Age and disease-related changes in the mineral of bone

Grynpas, M.<sup>1,2</sup>

Year	Entry
2021	Gamsjaeger S, Fratzl P, Paschalis EP. Interplay between mineral crystallinity and mineral accumulation in health and postmenopausal osteoporosis. Acta Biomater. April 2021;124:374.
2002	Banse X. When density fails to predict bone strength. Acta Orthop Scand. 2002;73(2)(suppl 303):2-57.
1995	Boyde A, Jones SJ, Aerssens J, Dequeker J. Mineral density quantitation of the human cortical iliac crest by backscattered electron image analysis: variations with age, sex, and degree of osteoarthritis. Bone. June 1995;16(6):619-627.
1997	Roschger P, Fratzl P, Klaushofer K, Rodan G. Mineralization of cancellous bone after alendronate and sodium fluoride treatment: a quantitative backscattered electron imaging study on minipig ribs. Bone. May 1997;20(5):393-397.
1997	Meunier PJ, Boivin G. Bone mineral density reflects bone mass but also the degree of mineralization of bone: therapeutic implications. Bone. November 1997;21(5):373-377.
1998	Boyde A, Compston JE, Reeve J, Bell KL, Noble BS, Jones SJ, Loveridge N. Effect of estrogen suppression on the mineralization density of iliac crest biopsies in young women as assessed by backscattered electron imaging. Bone. March 1998;22(3):241-250.
2000	Boivin GY, Chavassieux PM, Santora AC, Yates J, Meunier PJ. Alendronate increases bone strength by increasing the mean degree of mineralization of bone tissue in osteoporotic women. Bone. November 2000;27(5):687-694.
2002	Burr DB. The contribution of the organic matrix to bone's material properties. Bone. July 2002;31(1):8-11.
2003	Ciarelli TE, Fyhrie DP, Parfitt AM. Effects of vertebral bone fragility and bone formation rate on the mineralization levels of cancellous bone from white females. Bone. March 2003;32(3):311-315.
2006	McCreadie BR, Morris MD, Chen T-c, Rao DS, Finney WF, Widjaja E, Goldstein SA. Bone tissue compositional differences in women with and without osteoporotic fracture. Bone. December 2006;39(6):1190-1195.
2007	Ruffoni D, Fratzl P, Roschger P, Klaushofer K, Weinkamer R. The bone mineralization density distribution as a fingerprint of the mineralization process. Bone. May 2007;40(5):1308-1319.
2008	Yerramshetty JS, Akkus O. The associations between mineral crystallinity and the mechanical properties of human cortical bone. Bone. March 2008;42(3):476-482.
2009	Busse B, Hahn M, Soltau M, Zustin J, Püschel K, Duda GN, Amling M. Increased calcium content and inhomogeneity of mineralization render bone toughness in osteoporosis: mineralization, morphology and biomechanics of human single trabeculae. Bone. December 2009;45(6):1034-1043.
2010	Bala Y, Farlay D, Delmas PD, Meunier PJ, Boivin G. Time sequence of secondary mineralization and microhardness in cortical and cancellous bone from ewes. Bone. April 2010;46(4):1204-1212.
2018	Milovanovic P, vom Scheidt A, Mletzko K, Sarau G, Püschel K, Djuric M, Amling M, Christiansen S, Busse B. Bone tissue aging affects mineralization of cement lines. Bone. May 2018;110:187-193.
2020	Rajapakse CS, Farid AR, Kargilis DC, Jones BC, Lee JS, Johncola AJ, Batzdorf AS, Shetye SS, Hast MW, Chang G. MRI-based assessment of proximal femur strength compared to mechanical testing. Bone. April 2020;133:115227.
2020	Rezaee T, Bouxsein ML, Karim L. Increasing fluoride content deteriorates rat bone mechanical properties. Bone. July 2020;136:115369.
1993	Parfitt AM. Bone age, mineral density, and fatigue damage. Calcif Tiss Int. February 1993;53(suppl 1):S82-S86.
1996	Paschalis EP, DiCarlo E, Betts F, Sherman P, Mendelsohn R, Boskey AL. FTIR microspectroscopic analysis of human osteonal bone. Calcif Tiss Int. December 1996;59(6):480-487.
