Lanyon, Lance Edward

Links

AcademicTree: 766080

Academic genealogy

Doctoral Descendants

Affiliations (4)

Name	Count	Oldest	Newest
Royal Veterinary College	38	1984	2012
University of London	11	1986	2012
University of Bristol	15	1969	2014
Tufts University	10	1981	1985

Papers (59)

Year	Article	Times Cited	Times Cited (no self-citations)
1981	Lanyon LE. The measurement and biological significance of bone strain in vivo. In: Cowin SC, ed. Mechanical Properties of Bone. The Joint ASME-ASCE Applied Mechnics, Fluids Engineering and Bioengineering Conference; June 22-24, 1981; Boulder, CO. New York, NY: American Society of Mechical Engineers; 1981:93-105.	13	12
1991	Lanyon LE. Biomechanical properties of bone and response of bone to mechanical stimuli: functional strain as a controlling influence on bone modeling and remodeling behavior. In: Hall BK, ed. Bone. Volume 3: Bone Matrix and Bone Specific Products. Boca Raton, FL: Inc., CRC Press; 1991:79-108.	8	8
1970	Lanyon LE, Smith RN. Bone strain in the tibia during normal quadrupedal locomotion. Acta Orthop Scand. 1970;41(3):238-248.	33	21
1975	Lanyon LE, Hampson WGJ, Goodship AE, Shah JS. Bone deformation recorded in vivo from strain gauges attached to the human tibial shaft. Acta Orthop Scand. 1975;46(2):256-268.	143	135
2003	Noble BS, Peet N, Stevens HY, Brabbs A, Mosley JR, Reilly GC, Reeve J, Skerry TM, Lanyon LE. Mechanical loading: biphasic osteocyte survival and targeting of osteoclasts for bone destruction in rat cortical bone. Am J Physiol Cell Physiol. April 2003;284(4):C934-C943.	48	42
1993	Riggs CM, Lanyon LE, Boyde A. Functional associations between collagen fibre orientation and locomotor strain direction in cortical bone of the equine radius. Anat Embryol. March 1993;187(3):231-238.	37	36
1993	Riggs CM, Vaughan LC, Evans GP, Lanyon LE, Boyde A. Mechanical implications of collagen fibre orientation in cortical bone of the equine radius. Anat Embryol. March 1993;187(3):239-248.	60	59
1992	Lanyon LE. The success and failure of the adaptive response to functional load-bearing in averting bone fracture. Bone. 1992;13(2):S17-S21.	25	24
1996	Lanyon LE. Using functional loading to influence bone mass and architecture: objectives, mechanisms, and relationship with estrogen of the mechanically adaptive process in bone. Bone. January 1996;18(1)(suppl):37S-43S.	39	35
1996	Rawlinson SCF, Pitsillides AA, Lanyon LE. Involvement of different ion channels in osteoblasts' and osteocytes' early responses to mechanical strain. Bone. December 1996;19(6):609-614.	47	43
1997	Mosley JR, March BM, Lynch J, Lanyon LE. Strain magnitude related changes in whole bone architecture in growing rats. Bone. March 1997;20(3):191-198.	85	77
1998	Mosley JR, Lanyon LE. Strain rate as a controlling influence on adaptive modeling in response to dynamic loading of the ulna in growing male rats. Bone. October 1998;23(4):313-318.	92	88
2002	Lee KCL, Maxwell A, Lanyon LE. Validation of a technique for studying functional adaptation of the mouse ulna in response to mechanical loading. Bone. September 2002;31(3):407-412.	45	41
2005	De Souza RL, Matsuura M, Eckstein F, Rawlinson SCF, Lanyon LE, Pitsillides AA. Non-invasive axial loading of mouse tibiae increases cortical bone formation and modifies trabecular organization: a new model to study cortical and cancellous compartments in a single loaded element. Bone. December 2005;37(6):810-818.	100	92
2008	Sugiyama T, Saxon LK, Zaman G, Moustafa A, Sunters A, Price JS, Lanyon LE. Mechanical loading enhances the anabolic effects of intermittent parathyroid hormone (1–34) on trabecular and cortical bone in mice. Bone. August 2008;43(2):238-248.	35	31
2010	Sugiyama T, Price JS, Lanyon LE. Functional adaptation to mechanical loading in both cortical and cancellous bone is controlled locally and is confined to the loaded bones. Bone. February 2010;46(2):314-321.	41	37
1984	Lanyon LE. Functional strain as a determinant for bone remodeling. Calcif Tiss Int. March 1984;36(suppl 1):S56-S61.	87	80
