Improved quantitation and discrimination of sulphated glycosaminoglycans by use of dimethylmethylene blue

Farndale, Richard W.; Buttle, David J.; Barrett, Alan J.

Year	Entry
1997	Ishihara H, Warensjo K, Roberts S, Urban JPG. Proteoglycan synthesis in the intervertebral disk nucleus: the role of extracellular osmolality. Am J Physiol Cell Physiol. May 1997;272(5):C1499-C1506.
1996	Enobakhare BO, Bader DL, Lee DA. Quantification of sulfated glycosaminoglycans in chondrocyte/alginate cultures, by use of 1,9-dimethylmethylene blue. Anal Ciochem. December 1, 1996;243(1):189-191.
2004	Hung CT, Mauck RL, Wang CC-B, Lima EG, Ateshian GA. A paradigm for functional tissue engineering of articular cartilage via applied physiologic deformational loading. Ann Biomed Eng. January 2004;32(1):35-49.
1991	Sah RL-Y, Doong J-YH, Grodzinsky AJ, Plaas AHK, Sandy JD. Effects of compression on the loss of newly synthesized proteoglycans and proteins from cartilage explants. Arch Biochem Biophys. April 1991;286(1):209-29.
1994	Sah RL, Chen AC, Grodzinsky AJ, Trippel SB. Differential effects of bFGF and IGF-I on matrix metabolism in calf and adult bovine cartilage explants. Arch Biochem Biophys. January 1994;308(1):137-147.
1994	Kim Y-J, Sah RLY, Grodzinsky AJ, Plaas AHK, Sandy JD. Mechanical regulation of cartilage biosynthetic behavior: physical stimuli. Arch Biochem Biophys. May 1994;311(1):1-12.
1996	Kim Y-J, Grodzinsky AJ, Plaas AHK. Compression of cartilage results in differential effects on biosynthetic pathways for aggrecan, link protein, and hyaluronan. Arch Biochem Biophys. April 15, 1996;328(2):331-340.
1995	Bonassar LJ, Frank EH, Murray JC, Paguio CG, Moore VL, Lark MW, Sandy JD, Wu J-J, Eyre DR, Grodzinsky AJ. Changes in cartilage composition and physical properties due to stromelysin degradation. Arthritis Rheum. February 1995;38(2):173-183.
2003	Patwari P, Cook MN, DiMicco MA, Blake SM, James IE, Kumar S, Cole AA, Lark MW, Grodzinsky AJ. Proteoglycan degradation after injurious compression of bovine and human articular cartilage in vitro: interaction with exogenous cytokines. Arthritis Rheum. May 2003;48(5):1292-1301.
2007	Asanbaeva A, Masuda K, Thonar EJ-MA, Klisch SM, Sah RL. Mechanisms of cartilage growth: modulation of balance between proteoglycan and collagen in vitro using chondroitinase ABC. Arthritis Rheum. January 2007;56(1):188-198.
2007	Schmidt TA, Gastelum NS, Nguyen QT, Schumacher BL, Sah RL. Boundary lubrication of articular cartilage: role of synovial fluid constituents. Arthritis Rheum. March 2007;56(3):882-891.
2001	Gooch KJ, Blunk T, Courter DL, Sieminski AL, Bursac PM, Vunjak-Novakovic G, Freed LE. IGF-I and mechanical environment interact to modulate engineered cartilage development. Biochem Biophys Res Commun. September 7, 2001;286(5):909-915.
2002	Hunter CJ, Imler SM, Malaviya P, Nerem RM, Levenston ME. Mechanical compression alters gene expression and extracellular matrix synthesis by chondrocytes cultured in collagen I gels. Biomaterials. February 15, 2002;23(4):1249-1259.
2005	Li W-J, Tuli R, Okafor C, Derfoul A, Danielson KG, Hall DJ, Tuan RS. A three-dimensional nanofibrous scaffold for cartilage tissue engineering using human mesenchymal stem cells. Biomaterials. February 2005;26(6):599-609.
2007	Baker BM, Mauck RL. The effect of nanofiber alignment on the maturation of engineered meniscus constructs. Biomaterials. April 2007;28(11):1967-1977.
2014	Bajpayee AG, Wong CR, Bawendi MG, Frank EH, Grodzinsky AJ. Avidin as a model for charge driven transport into cartilage and drug delivery for treating early stage post-traumatic osteoarthritis. Biomaterials. January 2014;35(1):538-549.
2007	Mauck RL, Byers BA, Yuan X, Tuan RS. Regulation of cartilaginous ECM gene transcription by chondrocytes and MSCs in 3D culture in response to dynamic loading. Biomech Model Mechanobiol. January 2007;6(1-2):113-125.
1995	Dunkelman NS, Zimber MP, LeBaron RG, Pavelec R, Kwan M, Purchio AF. Cartilage production by rabbit articular chondrocytes on polyglycolic acid scaffolds in a closed bioreactor system. Biotechnol Bioeng. May 20, 1995;46(4):299-305.
1999	Carver SE, Heath CA. Increasing extracellular matrix production in regenerating cartilage with intermittent physiological pressure. Biotechnol Bioeng. 1999;62(2):166-174.
1999	Carver SE, Heath CA. Influence of intermittent pressure, fluid flow, and mixing on the regenerative properties of articular chondrocytes. Biotechnol Bioeng. 1999;65(3):274-281.
1998	Vunjak-Novakovic G, Obradovic B, Martin I, Bursac PM, Langer R, Freed LE. Dynamic cell seeding of polymer scaffolds for cartilage tissue engineering. Biotechnol Prog. March–April 1998;14(2):193-202.
1998	Freed LE, Hollander AP, Martin I, Barry JR, Langer R, Vunjak-Novakovic G. Chondrogenesis in a cell-polymer-bioreactor system. Exp Cell Res. April 10, 1998;240(1):58-65.
