Is there a role for bone quality in fragility fractures?

Heaney, Robert P.

Affiliations

¹Creighton University, 2500 California Plaza, Omaha, Nebraska 68178, USA

Links

DOI: 10.1007/BF01673394

PubMed: 8275377

WoS: A1993LW98700003

History

Received: 1992-09-03

Accepted: 1992-12-28

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1989	Schaffler MB, Radin EL, Burr DB. Mechanical and morphological effects of strain rate on fatigue of compact bone. Bone. 1989;10(3):207-214.
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1990	Schaffler MB, Radin EL, Burr DB. Long-term fatigue behavior of compact bone at low strain magnitude and rate. Bone. 1990;11(5):321-326.
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Cited By (42)

Year	Entry
2001	Guo XE. Mechanical properties of cortical and cancellous bone tissue. In: Cowin SC, ed. Bone Mechanics Handbook. 2nd ed. Boca Raton, FL: CRC Press; 2001:10-1–10-23.
2002	Banse X. When density fails to predict bone strength. Acta Orthop Scand. 2002;73(2)(suppl 303):2-57.
2003	Frost HM. Bone's mechanostat: a 2003 update. Anat Rec. 2003;275A(2):1081-1101.
1995	Burr DB, Hooser M. Alterations to the en bloc basic fuchsin staining protocol for the demonstration of microdamage produced in vivo. Bone. October 1995;17(4):431-433.
1995	Schaffler MB, Choi K, Milgrom C. Aging and matrix microdamage accumulation in human compact bone. Bone. December 1995;17(6):521-525.
1998	Zioupos P, Currey JD. Changes in the stiffness, strength, and toughness of human cortical bone with age. Bone. January 1998;22(1):57-66.
2000	Hoffler CE, Moore KE, Kozloff K, Zysset PK, Brown MB, Goldstein SA. Heterogeneity of bone lamellar-level elastic moduli. Bone. June 2000;26(6):603-609.
2000	Hirano T, Turner CH, Forwood MR, Johnston CC, Burr DB. Does suppression of bone turnover impair mechanical properties by allowing microdamage accumulation? Bone. July 2000;27(1):13-20.
2006	Yerramshetty JS, Lind C, Akkus O. The compositional and physicochemical homogeneity of male femoral cortex increases after the sixth decade. Bone. December 2006;39(6):1236-1243.
2005	Morgan EF, Yeh OC, Keaveny TM. Damage in trabecular bone at small strains. Euro J Morphol. February–April 2005;42(1-2):13-21.
1997	Guo XE, Goldstein SA. Is trabecular bone tissue different from cortical bone tissue? Forma. 1997;12(3-4):185-196.
2000	Lee TC, O'Brien FJ, Taylor D. The nature of fatigue damage in bone. Int J Fract. November 2000;22(10):847-853.
2007	Vashishth D. Hierarchy of bone microdamage at multiple length scales. Int J Fatigue. June 2007;29(6):1024-1033.
1998	Cummings SR, Black DM, Thompson DE, Applegate WB, Barrett-Connor E, Musliner TA, Palermo L, Prineas R, Rubin SM, Scott JC, Vogt T, Wallace R, Yates AJ, LaCroix AZ; Fracture Intervention Trial Research Group. Effect of alendronate on risk of fracture in women with low bone density but without vertebral fractures: results from the Fracture Intervention Trial. JAMA. December 23, 1998;280(24):2077-2082.
2003	Lee TC, Mohsin S, Taylor D, Parkesh R, Gunnlaugsson T, O'Brien FJ, Giehl M, Gowin W. Detecting microdamage in bone. J Anat. August 2003;203(2):161-172.
2006	Mohsin S, O'Brien FJ, Lee TC. Osteonal crack barriers in ovine compact bone. J Anat. January 2006;208(1):81-89.
2001	Zioupos P. Ageing human bone: factors affecting its biomechanical properties and the role of collagen. J Biomater Appl. January 2001;15(3):187-229.
2004	Bayraktar HH, Morgan EF, Niebur GL, Morris GE, Wong EK, Keaveny TM. Comparison of the elastic and yield properties of human femoral trabecular and cortical bone tissue. J Biomech. January 2004;37(1):27-35.
2004	Bayraktar HH, Keaveny TM. Mechanisms of uniformity of yield strains for trabecular bone. J Biomech. November 2004;37(11):1671-1678.
