hip and lumbar spine: determining the physiologic feasibility of delivering low-level anabolic mechanical stimuli to skeletal regions at greatest risk of fracture because of osteoporosis.
Spine
. December 1, 2003;28(23):2621-2627.
2003
Rüberg T.
Computer Simulation of Adaptive Bone Remodeling
[Master's thesis]. Universidad de Zaragoza; 2003.
2004
Warden SJ, Turner CH. Mechanotransduction in the cortical bone is most efficient at loading frequencies of 5–10 hz.
Bone
. February 2004;34(2):261-270.
2004
Rubin C, Recker R, Cullen D, Ryaby J, McCabe J, McLeod K. Prevention of postmenopausal bone loss by a low‐magnitude, high‐frequency mechanical stimuli: a clinical trial assessing compliance, efficacy, and safety.
J Bone Miner Res
. March 2004;19(3):343-351.
2004
Ward K, Alsop C, Caulton J, Rubin C, Adams J, Mughal Z. Low magnitude mechanical loading is osteogenic in children with disabling conditions.
J Bone Miner Res
. March 2004;19(3):360-369.
2004
Pearson OM, Lieberman DE. The aging of Wolff's “law”: ontogeny and responses to mechanical loading in cortical bone.
Yearb Phys Anthropol
. 2004;47:63-99.
2004
Samuel SP.
Fluid/solid Interactions in Cancellous Bone
[PhD thesis]. Cleveland State University; August 2004.
2004
LaMothe JM.
Functional Adaptation of Bone
[PhD thesis]. Calgary, AB: University of Calgary; September 2004.
2004
Taboas JM.
Mechanobiologic Regulation of Skeletal Progenitor Cell Differentiation
[PhD thesis]. University of Michigan; 2004.
2005
Day JS.
Bone Quality: The Mechanical Effects of Microarchitecture and Matrix Properties
[PhD thesis]. Erasmus University Rotterdam; 2005.
2005
Ashe MC.
Upper Limb Bone Health: Cadaveric, Imaging and Clinical Studies With Special Emphasis on Peripheral Quantitative Computed Tomography
[PhD thesis]. Vancouver, BC: University of British Columbia; April 2005.
2006
Robling AG, Castillo AB, Turner CH. Biomechanical and molecular regulation of bone remodeling.
Annu Rev Biomed Eng
. 2006;8:455-498.
2006
Rubin J, Rubin C, Jacobs CR. Molecular pathways mediating mechanical signaling in bone.
Gene
. February 15, 2006;367:1-16.
2006
Gilsanz V, Wren TAL, Sanchez M, Dorey F, Judex S, Rubin C. Low‐level, high‐frequency mechanical signals enhance musculoskeletal development of young women with low bmd.
J Bone Miner Res
. September 2006;21(9):1464-1474.
2006
Poole KES.
The Effects of Stroke on the Skeleton
[PhD thesis]. Cambridge, UK: University of Cambridge; 2006.
2006
Hannay G.
Mechanical and Electrical Environments to Stimulate Bone Cell Development
[PhD thesis]. Queensland University of Technology; August 2006.
2006
Garman RA.
Low-Level Accelerations Applied in the Absence of Weight Bearing Can Alter Cellular Activity and Tissue Morphology in the Skeleton
[PhD thesis]. Stony Brook, NY: Stony Brook University; May 2006.
2006
Xie L.
Low Level Mechanical Vibrations Enhance Musculoskeletal Accretion in Growing Mice
[PhD thesis]. Stony Brook, NY: Stony Brook University; December 2006.
2007
Judex S, Lei X, Han D, Rubin C. Low-magnitude mechanical signals that stimulate bone formation in the ovariectomized rat are dependent on the applied frequency but not on the strain magnitude.
J Biomech
. 2007;40(6):1333-1339.
2007
Garman R, Gaudette G, Donahue L-R, Rubin C, Judex S. Low-level accelerations applied in the absence of weight bearing can enhance trabecular bone formation.
J Orthop Res
. June 2007;25(6):732-740.
2007
Skedros JG, Baucomb SL. Mathematical analysis of trabecular “trajectories” in apparent trajectorial structures: the unfortunate historical emphasis on the human proximal femur.
J Theo Biol
. January 7, 2007;244(1):15-45.
2007
Wang Y, McNamara LM, Schaffler MB, Weinbaum S. A model for the role of integrins in flow induced mechanotransduction in osteocytes.
Proc Natl Acad Sci USA
. October 2, 2007;104(40):15941-15946.
2007
Fratzl P, Weinkamer R. Nature’s hierarchical materials.