1996	Ishihara H, McNally DS, Urban JP, Hall AC. Effects of hydrostatic pressure on matrix synthesis in different regions of the intervertebral disk. J Appl Physiol. March 1996;80(3):839-846.
1997	Torzilli PA, Arduino JM, Gregory JD, Bansal M. Effect of proteoglycan removal on solute mobility in articular cartilage. J Biomech. September 1997;30(9):895-902.
1999	Narmoneva DA, Wang JY, Setton LA. Nonuniform swelling-induced residual strains in articular cartilage. J Biomech. April 1999;32(4):401-408.
2001	Chen AC, Bae WC, Schinagl RM, Sah RL. Depth- and strain-dependent mechanical and electromechanical properties of full-thickness bovine articular cartilage in confined compression. J Biomech. January 2001;34(1):1-12.
2005	Iatridis JC, MacLean JJ, Ryan DA. Mechanical damage to the intervertebral disc annulus fibrosus subjected to tensile loading. J Biomech. March 2005;38(3):557-565.
2006	Kelly T-AN, Ng KW, Wang CC-B, Ateshian GA, Hung CT. Spatial and temporal development of chondrocyte-seeded agarose constructs in free-swelling and dynamically loaded cultures. J Biomech. 2006;39(8):1489-1497.
2007	Klein TJ, Chaudhry M, Bae WC, Sah RL. Depth-dependent biomechanical and biochemical properties of fetal, newborn, and tissue-engineered articular cartilage. J Biomech. January 2007;40(1):182-190.
2015	Oungoulian SR, Durney KM, Jones BK, Ahmad CS, Hung CT, Ateshian GA. Wear and damage of articular cartilage with friction against orthopedic implant materials. J Biomech. July 16, 2015;48(10):1957-1964.
2023	Szapary HJ, Flaman L, Frank E, Chubinskaya S, Dwivedi G, Grodzinsky AJ. Effects of dexamethasone and dynamic loading on cartilage of human osteochondral explants challenged with inflammatory cytokines. J Biomech. March 2023;149:111480.
2010	Elkin BS, Ilankovan A, Morrison B III. Age-dependent regional mechanical properties of the rat hippocampus and cortex. J Biomech Eng. January 2010;132(1):011010.
1993	Freed LE, Marquis JC, Nohria A, Emmanual J, Mikos AG, Langer R. Neocartilage formation in vitro and in vivo using cells cultured on synthetic biodegradable polymers. J Biomed Mater Res. January 1993;27(1):11-23.
2001	Jakob M, Démarteau O, Schäfer D, Hintermann B, Dick W, Heberer M, Martin I. Specific growth factors during the expansion and redifferentiation of adult human articular chondrocytes enhance chondrogenesis and cartilaginous tissue formation in vitro. J Cell Biochem. May 1, 2001;81(2):368-377.
1995	Buschmann MD, Gluzband YA, Grodzinsky AJ, Hunziker EB. Mechanical compression modulates matrix biosynthesis in chondrocyte/agarose culture. J Cell Sci. April 1995;108(4):1497-1508.
1996	Antoniou J, Steffen T, Nelson F, Winterbottom N, Hollander AP, Poole RA, Aebi M, Alini M. The human lumbar intervertebral disc: evidence for changes in the biosynthesis and denaturation of the extracellular matrix with growth, maturation, ageing, and degeneration. J Clin Invest. August 15, 1996;98(4):996-1003.
1989	Sah RL-Y, Kim Y-J, Doong J-YH, Grodzinsky AJ, Plass AHK, Sandy JD. Biosynthetic response of cartilage explants to dynamic compression. J Orthop Res. 1989;7(5):619-636.
1992	Buschmann MD, Gluzband YA, Grodzinsky AJ, Kimura JH, Hunziker EB. Chondrocytes in agarose culture synthesize a mechanically functional extracellular matrix. J Orthop Res. November 1992;10(6):745-758.
1993	Setton LA, Zhu W, Weidenbaum M, Ratcliffe A, Mow VC. Compressive properties of the cartilaginous end-plate of the baboon lumbar spine. J Orthop Res. March 1993;11(2):228-239.
1993	Roberts S, Menage J, Eisenstein SM. The cartilage end-plate and intervertebral disc in scoliosis: calcification and other sequelae. J Orthop Res. September 1993;11(5):747-757.
1995	Reindel ES, Ayroso AM, Chen AC, Chun DM, Schinagl RM, Sah RL. Integrative repair of articular cartilage in vitro: adhesive strength of the interface region. J Orthop Res. September 1995;13(5):751-760.
1996	Sah RL, Trippel SB, Grodzinsky AJ. Differential effects of serum, insulin-like growth factor-I, and fibroblast growth factor-2 on the maintenance of cartilage physical properties during long-term culture. J Orthop Res. January 1996;14(1):44-52.
1997	Sah RL, Yang AS, Chen AC, Hant JJ, Halili RB, Yoshioka M, Amiel D, Coutts RD. Physical properties of rabbit articular cartilage after transection of the anterior cruciate ligament. J Orthop Res. March 1997;15(2):197-203.
1998	Quinn TM, Grodzinsky AJ, Hunziker EB, Sandy JD. Effects of injurious compression on matrix turnover around individual cells in calf articular cartilage explants. J Orthop Res. July 1998;16(4):490-499.
1999	Vunjak-Novakovic G, Martin I, Obradovic B, Treppo S, Grodzinsky AJ, Langer R, Freed LE. Bioreactor cultivation conditions modulate the composition and mechanical properties of tissue-engineered cartilage. J Orthop Res. January 1999;17(1):130-138.
1999	Ragan PM, Badger AM, Cook M, Chin VI, Gowen M, Grodzinsky AJ, Lark MW. Down-regulation of chondrocyte aggrecan and type-II collagen gene expression correlates with increases in static compression magnitude and duration. J Orthop Res. November 1999;17(6):836-842.