1997	Paschalis EP, Betts F, DiCarlo E, Mendelsohn R, Boskey AL. FTIR microspectroscopic analysis of normal human cortical and trabecular bone. Calcif Tiss Int. December 1997;61(6):480-486.
1999	Rinnerthaler S, Roschger P, Jakob HF, Nader A, Klaushofer K, Fratzl P. Scanning small angle X-ray scattering analysis of human bone sections. Calcif Tiss Int. May 1999;64(5):422-429.
2002	Boivin G, Meunier PJ. The degree of mineralization of bone tissue measured by computerized quantitative contact microradiography. Calcif Tiss Int. June 2002;70(6):503-511.
2005	Busa B, Miller LM, Rubin CT, Qin Y-X, Judex S. Rapid establishment of chemical and mechanical properties during lamellar bone formation. Calcif Tiss Int. December 2005;77(6):386-394.
2006	Saito M, Fujii K, Marumo K. Degree of mineralization-related collagen crosslinking in the femoral neck cancellous bone in cases of hip fracture and controls. Calcif Tiss Int. September 2006;79(3):160-168.
2003	Judex S, Boyd S, Qin Y-X, Miller L, Müller R, Rubin C. Combining high-resolution micro-computed tomography with material composition to define the quality of bone tissue. Curr Osteoporos Rep. June 2003;1(1):11-19.
2020	Wang M, Li S, vom Scheidt A, Qwamizadeh M, Busse B, Silberschmidt VV. Numerical study of crack initiation and growth in human cortical bone: effect of micro-morphology. Eng Fract Mech. June 1, 2020;232:107051.
2006	Zioupos P, Kaffy C, Currey JD. Tissue heterogeneity, composite architecture and fractal dimension effects in the fracture of ageing human bone. Int J Fract. June 2006;139(3-4):407-424.
2001	Zioupos P. Ageing human bone: factors affecting its biomechanical properties and the role of collagen. J Biomater Appl. January 2001;15(3):187-229.
2001	van der Linden JC, Birkenhäger-Frenkel DH, Verhaar JAN, Weinans H. Trabecular bone's mechanical properties are affected by its non-uniform mineral distribution. J Biomech. December 2001;34(12):1573-1580.
2002	Rho JY, Zioupos P, Currey JD, Pharr GM. Microstructural elasticity and regional heterogeneity in human femoral bone of various ages examined by nano-indentation. J Biomech. February 2002;35(2):189-198.
2002	Jaasma MJ, Bayraktar HH, Niebur GL, Keaveny TM. Biomechanical effects of intraspecimen variations in tissue modulus for trabecular bone. J Biomech. 2002;35(2):237-246.
2011	Feng L, Jasiuk I. Multi-scale characterization of swine femoral cortical bone. J Biomech. January 11, 2011;44(2):313-320.
2011	Brennan O, Kennedy OD, Lee TC, Rackard SM, O’Brien FJ, McNamara LM. The effects of estrogen deficiency and bisphosphonate treatment on tissue mineralisation and stiffness in an ovine model of osteoporosis. J Biomech. February 3, 2011;44(3):386-390.
1996	Hangartner TN, Gilsanz V. Evaluation of cortical bone by computed tomography. J Bone Miner Res. October 1996;11(10):1518-1525.
2000	McCreadie BR, Goldstein SA. Biomechanics of fracture: is bone mineral density sufficient to assess risk? J Bone Miner Res. December 2000;15(12):2305-2308.
2003	Akkus O, Polyakova‐Akkus A, Adar F, Schaffler MB. Aging of microstructural compartments in human compact bone. J Bone Miner Res. June 2003;18(6):1012-1019.
2004	Fernández-Seara MA, Wehrli SL, Takahashi M, Wehrli FW. Water content measured by proton-deuteron exchange NMR predicts bone mineral density and mechanical properties. J Bone Miner Res. February 2004;19(2):289-296.
