Rubin, Clinton T.

Links

AcademicTree: 249886

Academic genealogy

Doctoral Descendants

Affiliations (3)

Name	Count	Oldest	Newest
University of Bristol	1	1982	1982
Stony Brook University	43	1990	2021
Tufts University	8	1982	1987

Papers (54)

Year	Article	Times Cited	Times Cited (no self-citations)
2001	Fritton SP, Rubin CT. Dense bone tissue as a molecular composite. In: Cowin SC, ed. Bone Mechanics Handbook. 2nd ed. Boca Raton, FL: CRC Press; 2001:8-1–8-41.	1	1
1990	Rubin CT, McLeod KJ. Biologic modulation of mechanical influences in bone remodeling. In: Mow VC, Ratcliffe A, Woo SL-Y, eds. Biomechanics of Diarthrodial Joints. Vol 2. New York, NY: Springer-Verlag; 1990:97-118.	7	5
1994	Guilak F, Donahue HJ, Zell RA, Grande D, McLeod KJ, Rubin CT. Deformation-induced calcium signaling in articular chondrocytes. In: Mow VC, Tran-Son-Tay R, Guilak F, Hochmuth RM, eds. Cell Mechanics and Cellular Engineering. Symposium on Cell Mechanics and Cellular Engineering; July 10-15, 1994. New York, NY: Springer-Verlag; 1994:380-397.	15	10
1997	Fritton JC, Rubin CT, Qin Y-X, McLeod KJ. Whole-body vibration in the skeleton: development of a resonance-based testing device. Ann Biomed Eng. September–October 1997;25(5):831-839.	17	7
2002	Qin Y-X, Lin W, Rubin C. The pathway of bone fluid flow as defined by in vivo intramedullary pressure and streaming potential measurements. Ann Biomed Eng. May 2002;30(5):693-702.	25	21
2003	Judex S, Boyd S, Qin Y-X, Turner S, Ye K, Müller R, Rubin C. Adaptations of trabecular bone to low magnitude vibrations result in more uniform stress and strain under load. Ann Biomed Eng. January 2003;31(1):12-20.	26	12
2002	Rubin C, Turner AS, Mallinckrodt C, Jerome C, Mcleod K, Bain S. Mechanical strain, induced noninvasively in the high-frequency domain, is anabolic to cancellous bone, but not cortical bone. Bone. March 2002;30(3):445-452.	43	33
2006	Xie L, Jacobson JM, Choi ES, Busa B, Donahue LR, Miller LM, Rubin CT, Judex S. Low-level mechanical vibrations can influence bone resorption and bone formation in the growing skeleton. Bone. November 2006;39(5):1059-1066.	33	20
2021	Pagnotti GM, Thompson WR, Guise TA, Rubin CT. Suppression of cancer-associated bone loss through dynamic mechanical loading. Bone. September 2021;150:115998.	0	0
1984	Rubin CT. Skeletal strain and the functional significance of bone architecture. Calcif Tiss Int. March 1984;36(suppl 1):S11-S18.	74	67
1985	Rubin CT, Lanyon LE. Regulation of bone mass by mechanical strain magnitude. Calcif Tiss Int. 1985;37(4):411-417.	271	218
1986	Lanyon LE, Rubin CT, Baust G. Modulation of bone loss during calcium insufficiency by controlled dynamic loading. Calcif Tiss Int. July 1986;38(4):209-216.	23	12
1992	Rubin CT, Bain SD, McLeod KJ. Suppression of the osteogenic response in the aging skeleton. Calcif Tiss Int. April 1992;50(4):306-313.	50	46
2005	Busa B, Miller LM, Rubin CT, Qin Y-X, Judex S. Rapid establishment of chemical and mechanical properties during lamellar bone formation. Calcif Tiss Int. December 2005;77(6):386-394.	25	18
1994	Rubin CT, McLeod KJ. Promotion of bony ingrowth by frequency-specific, low-amplitude mechanical strain. Clin Orthop Relat Res. January 1994;298:165-174.	55	43
2003	Judex S, Boyd S, Qin Y-X, Miller L, Müller R, Rubin C. Combining high-resolution micro-computed tomography with material composition to define the quality of bone tissue. Curr Osteoporos Rep. June 2003;1(1):11-19.	31	16
1989	Jones BH, Harris JM, Vinh TN, Rubin C. Exercise-induced stress fractures and stress reactions of bone: epidemiology, etiology, and classification. Exerc Sport Sci Rev. January 1989;17(1):379-422.	35	32
