The influence of function on the development of bone curvature:​ an experimental study on the rat tibia

Lanyon, L. E.

Affiliations

¹Biomechanics Research Group, University of Bristol, Department of Anatotny, Park Row, Bristol, U. K.

Abstract

The effect of depriving the tibia of normal mechanical function during its growing period was investigated by performing a unilateral sciatic neurectomy in the gluteal region of young rats. The animals were kept for 16 months, after which their tibias were examined. On the neurectomized side there was a failure of this bone to attain its normal weight, thickness, cross sectional shape or longitudinal curvature. Attainment of the bone's overall length was uneffected.

Links

DOI: 10.1111/j.1469-7998.1980.tb04243.x

WoS: A1980KW51500002

History

Accepted: 1980-02-12

Cited Works (5)

Year	Entry
1979	Lanyon LE, Bourn S. The influence of mechanical function on the development and remodeling of the tibia: an experimental study in sheep. J Bone Joint Surg. March 1979;61A(2):263-273.
1975	Reilly DT, Burstein AH. The elastic and ultimate properties of compact bone tissue. J Biomech. 1975;8(6):393-405.
1979	Lanyon LE, Magee PT, Baggott DG. The relationship of functional stress and strain to the processes of bone remodelling: an experimental study on the sheep radius. J Biomech. 1979;12(8):593-600.
1976	Lanyon LE, Baggott DG. Mechanical function as an influence on the structure and form of bone. J Bone Joint Surg. November 1976;58B(4):436-443.
1979	Goodship AE, Lanyon LE, McFie H. Functional adaptation of bone to increased stress: an experimental study. J Bone Joint Surg. June 1979;61A(4):539-546.

Cited By (37)