2010	Boskey AL, Coleman R. Aging and bone. J Dent Res. December 2010;89(2):1333-1348.
2016	Wen X-X, Xua C, Zong C-L, Feng Y-F, Ma X-Y, Wang F-Q, Yan Y-B, Lei W. Relationship between sample volumes and modulus of human vertebral trabecular bone in micro-finite element analysis. J Mech Behav Biomed Mater. July 2016;60:468-475.
2022	Shaffer SK, Garcia TC, Stover SM, Fyhrie DP. Exercise history predicts focal differences in bone volume fraction, mineral density and microdamage in the proximal sesamoid bones of thoroughbred racehorses. J Orthop Res. December 2022;40(12):2831-2842.
2023	Konow T, Schlieker PJ, Lampe F, Ondruschka B, Morlock MM, Huber G. Influence of bone morphology and femur preparation method on the primary stability of hip revision stems. J Orthop Res. June 2023;41(6):1283-1290.
2001	Roschger P, Grabner BM, Rinnerthaler S, Tesch W, Kneissel M, Berzlanovich A, Klaushofer K, Fratzl P. Structural development of the mineralized tissue in the human L4 vertebral body. J Struct Biol. November 2001;136(2):126-136.
2008	Fuchs RK, Allen MR, Ruppel ME, Diab T, Phipps RJ, Miller LM, Burr DB. In situ examination of the time-course for secondary mineralization of Haversian bone using synchrotron Fourier transform infrared microspectroscopy. Matrix Biol. January 2008;27(1):34-41.
2002	Nuzzo S, Peyrin F, Cloetens P, Baruchel J, Boivin G. Quantification of the degree of mineralization of bone in three dimensions using synchrotron radiation microtomography. Med Phys. November 2002;29(11):2672-2681.
2005	Nyman JS, Reyes M, Wang X. Effect of ultrastructural changes on the toughness of bone. Micron. October–December 2005;36(7-8):566-582.
1996	Boyde A, Jones SJ. Scanning electron microscopy of bone: instrument, specimen, and issues. Microsc Res Tech. February 1, 1996;33(2):92-120.
2003	Boskey A. Bone mineral crystal size. Osteoporos Int. September 2003;14(suppl 5):S16-S20.
2009	Slyfield CR Jr. Automated Sub-Micron Resolution Serial Block Face Imaging of Cancellous Bone Using Epifluorescence Microscopy [Master's thesis]. Cleveland, OH: Case Western Reserve University; January 2009.
2017	Yu Y. Contributions of Anisotropic and Heterogeneous Tissue Modulus to Apparent Trabecular Bone Mechanical Properties [PhD thesis]. New York, NY: Columbia University; 2017.
2007	Cole JH. The Role of Architecture and Tissue Properties in the Structural Integrity of Human Vertebral Cancellous Bone [PhD thesis]. Ithaca, NY: Cornell University; May 2007.
2013	Burket JC. Alterations in Tissue Composition and Nanomechanical Properties With Ageing, Osteoporosis, and Treatment [PhD thesis]. Ithaca, NY: Cornell University; January 2013.
2013	Kim G. The Effects of Mineralization and Crystallinity on the Mechanical Behavior of Bone [PhD thesis]. Ithaca, NY: Cornell University; May 2013.
2006	Nagaraja S. Microstructural Stresses and Strains Associated With Trabecular Bone Microdamage [PhD thesis]. Atlanta, GA: Georgia Institute of Technology; December 2006.
2010	Feng L. Multi-Scale Characterization of Swine Femoral Cortical Bone and Long Bone Defect Repair by Regeneration [PhD thesis]. University of Illinois at Urbana-Champaign; 2010.
2015	Rodriguez-Florez N. Mechanics of Cortical Bone: Exploring the Micro- and Nano-Scale [PhD thesis]. Imperial College London; January 2015.
2020	Lamarche BA. Morphometric Changes With Age in Human Trabecular Bone Structural Units (BSU) of the Lumbar Spine [Master's thesis]. Sudbury, ON: Laurentian University; 2020.