2000	Treppo S, Koepp H, Quan EC, Cole AA, Kuettner KE, Grodzinsky AJ. Comparison of biomechanical and biochemical properties of cartilage from human knee and ankle pairs. J Orthop Res. September 2000;18(5):739-748.
2001	Quinn TM, Allen RG, Schalet BJ, Perumbuli P, Hunziker EB. Matrix and cell injury due to sub-impact loading of adult bovine articular cartilage explants: effects of strain rate and peak stress. J Orthop Res. March 2001;19(2):242-249.
2001	Obradovic B, Martin I, Padera RF, Treppo S, Freed LE, Vunjak-Navakovic G. Integration of engineered cartilage. J Orthop Res. November 2001;19(6):1089-1097.
2001	Williamson AK, Chen AC, Sah RL. Compressive properties and function—composition relationships of developing bovine articular cartilage. J Orthop Res. November 2001;19(6):1113-1121.
2003	Williamson AK, Chen AC, Masuda K, Thonar EJ, Sah RL. Tensile mechanical properties of bovine articular cartilage: variations with growth and relationships to collagen network components. J Orthop Res. September 2003;21(5):872-880.
2020	Connizzo BK, Grodzinsky AJ. Lose‐dose administration of dexamethasone is beneficial in preventing secondary tendon damage in a stress‐deprived joint injury explant model. J Orthop Res. January 2020;38(1):139-149.
2023	Andress B, Hoffman M, McNulty AL. Analytical validation and quality control/quality assurance practices for improved rigor and reproducibility of biochemical assays in orthopaedic research. J Orthop Res. July 2023;41(7):1618-1623.
2023	Aggouras AN, Connizzo BK. Earlier proteoglycan turnover promotes higher efficiency matrix remodeling in MRL/MpJ tendons. J Orthop Res. October 2023;41(10):2261-2272.
2023	Rydén M, Lindblom K, Yifter-Lindgren A, Turkiewicz A, Aspberg A, Tillgren V, Englund M, Önnerfjord P. A human meniscus explant model for studying early events in osteoarthritis development by proteomics. J Orthop Res. December 2023;41(12):2765-2778.
2003	Ng L, Grodzinsky AJ, Patwari P, Sandy J, Plaas A, Ortiz C. Individual cartilage aggrecan macromolecules and their constituent glycosaminoglycans visualized via atomic force microscopy. J Struct Biol. September 2003;143(3):242-257.
2002	Zuk PA, Zhu M, Ashjian P, De Ugarte DA, Huang JI, Mizuno H, Alfonso ZC, Fraser JK, Benhaim P, Hedrick MH. Human adipose tissue is a source of multipotent stem cells. Mol Biol Cell. December 2002;13(12):4279-4295.
2005	Glasson SS, Askew R, Sheppard B, Carito B, Blanchet T, Ma H-L, Flannery CR, Peluso D, Kanki K, Yang Z, Majumdar MK, Morris EA. Deletion of active ADAMTS5 prevents cartilage degradation in a murine model of osteoarthritis. Nature. March 31, 2005;434(7033):644-648.
2002	McGowan KB, Kurtis MS, Lottman LM, Watson D, Sah RL. Biochemical quantification of DNA in human articular and septal cartilage using PicoGreen^® and Hoechst 33258. Osteoarthritis Cartilage. July 2002;10(7):580-587.
2003	Klein TJ, Schumacher BL, Schmidt TA, Li KW, Voegtline MS, Masuda K, Thonar EJ-MA, Sah RL. Tissue engineering of stratified articular cartilage from chondrocyte subpopulations. Osteoarthritis Cartilage. August 2003;11(8):595-602.
2003	Mauck RL, Wang CC-B, Oswald ES, Ateshian GA, Hung CT. The role of cell seeding density and nutrient supply for articular cartilage tissue engineering with deformational loading. Osteoarthritis Cartilage. December 2003;11(12):879-890.
2004	Barbero A, Grogan S, Schäfer D, Heberer M, Mainil-Varlet P, Martin I. Age related changes in human articular chondrocyte yield, proliferation and post-expansion chondrogenic capacity. Osteoarthritis Cartilage. June 2004;12(6):476-484.
2006	Mauck RL, Yuan X, Tuan RS. Chondrogenic differentiation and functional maturation of bovine mesenchymal stem cells in long-term agarose culture. Osteoarthritis Cartilage. February 2006;14(2):179-189.
1997	Freed LE, Langer R, Martin I, Pellis NR, Vunjak-Novakovic G. Tissue engineering of cartilage in space. Proc Natl Acad Sci USA. December 9, 1997;94(25):13885-13890.
1989	Roberts S, Menage J, Urban JPG. Biochemical and structural properties of the cartilage end-plate and its relation to the intervertebral disc. Spine. February 1989;14(2):166-174.
1992	Ohshima H, Urban JPG. The effect of lactate and pH on proteoglycan and protein synthesis rates in the intervertebral disc. Spine. September 1992;17(9):1079-1082.
1996	Roberts S, Urban JPG, Evans H, Eisenstein SM. Transport properties of the human cartilage endplate in relation to its composition and calcification. Spine. March 15, 1996;21(4):415-420.
2005	Johannessen W, Elliott DM. Effects of degeneration on the biphasic material properties of human nucleus pulposus in confined compression. Spine. December 15, 2005;30(24):E724-E729.
2006	Gemmiti CV, Guldberg RE. Fluid flow increases type II collagen deposition and tensile mechanical properties in bioreactor-grown tissue-engineered cartilage. Tissue Eng. March 2006;12(3):469-479.
2008	Byers BA, Mauck RL, Chiang IE, Tuan RS. Transient exposure to transforming growth factor beta 3 under serum-free conditions enhances the biomechanical and biochemical maturation of tissue-engineered cartilage. Tissue Eng Part A. November 2008;14(11):1821-1834.
