The relationship between bone density, mineral content, and mechanical strength in the femoral neck

Leichter, I.; Margulies, J. Y.; Weinreb, A.; Mizrahi, J.; Robin, G. C.; Conforty, B.; Makin, M.; Bloch, B.

Affiliations

¹The Division of Medical Physics, Racah Institute of Physics, Hebrew University, Jerusalem

²The Jerusalem Osteoporosis Center

³Biomechanics Laboratory, Loewenstein Hospital, Raanana

⁴Meir Hospital, Kfar Saba and Sackler Medical School, Tel-Aviv University

⁵Forensic Medicine Institute, Abu Kabir

Links

DOI: 10.1097/00003086-198203000-00041

PubMed: 7067262

WoS: A1982NE63000041

Ovid: 00003086-198203000-00041

History

Received: 1981-01-13

Cited Works (16)

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1976	Dalén N, Hellström L-G, Jacobson B. Bone mineral content and mechanical strength of the femoral neck. Acta Orthop Scand. 1976;47(5):503-508.
1976	Smith CB, Smith DA. Relations between age, mineral density and mechanical properties of human femoral compacta. Acta Orthop Scand. 1976;47(5):496-502.
1970	Singh M, Nagrath AR, Maini PS. Changes in trabecular pattern of the upper end of the femur as an index of osteoporosis. J Bone Joint Surg. April 1970;52A(3):457-467.
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Cited By (35)