2022	Rahovich P. Effects of Bone Structural Unit (BSU) Geometry and Material Properties on Crack Growth Through Idealized Trabecular Microstructures [Master's thesis]. Sudbury, ON: Laurentian University; 2022.
2002	Egerer AK. The Relationship Between the Osteonal Cement Line and Bone Strength [PhD thesis]. Loma Linda University; June 2002.
2001	Arthur Moore TL. Microdamage Accumulation in Bovine Trabecular Bone [PhD thesis]. Cambridge, MA: Massachusetts Institute of Technology; June 2001.
2011	Wu Z. Measures of Bone Quality and Their Relationship to Bone Mechanical Properties [PhD thesis]. University of Notre Dame; December 2011.
2012	Jimenez Palomar I. Mechanical Properties of Bone At the Sub-lamellar Level [PhD thesis]. London, England: Queen Mary University of London; September 2012.
2005	George WT. Multiaxial Fracture Characteristics of Aging Human Bone [PhD thesis]. Troy, NY: Rensselaer Polytechnic Institute; April 2005.
2006	Diab T. The Role of Damage Morphology in Age-Related Increase in Bone Fragility [PhD thesis]. Troy, NY: Rensselaer Polytechnic Institute; 2006.
2012	Brennan MA. Close to the Bone: Investigations Into Bone Tissue Mineralisation and Mechanobiology of Osteoporosis [PhD thesis]. University of Southampton; January 2012.
2021	Shaffer SK. High-Speed Exercise and Fetlock Kinematics Affect the Development of Stress-Reactions in Racehorse Proximal Sesamoid Bones [PhD thesis]. Davis, University of California; 2021.
2022	Rezaee T. Effect of Clinically Relevant Alterations of Mineral and Protein on Bone Biomechanics [PhD thesis]. University of Massachusetts at Dartmouth; May 2022.
1998	Ciarelli TE. Architectural and Material Contributions to Fracture of the Spine and Proximal Femur [PhD thesis]. University of Michigan; 1998.
2000	McCreadie BR. Structural and Material Changes in Osteoporosis: Their Impact on the Mechanical Environment of the Osteocyte [PhD thesis]. University of Michigan; 2000.
2003	Rajachar RM. Effects of Age -Related Ultra-Structural Level Changes in Bone on Microdamage Mechanisms [PhD thesis]. University of Michigan; 2003.
2009	Sahar ND. Investigating the Effects of Age and Exercise on Bone Composition and the Impact of Composition on Mechanical Integrity. [PhD thesis]. University of Michigan; 2009.
2015	Lin C-L. A Study of Human and Bovine Trabecular Bones Using Nanoindentation and Quantitative Backscattered Electron Imaging [PhD thesis]. Brisbane, Australia: University of Queensland; 2015.
2016	Lin C-l. A Study of Human and Bovine Trabecular Bones Using Nanoindentation and Quantitative Backscattered Electron Imaging [PhD thesis]. Brisbane, Australia: University of Queensland; 2016.
1998	Vajda EG. Age-Related Changes in the Microstructure and Mineralization of the Female Proximal Femur [PhD thesis]. University of Utah; March 1998.
2007	Rosenbaum TG. Effects of a Femoral Component and Patient Factors on Periprosthetic Cortical Bone [PhD thesis]. University of Utah; May 2007.
2010	Beckstrom AB. Histologic and Geometric Data Challenge the Assumption of Habitual Superior-Inferior (tension-Compression) Bending Across the Chimpanzee Proximal Femur [Master's thesis]. University of Utah; August 2010.
2010	Kyle KA. Differential Effects of PPAR-Γ Activation Vs. Chemical or Genetic Reduction of DPP-4 Activity on Murine Bone Quality [Master's thesis]. University of Toronto; 2010.
2010	Magalhaes JKRS. The Role of Rac1 and Rac2 in Determining Bone Quality in Aged and Osteoporotic Female Mouse Models [Master's thesis]. University of Toronto; 2010.
2010	Wynnyckyj C. The Consequences of Collagen Degradation on Bone Mechanical Properties [PhD thesis]. University of Toronto; 2010.