2005	Nagaraja S, Couse TL, Guldberg RE. Trabecular bone microdamage and microstructural stresses under uniaxial compression. J Biomech. 2005;38(4):707-716.
2005	Hoffler CE, Guo XE, Zysset PK, Goldstein SA. An application of nanoindentation technique to measure bone tissue lamellae properties. J Biomech Eng. January 2005;127(7):1046-1053.
1999	Zioupos P, Currey JD, Hamer AJ. The role of collagen in the declining mechanical properties of aging human cortical bone. J Biomed Mater Res. May 1999;A45(2):108-116.
2001	Jepsen KJ, Pennington DE, Lee Y, Warman M, Nadeau J. Bone brittleness varies with genetic background in A/J and C57BL/6J inbred mice. J Bone Miner Res. October 2001;16(10):1854-1862.
2000	Guo XE, Goldstein SA. Vertebral trabecular bone microscopic tissue elastic modulus and hardness do not change in ovariectomized rats. J Orthop Res. March 2000;18(2):333-336.
2000	Hoffler CE, Moore KE, Kozloff K, Zysset PK, Goldstein SA. Age, gender, and bone lamellae elastic moduli. J Orthop Res. May 2000;18(3):432-437.
2000	Heaney RP, Abrams S, Dawson-Hughes B, Looker A, Marcus R, Matkovic V, Weaver C. Peak bone mass. Osteoporos Int. December 2000;11(12):985-1009.
2012	Moore E. The Frequency, Aqueous Solution, Stress Amplitude, Temperature (FAST) Machine: A Device Proposed for Accelerated Fatigue Testing of Cortical Bone [Master's thesis]. Cleveland, OH: Case Western Reserve University; August 2012.
2007	Schneider P. Ultrastructural Phenotyping of Murine Bone Using Synchrotron Micro- and Nano-Computed Tomography [PhD thesis]. Swiss Federal Institute of Technology Zürich; 2007.
2007	Voide R. Functional Phenotyping of Bone: A Hierarchical Assessment of Bone Failure Characteristics [PhD thesis]. Swiss Federal Institute of Technology Zürich; 2007.
2006	Nagaraja S. Microstructural Stresses and Strains Associated With Trabecular Bone Microdamage [PhD thesis]. Atlanta, GA: Georgia Institute of Technology; December 2006.
2002	Egerer AK. The Relationship Between the Osteonal Cement Line and Bone Strength [PhD thesis]. Loma Linda University; June 2002.
2001	Arthur Moore TL. Microdamage Accumulation in Bovine Trabecular Bone [PhD thesis]. Cambridge, MA: Massachusetts Institute of Technology; June 2001.
2005	George WT. Multiaxial Fracture Characteristics of Aging Human Bone [PhD thesis]. Troy, NY: Rensselaer Polytechnic Institute; April 2005.
2000	O’Brien FJ. Microcracks and the Fatigue Behaviour of Compact Bone [PhD thesis]. Trinity College Dublin; October 2000.
2003	Bayraktar HH. Multiaxial Strength and Micromechanics of Human Bone [PhD thesis]. Berkeley, CA: Berkeley, University of California; 2003.
1998	Ciarelli TE. Architectural and Material Contributions to Fracture of the Spine and Proximal Femur [PhD thesis]. University of Michigan; 1998.
2003	Rajachar RM. Effects of Age -Related Ultra-Structural Level Changes in Bone on Microdamage Mechanisms [PhD thesis]. University of Michigan; 2003.
1998	Vajda EG. Age-Related Changes in the Microstructure and Mineralization of the Female Proximal Femur [PhD thesis]. University of Utah; March 1998.
2010	Sardone LD. The Effect of Rosiglitazone on Bone Quality in a Rat Model of Insulin Resistance and Osteoporosis [Master's thesis]. University of Toronto; 2010.
2010	Thang HHM. The in Vivo Effects of Rac1 and Rac2 on Bone Quality and Aging [Master's thesis]. University of Toronto; 2010.
2015	Ng AH-M. A Mouse Model of Adynamic Bone Disease (ABD) and Its Consequences on Bone Quality With Age [PhD thesis]. University of Toronto; 2015.
2018	Zhang L. Effects of Osteoblast-Specific Gα_S Overexpression on Skeletal Development and Response to Catabolic and Anabolic Stimuli Using a Transgenic Mouse Model [PhD thesis]. University of Toronto; 2018.