2001	Rubin C, Xu G, Judex S. The anabolic activity of bone tissue, suppressed by disuse, is normalized by brief exposure to extremely low‐magnitude mechanical stimuli. FASEB J. October 2001;15(12):2225-2229.	40	20
2002	Judex S, Donahue L, Rubin C. Genetic predisposition to low bone mass is paralleled by an enhanced sensitivity to signals anabolic to the skeleton. FASEB J. August 2002;16(10):1280-1282.	36	16
2006	Rubin J, Rubin C, Jacobs CR. Molecular pathways mediating mechanical signaling in bone. Gene. February 15, 2006;367:1-16.	42	35
2012	Thompson WR, Rubin CT, Rubin J. Mechanical regulation of signaling pathways in bone. Gene. July 25, 2012;503(2):179-193.	32	28
1984	Lanyon LE, Rubin CT. Static vs dynamic loads as an influence on bone remodelling. J Biomech. 1984;17(12):897-905.	167	144
1990	Rubin CT, McLeod KJ, Bain SD. Functional strains and cortical bone adaptation: epigenetic assurance of skeletal integrity. J Biomech. 1990;23(suppl 1):43-54.	35	31
1990	Brown TD, Pedersen DR, Gray ML, Brand RA, Rubin CT. Toward an identification of mechanical parameters initiating periosteal remodeling: a combined experimental and analytic approach. J Biomech. 1990;23(9):893-905.	47	33
1992	Gross TS, McLeod KJ, Rubin CT. Characterizing bone strain distributions in vivo using three triple rosette strain gages. J Biomech. September 1992;25(9):1081-1087.	53	44
1997	Adams DJ, Spirt AA, Brown TD, Fritton SP, Rubin CT, Brand RA. Testing the daily stress stimulus theory of bone adaptation with natural and experimentally controlled strain histories. J Biomech. July 1997;30(7):671-678.	25	16
2000	Fritton SP, McLeod KJ, Rubin CT. Quantifying the strain history of bone: spatial uniformity and self-similarity of low-magnitude strains. J Biomech. March 2000;33(3):317-325.	84	64
2003	Qin Y-X, Kaplan T, Saldanha A, Rubin C. Fluid pressure gradients, arising from oscillations in intramedullary pressure, is correlated with the formation of bone and inhibition of intracortical porosity. J Biomech. October 2003;36(10):1427-1437.	48	36
2005	Mittra E, Rubin C, Qin Y-X. Interrelationship of trabecular mechanical and microstructural properties in sheep trabecular bone. J Biomech. June 2005;38(6):1229-1237.	34	33
2007	Judex S, Lei X, Han D, Rubin C. Low-magnitude mechanical signals that stimulate bone formation in the ovariectomized rat are dependent on the applied frequency but not on the strain magnitude. J Biomech. 2007;40(6):1333-1339.	31	21
2008	Mittra E, Rubin C, Gruber B, Qin Y-X. Evaluation of trabecular mechanical and microstructural properties in human calcaneal bone of advanced age using mechanical testing, μCT, and DXA. J Biomech. 2008;41(2):368-375.	13	12
2011	Sen B, Xie Z, Case N, Styner M, Rubin CT, Rubin J. Mechanical signal influence on mesenchymal stem cell fate is enhanced by incorporation of refractory periods into the loading regimen. J Biomech. February 24, 2011;44(4):593-599.	14	7
1984	Rubin CT, Lanyon LE. Regulation of bone formation by applied dynamic loads. J Bone Joint Surg. March 1984;66A(3):397-402.	307	254
1996	Rubin C, Gross T, Qin Y-X, Fritton S, Guilak F, McLeod K. Differentiation of the bone-tissue remodeling response to axial and torsional loading in the turkey ulna. J Bone Joint Surg. October 1996;78A(11):1665-1676.	15	13
1995	Rubin CT, Gross TS, McLeod KJ, Bain SD. Morphologie stages in lamellar bone formation stimulated by a potent mechanical stimulus. J Bone Miner Res. March 1995;10(3):488-495.	30	21
1995	Donahue HJ, McLeod KJ, Rubin CT, Andersen J, Grine EA, Hertzberg EL, Brink PR. Cell-to-cell communication in osteoblastic networks: cell line–dependent hormonal regulation of gap junction function. J Bone Miner Res. June 1995;10(6):881-889.	23	19
