Correlation of mechanical properties of vertebral trabecular bone with equivalent mineral density as measured by computed tomography

wbldb

Lang, S. M.¹; Moyle, D. D.¹; Berg, E. W.¹; Detorie, N.¹; Gilpin, A. T.¹; Pappas, Jr, N. J.¹; Reynolds, J. C.¹; Tkacik, M.¹; Waldron, II, R. L.¹

Correlation of mechanical properties of vertebral trabecular bone with equivalent mineral density as measured by computed tomography

J Bone Joint Surg. December 1988;70A(10):1531-1538

©1988 The Journal of Bone and Joint Surgery, Incorporated

Affiliations

¹

²

³
Abstract and keywords

We tried to determine whether mineral-equivalent measurements that were obtained using computed tomography could be used to predict the mechanical properties of vertebral trabecular bone. Vertebral bodies that had been obtained during routine autopsy were evaluated by computed tomography. The mechanical properties of the vertebral trabecular bone were determined by subjecting cylindrical specimens to simple compression until failure occurred. The ultimate strength and elastic modulus were determined from load time curves, using constant displacement rate loading. Atomic absorption spectrophotometry was used to determine the weight per cent calcium of each specimen, and quantitative light microscopy was used to determine area fraction bone. Significant positive correlations were found between the observed mechanical properties of the trabecular bone and the equivalent mineral density as measured by computed tomography. Compressive strength (r = 0.720), elastic modulus (r = 0.574), trabecular calcium density (r = 0.780), and area fraction bone (r = 0.579) were all correlated with the equivalent mineral density.

Keywords:
Links

DOI: 10.2106/00004623-198870100-00013

PubMed: 3198678

WoS: A1988R568400013

Cited By (34)