2011	Bansal PN. Contrast Enhanced Computed Tomographic Imaging of Articular Cartilage: Interrelationships With Biochemical and Biomechanical Properties [PhD thesis]. Boston University; 2011.
2014	Stewart RC. A Diagnostic Imaging Technique and Therapeutic Strategy for Early Osteoarthritis [PhD thesis]. Boston University; 2014.
2015	Freedman JD. Synthesis and Characterization of Cationic Contrast Agents & Imaging of Articular Cartilage Using X-Ray Computed Tomography and Magnetic Resonance [PhD thesis]. Boston University; 2015.
2015	Lakin BA. Developing a Cationic Contrast Agent for Computed Tomographic Imaging of Articular Cartilage and Synthetic Biolubricants for Early Diagnosis and Treatment of Osteoarthritis [PhD thesis]. Boston University; 2015.
2020	Ghobrial NM. Using Heparin-Coated Nanoparticles in the Treatment of Neointimal Hyperplasia [PhD thesis]. Clemson, SC: Clemson University; August 2020.
2016	Kramer EA. Thermal Fusion for Sutureless Closure: Devices, Composition, Methods [PhD thesis]. University of Colorado; 2016.
2017	Tangtrongsup S. Effects of Dexamethasone and Oxidative Environment on Chondrogenesis of Bone Marrow-Derived Mesenchymal Stem Cells [PhD thesis]. Colorado State University; 2017.
2018	Steineman BD. Meniscal Root Tears and Repairs [PhD thesis]. Colorado State University; 2018.
2001	Wang C. Digital Video Microscopy-Based Determination of Cartilage Inhomogeneity, Anisotropy and Tension -Compression Nonlinearity: Implications on Chondrocyte Environment [PhD thesis]. Columbia University; 2001.
2002	Sun D. Theoretical and Experimental Investigations of the Mechano-Electrochemical Properties of Articular Cartilage, a Charged -Hydrated -Soft, Biological Tissue [PhD thesis]. Columbia University; 2002.
2003	Mauck RL. Functional Tissue Engineering of Articular Cartilage: The Effect of Physical Forces on the in Vitro Growth of Engineered Constructs [PhD thesis]. Columbia University; 2003.
2006	Kelly T-AN. Functional Tissue Engineering of Articular Cartilage: Characterization and Optimization of Chondrocyte-Seeded Agarose Hydrogels [PhD thesis]. Columbia University; 2006.
2008	Lima EG. The Tissue-Engineering of Functional Osteochondral Constructs for Cartilage Repair [PhD thesis]. Columbia University; 2008.
2010	Elkin BS. Biomechanics and Biological Consequences of Traumatic Brain Injury [PhD thesis]. Columbia University; 2010.
2010	Simon MJ. Evaluation and Development of Cell-Penetrating Peptides for Brain Cell Delivery [PhD thesis]. Columbia University; 2010.
2015	Kang WH. Reducing the Societal Costs of Traumatic Brain Injury: Astrocyte-Based Therapeutics and Functional Injury Tolerance of the Living Brain [PhD thesis]. Columbia University; 2015.
2015	Oungoulian SR. Friction and Wear Measurements of Bovine Articular Cartilage Against Non-Native Materials [PhD thesis]. Columbia University; 2015.
2016	Cigan AD. Nutrient Channels to Aid the Growth of Articular Surface-Sized Engineered Cartilage Constructs [PhD thesis]. Columbia University; 2016.
2017	Nims RJ. Optimizing Cartilage Tissue Engineering Through Computational Growth Models and Experimental Culture Protocols [PhD thesis]. Columbia University; 2017.
2017	Roach BL. Modulation of the in Vitro Mechanical and Chemical Environment for the Optimization of Tissue-Engineered Articular Cartilage [PhD thesis]. Columbia University; 2017.
2017	Silverstein AM. Development of Biofidelic Culture Models of Osteoarthritis [PhD thesis]. Columbia University; 2017.
2021	Hu YJ. Microstructure and Biomechanics of the Subchondral Bone in the Development of Knee Osteoarthritis [PhD thesis]. Columbia University; 2021.
2001	Matthews GL. Evaluation of Antisense Oligonucleotide Suppression of Fibronectin Gene Expression for Characterization of the Role of Fibronectin in Cartilage Matrix Biology [PhD thesis]. Ithaca, NY: Cornell University; May 2001.
2006	Roy R. Non-Enzymatic Glycation for the Processing of Type I Collagen Gels for Cartilage Tissue Engineering [PhD thesis]. Ithaca, NY: Cornell University; January 2006.
2022	Chang JM. Leveraging Biological Insight from the Regenerative MRL/MpJ Mouse Strain for Tendon Mechanistic Discovery and Guiding Therapeutic Development [PhD thesis]. Ithaca, NY: Cornell University; August 2022.
2020	Han B. Decorin Regulates the Structure and Biomechanical Functions of Articular Cartilage Extracellular Matrix in Health and Disease [PhD thesis]. Drexel University; October 2020.
2000	Clark AEG. The Effects of Ascorbic Acid on Cartilage Metabolism and Osteoarthritis [PhD thesis]. Duke University; 2000.
2000	Narmoneva DA. Material Property Determination for Normal and Osteoarthritic Articular Cartilage Using a Triphasic Mechano -Chemical Theoretical Model of Osmotic Loading [PhD thesis]. Duke University; 2000.
2007	Nettles DL. Artificial Neural Network Modeling of Crosslinked Elastin -Like Polypeptide Formulations Parameters Effects on Physical Properties and Cellular Interactions for Cartilage Tissue Engineering [PhD thesis]. Duke University; 2007.