1997	Gross TS, Edwards JL, Mcleod KJ, Rubin CT. Strain gradients correlate with sites of periosteal bone formation. J Bone Miner Res. June 1997;12(6):982-988.	59	51
2002	Rubin C, Turner AS, Müller R, Mittra E, McLeod K, Lin W, Qin Y. Quantity and quality of trabecular bone in the femur are enhanced by a strongly anabolic, noninvasive mechanical intervention. J Bone Miner Res. February 2002;17(2):349-357.	57	37
2004	Rubin C, Recker R, Cullen D, Ryaby J, McCabe J, McLeod K. Prevention of postmenopausal bone loss by a low‐magnitude, high‐frequency mechanical stimuli: a clinical trial assessing compliance, efficacy, and safety. J Bone Miner Res. March 2004;19(3):343-351.	53	38
2004	Ward K, Alsop C, Caulton J, Rubin C, Adams J, Mughal Z. Low magnitude mechanical loading is osteogenic in children with disabling conditions. J Bone Miner Res. March 2004;19(3):360-369.	36	23
2004	Judex S, Garman R, Squire M, Donahue L, Rubin C. Genetically based influences on the site‐specific regulation of trabecular and cortical bone morphology. J Bone Miner Res. April 2004;19(4):600-606.	34	20
2004	Judex S, Garman R, Squire M, Busa B, Donahue L-R, Rubin C. Genetically linked site-specificity of disuse osteoporosis. J Bone Miner Res. April 2004;19(4):607-613.	33	26
2006	Gilsanz V, Wren TAL, Sanchez M, Dorey F, Judex S, Rubin C. Low‐level, high‐frequency mechanical signals enhance musculoskeletal development of young women with low bmd. J Bone Miner Res. September 2006;21(9):1464-1474.	29	16
2009	Luu YK, Capilla E, Rosen CJ, Gilsanz V, Pessin JE, Judex S, Rubin CT. Mechanical stimulation of mesenchymal stem cell proliferation and differentiation promotes osteogenesis while preventing dietary-induced obesity. J Bone Miner Res. January 2009;24(1):50-61.	25	10
1982	Rubin CT, Lanyon LE. Limb mechanics as a function of speed and gait: a study of functional strains in the radius and tibia of horse and dog. J Exp Biol. December 1982;101:187-211.	136	118
1987	Rubin CT, Lanyon LE. Osteoregulatory nature of mechanical stimuli: function as a determinant for adaptive remodeling in bone. J Orthop Res. 1987;5(2):300-310.	113	96
1995	Gross TS, Rubin CT. Uniformity of resorptive bone loss induced by disuse. J Orthop Res. September 1995;13(5):708-714.	14	8
1998	Qin Y, Rubin CT, McLeod KJ. Nonlinear dependence of loading intensity and cycle number in the maintenance of bone mass and morphology. J Orthop Res. July 1998;16(4):482-489.	50	28
1999	Guilak F, Zell RA, Erickson GR, Grande DA, Rubin CT, McLeod KJ, Donahue HJ. Mechanically induced calcium waves in articular chondrocytes are inhibited by gadolinium and amiloride. J Orthop Res. May 1999;17(3):421-429.	26	20
2007	Garman R, Gaudette G, Donahue L-R, Rubin C, Judex S. Low-level accelerations applied in the absence of weight bearing can enhance trabecular bone formation. J Orthop Res. June 2007;25(6):732-740.	18	11
1984	Rubin CT, Lanyon LE. Dynamic strain similarity in vertebrates: an alternative to allometric limb bone scaling. J Theo Biol. March 21, 1984;107(2):321-327.	93	67
2010	Ozcivici E, Luu YK, Adler B, Qin Y-X, Rubin J, Judex S, Rubin CT. Mechanical signals as anabolic agents in bone. Nat Rev Rheumatol. January 2010;6(1):50-59.	34	25
2001	Rubin C, Turner AS, Bain S, Mallinckrodt C, McLeod K. Low mechanical signals strengthen long bones. Nature. August 9, 2001;412(6847):603-604.	75	53
1990	Bain SD, Impeduglia TM, Rubin CT. Cement line staining in undecalcified thin sections of cortical bone. Stain Tech. 1990;65(4):159-163.	8	5

