Understanding bone strength:​ size isn’t everything

van der Meulen, M. C. H.; Jepsen, K. J.; Mikić, B.

Year	Entry
2025	Skedros JG. Biomechanical foundations of histological analysis in limb bones: the crucial role of load-complexity categorization and collagen fiber orientation analysis when interpreting bone adaptation. In: Stout SD, Crowder C, eds. Bone Histology: A Biological Anthropological Perspective. 2nd ed. Boca Raton, FL: CRC Press; 2025:150-224.
2006	Ruff C, Holt B, Trinkaus E. Who's afraid of the big bad Wolff? “Wolff's law” and bone functional adaptation. Am J Phys Anthropol. April 2006;129(4):484-498.
2006	Hernandez CJ, Keaveny TM. A biomechanical perspective on bone quality. Bone. December 2006;39(6):1173-1181.
2006	Nyman JS, Roy A, Acuna RL, Gayle HJ, Reyes MJ, Tyler JH, Dean DD, Wang X. Age-related effect on the concentration of collagen crosslinks in human osteonal and interstitial bone tissue. Bone. December 2006;39(6):1210-1217.
2008	Nyman JS, Ni Q, Nicolella DP, Wang X. Measurements of mobile and bound water by nuclear magnetic resonance correlate with mechanical properties of bone. Bone. January 2008;42(1):193-199.
2013	Burket JC, Brooks DJ, MacLeay JM, Baker SP, Boskey AL, van der Meulen MCH. Variations in nanomechanical properties and tissue composition within trabeculae from an ovine model of osteoporosis and treatment. Bone. January 2013;52(1):326-336.
2005	Busa B, Miller LM, Rubin CT, Qin Y-X, Judex S. Rapid establishment of chemical and mechanical properties during lamellar bone formation. Calcif Tiss Int. December 2005;77(6):386-394.
2010	Donnelly E, Chen DX, Boskey AL, Baker SP, van der Meulen MCH. Contribution of mineral to bone structural behavior and tissue mechanical properties. Calcif Tiss Int. November 2010;87(5):450-460.
2011	Donnelly E. Methods for assessing bone quality: a review. Clin Orthop Relat Res. August 2011;469:2128-2138.
2011	Cole JH, van der Meulen MCH. Whole bone mechanics and bone quality. Clin Orthop Relat Res. August 2011;469(8):2139-2149.
2016	Hunt HB, Donnelly E. Bone quality assessment techniques: geometric, compositional, and mechanical characterization from macroscale to nanoscale. Clin Rev Bone Miner Metab. September 2016;14(3):133-149.
2004	Silva MJ, Brodt MD, Fan Z, Rho J-Y. Nanoindentation and whole-bone bending estimates of material properties in bones from the senescence accelerated mouse SAMP6. J Biomech. November 2004;37(11):1639-1646.
2010	Main RP, Lynch ME, van der Meulen MCH. In vivo tibial stiffness is maintained by whole bone morphology and cross-sectional geometry in growing female mice. J Biomech. October 19, 2010;43(14):2689-2694.
2011	Bi X, Patil CA, Lynch CC, Pharr GM, Mahadevan-Jansen A, Nyman JS. Raman and mechanical properties correlate at whole bone- and tissue-levels in a genetic mouse model. J Biomech. January 11, 2011;44(2):297-303.
2005	Boskey AL, Mendelsohn R. Infrared analysis of bone in health and disease. J Biomed Opt. May–June 2005;10(3):031102.
2004	Eckstein F, Wunderer C, Boehm H, Kuhn V, Priemel M, Link TM, Lochmüller E-M. Reproducibility and side differences of mechanical tests for determining the structural strength of the proximal femur. J Bone Miner Res. March 2004;19(3):379-385.
2005	Tommasini SM, Morgan TG, van der Meulen MCH, Jepsen KJ. Genetic variation in structure‐function relationships for the inbred mouse lumbar vertebral body. J Bone Miner Res. May 2005;20(5):817-827.
2005	Tommasini SM, Nasser P, Schaffler MB, Jepsen KJ. Relationship between bone morphology and bone quality in male tibias: implications for stress fracture risk. J Bone Miner Res. August 2005;20(8):1372-1380.
2007	Glatt V, Canalis E, Stadmeyer L, Bouxsein ML. Age‐related changes in trabecular architecture differ in female and male C57BL/6J mice. J Bone Miner Res. August 2007;22(8):1197-1207.
2015	Jepsen KJ, Silva MJ, Vashishth D, Guo XE, van der Meulen MCH. Establishing biomechanical mechanisms in mouse models: practical guidelines for systematically evaluating phenotypic changes in the diaphyses of long bones. J Bone Miner Res. June 2015;30(6):951-966.
2007	Nyman JS, Roy A, Tyler JH, Acuna RL, Gayle HJ, Wang X. Age‐related factors affecting the postyield energy dissipation of human cortical bone. J Orthop Res. May 2007;25(7):646-655.