2008	Estes BT. Functional Tissue Engineering of Cartilage Using Adipose-Derived Stem Cells [PhD thesis]. Duke University; 2008.
2009	Moutos FT. Biomimetic Composite Scaffolds for the Functional Tissue Engineering of Articular Cartilage [PhD thesis]. Duke University; 2009.
2015	Brunger JM. Cellular and Biomaterial Engineering for Orthopaedic Regenerative Medicine [PhD thesis]. Duke University; 2015.
2015	Rowland CR. Development of Cartilage-Derived Matrix Scaffolds Via Crosslinking Decellularization, and Ice-templating [PhD thesis]. Duke University; 2015.
2016	Glass KA. Combined Gene Therapy and Functional Tissue Engineering for the Treatment of Osteoarthritis [PhD thesis]. Duke University; 2016.
2018	Huynh NPT. Bioinformatics and Molecular Approaches for the Development of Biological Artificial Cartilage [PhD thesis]. Duke University; 2018.
2011	Rigozzi S. Structure and Function in Tendon: Experimental Studies on the Ultrastructural Determinants of Tendon Biomechanical Function [PhD thesis]. Swiss Federal Institute of Technology Zürich; 2011.
2015	Nimeskern LG. Functional Characterization of Auricular Cartilage in Tissue Engineering and Regenerative Medicine [PhD thesis]. Swiss Federal Institute of Technology Zürich; 2015.
2016	Schätti OR. A Model to Study Articular Cartilage Mechanical and Biological Responses to Sliding and Rolling Loads [PhD thesis]. Swiss Federal Institute of Technology Zürich; 2016.
2001	Hunter CJ. Mechanical Stimulation of an in Vitro Articular Cartilage Defect Repair Model [PhD thesis]. Atlanta, GA: Georgia Institute of Technology; October 2001.
2004	Sitterle VB. Photoactivated Fixation of Cartilage Tissue [PhD thesis]. Atlanta, GA: Georgia Institute of Technology; August 2004.
2005	Case ND. Oscillatory Compressive Loading Effects on Mesenchymal Progenitor Cells Undergoing Chondrogenic Differentiation in Hydrogel Suspension [PhD thesis]. Atlanta, GA: Georgia Institute of Technology; May 2005.
2005	Imler SM. In Vitro Modulation of Meniscus Biosynthesis: A Basis for Understanding Cellular Response to Physiologically Relevant Stimuli [PhD thesis]. Atlanta, GA: Georgia Institute of Technology; August 2005.
2006	Gemmiti CV. Effect of Fluid Flow on Tissue-Engineered Cartilage in a Novel Bioreactor [PhD thesis]. Atlanta, GA: Georgia Institute of Technology; December 2006.
2007	Coleman R. Development of a Small Animal Model to Study Tissue Engineering Strategies for Growth Plate Defects [PhD thesis]. Atlanta, GA: Georgia Institute of Technology; August 2007.
2007	Connelly JT. Regulatory Mechanisms in the Chondrogenesis of Mesenchymal Progenitors: The Roles of Cyclic Tensile Loading and Cell-Matrix Interactions [PhD thesis]. Atlanta, GA: Georgia Institute of Technology; August 2007.
2007	Irrechukwu ON. The Role of Matrix Composition and Age in Solute Diffusion Within Articular Cartilage [PhD thesis]. Atlanta, GA: Georgia Institute of Technology; December 2007.
2007	Wilson CG. Mechanisms and Functional Implications of Aggrecan Catabolism in Cartilage and Meniscal Fibrocartilage [PhD thesis]. Atlanta, GA: Georgia Institute of Technology; May 2007.
2013	Moeini M. Solute Transport in Articular Cartilage: Toward Applications of Diffusion, Partitioning and Adsorption for Tissue Functional Assessment [PhD thesis]. McGill University; August 2013.
2013	Shafieyan Y. Mechanical Stimulation of Orthopaedic Tissues: Regulation of Bone Resorption and Solute Transport Through Articular Cartilage [PhD thesis]. McGill University; August 2013.
2014	Gonzales SD. The Effects of ATP and Adenosine on the Extracellular Matrix Biosynthesis Via Purinergic Pathways [PhD thesis]. University of Miami; August 2014.
2020	Yin X. ATP Metabolism of Intervertebral Disc Cells Under Physiological Nutritional Conditions [PhD thesis]. University of Miami; May 2020.
1990	Sah RL-Y. Biophysical Regulation of Matrix Systhesis, Assembly, and Degradation in Dynamically Compressed Calf Cartilage [PhD thesis]. Cambridge, MA: Massachusetts Institute of Technology; 1990.
1993	Lesperance LM. Compositional Studies of Cartilage Matrix Using NMR Spectroscopy [PhD thesis]. Cambridge, MA: Massachusetts Institute of Technology; September 1993.
1995	Bashir A. Sodium NMR Relaxation Parameters in Cartilage: Implications for MR Imaging [Master's thesis]. Cambridge, MA: Massachusetts Institute of Technology; 1995.
1995	Bonassar LJ. Matrix Metalloproteinase Activity and Inhibition in Articular Cartilage: Effects on Composition and Biophysical Properties and Relevance to Osteoarthritis [PhD thesis]. Cambridge, MA: Massachusetts Institute of Technology; February 1995.
1996	Berkenblit SI. Spatial Localization of Cartilage Degradation Using Electromechanical Surface Spectroscopy With Variable Wavelength and Frequency [PhD thesis]. Cambridge, MA: Massachusetts Institute of Technology; June 1996.
1996	García AM. Mechanisms of Macromolecular Transport Through Articular Cartilage: Relevance to Loading [PhD thesis]. Cambridge, MA: Massachusetts Institute of Technology; June 1996.
1996	Quinn TM. Articular Cartilage: Matrix Assembly, Mediation of Chondrocyte Metabolism, and Response to Compression [PhD thesis]. Cambridge, MA: Massachusetts Institute of Technology; May 1996.
