Stereology and histogram analysis of backscattered electron images:​ age changes in bone

Boyde, A.; Elliott, J. C.; Jones, S. J.

Affiliations

¹Department of Anatomy, University College London, London WC1E 6BT UK

²London Hospital Medical College, London E1 2AD, UK

Links

DOI: 10.1016/8756-3282(93)90142-W

PubMed: 8363858

WoS: A1993LD83300005

Cited Works (2)

Year	Entry
1983	Boyde A, Jones SJ. Back-scattered electron imaging of skeletal tissues. Metab Bone Dis Rel Res. 1983;5(3):145-150.
1987	Reid SA, Boyde A. Changes in the mineral density distribution in human bone with age: image analysis using backscattered electrons in the SEM. J Bone Miner Res. February 1987;2(1):13-22.

Cited By (31)

Year	Entry
2001	Zioupos P. Ageing human bone: factors affecting its biomechanical properties and the role of collagen. J Biomater Appl. January 2001;15(3):187-229.
1995	Boyde A, Jones SJ, Aerssens J, Dequeker J. Mineral density quantitation of the human cortical iliac crest by backscattered electron image analysis: variations with age, sex, and degree of osteoarthritis. Bone. June 1995;16(6):619-627.
1997	Bloebaum RD, Skedros JG, Vajda EG, Bachus KN, Constantz BR. Determining mineral content variations in bone using backscattered electron imaging. Bone. May 1997;20(5):485-490.
1998	Boyde A, Compston JE, Reeve J, Bell KL, Noble BS, Jones SJ, Loveridge N. Effect of estrogen suppression on the mineralization density of iliac crest biopsies in young women as assessed by backscattered electron imaging. Bone. March 1998;22(3):241-250.
1998	Roschger P, Fratzl P, Eschberger J, Klaushofer K. Validation of quantitative backscattered electron imaging for the measurement of mineral density distribution in human bone biopsies. Bone. October 1998;23(4):319-326.
2003	Roschger P, Gupta HS, Berzlanovich A, Ittner G, Dempster DW, Fratzl P, Cosman F, Parisien M, Lindsay R, Nieves JW, Klaushofer K. Constant mineralization density distribution in cancellous human bone. Bone. March 2003;32(3):316-323.
2004	Loveridge N, Power J, Reeve J, Boyde A. Bone mineralization density and femoral neck fragility. Bone. October 2004;35(4):929-941.
2006	McNamara LM, Ederveen AGH, Lyons CG, Price C, Schaffler MB, Weinans H, Prendergast PJ. Strength of cancellous bone trabecular tissue from normal, ovariectomized and drug-treated rats over the course of ageing. Bone. August 2006;39(2):392-400.
2007	Ruffoni D, Fratzl P, Roschger P, Klaushofer K, Weinkamer R. The bone mineralization density distribution as a fingerprint of the mineralization process. Bone. May 2007;40(5):1308-1319.
2010	Wolfram U, Wilke H-J, Zysset PK. Rehydration of vertebral trabecular bone: influences on its anisotropy, its stiffness and the indentation work with a view to age, gender and vertebral level. Bone. February 2010;46(2):348-354.
2001	van der Linden JC, Birkenhäger-Frenkel DH, Verhaar JAN, Weinans H. Trabecular bone's mechanical properties are affected by its non-uniform mineral distribution. J Biomech. December 2001;34(12):1573-1580.
2006	McNamara LM, Van der Linden JC, Weinans H, Prendergast PJ. Stress-concentrating effect of resorption lacunae in trabecular bone. J Biomech. 2006;39(4):734-741.
2007	Chevalier Y, Pahr D, Allmer H, Charlebois M, Zysset P. Validation of a voxel-based FE method for prediction of the uniaxial apparent modulus of human trabecular bone using macroscopic mechanical tests and nanoindentation. J Biomech. 2007;40(15):3333-3340.
2011	Feng L, Jasiuk I. Multi-scale characterization of swine femoral cortical bone. J Biomech. January 11, 2011;44(2):313-320.
2011	Renders GAP, Mulder L, van Ruijven LJ, Langenbach GEJ, van Eijden TMGJ. Mineral heterogeneity affects predictions of intratrabecular stress and strain. J Biomech. February 3, 2011;44(3):402-407.
2002	Halloran BP, Ferguson VL, Simske SJ, Burghardt A, Venton LL, Majumdar S. Changes in bone structure and mass with advancing age in the male C57BL/6J mouse. J Bone Miner Res. June 2002;17(6):1044-1050.
2022	Costantini A, Mäkitie RE, Hartmann MA, Fratzl-Zelman N, Zillikens MC, Kornak U, Søe K, Mäkitie O. Early-onset osteoporosis: rare monogenic forms elucidate the complexity of disease pathogenesis beyond type I collagen. J Bone Miner Res. September 2022;37(9):1623-1641.
2016	Wen X-X, Xua C, Zong C-L, Feng Y-F, Ma X-Y, Wang F-Q, Yan Y-B, Lei W. Relationship between sample volumes and modulus of human vertebral trabecular bone in micro-finite element analysis. J Mech Behav Biomed Mater. July 2016;60:468-475.
2008	Utku FS, Klein E, Saybasili H, Yucesoy CA, Weiner S. Probing the role of water in lamellar bone by dehydration in the environmental scanning electron microscope. J Struct Biol. 2008;162(3):361-367.
1996	Boyde A, Jones SJ. Scanning electron microscopy of bone: instrument, specimen, and issues. Microsc Res Tech. February 1, 1996;33(2):92-120.
2010	Campbell SE. Nanoindentation of Bio- and Geo-Mineralized Composites: Contribution of Microstructure and Composition [PhD thesis]. University of Colorado; 2010.
2017	Yu Y. Contributions of Anisotropic and Heterogeneous Tissue Modulus to Apparent Trabecular Bone Mechanical Properties [PhD thesis]. New York, NY: Columbia University; 2017.
2010	Feng L. Multi-Scale Characterization of Swine Femoral Cortical Bone and Long Bone Defect Repair by Regeneration [PhD thesis]. University of Illinois at Urbana-Champaign; 2010.
2020	O’Sullivan LM. Time-Sequence of Biomechanical Adaption in Trabecular Tissue During Estrogen Deficiency [PhD thesis]. National University of Ireland Galway; March 2020.
2007	Doube M. Calcified Tissue Structure in the Distal Condyle of the Third Metacarpal Bone in Young Thoroughbred Horses [PhD thesis]. Queen Mary University of London; December 2007.
2004	McNamara LM. Biomechanical Origins of Osteoporosis [PhD thesis]. Trinity College Dublin; March 2004.
2008	Mulvihill BMC. Computational Investigation Into the Mechanoregulation of Osteoporosis [PhD thesis]. Trinity College Dublin; December 2008.
2003	Rajachar RM. Effects of Age -Related Ultra-Structural Level Changes in Bone on Microdamage Mechanisms [PhD thesis]. University of Michigan; 2003.
2009	Sahar ND. Investigating the Effects of Age and Exercise on Bone Composition and the Impact of Composition on Mechanical Integrity. [PhD thesis]. University of Michigan; 2009.
2011	Wolfram U. Mechanical Multiscale Characterisation of Vertebral Trabecular Bone for the Prediction of Vertebral Fracture Risk [PhD thesis]. University of Ulm; 2011.
1998	Vajda EG. Age-Related Changes in the Microstructure and Mineralization of the Female Proximal Femur [PhD thesis]. University of Utah; March 1998.