1985	Rubin CT, Lanyon LE. Regulation of bone mass by mechanical strain magnitude. Calcif Tiss Int. 1985;37(4):411-417.	270	217
1986	Lanyon LE, Rubin CT, Baust G. Modulation of bone loss during calcium insufficiency by controlled dynamic loading. Calcif Tiss Int. July 1986;38(4):209-216.	23	12
1988	Pead MJ, Suswillo R, Skerry TM, Vedi S, Lanyon LE. Increased ³H-uridine levels in osteocytes following a single short period of dynamic bone loadingin vivo. Calcif Tiss Int. August 1988;43(2):92-96.	47	32
1989	Pead MJ, Lanyon LE. Indomethacin modulation of load-related stimulation of new bone formation in vivo. Calcif Tiss Int. January 1989;45(1):34-40.	39	24
1990	Skerry TM, Suswillo R, El Haj AJ, Ali NN, Dodds RA, Lanyon LE. Load-induced proteoglycan orientation in bone tissuein vivo and in vitro. Calcif Tiss Int. May 1990;46(5):318-326.	21	16
1993	Lanyon LE. Osteocytes, strain detection, bone modeling and remodeling. Calcif Tiss Int. February 1993;53(suppl 1):S102-S107.	97	94
1993	Rawlinson SCF, Mohan S, Baylink DJ, Lanyon LE. Exogenous prostacyclin, but not prostaglandin E₂, produces similar responses in both G6PD activity and RNA production as mechanical loading, and increases IGF-II release, in adult cancellous bone in culture. Calcif Tiss Int. November 1993;53(5):324-329.	21	14
1994	Torrance AG, Mosley JR, Suswillo RFL, Lanyon LE. Noninvasive loading of the rat ulna in vivo induces a strain-related modeling response uncomplicated by trauma or periostal pressure. Calcif Tiss Int. March 1994;54(3):241-247.	104	95
1995	Pitsillides AA, Rawlinson SCF, Suswillo RFL, Bourrin S, Zaman G, Lanyon LE. Mechanical strain‐induced NO production by bone cells: a possible role in adaptive bone (re)modeling? FASEB J. December 1995;9(15):1614-1622.	54	49
1973	Lanyon LE. Analysis of surface bone strain in the calcaneus of sheep during normal locomotion: strain analysis of the calcaneus. J Biomech. 1973;6(1):41-49.	36	30
1979	Lanyon LE, Magee PT, Baggott DG. The relationship of functional stress and strain to the processes of bone remodelling: an experimental study on the sheep radius. J Biomech. 1979;12(8):593-600.	37	26
1982	Lanyon LE, Goodship AE, Pye CJ, MacFie JH. Mechanically adaptive bone remodelling. J Biomech. 1982;15(3):141-154.	137	114
1982	O'Connor JA, Lanyon LE, MacFie H. The influence of strain rate on adaptive bone remodelling. J Biomech. 1982;15(10):767-781.	139	122
1983	Biewener AA, Thomason J, Goodship A, Lanyon LE. Bone stress in the horse forelimb during locomotion at different gaits: a comparison of two experimental methods. J Biomech. 1983;16(8):565-576.	50	40
1984	Lanyon LE, Rubin CT. Static vs dynamic loads as an influence on bone remodelling. J Biomech. 1984;17(12):897-905.	166	143
1987	Lanyon LE. Functional strain in bone tissue as an objective, and controlling stimulus for adaptive bone remodelling. J Biomech. 1987;20(11-12):1083-1093.	72	62
1979	Lanyon LE, Bourn S. The influence of mechanical function on the development and remodeling of the tibia: an experimental study in sheep. J Bone Joint Surg. March 1979;61A(2):263-273.	51	45
1979	Goodship AE, Lanyon LE, McFie H. Functional adaptation of bone to increased stress: an experimental study. J Bone Joint Surg. June 1979;61A(4):539-546.	123	108
1984	Rubin CT, Lanyon LE. Regulation of bone formation by applied dynamic loads. J Bone Joint Surg. March 1984;66A(3):397-402.	304	251
1974	Lanyon LE. Experimental support for the trajectorial theory of bone structure. J Bone Joint Surg. 1974;56B(1):160-166.	45	38
1976	Lanyon LE, Baggott DG. Mechanical function as an influence on the structure and form of bone. J Bone Joint Surg. November 1976;58B(4):436-443.	47	37
1988	Pead MJ, Skerry TM, Lanyon LE. Direct transformation from quiescence to bone formation in the adult periosteum following a single brief period of bone loading. J Bone Miner Res. December 1988;3(6):647-656.	58	43
1989	Skerry TM, Bitensky L, Chayen J, Lanyon LE. Early strain‐related changes in enzyme activity in osteocytes following bone loading in vivo. J Bone Miner Res. October 1989;4(5):783-788.	84	66