1999	Ragan PM. The Effect of Mechanical Compression on Chondrocyte Gene Expression [PhD thesis]. Cambridge, MA: Massachusetts Institute of Technology; May 1999.
1999	Treppo S. Physical Diagnostics of Cartilage Degeneration [PhD thesis]. Cambridge, MA: Massachusetts Institute of Technology; February 1999.
2003	Patwari P. In Vitro Models for Injurious Compression of Bovine and Human Articular Cartilage Cambridge, MA: Massachusetts Institute of Technology; June 2003.
2003	Seog J. Molecular Mechanics of Cartilage: Quantification of GAG Electrostatic Interactions Via High-Resolution Force Spectroscopy Cambridge, MA: Massachusetts Institute of Technology; June 2003.
2005	Dean DMD. Modeling and Measurement of Intermolecular Interaction Forces Between Cartilage ECM Macromolecules [PhD thesis]. Cambridge, MA: Massachusetts Institute of Technology; February 2005.
2005	Ng LJ. Probing Nanomechanics of Aggrecan and the Aggrecan-Rich Pericellular Matrix of Chondrocytes in Cartilage [PhD thesis]. Cambridge, MA: Massachusetts Institute of Technology; September 2005.
2006	Stevens AL. Mechanical Injury and Inflammatory Cytokines Affect Cartilage Integrity and Tissue Homeostasis: A Mass Spectrometric Analysis of Proteins With Relevance to Arthritis [PhD thesis]. Cambridge, MA: Massachusetts Institute of Technology; September 2006.
2007	Han L. Nanomechanics of Cartilage Extracellular Matrix Macromolecules [PhD thesis]. Cambridge, MA: Massachusetts Institute of Technology; September 2007.
2008	Wheeler CA. Cartilage Response to in Vitro Models of Injury in Combination With Growth Factor and Antioxidant Treatments [PhD thesis]. Cambridge, MA: Massachusetts Institute of Technology; February 2008.
2009	Lee B. Time-Dependent Mechanical Behavior of Newly Developing Matrix of Bovine Primary Chondrocytes and Bone Marrow Stromal Cells Using Atomic Force Microscopy [PhD thesis]. Cambridge, MA: Massachusetts Institute of Technology; September 2009.
2010	Lee H-Y. Ultrastructure and Nanomechanical Properties of Aggrecan from Native Cartilage and Engineered Tissue [PhD thesis]. Cambridge, MA: Massachusetts Institute of Technology; June 2010.
2010	Lu YCS. In Vitro Models of Cartilage Degradation Following Joint Injury: Mechanical Overload, Inflammatory Cytokines and Therapeutic Approaches [PhD thesis]. Cambridge, MA: Massachusetts Institute of Technology; February 2010.
2013	Li Y. In Vitro Model of Injury/cytokine-Induced Cartilage Catabolism Modulated by Dynamic Compression, Growth Factors, and Glucocorticoids [PhD thesis]. Cambridge, MA: Massachusetts Institute of Technology; June 2013.
2013	Nia HT. Nanomechanics of Cartilage At the Matrix and Molecular Levels [PhD thesis]. Cambridge, MA: Massachusetts Institute of Technology; June 2013.
2015	Bajpayee AG. Charge-Based Transport and Drug Delivery Into Cartilage for Localized Treatment of Degenerative Joint Diseases [PhD thesis]. Cambridge, MA: Massachusetts Institute of Technology; February 2015.
2016	Wang Y. Molecular Pathway Analysis and Therapeutics Development in Post-Traumatic Osteoarthritis [PhD thesis]. Cambridge, MA: Massachusetts Institute of Technology; September 2016.
2016	Young WT. Cartilage Stress Relaxation Induced by Intra-Tissue Transport of Cationic Nanoparticles: Implications for Post-Traumatic Osteoarthritis Drug Delivery [Master's thesis]. Cambridge, MA: Massachusetts Institute of Technology; June 2016.
2020	Krishnan Y. Intra/extracellular Multi-Drug Delivery for Osteoarthritis [PhD thesis]. Cambridge, MA: Massachusetts Institute of Technology; September 2020.
2007	Zielinska B. Mechanotransduction in Meniscal Tissue [PhD thesis]. Houghton, MI: Michigan Technological University; 2007.
2021	Mehta S. Development of Age and Injury Induced Osteoarthritis Models for Evaluation of Therapeutics and Their Delivery Systems [PhD thesis]. Northeastern University; August 2021.
2010	Bahney CS. Cartilage Engineering: Designing an Improved System for Effecting Repair of Articular Cartilage Defects [PhD thesis]. Portland, OR: Oregon Health & Science University; August 2010.
2017	Sim S. Développement d'une base de données cartographiques et de modèles statistiques pour la caractérisation du cartilage articulaire [PhD thesis]. École polytechnique de Montréal; May 2017.
2009	Fan CY. Effects of Intermittent Static and Dynamic Tension on Articular Chondrocytes in High Density Culture [Master's thesis]. Queen's University; March 2009.
2009	McGregor AJ. A Method to Improve Cartilage Integration [Master's thesis]. Queen's University; December 2009.
2010	Usprech JF. A Therapeutic Dose of Adenosine Triphosphate (ATP) for Cartilage Tissue Engineering [Master's thesis]. Queen's University; September 2010.
2011	Bow JK. Using Adenosine Triphosphate (ATP) as a Substitute for Mechanical Stimulation for Tissue Engineering Applications [Master's thesis]. Queen's University; January 2011.
2011	Surrao DC. Biomimetic Scaffolds for Ligament Tissue Engineering [PhD thesis]. Queen's University; December 2011.
2011	Zhao Y. The Characterization of Bovine Adipose-Derived Stem Cells in Conventional and Co-Culture Environments for Tissue Engineering [Master's thesis]. Queen's University; February 2011.