Theses (1)

Year	Article	Times Cited	Times Cited (no self-citations)
1982	Rubin CT. Dynamic Strain Similarity: The Origin and Objective of Structural Adaptation in Bone [PhD thesis]. Bristol, UK: University of Bristol; 1982.	1	1

Student Theses (14)

Year	Article	Times Cited	Times Cited (no self-citations)
2018	Patel VS. Harnessing Cell Mechanosensitivity to Combat Obesity-Induced Systemic Metabolic Disruptions and to Promote Protein Production for Bioprocessing [PhD thesis]. Stony Brook, NY: Stony Brook University; December 2018.	0	0
2017	Pamon TJ. The Development and Retention of Articular Cartilage, Disrupted by Metabolic Stressors, is Protected by Low Intensity Vibration [PhD thesis]. Stony Brook, NY: Stony Brook University; May 2017.	0	0
2017	Krishnamoorthy D. The Impact of Obesity on Bone Marrow Hematopoietic Stem Cell Function and Acute Immune Response [PhD thesis]. Stony Brook, NY: Stony Brook University; January 2017.	0	0
2016	Frechette DM. The Contribution of Bone Marrow Cells to the Formation of Bone, Fat, and Muscle, a Commitment Disrupted by Systemic Distress and Normalized by Mechanical Stimulation [PhD thesis]. Stony Brook, NY: Stony Brook University; December 2016.	0	0
2014	Pagnotti GM. Low Intensity Vibrations Mitigate Cancer-Induced Bone Loss With Indications of Reduced Tumor Progression [PhD thesis]. Stony Brook, NY: Stony Brook University; August 2014.	0	0
2013	Green DE. Bone Marrow Suppression and Bone Architectural Destruction Following Sub-Lethal Doses of Radiation [PhD thesis]. Stony Brook, NY: Stony Brook University; 2013.	0	0
2013	Adler B. High Fat Diet Rapidly Suppresses B Lymphopoiesis by Disrupting the Supportive Capacity of the Bone Marrow Niche [PhD thesis]. Stony Brook, NY: Stony Brook University; August 2013.	0	0
2011	Patri N. Low Intensity Vibrations Applied Locally Can be Transmitted to the Alveolar Bone Thereby Enhancing the Quality of the Bone in Adults Rats [Master's thesis]. Stony Brook, NY: Stony Brook University; May 2011.	0	0
2011	Muir JW. Evaluating the Potential of Low Magnitude Mechanical Signals as a Means of Preserving Postural Control in the Aged and Disabled [PhD thesis]. Stony Brook, NY: Stony Brook University; August 2011.	0	0
2011	Appiah-Nkansah K. Integration of Refractory Periods in the Administration of Low-Magnitude Mechanical Signals Increases Mesenchymal Stem Cell Numbers in the Bone Marrow [Master's thesis]. Stony Brook, NY: Stony Brook University; May 2011.	1	0
2008	Luu YK. Biomechanical Promotion of Mesenchymal Stem Cell Proliferation as a Countermeasure to the Development of Obesity and Osteoporosis [PhD thesis]. Stony Brook, NY: Stony Brook University; May 2008.	0	0
2001	Lin W. Development of Quantitative Ultrasound to Determine the Physical Properties of Bone [PhD thesis]. Stony Brook, NY: State University of New York at Stony Brook; May 2001.	0	0
1997	Qin Y-X. Fluid Flow, Matrix Strain and Loading Frequency as Interdependent Control Parameters in Skeletal Adaptation [PhD thesis]. Stony Brook, NY: State University of New York at Stony Brook; May 1997.	3	3
1993	Gross TS. Isolating Strain Parameters Correlated to Skeletal Adaptation [PhD thesis]. Stony Brook, NY: State University of New York at Stony Brook; 1993.	3	3

Collaborators (33)

Name	Count	Oldest	Newest
Rosen, Clifford J.	1	2009	2009
Lanyon, Lance Edward	7	1982	1987
Guilak, Farshid	3	1994	1999
Donahue, Henry J.	3	1994	1999
Qin, Yi-Xian	12	1996	2010
Mittra, Erik Supratik	3	2002	2008
Donahue, Leah Rae	5	2002	2007
Rubin, Janet	4	2006	2012
Cullen, Diane M.	1	2004	2004
Fritton, Susannah Parrish	4	1996	2001
Judex, Stefan	13	2001	2010
Erickson, Geoffrey Richard	1	1999	1999
Boyd, Steven K.	2	2003	2003
Bain, Steven D.	6	1990	2002
Case, Natasha D.	1	2011	2011
Adams, Douglas J.	1	1997	1997
Guise, Theresa A.	1	2021	2021
Wren, Tishya A. L.	1	2006	2006
Brand, Richard A.	2	1990	1997
Fritton, J. Christopher	1	1997	1997
Recker, Robert R.	1	2004	2004
Pedersen, Douglas Ray	1	1990	1990
Thompson, William Roy	2	2012	2021
Gilsanz, Vicente	2	2006	2009
McLeod, Kenneth J.	18	1990	2004
Gray, Martha L.	1	1990	1990
Turner, Anthony Simon	4	2001	2003
Brown, Thomas Dudley	2	1990	1997
Müller, Ralph	3	2002	2003
Ward, Kathryn (Kate) Anna	1	2004	2004
Miller, Lisa M.	3	2003	2006
Jacobs, Christopher Rae	1	2006	2006
Gross, Ted S.	5	1992	1997