1990	El Haj AJ, Minter SL, Rawlinson SCF, Suswillo R, Lanyon LE. Cellular responses to mechanical loading in vitro. J Bone Miner Res. September 1990;5(9):923-932.	49	37
1991	Rawlinson SCF, El‐Haj AJ, Minter SL, Tavares IA, Bennett A, Lanyon LE. Loading‐related increases in prostaglandin production in cores of adult canine cancellous bone in vitro: a role for prostacyclin in adaptive bone remodeling? J Bone Miner Res. December 1991;6(12):1345-1351.	37	25
1992	Lanyon LE. Control of bone architecture by functional load bearing. J Bone Miner Res. December 1992;7(suppl 2):S369-S375.	25	23
1993	Dallas SL, Zaman G, Pead MJ, Lanyon LE. Early strain-related changes in cultured embryonic chick tibiotarsi parallel those associated with adaptive modeling in vivo. J Bone Miner Res. March 1993;8(3):251-259.	24	15
1993	Dodds RA, Ali N, Pead MJ, Lanyon LE. Early loading-related changes in the activity of glucose 6-phosphate dehydrogenase and alkaline phosphatase in osteocytes and periosteal osteoblasts in rat fibulae in vivo. J Bone Miner Res. March 1993;8(3):261-267.	19	15
1995	Rawlinson SCF, Mosley JR, Suswillo RFL, Pitsillides AA, Lanyon LE. Calvarial and limb bone cells in organ and monolayer culture do not show the same early responses to dynamic mechanical strain. J Bone Miner Res. 1995;10(8):1225-1232.	29	25
1999	Zaman G, Pitsillides AA, Rawlinson SCF, Suswillo RFL, Mosley JR, Cheng MZ, Platts LAM, Hukkanen M, Polak JM, Lanyon LE. Mechanical strain stimulates nitric oxide production by rapid activation of endothelial nitric oxide synthase in osteocytes. J Bone Miner Res. July 1999;14(7):1123-1131.	39	37
2001	Lanyon L, Skerry T. Postmenopausal osteoporosis as a failure of bone's adaptation to functional loading: a hypothesis. J Bone Miner Res. November 2001;16(11):1937-1947.	26	23
2012	Sugiyama T, Meakin LB, Browne WJ, Galea GL, Price JS, Lanyon LE. Bones' adaptive response to mechanical loading is essentially linear between the low strains associated with disuse and the high strains associated with the lamellar/woven bone transition. J Bone Miner Res. August 2012;27(8):1784-1793.	35	33
2014	Meakin LB, Galea GL, Sugiyama T, Lanyon LE, Price JS. Age-related impairment of bones' adaptive response to loading in mice is associated with sex-related deficiencies in osteoblasts but no change in osteocytes. J Bone Miner Res. August 2014;29(8):1859-1871.	24	22
1982	Rubin CT, Lanyon LE. Limb mechanics as a function of speed and gait: a study of functional strains in the radius and tibia of horse and dog. J Exp Biol. December 1982;101:187-211.	134	116
1987	Rubin CT, Lanyon LE. Osteoregulatory nature of mechanical stimuli: function as a determinant for adaptive remodeling in bone. J Orthop Res. 1987;5(2):300-310.	112	95
1988	Skerry TM, Bitensky L, Chayen J, Lanyon LE. Loading-related reorientation of bone proteoglycan in vivo: strain memory in bone tissue? J Orthop Res. July 1988;6(4):547-551.	23	13
1984	Rubin CT, Lanyon LE. Dynamic strain similarity in vertebrates: an alternative to allometric limb bone scaling. J Theo Biol. March 21, 1984;107(2):321-327.	93	67
1980	Lanyon LE. The influence of function on the development of bone curvature: an experimental study on the rat tibia. J Zool. 1980;192(4):457-466.	36	30
1983	Biewener AA, Thomason J, Lanyon LE. Mechanics of locomotion and jumping in the forelimb of the horse (Equus): in vivo stress developed in the radius and metacarpus. J Zool. 1983;201(1):67-82.	25	15
2003	Lee K, Jessop H, Suswillo R, Zaman G, Lanyon L. Bone adaptation requires oestrogen receptor-α. Nature. July 24, 2003;424(6947):389.	42	40
2002	Ehrlich PJ, Lanyon LE. Mechanical strain and bone cell function: a review. Osteoporos Int. September 2002;13(9):688-700.	41	40
2012	Moustafa A, Sugiyama T, Prasad J, Zaman G, Gross TS, Lanyon LE, Price JS. Mechanical loading-related changes in osteocyte sclerostin expression in mice are more closely associated with the subsequent osteogenic response than the peak strains engendered. Osteoporos Int. April 2012;23(4):1225-1234.	35	31

