Biomechanical computed tomography: noninvasive bone strength analysis using clinical computed tomography scans

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Keaveny, Tony M.¹

Biomechanical computed tomography: noninvasive bone strength analysis using clinical computed tomography scans

Annals NY Acad Sci. 2010;1192(1):57-65

©2010 New York Academy of Sciences

Affiliations

¹Departments of Mechanical Engineering and Bioengineering, University of California, Berkeley, California, USA
Abstract and keywords

The combination of finite element modeling, biomechanics, and clinical computed tomography (CT) scanning—biomechanical CT (BCT)—is a powerful research technique for noninvasive assessment of whole‐bone strength and is now being used in clinical research studies. Well supported by cadaver studies, the technique is providing substantial new insight into drug treatment effects, can show treatment effects earlier than dual‐energy X‐ray absorptiometry (DXA), and has shown greater sensitivity than DXA in fracture risk assessment. Because the technique can be used as an ancillary “add‐on” analysis to previously acquired CT scans containing either the hip or spine, it should be possible to implement this technology clinically in a highly cost‐effective manner. This strategy, if applied to those not previously tested by DXA, has the potential to greatly increase the number of individuals identified as being at high risk for osteoporotic fracture.

Keywords: bone strength; biomechanics; finite element analysis; osteoporosis
Links

DOI: 10.1111/j.1749-6632.2009.05348.x

PubMed: 20392218

WoS: 000277762400009
History

Online: 2010-04-5

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Cited By (18)

Year	Entry
2021	Orwig DL, Kopperdahl D, Keaveny T, Magaziner J, Hochberg M. Change in vertebral strength and bone mineral density in men and women over the year post-hip fracture: a subgroup analysis. Arch Osteoporos. December 2021;16(1):37.
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2011	Trabelsi N, Yosibash Z, Wutte C, Augat P, Eberle S. Patient-specific finite element analysis of the human femur: a double-blinded biomechanical validation. J Biomech. June 3, 2011;44(9):1666-1672.
2016	Jackman TM, DelMonaco AM, Morgan EF. Accuracy of finite element analyses of CT scans in predictions of vertebral failure patterns under axial compression and anterior flexion. J Biomech. January 25, 2016;49(2):267-275.
2014	Kopperdahl DL, Aspelund T, Hoffmann PF, Sigurdsson S, Siggeirsdottir K, Harris TB, Gudnason V, Keaveny TM. Assessment of incident spine and hip fractures in women and men using finite element analysis of CT scans. J Bone Miner Res. March 2014;29(3):570-580.
2015	Zysset P, Qin L, Lang T, Khosla S, Leslie WD, Shepherd JA, Schousboe JT, Engelke K. Clinical use of quantitative computed tomography–based finite element analysis of the hip and spine in the management of osteoporosis in adults: the 2015 ISCD official positions—part II. J Clin Densitom. July–September 2015;18(3):359-392.
2019	Lee Y, Ogihara N, Lee T. Assessment of finite element models for prediction of osteoporotic fracture. J Mech Behav Biomed Mater. September 2019;97:312-320.
2020	Löffler MT, Sollmann N, Mei K, Valentinitsch A, Noël PB, Kirschke JS, Baum T. X-ray-based quantitative osteoporosis imaging at the spine. Osteoporos Int. February 2020;31(2):233-250.
2020	Bouxsein ML, Zysset P, Glüer CC, McClung M, Biver E, Pierroz DD, Ferrari SL; IOF Working Group on Hip Bone Strength as a Therapeutic Target. Perspectives on the non-invasive evaluation of femoral strength in the assessment of hip fracture risk. Osteoporos Int. March 2020;31(3):393-408.
2020	Keaveny TM, Clarke BL, Cosman F, Orwoll ES, Siris ES, Khosla S, Bouxsein ML. Biomechanical computed tomography analysis (BCT) for clinical assessment of osteoporosis. Osteoporos Int. June 2020;31(6):1025-1048.
2019	Colombo C, Libonati F, Rinaudo L, Bellazzi M, Ulivieri FM, Vergani L. A new finite element based parameter to predict bone fracture. PLoS One. December 5, 2019;14(12):e0225905.
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2018	Chen JTH. Alterations in Bone Tissue Properties With Parathyroid Hormone Treatment [PhD thesis]. Ithaca, NY: Cornell University; May 2018.
2017	Laubie HH. Elastic Properties and Failure Behavior of Disordered Porous Solids: A Potential-of-Mean-Force-Based Lattice Element Approach [PhD thesis]. Cambridge, MA: Massachusetts Institute of Technology; June 2017.
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2021	Sharif Ahmadian A. Development of Statistical Shape and Intensity Models of Eroded Scapulae to Improve Shoulder Arthroplasty [Master's thesis]. University of Victoria; 2021.