Prog Mater Sci
. November 2007;52(8):1263-1334.
2007
Wallace JM III.
Investigating the Inbred Strain-Specific Response to Biglycan-Deficiency and Exercise: A Study in Genetically-Mediated Skeletal Adaptation
[PhD thesis]. University of Michigan; 2007.
2007
Christiansen BA.
Vibrational Stimulation of Bone Formation in Mice
[PhD thesis]. St. Louis, MO: Washington University in St. Louis; December 2007.
2008
Kiiski J, Heinonen A, Järvinen TL, Kannus P, Sievänen H. Transmission of vertical whole body vibration to the human body.
J Bone Miner Res
. August 2008;23(8):1318-1325.
2008
Webster DJ.
A Combined Experimental and Computational Model for Genetic Control of Micro Structural Bone Adaptation
[PhD thesis]. Swiss Federal Institute of Technology Zürich; 2008.
2008
Weeks BK.
Improving Bone Health With Physical Activity: The Power PE Study and Development of the Bone-Specific Physical Activity Questionnaire (BPAQ)
[PhD thesis]. Brisbane, Australia: Griffith University; January 2008.
2008
Luu YK.
Biomechanical Promotion of Mesenchymal Stem Cell Proliferation as a Countermeasure to the Development of Obesity and Osteoporosis
[PhD thesis]. Stony Brook, NY: Stony Brook University; May 2008.
2009
Wang Y.
Roles of Integrins in Flow Induced Mechanotransduction in Osteocytes
[PhD thesis]. New York, NY: The City University of New York; 2009.
2009
Ferreri SL.
Anti-Catabolic Role of Ultrasonic Mechanical Perturbation in Prevention of Bone Loss and Turnover in OVX Rat Model: A Combined Empirical, Nanomechanical and Micro-Numerical Simulation Approach
[PhD thesis]. Stony Brook, NY: Stony Brook University; August 2009.
2009
Ozcivici E.
Recovery of Trabecular Bone from Disuse Induced Deterioration in Cellular, Morphological and Biomechanical Properties
[PhD thesis]. Stony Brook, NY: Stony Brook University; May 2009.
2010
Sugiyama T, Price JS, Lanyon LE. Functional adaptation to mechanical loading in both cortical and cancellous bone is controlled locally and is confined to the loaded bones.
Bone
. February 2010;46(2):314-321.
2010
Ozcivici E, Luu YK, Adler B, Qin Y-X, Rubin J, Judex S, Rubin CT. Mechanical signals as anabolic agents in bone.
Nat Rev Rheumatol
. January 2010;6(1):50-59.
2010
Chennimalai Kumar N.
Numerical Modeling of Cortical Bone Adaptation Due to Mechanical Loading Using the Finite Element Method
[PhD thesis]. University of Illinois at Urbana-Champaign; 2010.
2010
Manske SL.
Muscle Disuse and Vibration Effects on Bone Morphology
[PhD thesis]. Calgary, AB: University of Calgary; December 2010.
2010
Beckstrom AB.
Histologic and Geometric Data Challenge the Assumption of Habitual Superior-Inferior (tension-Compression) Bending Across the Chimpanzee Proximal Femur
[Master's thesis]. University of Utah; August 2010.
2011
Sen B, Xie Z, Case N, Styner M, Rubin CT, Rubin J. Mechanical signal influence on mesenchymal stem cell fate is enhanced by incorporation of refractory periods into the loading regimen.
J Biomech
. February 24, 2011;44(4):593-599.
2011
Appiah-Nkansah K.
Integration of Refractory Periods in the Administration of Low-Magnitude Mechanical Signals Increases Mesenchymal Stem Cell Numbers in the Bone Marrow
[Master's thesis]. Stony Brook, NY: Stony Brook University; May 2011.
2011
Patri N.
Low Intensity Vibrations Applied Locally Can be Transmitted to the Alveolar Bone Thereby Enhancing the Quality of the Bone in Adults Rats
[Master's thesis]. Stony Brook, NY: Stony Brook University; May 2011.
2012
Thompson WR, Rubin CT, Rubin J. Mechanical regulation of signaling pathways in bone.
Gene
. July 25, 2012;503(2):179-193.
2012
Lu XL, Huo B, Chiang V, Guo XE. Osteocytic network is more responsive in calcium signaling than osteoblastic network under fluid flow.
J Bone Miner Res
. March 2012;27(3):563-574.
2012
Hu M.
Mitigation of Bone Loss and Augment of Anabolic Adaptation by Physiological Dynamic Fluid Flow Stimulation
[PhD thesis]. Stony Brook, NY: Stony Brook University; December 2012.