Year	Entry
1981	Lanyon LE. The measurement and biological significance of bone strain in vivo. In: Cowin SC, ed. Mechanical Properties of Bone. The Joint ASME-ASCE Applied Mechnics, Fluids Engineering and Bioengineering Conference; June 22-24, 1981; Boulder, CO. New York, NY: American Society of Mechical Engineers; 1981:93-105.
1993	Riggs CM, Vaughan LC, Evans GP, Lanyon LE, Boyde A. Mechanical implications of collagen fibre orientation in cortical bone of the equine radius. Anat Embryol. March 1993;187(3):239-248.
2006	Robling AG, Castillo AB, Turner CH. Biomechanical and molecular regulation of bone remodeling. Annu Rev Biomed Eng. 2006;8:455-498.
1991	Bertram JEA, Swartz SM. The “law of bone transformation”: a case of crying Wolff? Biol Rev. August 1991;66(3):245-273.
1990	Boyde A, Riggs CM. The quantitative study of the orientation of collagen in compact bone slices. Bone. 1990;11(1):35-39.
1991	Turner CH, Akhter MP, Raab DM, Kimmel DB, Recker RR. A noninvasive, in vivo model for studying strain adaptive bone modeling. Bone. 1991;12(2):73-79.
1996	Lanyon LE. Using functional loading to influence bone mass and architecture: objectives, mechanisms, and relationship with estrogen of the mechanically adaptive process in bone. Bone. January 1996;18(1)(suppl):37S-43S.
1998	Turner CH. Three rules for bone adaptation to mechanical stimuli. Bone. November 1998;23(5):399-407.
1993	Forwood MR, Burr DB. Physical activity and bone mass: exercises in futility? Bone Miner. May 1993;21(2):89-112.
1984	Rubin CT. Skeletal strain and the functional significance of bone architecture. Calcif Tiss Int. March 1984;36(suppl 1):S11-S18.
1986	Biewener AA, Swartz SM, Bertram JEA. Bone modeling during growth: dynamic strain equilibrium in the chick tibiotarsus. Calcif Tiss Int. November 1986;39(6):390-395.
1994	Biewener AA, Bertram JE. Structural response of growing bone to exercise and disuse. J Appl Physiol. February 1994;76(2):946-955.
1987	Lanyon LE. Functional strain in bone tissue as an objective, and controlling stimulus for adaptive bone remodelling. J Biomech. 1987;20(11-12):1083-1093.
1990	Rubin CT, McLeod KJ, Bain SD. Functional strains and cortical bone adaptation: epigenetic assurance of skeletal integrity. J Biomech. 1990;23(suppl 1):43-54.
1991	Biewener AA. Musculoskeletal design in relation to body size. J Biomech. 1991;24(suppl 1):19-29.
2000	Reilly GC, Currey JD. The effects of damage and microcracking on the impact strength of bone. J Biomech. March 2000;33(3):337-343.
1998	Bradney M, Pearce G, Naughton G, Sullivan C, Bass S, Beck T, Carlson J, Seeman E. Moderate exercise during growth in prepubertal boys: changes in bone mass, size, volumetric density, and bone strength: a controlled prospective study. J Bone Miner Res. December 1998;13(12):1814-1821.
2000	Robling AG, Burr DB, Turner CH. Partitioning a daily mechanical stimulus into discrete loading bouts improves the osteogenic response to loading. J Bone Miner Res. August 2000;15(8):1596-1602.
1982	Rubin CT, Lanyon LE. Limb mechanics as a function of speed and gait: a study of functional strains in the radius and tibia of horse and dog. J Exp Biol. December 1982;101:187-211.
1983	Biewener AA, Thomason J, Lanyon LE. Mechanics of locomotion and jumping in the forelimb of the horse (Equus): in vivo stress developed in the radius and metacarpus. J Zool. 1983;201(1):67-82.
1996	Hillam RA. Response of Bone to Mechanical Load and Alterations in Circulating Hormones [PhD thesis]. Bristol, UK: University of Bristol; October 1996.
2014	Ferro Pereira A. Cortical Bone Adaptation: A Finite-Element Study of the Mouse Tibia [PhD thesis]. Imperial College London; January 2014.
1999	Egi N. Functional Morphology of the Limb Bones in Recent Carnivores and Its Application to North American Hyaenodontid Creodonta [PhD thesis]. Johns Hopkins University; 1999.
2018	Burgess ML. Ontogenetic Changes in Limb Bone Structural Properties and Locomotor Behavior in Pan [PhD thesis]. Johns Hopkins University; June 2018.
2002	Hudson JA. The Ontogeny of Transverse Femoral Geometry and Bone Modeling in the Ward Skeletal Population [PhD thesis]. Kent State University; August 2002.
1998	Robling AG. Histomorphometric Assessment of Mechanical Loading History from Human Skeletal Remains: The Relation Between Micromorphology and Macromorphology At the Femoral Midshaft [PhD thesis]. University of Missouri; December 1998.
2023	Young LAM. Analysis of Bone Structure in Peromyscus: Effects of Burrowing Behavior [Master's thesis]. Northeastern University; May 2023.
2013	Turnbull TL. The Spatial Distribution of Fatigue Microdamage Accumulation in Cortical Bone and Factors Influencing Fracture Risk [PhD thesis]. University of Notre Dame; July 2013.
2023	Ning B. In Vivo Experimental Platform Evaluating Synchronously 3D Bone Growth, (re)modeling, Microdamage and Mechanical Properties [PhD thesis]. École polytechnique de Montréal; August 2023.
1990	Wong M. The Role of Mechanical Loading Histories in Skeletal Morphogenesis [PhD thesis]. Stanford University; June 1990.
1993	van der Meulen MCH. The Influence of Mechanics on Long Bone Development and Adaptation [PhD thesis]. Stanford University; June 1993.
1994	Levenston ME. Simulation of Functional Adaptation in Trabecular and Cortical Bone [PhD thesis]. Stanford University; September 1994.
1996	Mikic B. Epigenetic Influences on Long Bone Growth, Development, and Evolution [PhD thesis]. Stanford University; June 1996.
2006	Carpenter RD. Mechanobiology of Bone Cross-Sectional Development, Adaptation, and Strength [PhD thesis]. Stanford University; June 2006.
2004	Roberts MD. Adaptation of Bone to Mechanical and Nonmechanical Stimuli: An Integrated Experimental and Computational Study [PhD thesis]. Tulane University; 2004.
2006	Macdonald HM. Effectiveness of a School-Based Physical Activity Intervention for Increasing Bone Strength in Children: Action Schools! British Columbia [PhD thesis]. Vancouver, BC: University of British Columbia; July 2006.
1985	Schaffler MB. Stiffness and Fatigue of Compact Bone At Physiological Strains and Strain Rates [PhD thesis]. West Virginia University; 1985.