The cartilage end-plate and intervertebral disc in scoliosis: calcification and other sequelae

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Roberts, S.¹; Menage, J.¹; Eisenstein, S. M.¹

The cartilage end-plate and intervertebral disc in scoliosis: calcification and other sequelae

J Orthop Res. September 1993;11(5):747-757

©1993 Orthopaedic Research Society

Affiliations

¹Centre for Spinal Studies, Robert Jones and Agnes Hunt Orthopaedic Hospital, Oswestry, Shropshire, England
Abstract

The morphology and composition of the intervertebral disc and also of the cartilage end-plate were studied in patients with idiopathic or congenital scoliosis. The cartilage end-plate was investigated because of its function as an epiphyseal plate in humans and the associaition between growth and progression of the scoliotic curve. The proteoglycan and water contents were reduced in both structures in specimens from scoliotic patients, particularly toward the concavity of the curve, compared with autopsy material. The distribution of some collagen types differed in tissue from scoliotic patients and autopsy tissue. Calcification of the cartilage end-plate, and sometimes of the adjacent disc, occurred in all but three scoliotic patients, whereas there was minimal calcification in the autopsy specimens. We suggest that, although these changes are probably a secondary response to altered loading in the scoliotic patients, they may be highly significant to the progression of the scoliotic curve.
Links

DOI: 10.1002/jor.1100110517

PubMed: 8410475

WoS: A1993ME48600016
History

Received: 1992-05-26

Accepted: 1993-01-27

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Cited By (20)

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2003	Urban JPG, Roberts S. Degeneration of the intervertebral disc. Arthritis Res Ther. 2003;5(3):120-130.
2004	Bibby SRS, Urban JPG. Effect of nutrient deprivation on the viability of intervertebral disc cells. Eur Spine J. December 2004;13(8):695-701.
2006	Roberts S, Evans H, Trivedi J, Menage J. Histology and pathology of the human intervertebral disc. J Bone Joint Surg. April 2006;88A(suppl 2):10-14.
1996	Roberts S, Urban JPG, Evans H, Eisenstein SM. Transport properties of the human cartilage endplate in relation to its composition and calcification. Spine. March 15, 1996;21(4):415-420.
2001	Horner HA, Urban JPG. Effect of nutrient supply on the viability of cells from the nucleus pulposus of the intervertebral disc. Spine. December 1, 2001;26(23):2543-2549.
2004	Urban JPG, Smith S, Fairbank JCT. Nutrition of the intervertebral disc. Spine. December 1, 2004;29(23):2700-2709.
2006	Adams MA, Roughley PJ. What is intervertebral disc degeneration, and what causes it? Spine. August 15, 2006;31(18):2151-2161.
2015	Jackman TM. Prediction of Vertebral Fractures Under Axial Compression and Anterior Flexion [PhD thesis]. Boston University; 2015.
2013	Wu Y. Integrating Biomechanics and Cell Physiology to Understanding IVD Nutrition and Cell Homeostasis [PhD thesis]. Clemson, SC: Clemson University; May 2013.
2016	Cisewski SE. Nutrient Related Mechanisms of Intervertebral Disc Degeneration [PhD thesis]. Clemson, SC: Clemson University; August 2016.
2013	Paietta RC. Microscale Material Properties of Bone and the Mineralized Tissues of the Intervertebral Disc-Vertebral Body Interface [PhD thesis]. Boulder, CO: University of Colorado; 2013.
2022	El Bojairami I. Assessment of Static Spinal Stability and Muscle Activation Strategies: A Comprehensive Approach Via a Novel Validated Finite Elements Spine Model Inclusive of Thoracolumbar Fascia, Intramuscular Pressure, and Intra-Abdominal Pressure [PhD thesis]. McGill University; April 2022.
2010	Jackson AR. Transport and Metabolism of Glucose in Intervertebral Disc [PhD thesis]. University of Miami; December 2010.
2008	Mokhbi-Soukane D. Études numériques de la diffusion couplée d'oxygène, glucose et d'acide lactique dans le disque intervertébral [PhD thesis]. École polytechnique de Montréal; June 2008.
2011	Driscoll M. Design, Optimization, and Evaluation of a Fusionless Device to Induce Growth Modulation and Correct Spinal Curvatures in Adolescent Idiopathic Scoliosis [PhD thesis]. École polytechnique de Montréal; June 2011.
2010	Rodriguez AG. Human Endplate Permeability and Microstructure and Their Relationship to Disc Degeneration [PhD thesis]. San Francisco, University of California; 2010.
2021	Iriondo C. Characterizing Phenotypes of Musculoskeletal Degeneration Using Medical Imaging and Deep Learning [PhD thesis]. San Francisco, University of California; 2021.
2018	DeLucca JF. Development and Validation of a Finite Element Model of Human Intervertebral Disc in Multiaxial Loading Including the Contributions of Cartilage Endplate and Residual Strains in the Annulus Fibrosus [PhD thesis]. University of Delaware; 2018.
2014	Yoder JH. Intervertebral Disc Structure and Mechanical Function Under Physiological Loading Quantified Non-Invasively Utilizing MRI and Image Registration [PhD thesis]. Philadelphia, PA: University of Pennsylvania; 2014.
2006	Lau AG. Development of a Microstructural Homogenization Model for Calcifying Cartilage Using the Generalized Method of Cells [PhD thesis]. Charlottesville, VA: University of Virginia; January 2006.