2013	Liu CC. Effects of a New Conjugate Drug in a Rat Model of Postmenopausal Osteoporosis [Master's thesis]. University of Toronto; 2013.
2015	Ng AH-M. A Mouse Model of Adynamic Bone Disease (ABD) and Its Consequences on Bone Quality With Age [PhD thesis]. University of Toronto; 2015.
2019	Clement A. Image Based and Biomechanical Characterization of Osteoblastic Vertebral Metastases [Master's thesis]. University of Toronto; 2019.
2010	Reyes MJ. Age-Related Influence of Bone Remodeling on Local Tissue Properties of Human Cortical Bone [PhD thesis]. San Antionio, TX: University of Texas at San Antonio; December 2010.
2011	Islam A. Mechanistic Model of Nanoscratch Test to Determine the in Situ Toughness of Bone [Master's thesis]. San Antionio, TX: University of Texas at San Antonio; May 2011.
1998	Yeni YN. Fracture Mechanics of Human Cortical Bone: The Relationship of Geometry, Microstructure and Composition With the Fracture of the Tibia, Femoral Shaft and the Femoral Neck [PhD thesis]. Morgantown, WV: West Virginia University; 1998.

Year	Entry
1983	Bonar LC, Roufosse AH, Sabine WK, Grynpas MD, Glimcher MJ. X-ray diffraction studies of the crystallinity of bone mineral in newly synthesized and density fractionated bone. Calcif Tiss Int. December 1983;35(2):202-209.
1982	Riggs BL, Wahner HW, Seeman E, Offord KP, Dunn WL, Mazess RB, Johnson KA, Melton LJ III. Changes in bone mineral density of the proximal femur and spine with aging: differences between the postmenopausal and senile osteoporosis syndromes. J Clin Invest. October 1982;70(4):716-723.
1952	Amprino R, Engström A. Studies on x-ray absorption and diffraction of bone tissue. Acta Anat. 1952;15(1-2):1-22.
1990	Boyce TM, Bloebaum RD, Bachus KN, Skedros JG. Reproducible methods for calibrating the backscattered electron signal for quantitative assessment of mineral content in bone. Scanning Microsc. September 1990;4(3):591-600.
1978	Uhthoff HK, Jaworski ZF. Bone loss in response to long-term immobilisation. J Bone Joint Surg. August 1978;60B(3):420-429.
1952	Robinson RA. An electron-microscopic study of the crystalline inorganic component of bone and its relationship to the organic matrix. J Bone Joint Surg. April 1952;34A(2):389-435, 476.
1982	Riggs BL, Seeman E, Hodgson SF, Taves DR, O'Fallon WM. Effect of the fluoride/calcium regimen on vertebral fracture occurrence in postmenopausal osteoporosis: comparison with conventional therapy. NEJM. February 25, 1982;306(8):446-450.
1982	Mazess RB. On aging bone loss. Clin Orthop Relat Res. May 1982;165:239-252.
1983	Laval-Jeantet A-M, Bergot C, Carroll R, Garcia-Schaefer F. Cortical bone senescence and mineral bone density of the humerus. Calcif Tiss Int. 1983;35(3):268-272.
1980	Martin RB, Pickett JC, Zinaich S. Studies of skeletal remodeling in aging men. Clin Orthop Relat Res. June 1980;149:268-282.
1989	Melton LJ III, Kan SH, Frye MA, Wahner HW, O'Fallon WM, Riggs BL. Epidemiology of vertebral fractures in women. Am J Epidemiol. May 1989;129(5):1000-1011.
1987	Reid SA, Boyde A. Changes in the mineral density distribution in human bone with age: image analysis using backscattered electrons in the SEM. J Bone Miner Res. February 1987;2(1):13-22.
1983	Boyde A, Jones SJ. Back-scattered electron imaging of skeletal tissues. Metab Bone Dis Rel Res. 1983;5(3):145-150.
1985	Frost HM. The pathomechanics of osteoporoses. Clin Orthop Relat Res. November 1985;200:198-225.
1980	Thompson DD. Age changes in bone mineralization, cortical thickness, and Haversian canal area. Calcif Tiss Int. December 1980;31(1):5-11.