Theses (1)

Year	Article	Times Cited	Times Cited (no self-citations)
1969	Lanyon LE. Measurement of Natural Bone Strain in the Mammalian Vertebral Column [PhD thesis]. Bristol, UK: University of Bristol; 1969.	1	1

Student Theses (18)

Year	Article	Times Cited	Times Cited (no self-citations)
2008	Armstrong VJ. Involvement of the Wnt/β-Catenin Signalling Pathway and the Estrogen Receptor in Bone Cells' Adaptive Responses to Mechanical Strains [PhD thesis]. Royal Veterinary College; 2008.	0	0
2003	Lee KCL. Structural Adaptation of the Mouse Ulna to Mechanical Loading and the Involvement of Estrogen Receptor Α [PhD thesis]. Royal Veterinary College; 2003.	0	0
2002	Ehrlich PJ. Dynamics of Estrogen Receptor-Α in Osteocytes: Effects of Mechanical [PhD thesis]. Royal Veterinary College; 2002.	0	0
2000	Damien E. The Estrogen Receptor's Involvement in Osteoblasts' Response to Mechanical Strain [PhD thesis]. Royal Veterinary College; 2000.	0	0
1999	Rawlinson SCF. Early Loading-Related Responses of Bone Cells [PhD thesis]. Royal Veterinary College; 1999.	1	0
1996	Mosley JR. The Influence of Mechanical Load and Oestrogen on the Development of Long-Bone Architecture [PhD thesis]. Royal Veterinary College; 1996.	4	1
1995	Cheng MZ. The Interaction of Mechanical Strain and Sex Hormones in Bone's Adaptive Responses to Load-Bearing [PhD thesis]. Royal Veterinary College; 1995.	0	0
1993	Torrance AG. The Effect of Controlled Mechanical Loading Upon the Development of Longbone Architecture [PhD thesis]. Royal Veterinary College; 1993.	2	1
1991	Pead MJ. Cellular Control of Bone Architecture in Relation to Mechanical Loading [PhD thesis]. Royal Veterinary College; 1991.	0	0
1991	Minter SL. The Use of in Vitro Techniques to Investigate Cellular Responses to Mechanical Load in Bone [PhD thesis]. Royal Veterinary College; 1991.	1	0
1989	Goode NT. Protein Kinase “C” Activity and C-Fos Expression in Cellular Proliferation Control of a Murine Macrophage Tumour [PhD thesis]. Royal Veterinary College; 1989.	0	0
1989	Skerry TM. Load Related Changes in Bone Cells and Matrix [PhD thesis]. Royal Veterinary College; 1989.	1	0
2013	Meakin LB. The Effect of Ageing on Bone's Adaptive Response to Mechanical Loading [PhD thesis]. Bristol, UK: University of Bristol; 2013.	0	0
2013	Galea G. The Regulation in Bone Cells of Sost/sclerostin by Mechanical Strain [PhD thesis]. Bristol, UK: University of Bristol; 2013.	0	0
1982	Rubin CT. Dynamic Strain Similarity: The Origin and Objective of Structural Adaptation in Bone [PhD thesis]. Bristol, UK: University of Bristol; 1982.	1	1
1981	O'Connor JA. Mechanically Adaptive Remodelling in Bone [PhD thesis]. Bristol, UK: University of Bristol; 1981.	4	4
1978	Baggott DG. A Study of Functional Adaptation of Bone [PhD thesis]. Bristol, UK: University of Bristol; 1978.	0	0
1976	Goodship AE. A Study of Functional Adaptation of Bone [PhD thesis]. Bristol, UK: University of Bristol; 1976.	0	0

Collaborators (24)

Name	Count	Oldest	Newest
Eckstein, Felix	1	2005	2005
Reeve, Jonathan	1	2003	2003
Sugiyama, Toshihiro	5	2008	2014
Mohan, Subburaman	1	1993	1993
Pitsillides, Andrew A.	4	1995	2005
Baylink, David J.	1	1993	1993
Matsuura, Maiko	1	2005	2005
Vedi, Shobna	1	1988	1988
Pead, Matthew Justin	5	1988	1993
Rubin, Clinton T.	7	1982	1987
Biewener, Andrew A.	2	1983	1983
Rawlinson, Simon C. F.	8	1990	2005
Noble, Brendon S.	1	2003	2003
Zaman, Gul	6	1993	2012
Boyde, Alan	2	1993	1993
Stevens, Hazel Y.	1	2003	2003
Reilly, Gwendolen C.	1	2003	2003
Price, Joanna Susan	5	2008	2014
Skerry, Timothy M.	7	1988	2003
Dallas, Sarah L.	1	1993	1993
Goodship, Allen E.	4	1975	1983
Suswillo, Rosemary F. L.	8	1988	2003
Gross, Ted S.	1	2012	2012
Mosley, John R.	6	1994	2003