2003	Jepsen KJ, Akkus OJ, Majeska RJ, Nadeau JH. Hierarchical relationship between bone traits and mechanical properties in inbred mice. Mamm Genome. February 2003;14(2):97-104.
2017	Unal M. Classification of Bound Water and Collagen Denaturation Status of Cortical Bone by Raman Spectroscopy [PhD thesis]. Cleveland, OH: Case Western Reserve University; January 2017.
2021	Coulombe JC. Diminished Bone Structural Quality in Aging and Microgravity Follow Impairments of the Osteocyte Lacunar-Canalicular System [PhD thesis]. University of Colorado; 2021.
2022	Senwar B. Bone Material Quality, Structure, and Functional Relationships Contribute to Bone Strength and Toughness [Master's thesis]. University of Colorado; 2022.
2006	Fritton JC. Mechanical Loading Induced Adaptation of the Mouse Tibia [PhD thesis]. Ithaca, NY: Cornell University; January 2006.
2013	Burket JC. Alterations in Tissue Composition and Nanomechanical Properties With Ageing, Osteoporosis, and Treatment [PhD thesis]. Ithaca, NY: Cornell University; January 2013.
2014	Melville KM. Estrogen Receptor Alpha in Osteoblasts Mediates Bone Mass and Bone's Response to in Vivo Loading [PhD thesis]. Ithaca, NY: Cornell University; August 2014.
2018	Chen JTH. Alterations in Bone Tissue Properties With Parathyroid Hormone Treatment [PhD thesis]. Ithaca, NY: Cornell University; May 2018.
2018	Hunt HB. Characterization of Material Properties, Microarchitecture, and Mechanics of Bone from Subjects With Type 2 Diabetes Mellitus [PhD thesis]. Ithaca, NY: Cornell University; December 2018.
2019	Arora D. Characterization of Bone Structural, Geomteric, and Material Properties in the TallyHO Mouse Model of Type 2 Diabetes Mellitus [Master's thesis]. Ithaca, NY: Cornell University; December 2019.
2008	Tommasini SM. Phenotypic Integration Contributes to Skeletal Functionality and Fragility [PhD thesis]. New York, NY: The City University of New York; 2008.
2015	Weatherholt AM. Translational Studies Into the Effects of Exercise on Estimated Bone Strength [PhD thesis]. Indianapolis, IN: Indiana University; September 2015.
2021	Scott MC. Exercise and Bone: Older Adults, Type II Diabetes, and Ketogenic Diets [PhD thesis]. Louisiana State University; May 2021.
2017	Mathavan N. The Anabolic - Anti-Catabolic Paradigm of Augmenting Skeletal Regeneration: A Bone Quality Perspective [PhD thesis]. Lund, Sweden: Lund University; 2017.
2004	Giangregorio L. Musculoskeletal Changes After Spinal Cord Injury: Effects of Body Weight Supported Treadmill Training [PhD thesis]. Hamilton, ON: McMaster University; November 2004.
2021	Fraschetti A. The Effects of Exposure to Trace Elements on the Skeletal Health of American Mink [Master's thesis]. Hamilton, ON: McMaster University; December 2021.
2008	Courtland H-W. Intra-Species Variation in Skeletal Mechanical Function is Achieved Through Genetic Regulation of Both the Quality and Morphology of Bone [PhD thesis]. Mount Sinai School of Medicine; 2008.
2008	Price C. Systems Based Approaches to Identifying How Genetically Varying Skeletal Growth Affects Skeletal Functionality and Fragility [PhD thesis]. Mount Sinai School of Medicine; 2008.
2017	McCormick CM. Altered Trabecular Microarchitecture Near the Glenohumeral Joint of a Rat Model With Neonatal Brachial Plexus Injury [Master's thesis]. North Carolina State University; 2017.
2019	Hanne NJ. Characterizing Osteovascular Structure and Function With High Fat Diet-Induced Obesity and Stroke [PhD thesis]. North Carolina State University; 2019.
2016	Berman AG. Influence of Mechanical Stimulation on the Quantity and Quality of Bone During Modeling [Master's thesis]. Purdue University; August 2016.
2019	Powell KM. The Effects of Zoledronate and Raloxifene Combination Therapy on Diseased Mouse Bone [Master's thesis]. Indianapolis, IN: Purdue University; May 2019.
2019	Beltejar M-JG. Understanding the Genetic Basis for Bone-Matrix Quality [PhD thesis]. University of Rochester; 2019.
2009	Bhatia A. Quantification of Skeletal Phenotype of Transgenic Mice Overexpressing DMP1 Using ΜCT and Mechanical Testing [Master's thesis]. Rush University; 2009.
2012	Acerbo AS. Local Chemical and Nanostructural Properties of Rat Cortical Bone Are Altered by Osteoporosis and Pharmaceutical Treatments [PhD thesis]. Stony Brook, NY: Stony Brook University; August 2012.
2014	Butler TA. The Effects of Post Pubertal Food Restriction on Bone Architecture, Strength, and Medullary Adipose Composition [PhD thesis]. Temple University; January 2014.
