Prediction of vertebral strength by dual photon absorptiometry and quantitative computed tomography

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Eriksson, Staffan A. V.¹; Isberg, Bengt O.²; Lindgren, J. Urban¹

Prediction of vertebral strength by dual photon absorptiometry and quantitative computed tomography

Calcif Tiss Int. April 1989;44(4):243-250

©1989 Springer-Verlag New York Inc.

Affiliations

¹Department of Orthopaedic Surgery, Karolinska Institute, Huddinge University Hospital, Huddinge, Sweden

²Department of Diagnostic Radiology, Karolinska Institute, Huddinge University Hospital, Huddinge, Sweden
Abstract and keywords

We measured the lumbar bone mineral of 19 cadavers (10 women, 9 men) by dual photon absorptiometry (DPA) and quantitative computed tomography (QCT). In addition, we determined the ultimate load and stress of each vertebra, and finally ash content and volumetric ash density of the vertebral body. We found that single energy QCT was inferior to DPA and dual energy QCT in the prediction of the ultimate load or stress of vertebrae (P<0.001). The ultimate stress of predicted by using the dual energy QCT results (r=0.71; SEE=36.3 N/cm²) whereas the ultimate vertebral load was best predicted by using the DPA (BMC) results (r=0.80; SEE=740 N). If the QCT finding was multiplied with the surface area of the vertebral body it could be used to predict the ultimate load with good accuracy (r=0.74; SEE=841 N). All the above correlations were higher in women than in men. The frequency of vertebral compression fractures in the material was wel correlated with the bone mineral findings. A nonlinear (third degree) relationship between mineral content and mechanical characteristics is proposed but within the area of measurement used in clinical practice a linear (first degree) equation is preferred.

Keywords: Lumbar bone mineral content; Quantitative computed tomography; Dual photon absorptiometry; Load and stress
Links

DOI: 10.1007/BF02553758

PubMed: 2501006

WoS: A1989U078500002
History

Received: 1987-07-31

Revised: 1988-05-27

Cited Works (11)

Year	Entry
1986	Riggs BL, Melton LJ III. Involutional osteoporosis. NEJM. June 26, 1986;314(26):1676-1686.
1985	Cann CE, Genant HK, Kolb FO, Ettinger B. Quantitative computed tomography for prediction of vertebral fracture risk. Bone. 1985;6(1):1-7.
1954	Hirsch C, Nachemson A. New observations on the mechanical behavior of lumbar discs. Acta Orthop Scand. 1954;23(4):254-283.
1980	Cann CE, Genant HK. Precise measurement of vertebral mineral content using computed tomography. J Comput Assist Tomogr. 1980;4(4):493-500.
1980	Hansson T, Roos B, Nachemson A. The bone mineral content and ultimate compressive strength of lumbar vertebrae. Spine. January–February 1980;5(1):46-55.
1969	Rockoff SD, Sweet E, Bleustein J. The relative contribution of trabecular and cortical bone to the strength of human lumbar vertebrae. Calcif Tiss Res. December 1969;3(1):163-175.
1977	Kazarian L, Graves GA Jr. Compressive strength characteristics of the human vertebral centrum. Spine. March 1977;2(1):1-14.
1967	Bell GH, Dunbar O, Beck JS, Gibb A. Variations in strength of vertebrae with age and their relation to osteoporosis. Calcif Tiss Res. 1967;1(1):75-86.
1970	Galante J, Rostoker W, Ray RD. Physical properties of trabecular bone. Calcif Tiss Res. 1970;5(1):236-246.
1957	Perey O. Fracture of the vertebral end-plate in the lumbar spine: an experimental biomechanical investigation. Acta Orthop Scand. 1957;28(suppl 25):1-101.
1985	McBroom RJ, Hayes WC, Edwards WT, Goldberg RP, White AA III. Prediction of vertebral body compressive fracture using quantitative computed tomography. J Bone Joint Surg. 1985;67A(8):1206-1214.