2012	Brenner JM. Development and Validation of Large-Sized Engineered Cartilage Constructs in Full –thickness Chondral Defects in a Rabbit Model [Master's thesis]. Queen's University; January 2012.
2012	Kaupp JA. Simulated Joint Loading Enhances the Expression of of Superficial Zone Markers in Tissue Engineered Cartilage Constructs [PhD thesis]. Queen's University; February 2012.
2012	Khan AA. Effects of Additional Sodium Bicarbonate on Extra/intra Cellular Factors in a Continuous Flow Bioreactor for the Production of Tissue Engineered Articular Cartilage [PhD thesis]. Queen's University; October 2012.
2015	Weber JF. The Sensitivity of Articular Chondrocytes to Dynamic Mechanical Stimulation [PhD thesis]. Queen's University; December 2015.
2010	Schrobback K. In Vitro Cultivation of Adult Human Chondrocytes: Importance of Culture System, Oxygen and Zonal Differences [PhD thesis]. Queensland University of Technology; 2010.
2015	Kuaha K. Environments for Zonal Cartilage Tissue Engineering [PhD thesis]. Queensland University of Technology; 2015.
2016	Levett PA. Photocrosslinkable Hydrogels for Cartilage Tissue Engineering [PhD thesis]. Queensland University of Technology; 2016.
2017	Meinert AC. Hydrogels and Bioreactors for Cartilage Research and Functional Tissue Engineering [PhD thesis]. Queensland University of Technology; 2017.
2021	Pahoff S. Fibre-Reinforced Hydrogels for Functional Cartilage Tissue Engineering [PhD thesis]. Queensland University of Technology; 2021.
2013	Nishimuta JF. Degradation of Cartilage and Meniscus Tissues: An in Vitro Investigation in Osteoarthritis Development [PhD thesis]. Stanford University; March 2013.
2013	Son M-S. Defining and Detecting Meniscal Heterogeneityc: Implications on Treatment and Diagnosis of Osteoarthritis [PhD thesis]. Stanford University; March 2013.
2013	Zheng Ch. Effects of Biochemical Factors and Mechanical Loading on Chondrogenesis of Human Adipose-Derived Stem Cells [PhD thesis]. Stanford University; December 2013.
2018	Baylon EG. Isn’t it Swell? The Effect of Osmotic Swelling on Articular Cartilage and Meniscal Fibrocartilage Mechanics and Diagnostic Approaches [PhD thesis]. Stanford University; March 2018.
2022	Crowder HA. Exploring Structure-Function Relationships in Knee Cartilage and Meniscus Using Medical Imaging and Soft Tissue Biomechanics Techniques [PhD thesis]. Stanford University; March 2022.
2017	Dai X. Characterization of OA Severity in Knee Articular Cartilage in-Vivo Using MR Imaging and Loading Techniques [PhD thesis]. Calgary, AB: University of Calgary; August 2017.
2019	Bezci SE. Time-Dependent Characterization of Fluid Flow Into the Intervertebral Disc [PhD thesis]. Berkeley, CA: Berkeley, University of California; 2019.
2020	Salinas EY. Using Mechanical Stimulation to Improve Tissue-Engineered Articular Cartilage for Implantation in the Knee Joint [PhD thesis]. Irvine, CA: Irvine, University of California; 2020.
1997	Chen AC. Electromechanical Properties of Normal Cartilage and Biomechanical Regulation of Transplanted Chondrocytes: Implications for Articular Cartilage Tissue Engineering [PhD thesis]. San Diego (UCSD), University of California; 1997.
1998	Ahsan T. Integrative Repair and Collagen Crosslinking in Articular Cartilage [PhD thesis]. San Diego (UCSD), University of California; 1998.
1999	Chang DG. Structure and Function Relationships of Articular Cartilage in Osteoarthritis [PhD thesis]. San Diego (UCSD), University of California; 1999.
2001	Davisson TH. Biophysical Regulation of Metabolic Balance in Tissue Engineered Articular Cartilage [PhD thesis]. San Diego (UCSD), University of California; 2001.
2001	Kurtis MS. Cell Adhesion and Matrix Metabolism Following Chondrocyte Transplantation [PhD thesis]. San Diego (UCSD), University of California; 2001.
2002	Williamson AK. Development and Growth of Bovine Articular Cartilage: Biomechanical Function and Function-Composition Relationships [PhD thesis]. San Diego (UCSD), University of California; 2002.
2005	Klein TJ. Cartilage Tissue Engineering: Biophysical Modulation of Functional Depth-Dependent Properties [PhD thesis]. San Diego (UCSD), University of California; 2005.
2005	Temple MM. Age- and Site-Associated Biomechanical Weakening of Human Articular Cartilage: Relationship to Cellularity, Wear, Matrix Fragmentation and the Progression to Osteoarthritis [PhD thesis]. San Diego (UCSD), University of California; 2005.
2006	Asanbaeva A. Cartilage Growth and Remodeling: Modulation of Growth Phenotype and Tensile Integrity [PhD thesis]. San Diego (UCSD), University of California; 2006.
2006	Chawla K. Mechanisms of Articular Cartilage Defect Repair in Vivo After Implantation of Stratified Cartilaginous Tissue [PhD thesis]. San Diego (UCSD), University of California; 2006.
2006	Schmidt TA. Proteoglycan 4 Metabolism and Boundary Lubrication of Articular Cartilage [PhD thesis]. San Diego (UCSD), University of California; 2006.
2009	Hsieh-Bonassera ND. Cartilage Tissue Engineering With Human Chondrocytes from Osteoarthritic Knees and a Semi-Permeable Membrane [PhD thesis]. San Diego (UCSD), University of California; 2009.