Year	Entry
2001	Villarraga ML, Ford CM. Applications of bone mechanics. In: Cowin SC, ed. Bone Mechanics Handbook. 2nd ed. Boca Raton, FL: CRC Press; 2001:33-1–33-33.
1988	Melton LJ III, Chao EYS, Lane J. Biomechanical aspects of fractures. In: Riggs BL, Melton LJ III, eds. Osteoporosis: Etiology, Diagnosis, and Management. New York, NY: Raven Press; 1988:111-131.
1988	Mazess RB, Wahner HW. Nuclear medicine and densitometry. In: Riggs BL, Melton LJ III, eds. Osteoporosis: Etiology, Diagnosis, and Management. New York, NY: Raven Press; 1988:251-295.
1992	Myers ER, Greenspan SL, Hayes WC. Biomechanics of hip fracture risk. In: Proceedings of the 2nd Injury Prevention Through Biomechanics Symposium. April 10-11, 1992; Detroit, MI.41-46.
2000	Takahashi Y, Kikuchi Y, Konosu A, Ishikawa H. Development and validation of the finite element model for the human lower limb of pedestrians. Stapp Car Crash J. 2000;44:335-355. SAE 2000-01-SC22.
1997	Cheng XG, Lowet G, Boonen S, Nicholson PHF, Brys P, Nijs J, Dequeker J. Assessment of the strength of proximal femur in vitro: relationship to femoral bone mineral density and femoral geometry. Bone. March 1997;20(3):213-218.
1993	Myers ER, Hecker AT, Rooks DS, Hipp JA, Hayes WC. Geometric variables from DXA of the radius predict forearm fracture load in vitro. Calcif Tiss Int. March 1993;52(3):199-204.
1995	Bouxsein ML, Courtney AC, Hayes WC. Ultrasound and densitometry of the calcaneus correlate with the failure loads of cadaveric femurs. Calcif Tiss Int. February 1995;56(2):99-103.
1998	Aerssens J, Boonen S, Lowet G, Dequeker J. Interspecies differences in bone composition, density, and quality: potential implications for in vivo bone research. Endocrinology. February 1998;139(2):663-670.
1985	Hvid I, Jensen NC, Bünger C, Sølund K, Djurhuus JC. Bone mineral assay: its relation to the mechanical strength of cancellous bone. Eng Med. 1985;14(2):79-83.
1990	Beck TJ, Ruff CB, Warden KE, Scott wW Jr, Rao GU. Predicting femoral neck strength from bone mineral data: a structural approach. Invest Radiol. January 1990;25(1):6-18.
1984	Martin RB, Burr DB. Non-invasive measurement of long bone cross-sectional moment of inertia by photon absorptiometry. J Biomech. 1984;17(3):195-201.
2010	Cory E, Nazarian A, Entezari V, Vartanians V, Müller R, Snyder BD. Compressive axial mechanical properties of rat bone as functions of bone volume fraction, apparent density and micro-CT based mineral density. J Biomech. March 22, 2010;43(5):953-960.
1991	Lotz JC, Cheal EJ, Hayes WC. Fracture prediction for the proximal femur using finite element models, I: linear analysis. J Biomech Eng. 1991;113(4):353-360.
1991	Robinovitch SN, Hayes WC, McMahon TA. Prediction of femoral impact forces in falls on the hip. J Biomech Eng. November 1991;113(4):366-374.
1990	Lotz JC, Hayes WC. The use of quantitative computed tomography to estimate risk of fracture of the hip from falls. J Bone Joint Surg. June 1990;72A(5):689-700.
1995	Courtney AC, Wachtel EF, Myers ER, Hayes WC. Age-related reductions in the strength of the femur tested in a fall-loading configuration. J Bone Joint Surg. March 1995;77A(3):387-395.
1988	Mazess RB, Barden H, Ettinger M, Schultz E. Bone density of the radius, spine, and proximal femur in osteoporosis. J Bone Miner Res. February 1988;3(1):13-18.
2004	Eckstein F, Wunderer C, Boehm H, Kuhn V, Priemel M, Link TM, Lochmüller E-M. Reproducibility and side differences of mechanical tests for determining the structural strength of the proximal femur. J Bone Miner Res. March 2004;19(3):379-385.
1988	Melton LJ III, Kan SH, Wahner HW, Riggs BL. Lifetime fracture risk: an approach to hip fracture risk assessment based on bone mineral density and age. J Clin Epidemiol. 1988;41(10):985-994.
1997	Aerssens J, Boonen S, Joly J, Dequeker J. Variations in trabecular bone composition with anatomical site and age: potential implications for bone quality assessment. J Endocrinol. December 1997;155(3):411-421.
1995	Liberman UA, Weiss SR, Bröll J, Minne HW, Quan H, Bell NH, Rodriguez-Portales J, Downs RW Jr, Dequeker J, Favus M, Seeman E, Recker RR, Capizzi T, Santora AC, Lombardi A, Shah RV, Hirsch LJ, Karpf DB; Group, Alendronate Phase III Osteoporosis Treatment Study. Effect of oral alendronate on bone mineral density and the incidence of fractures in postmenopausal osteoporosis. NEJM. November 30, 1995;333(22):1437-1443.
2003	Ammann P, Rizzoli R. Bone strength and its determinants. Osteoporos Int. March 2003;14(suppl 3):S13-S18.
2020	Bouxsein ML, Zysset P, Glüer CC, McClung M, Biver E, Pierroz DD, Ferrari SL; IOF Working Group on Hip Bone Strength as a Therapeutic Target. Perspectives on the non-invasive evaluation of femoral strength in the assessment of hip fracture risk. Osteoporos Int. March 2020;31(3):393-408.
1991	Hayes WC, Piazza SJ, Zysset PK. Biomechanics of fracture risk prediction of the hip and spine by quantitative computed tomography. Radiol Clin North Am. 1991;29(1):1-18.
1991	Edidin AA. Modeling of Bone Material Properties from CT Scans: Considerations in Biomechanical Structural Models [PhD thesis]. Ithaca, NY: Cornell University; May 1991.
2008	Nazarian A. Relative Interaction of Material and Structure in Normal and Pathologic Bone [PhD thesis]. Swiss Federal Institute of Technology Zürich; 2008.
1994	Courtney AC. Mechanical Properties of the Proximal Femur: Changes With Age [PhD thesis]. Cambridge, MA: Harvard University; May 1994.
2002	Egerer AK. The Relationship Between the Osteonal Cement Line and Bone Strength [PhD thesis]. Loma Linda University; June 2002.
1988	Lotz JC. Hip Fracture Risk Predictions by X-Ray Computed Tomography [PhD thesis]. Cambridge, MA: Massachusetts Institute of Technology; August 1988.
1999	Schaffner G. Assessment of Hip Fracture Risk in Astronauts Exposed to Long-Term Weightlessness [PhD thesis]. Cambridge, MA: Massachusetts Institute of Technology; August 1999.
2019	Surowiec R. Novel Models to Image and Quantify Bone Drug Efficacy and Disease Progression in Vivo: Addressing the Fragility Phenotype [PhD thesis]. University of Michigan; 2019.
1998	Vajda EG. Age-Related Changes in the Microstructure and Mineralization of the Female Proximal Femur [PhD thesis]. University of Utah; March 1998.
2010	Kyle KA. Differential Effects of PPAR-Γ Activation Vs. Chemical or Genetic Reduction of DPP-4 Activity on Murine Bone Quality [Master's thesis]. University of Toronto; 2010.
2010	Magalhaes JKRS. The Role of Rac1 and Rac2 in Determining Bone Quality in Aged and Osteoporotic Female Mouse Models [Master's thesis]. University of Toronto; 2010.