2012
Uzer G.
Role of Fluid Shear Modulation on Bone Cell Metabolism During High-Frequency Oscillatory Vibrations
[PhD thesis]. Stony Brook, NY: Stony Brook University; December 2012.
2013
Khayat G.
Low Frequency Stimulation of Stem Cells in Dynamic Culture Modulates Differentiation Pathways
[PhD thesis]. McGill University; July 2013.
2013
Friesenbichler BM.
The Influence of Externally Applied Vibration and Compression on Muscular Performance and Recovery
[PhD thesis]. Calgary, AB: University of Calgary; November 2013.
2014
Ferro Pereira A.
Cortical Bone Adaptation: A Finite-Element Study of the Mouse Tibia
[PhD thesis]. Imperial College London; January 2014.
2014
Pagnotti GM.
Low Intensity Vibrations Mitigate Cancer-Induced Bone Loss With Indications of Reduced Tumor Progression
[PhD thesis]. Stony Brook, NY: Stony Brook University; August 2014.
2014
Hu Z.
The Development of a Digital X-Ray Imaging System for the Characterization of Transmission of Whole-Body Vibration in Mice
[Master's thesis]. London, ON: Western University; 2014.
2015
Coughlin TR.
Mechanobiological Signals in Trabecular Bone and Marrow
[PhD thesis]. University of Notre Dame; July 2015.
2015
Noble GJ.
Evaluation of a Press Fit, Percutaneous, Skeletally Anchored Endoprosthesis for Prosthetic Limb Attachment: Bone Response and the Effect of Low Intensity Vibration
[PhD thesis]. The Ohio State University; 2015.
2017
Saers JPP.
Ontogeny and Functional Adaptation of Trabecular Bone in the Human Foot
[PhD thesis]. Cambridge, UK: University of Cambridge; July 2017.
2017
Draghici AE.
Rescuing Osteoporotic Bone in Individuals With Spinal Cord Injury
[PhD thesis]. Northeastern University; April 2017.
2017
Kreipke TC.
Structural, Mechanical, and Biological Relationships of Trabecular Bone in Osteoporosis
[PhD thesis]. University of Notre Dame; April 2017.
2018
Patel VS.
Harnessing Cell Mechanosensitivity to Combat Obesity-Induced Systemic Metabolic Disruptions and to Promote Protein Production for Bioprocessing
[PhD thesis]. Stony Brook, NY: Stony Brook University; December 2018.
2019
Georgiou L, Kivell TL, Pahr DH, Buck LT, Skinner MM. Trabecular architecture of the great ape and human femoral head.
J Anat
. May 2019;234(5):679-693.
2019
Ruehle MA.
Cell-Based Vascular Therapeutics for Bone Regeneration
[PhD thesis]. Atlanta, GA: Georgia Institute of Technology; August 2019.
2020
Fox MC.
The Biomechanical Consequences of Body Size Differences in Humans
[PhD thesis]. University of Illinois at Urbana-Champaign; 2020.
2021
Saers JPP, DeMars LJ, Stephens NB, Jashashvili T, Carlson KJ, Gordon AD, Shaw CN, Ryan TM, Stock JT. Combinations of trabecular and cortical bone properties distinguish various loading modalities between athletes and controls.
Am J Phys Anthropol
. March 2021;174(3):434-450.
2021
Pagnotti GM, Thompson WR, Guise TA, Rubin CT. Suppression of cancer-associated bone loss through dynamic mechanical loading.
Bone
. September 2021;150:115998.
2021
Birks S, Uzer G. At the nuclear envelope of bone mechanobiology.
Bone
. October 2021;151:116023.
2021
Rajapakse CS, Johncola AJ, Batzdorf AS, Jones BC, Al Mukaddam M, Sexton K, Shults J, Leonard MB, Snyder PJ, Wehrli FW. Effect of low‐intensity vibration on bone strength, microstructure, and adiposity in pre‐osteoporotic postmenopausal women: a randomized placebo‐controlled trial.
J Bone Miner Res
. April 2021;36(4):673-684.
2022
Munford MJ, Xiao D, Jeffers JRT. Lattice implants that generate homeostatic and remodeling strains in bone.
J Orthop Res
. April 2022;40(4):871-877.
2023
Cosman MN.
Trabecular and Cortical Skeletal Correlates of Locomotor Ontogeny in
Pan
With Comparisonsto Skeletal Variation and Adaptation in
Gorilla
and
Pongo
[PhD thesis]. University of Michigan; 2023.