2010	Hwang J. Integration of Cartilage and Bone Through a Calcified Cartilage Interface to Form a Functional Osteochondral Graft [PhD thesis]. San Diego (UCSD), University of California; 2010.
2010	Williams GM. Biophysical and Biochemical Regulation of the Shape, Size, and Maturity of Calf Articular Cartilage [PhD thesis]. San Diego (UCSD), University of California; 2010.
2011	Han E. Tissue Engineering of Cartilaginous Grafts With Mechanically Functional Aggrecan [PhD thesis]. San Diego (UCSD), University of California; 2011.
2012	Nguyen QT. Mechanobiology and Biomechanics of Articular Cartilage Repair [PhD thesis]. San Diego (UCSD), University of California; 2012.
2010	Rodriguez AG. Human Endplate Permeability and Microstructure and Their Relationship to Disc Degeneration [PhD thesis]. San Francisco, University of California; 2010.
2018	Graham B. Novel Approaches to Determine the Role of Diffusive and Convective Transport Environments in Articular Cartilage Function [PhD thesis]. University of Delaware; 2018.
2007	Liao EE. Enhancement of Chondrogenesis by Directing Cellular Condensation Through Chondroinductive Microenvironments, And, Designed Solid Freeform Fabricated Scaffolds [PhD thesis]. University of Michigan; 2007.
2008	Kemppainen JM. Mechanically Stable Solid Freeform Fabricated Scaffolds With Permeability Optimized for Cartilage Tissue Engineering [PhD thesis]. University of Michigan; 2008.
2010	Jeong GC. The Effects of Designed Scaffold Architecture and Biodegradable Material on Chondrogenesis in Vitro and in Vivo [PhD thesis]. University of Michigan; 2010.
2014	O’Conor CJ. TRPV4-Mediated Mechanotransduction in Articular Cartilage Function and Disease [PhD thesis]. University of North Carolina at Chapel Hill; 2014.
2006	Johannessen W. Nucleus Pulposus Degeneration and Its Role in Intervertebral Disc Mechanical Function [PhD thesis]. Philadelphia, PA: University of Pennsylvania; 2006.
2009	Boxberger JI. Altered and Restored Function After Reduced Nucleus Pulposus Glycosaminoglycan Content in the Rat Lumbar Intervertebral Disc [PhD thesis]. Philadelphia, PA: University of Pennsylvania; 2009.
2010	Baker BM. Meniscus Tissue Engineering With Nanofibrous Scaffolds [PhD thesis]. Philadelphia, PA: University of Pennsylvania; 2010.
2010	Huang AH. Enhancing Mesenchymal Stem Cell Chondrogenesis for Cartilage Tissue Engineering [PhD thesis]. Philadelphia, PA: University of Pennsylvania; 2010.
2011	Erickson IE. Optimization and Translation of MSC-Based Hyaluronic Acid Hydrogels for Cartilage Repair [PhD thesis]. Philadelphia, PA: University of Pennsylvania; 2011.
2011	Silverman LI. Enhancing Meniscus Repair Through Biomaterial Design [PhD thesis]. Philadelphia, PA: University of Pennsylvania; 2011.
2013	Farrell MJ. Cartilage Tissue Engineering With Heterogeneous and Clonal Mesenchymal Stem Cell Populations: Multi-Scale Analysis of Maturation, Stability, and Response to Environmental Stressors [PhD thesis]. Philadelphia, PA: University of Pennsylvania; 2013.
2015	Driscoll TP. Nuclear Connectivity in Mesenchymal Stem Cell Differentiation and Its Role in Mechanotransduction [PhD thesis]. Philadelphia, PA: University of Pennsylvania; 2015.
2015	Szczesny SE. Analysis of the Contribution of Interfibrillar Sliding on Tendon Fascicle Multiscale Mechanics [PhD thesis]. Philadelphia, PA: University of Pennsylvania; 2015.
2016	Qu F. Biomaterial-Mediated Reprogramming of the Wound Interface to Enhance Meniscal Repair [PhD thesis]. Philadelphia, PA: University of Pennsylvania; 2016.
2017	Kim M. Multi-Cellular and Multi-Scale Approaches for Cartilage Repair [PhD thesis]. Philadelphia, PA: University of Pennsylvania; 2017.
2017	Mohanraj B. High Throughput and Mechano-Active Platforms to Promote Cartilage Regeneration and Repair [PhD thesis]. Philadelphia, PA: University of Pennsylvania; 2017.
2012	Reese SP. Multiscale Structure-Function Relationships in the Mechanical Behavior of Tendon and Ligament [PhD thesis]. University of Utah; May 2012.
2008	Korecki CL. Effects of Compression Loading, Injury, and Age on Intervertebral Disc Mechanics, Biology and Metabolism Using Large Animal Organ and Cell Culture Systems [PhD thesis]. University of Vermont; May 2008.
2014	Pourmohammadali H. Mechanical and Hydromechanical Stimulation of Chondrocytes for Articular Cartilage Tissue Engineering [PhD thesis]. University of Waterloo; 2014.
2020	Ross A. Tissue Engineering of Induced Pluripotent Stem Cells for the Development of Novel Treatment Strategies for Osteoarthritis [PhD thesis]. St. Louis, MO: Washington University in St. Louis; May 2020.
2021	Guang Y. Understanding a Role for Synovium in Intra-Articular Drug Clearance: A Computational and Experimental Approach [PhD thesis]. St. Louis, MO: Washington University in St. Louis; May 2021.
2021	Pferdehirt L. Synthetic Gene Circuits for Self-Regulating and Temporal Delivery of Anti-Inflammatory Biologic Drugs in Engineered Tissues [PhD thesis]. St. Louis, MO: Washington University in St. Louis; May 2021.
2023	Savadipour A. Mechanosensitive Ion Channels as Therapeutics Targets for Osteoarthritis [PhD thesis]. St. Louis, MO: Washington University in St. Louis; December 2023.