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Year	Entry
2001	Villarraga ML, Ford CM. Applications of bone mechanics. In: Cowin SC, ed. Bone Mechanics Handbook. 2nd ed. Boca Raton, FL: CRC Press; 2001:33-1–33-33.
1995	Singer K, Edmondston S, Day R, Breidahl P, Price R. Prediction of thoracic and lumbar vertebral body compressive strength: correlations with bone mineral density and vertebral region. Bone. August 1995;17(2):167-174.
1999	Ebbesen EN, Thomsen JS, Beck-Nielsen H, Nepper-Rasmussen HJ, Mosekilde L. Lumbar vertebral body compressive strength evaluated by dual-energy X-ray absorptiometry, quantitative computed tomography, and ashing. Bone. December 1999;25(6):713-724.
2007	Buckley JM, Loo K, Motherway J. Comparison of quantitative computed tomography-based measures in predicting vertebral compressive strength. Bone. March 2007;40(3):767-774.
2007	Eswaran SK, Gupta A, Keaveny TM. Locations of bone tissue at high risk of initial failure during compressive loading of the human vertebral body. Bone. October 2007;41(4):733-739.
2020	Harris D, Garrett K, Uppuganti S, Creecy A, Nyman JS. The BALB/c mouse as a preclinical model of the age-related deterioration in the lumbar vertebra. Bone. August 2020;137:115438.
1990	Mazess RB. Fracture risk: a role for compact bone. Calcif Tiss Int. October 1990;47(4):191-193.
1993	Snyder BD, Piazza S, Edwards WT, Hayes WC. Role of trabecular morphology in the etiology of age-related vertebral fractures. Calcif Tiss Int. February 1993;53(suppl 1):S14-S22.
1993	Flynn MJ, Cody DD. The assessment of vertebral bone macroarchitecture with x-ray computed tomography. Calcif Tiss Int. February 1993;53(suppl 1):S170-S175.
2000	Akhter MP, Iwaniec UT, Covey MA, Cullen DM, Kimmel DB, Recker RR. Genetic variations in bone density, histomorphometry, and strength in mice. Calcif Tiss Int. October 2000;67(4):337-344.
1995	McCubbrey DA, Cody DD, Peterson EL, Kuhn JL, Flynn MJ, Goldstein SA. Static and fatigue failure properties of thoracic and lumbar vertebral bodies and their relation to regional density. J Biomech. August 1995;28(8):891-899.
2009	Eswaran SK, Bevill G, Nagarathnam P, Allen MR, Burr DB, Keaveny TM. Effects of suppression of bone turnover on cortical and trabecular load sharing in the canine vertebral body. J Biomech. March 11, 2009;42(4):517-523.
1997	Cheng XG, Nicholson PHF, Boonen S, Lowet G, Brys P, Aerssens J, van der Perre G, Dequeker J. Prediction of vertebral strength in vitro by spinal bone densitometry and calcaneal ultrasound. J Bone Miner Res. October 1997;12(10):1721-1728.
2000	McCreadie BR, Goldstein SA. Biomechanics of fracture: is bone mineral density sufficient to assess risk? J Bone Miner Res. December 2000;15(12):2305-2308.
2007	Keaveny TM, Donley DW, Hoffmann PF, Mitlak BH, Glass EV, San Martin JA. Effects of teriparatide and alendronate on vertebral strength as assessed by finite element modeling of qct scans in women with osteoporosis. J Bone Miner Res. January 2007;22(1):149-157.
2009	Fields AJ, Eswaran SK, Jekir MG, Keaveny TM. Role of trabecular microarchitecture in whole‐vertebral body biomechanical behavior. J Bone Miner Res. September 2009;24(9):1523-1530.
2008	Engelke K, Adams JE, Armbrecht G, Augat P, Bogado CE, Bouxsein ML, Felsenberg D, Ito M, Prevrhal S, Hans DB, Lewiecki EM. Clinical use of quantitative computed tomography and peripheral quantitative computed tomography in the management of osteoporosis in adults: the 2007 ISCD official positions. J Clin Densitom. January–March 2008;11(1):123-162.
1993	Dempster DW, Ferguson-Pell MW, Mellish RWE, Cochran GVB, Xie F, Fey C, Horbert W, Parisien M, Lindsay R. Relationships between bone structure in the iliac crest and bone structure and strength in the lumbar spine. Osteoporos Int. March 1993;3(2):90-96.
1991	Faulkner KG, Cann CE, Hasegawa BH. Effect of bone distribution on vertebral strength: assessment with patient-specific nonlinear finite element analysis. Radiology. June 1991;179(3):669-674.
2004	Crawford RP, Keaveny TM. Relationship between axial and bending behaviors of the human thoracolumbar vertebra. Spine. October 15, 2004;29(20):2248-2255.
1999	Schaffner G. Assessment of Hip Fracture Risk in Astronauts Exposed to Long-Term Weightlessness [PhD thesis]. Cambridge, MA: Massachusetts Institute of Technology; August 1999.
2011	Wagnac É. Expérimentation et modélisation détaillée de la colonne vertébrale pour étudier le rôle de facteurs anatomiques et biomécaniques sur les traumatismes rachidiens [PhD thesis]. École polytechnique de Montréal; November 2011.
2010	Fields AJ. Trabecular Microarchitecture, Endplate Failure, and the Biomechanics of Human Vertebral Fractures [PhD thesis]. Berkeley, CA: Berkeley, University of California; 2010.
1993	Goulet RW. The Quantification of the Structure and Mechanical Properties of Trabecular Bone [PhD thesis]. University of Michigan; 1993.
1993	McCubbrey DA. The Macroscopic Architectural Properties of Vertebral Trabecular Bone and Their Relation to Whole Vertebral Failure Loads [PhD thesis]. University of Michigan; 1993.
2011	Howarth SJ. Mechanical Response of the Porcine Cervical Spine to Acute and Repetitive Anterior-Posterior Shear [PhD thesis]. University of Waterloo; 2011.