2014	Colombo A. La micro-architecture de l’os trabéculaire en croissance: Variabilité tridimensionnelle normale et pathologique analysée par microtomodensitométrie [PhD thesis]. Université de Bordeaux; December 15, 2014.
2016	Vrahna C. Investigating the Effects of Downstream Parathyroid Hormone (PTH) Targets on Bone Strength and Quality [PhD thesis]. Melbourne, Australia: The University of Melbourne; December 2016.
2022	Blank MA. Defining Mechanisms by Which EphrinB2 in Osteocytes Controls Bone Strength and Material Quality [PhD thesis]. University of Melbourne; September 2022.
2010	Beckstrom AB. Histologic and Geometric Data Challenge the Assumption of Habitual Superior-Inferior (tension-Compression) Bending Across the Chimpanzee Proximal Femur [Master's thesis]. University of Utah; August 2010.
2015	Ng AH-M. A Mouse Model of Adynamic Bone Disease (ABD) and Its Consequences on Bone Quality With Age [PhD thesis]. University of Toronto; 2015.
2018	Zhang L. Effects of Osteoblast-Specific Gα_S Overexpression on Skeletal Development and Response to Catabolic and Anabolic Stimuli Using a Transgenic Mouse Model [PhD thesis]. University of Toronto; 2018.
2012	Banglmaier RF. Enhancing the Mechanical Properties of a Hydroxyapatite-Collagen Bone Surrogate [PhD thesis]. Detroit, MI: Wayne State University; August 2012.

Year	Entry
1996	Jepsen KJ, Goldstein SA, Kuhn JL, Schaffler MB, Bonadio J. Type‐I collagen mutation compromises the post‐yield behavior of Mov13 long bone. J Orthop Res. May 1996;14(3):493-499.
2000	McCreadie BR, Goldstein SA. Biomechanics of fracture: is bone mineral density sufficient to assess risk? J Bone Miner Res. December 2000;15(12):2305-2308.
1970	Timoshenko SP, Goodier JN. Theory of Elasticity. 3rd ed. New York, NY: McGraw-Hill Book Co; 1970.
2000	Akhter MP, Iwaniec UT, Covey MA, Cullen DM, Kimmel DB, Recker RR. Genetic variations in bone density, histomorphometry, and strength in mice. Calcif Tiss Int. October 2000;67(4):337-344.
1999	Boskey AL, Wright TM, Blank RD. Collagen and bone strength. J Bone Miner Res. March 1999;14(3):330-335.
1982	Rubin CT, Lanyon LE. Limb mechanics as a function of speed and gait: a study of functional strains in the radius and tibia of horse and dog. J Exp Biol. December 1982;101:187-211.
1996	Beamer WG, Donahue LR, Rosen CJ, Baylink DJ. Genetic variability in adult bone density among inbred strains of mice. Bone. May 1996;18(5):397-403.
1999	Brodt MD, Ellis CB, Silva MJ. Growing C57Bl/6 mice increase whole bone mechanical properties by increasing geometric and material properties. J Bone Miner Res. December 1999;14(12):2159-2166.
1990	Bonadio J, Saunders TL, Tsai E, Goldstein SA, Morris-Wiman J, Brinkley L, Dolan DF, Altschuler RA, Hawkins JE Jr, Bateman JF, Mascara T, Jaenisch R. Transgenic mouse model of the mild dominant form of osteogenesis imperfecta. Proc Natl Acad Sci USA. September 1990;87(18):7145-7149.
1997	Jepsen KJ, Schaffler MB, Kuhn JL, Goulet RW, Bonadio J, Goldstein SA. Type I collagen mutation alters the strength and fatigue behavior of Mov13 cortical tissue. J Biomech. November–December 1997;30(11-12):1141-1147.
1993	van der Meulen MCH, Beaupré GS, Carter DR. Mechanobiologic influences in long bone cross-sectional growth. Bone. July–August 1993;14(4):635-642.
1998	Akhter MP, Cullen DM, Pedersen EA, Kimmel DB, Recker RR. Bone response to in vivo mechanical loading in two breeds of mice. Calcif Tiss Int. November 1998;63(5):442-449.
2000	Turner CH, Hsieh Y, Müller R, Bouxsein ML, Baylink DJ, Rosen CJ, Grynpas MD, Donahue LR, Beamer WG. Genetic regulation of cortical and trabecular bone strength and microstructure in inbred strains of mice. J Bone Miner Res. June 2000;15(6):1126-1131.
1993	Bonadio J, Jepsen KJ, Mansoura MK, Jaenisch R, Kuhn JL, Goldstein SA. A murine skeletal adaptation that significantly increases cortical bone mechanical properties: implications for human skeletal fragility. J Clin Invest. October 1993;92(4):1697-1705.
1993	Keaveny TM, Hayes WC. A 20-year perspective on the mechanical properties of trabecular bone. J Biomech Eng. November 1993;115(4B):534-542.
1993	Turner CH, Burr DB. Basic biomechanical measurements of bone: a tutorial. Bone. 1993;14(4):595-608.