Year	Entry
2001	Villarraga ML, Ford CM. Applications of bone mechanics. In: Cowin SC, ed. Bone Mechanics Handbook. 2nd ed. Boca Raton, FL: CRC Press; 2001:33-1–33-33.
2001	Kaufman JJ, Siffert RS. Noninvasive measurement of bone integrity. In: Cowin SC, ed. Bone Mechanics Handbook. 2nd ed. Boca Raton, FL: CRC Press; 2001:34-1–34-25.
1990	Snyder BD, Hayes WC. Multiaxial structure-property relations in trabecular bone. In: Mow VC, Ratcliffe A, Woo SL-Y, eds. Biomechanics of Diarthrodial Joints. Vol 2. New York, NY: Springer-Verlag; 1990:31-59.
1996	Tannous RE, Bandak FA, Toridis TG, Eppinger RH. A three-dimensional finite element model of the human ankle: development and preliminary application to axial impulsive loading. In: Proceedings of the 40th Stapp Car Crash Conference. November 4-6, 1996; Albuquerque, NM. Warrendale, PA: Society of Automotive Engineers:219-238.219-238. SAE 962427.
2005	Williams JM, Adewunmi A, Schek RM, Flanagan CL, Krebsbach PH, Feinberg SE, Hollister SJ, Das S. Bone tissue engineering using polycaprolactone scaffolds fabricated via selective laser sintering. Biomaterials. August 2005;26(23):4817-4827.
1999	Ebbesen EN, Thomsen JS, Beck-Nielsen H, Nepper-Rasmussen HJ, Mosekilde L. Lumbar vertebral body compressive strength evaluated by dual-energy X-ray absorptiometry, quantitative computed tomography, and ashing. Bone. December 1999;25(6):713-724.
1993	Snyder BD, Piazza S, Edwards WT, Hayes WC. Role of trabecular morphology in the etiology of age-related vertebral fractures. Calcif Tiss Int. February 1993;53(suppl 1):S14-S22.
1993	Flynn MJ, Cody DD. The assessment of vertebral bone macroarchitecture with x-ray computed tomography. Calcif Tiss Int. February 1993;53(suppl 1):S170-S175.
1995	Moro M, Hecker AT, Bouxsein ML, Myers ER. Failure load of thoracic vertebrae correlates with lumbar bone mineral density measured by DXA. Calcif Tiss Int. March 1995;56(3):206-209.
2000	Lidke RH, Patel D, Muehleman C. Calcaneal bone mineral density and mechanical strength of the metatarsals. J Am Podiatr Med Assoc. October 2000;90(9):435-440.
1993	Dalstra M, Huiskes R, Odgaard A, van Erning L. Mechanical and textural properties of pelvic trabecular bone. J Biomech. April–May 1993;26(4-5):523-535.
1995	McCubbrey DA, Cody DD, Peterson EL, Kuhn JL, Flynn MJ, Goldstein SA. Static and fatigue failure properties of thoracic and lumbar vertebral bodies and their relation to regional density. J Biomech. August 1995;28(8):891-899.
2010	Cory E, Nazarian A, Entezari V, Vartanians V, Müller R, Snyder BD. Compressive axial mechanical properties of rat bone as functions of bone volume fraction, apparent density and micro-CT based mineral density. J Biomech. March 22, 2010;43(5):953-960.
1993	Keaveny TM, Hayes WC. A 20-year perspective on the mechanical properties of trabecular bone. J Biomech Eng. November 1993;115(4B):534-542.
1989	Esses SI, Lotz JC, Hayes WC. Biomechanical properties of the proximal femur determined in vitro by single‐energy quantitative computed tomography. J Bone Miner Res. October 1989;4(5):715-722.
1994	Myers BS, Arbogast KB, Lobaugh B, Harper KD, Richardson WJ, Drezner MK. Improved assessment of lumbar vertebral body strength using supine lateral dual‐energy X‐ray absorptiometry. J Bone Miner Res. May 1994;9(5):687-693.
1996	Augat P, Reeb H, Claes LE. Prediction of fracture load at different skeletal sites by geometric properties of the cortical shell. J Bone Miner Res. September 1996;11(9):1356-1363.
1997	Melton LJ III, Thamer M, Ray NF, Chan JK, Chesnut CH III, Einhorn TA, Johnston CC, Raisz LG, Silverman SL, Siris ES. Fractures attributable to osteoporosis: report from the National Osteoporosis Foundation. J Bone Miner Res. January 1997;12(1):16-23.
1998	Link TM, Majumdar S, Augat P, Lin JC, Newitt D, Lu Y, Lane NE, Genant HK. In vivo high resolution MRI of the calcaneus: differences in trabecular structure in osteoporosis patients. J Bone Miner Res. July 1998;13(7):1175-1182.
1998	Jiang Y, Zhao J, Augat P, Ouyang X, Lu Y, Majumdar S, Genant HK. Trabecular bone mineral and calculated structure of human bone specimens scanned by peripheral quantitative computed tomography: relation to biomechanical properties. J Bone Miner Res. November 1998;13(11):1783-1790.
2000	McCreadie BR, Goldstein SA. Biomechanics of fracture: is bone mineral density sufficient to assess risk? J Bone Miner Res. December 2000;15(12):2305-2308.
1990	Lotz JC, Gerhart TN, Hayes WC. Mechanical properties of trabecular bone from the proximal femur: a quantitative CT study. J Comput Assist Tomogr. January–February 1990;14(1):107-114.
2020	Fleps I, Bahaloo H, Zysset PK, Ferguson SJ, Pálsson H, Helgason B. Empirical relationships between bone density and ultimate strength: a literature review. J Mech Behav Biomed Mater. October 2020;110:103866.
2003	Ammann P, Rizzoli R. Bone strength and its determinants. Osteoporos Int. March 2003;14(suppl 3):S13-S18.
1991	Hayes WC, Piazza SJ, Zysset PK. Biomechanics of fracture risk prediction of the hip and spine by quantitative computed tomography. Radiol Clin North Am. 1991;29(1):1-18.
1998	Wehrli FW, Hwang SN, Ma J, Song HK, Ford JC, Haddad JG. Cancellous bone volume and structure in the forearm: noninvasive assessment with MR microimaging and image processing. Radiology. February 1998;206(2):347-357.
1991	Cody DD, Goldstein SA, Flynn MJ, Brown EB. Correlations between vertebral regional bone mineral density (rBMD) and whole bone fracture load. Spine. 1991;16(2):146-154.
1991	Edidin AA. Modeling of Bone Material Properties from CT Scans: Considerations in Biomechanical Structural Models [PhD thesis]. Ithaca, NY: Cornell University; May 1991.
1998	Kopperdahl DL. Structural Consequences of Damage on the Mechanical Behavior of the Human Vertebral Body [PhD thesis]. Berkeley, CA: Berkeley, University of California; 1998.
2002	Graham JH. Fracture Toughness Testing of the Trabecular Bone/acrylic Bone Cement Interface [PhD thesis]. Berkeley, CA: Berkeley, University of California; 2002.
2019	Sadoughi S. Micromechanics of Human Bone: Role of Architecture and Tissue Material Properties [PhD thesis]. Berkeley, CA: Berkeley, University of California; 2019.
1993	Goulet RW. The Quantification of the Structure and Mechanical Properties of Trabecular Bone [PhD thesis]. University of Michigan; 1993.
1993	McCubbrey DA. The Macroscopic Architectural Properties of Vertebral Trabecular Bone and Their Relation to Whole Vertebral Failure Loads [PhD thesis]. University of Michigan; 1993.
2019	Surowiec R. Novel Models to Image and Quantify Bone Drug Efficacy and Disease Progression in Vivo: Addressing the Fragility Phenotype [PhD thesis]. University of Michigan; 2019.