| 1991 |
Lanyon LE. Biomechanical properties of bone and response of bone to mechanical stimuli: functional strain as a controlling influence on bone modeling and remodeling behavior. In: Hall BK, ed. Bone. Volume 3: Bone Matrix and Bone Specific Products. Boca Raton, FL: Inc., CRC Press; 1991:79-108. |
8 |
8 |
| 2001 |
Goodship AE, Cunningham JL. Pathophysiology of functional adaptation of bone in remodeling and repair in vivo. In: Cowin SC, ed. Bone Mechanics Handbook. 2nd ed. Boca Raton, FL: CRC Press; 2001:26-1–26-31. |
0 |
0 |
| 2003 |
Noble BS, Peet N, Stevens HY, Brabbs A, Mosley JR, Reilly GC, Reeve J, Skerry TM, Lanyon LE. Mechanical loading: biphasic osteocyte survival and targeting of osteoclasts for bone destruction in rat cortical bone. Am J Physiol Cell Physiol. April 2003;284(4):C934-C943. |
48 |
42 |
| 1993 |
Riggs CM, Lanyon LE, Boyde A. Functional associations between collagen fibre orientation and locomotor strain direction in cortical bone of the equine radius. Anat Embryol. March 1993;187(3):231-238. |
37 |
36 |
| 1993 |
Riggs CM, Vaughan LC, Evans GP, Lanyon LE, Boyde A. Mechanical implications of collagen fibre orientation in cortical bone of the equine radius. Anat Embryol. March 1993;187(3):239-248. |
60 |
59 |
| 1998 |
Bank RA, Bayliss MT, Lafeber FPJG, Maroudas A, Tekoppele JM. Ageing and zonal variation in post-translational modification of collagen in normal human articular cartilage: the age-related increase in non-enzymatic glycation affects biomechanical properties of cartilage. Biochem J. February 15, 1998;3301(1):345-351. |
46 |
43 |
| 1990 |
Boyde A, Riggs CM. The quantitative study of the orientation of collagen in compact bone slices. Bone. 1990;11(1):35-39. |
21 |
20 |
| 1992 |
Lanyon LE. The success and failure of the adaptive response to functional load-bearing in averting bone fracture. Bone. 1992;13(2):S17-S21. |
25 |
24 |
| 1996 |
Lanyon LE. Using functional loading to influence bone mass and architecture: objectives, mechanisms, and relationship with estrogen of the mechanically adaptive process in bone. Bone. January 1996;18(1)(suppl):37S-43S. |
39 |
35 |
| 1996 |
Rawlinson SCF, Pitsillides AA, Lanyon LE. Involvement of different ion channels in osteoblasts' and osteocytes' early responses to mechanical strain. Bone. December 1996;19(6):609-614. |
47 |
43 |
| 1997 |
Mosley JR, March BM, Lynch J, Lanyon LE. Strain magnitude related changes in whole bone architecture in growing rats. Bone. March 1997;20(3):191-198. |
85 |
77 |
| 1998 |
Mosley JR, Lanyon LE. Strain rate as a controlling influence on adaptive modeling in response to dynamic loading of the ulna in growing male rats. Bone. October 1998;23(4):313-318. |
92 |
88 |
| 1999 |
Muir P, Johnson KA, Ruaux-Mason CP. In vivo matrix microdamage in a naturally occurring canine fatigue fracture. Bone. November 1999;25(5):571-576. |
25 |
25 |
| 2002 |
Lee KCL, Maxwell A, Lanyon LE. Validation of a technique for studying functional adaptation of the mouse ulna in response to mechanical loading. Bone. September 2002;31(3):407-412. |
45 |
41 |
| 2005 |
De Souza RL, Matsuura M, Eckstein F, Rawlinson SCF, Lanyon LE, Pitsillides AA. Non-invasive axial loading of mouse tibiae increases cortical bone formation and modifies trabecular organization: a new model to study cortical and cancellous compartments in a single loaded element. Bone. December 2005;37(6):810-818. |
100 |
92 |
| 2008 |
Sugiyama T, Saxon LK, Zaman G, Moustafa A, Sunters A, Price JS, Lanyon LE. Mechanical loading enhances the anabolic effects of intermittent parathyroid hormone (1–34) on trabecular and cortical bone in mice. Bone. August 2008;43(2):238-248. |
35 |
31 |
| 2010 |
Sugiyama T, Price JS, Lanyon LE. Functional adaptation to mechanical loading in both cortical and cancellous bone is controlled locally and is confined to the loaded bones. Bone. February 2010;46(2):314-321. |
41 |
37 |
| 2010 |
Doube M, Kłosowski MM, Arganda-Carreras I, Cordelières FP, Dougherty RP, Jackson JS, Schmid B, Hutchinson JR, Shefelbine SJ. BoneJ: free and extensible bone image analysis in ImageJ. Bone. December 2010;47(6):1076-1079. |
142 |
130 |
| 2020 |
Galea GL, Delisser PJ, Meakin L, Price JS, Windahl SH. Bone gain following loading is site-specifically enhanced by prior and concurrent disuse in aged male mice. Bone. April 2020;133:115255. |
2 |
1 |
| 2020 |
Orriss IR. Extracellular pyrophosphate: the body's “water softener”. Bone. May 2020;134:115243. |
6 |
6 |
| 2023 |
Monzem S, Valkani D, Evans LAE, Chang Y-M, Pitsillides AA. Regional modular responses in different bone compartments to the anabolic effect of PTH (1-34) and axial loading in mice. Bone. May 2023;170:116720. |
0 |
0 |
| 2023 |
Bourne LE, Davies BK, Millan JL, Arnett TR, Wheeler-Jones CP, Keen JA, Roberts SJ, Orriss IR. Evidence that pyrophosphate acts as an extracellular signalling molecule to exert direct functional effects in primary cultures of osteoblasts and osteoclasts. Bone. November 2023;176:116868. |
0 |
0 |
| 1986 |
Lanyon LE, Rubin CT, Baust G. Modulation of bone loss during calcium insufficiency by controlled dynamic loading. Calcif Tiss Int. July 1986;38(4):209-216. |
23 |
12 |
| 1988 |
Pead MJ, Suswillo R, Skerry TM, Vedi S, Lanyon LE. Increased ³H-uridine levels in osteocytes following a single short period of dynamic bone loadingin vivo. Calcif Tiss Int. August 1988;43(2):92-96. |
46 |
31 |
| 1989 |
Pead MJ, Lanyon LE. Indomethacin modulation of load-related stimulation of new bone formation in vivo. Calcif Tiss Int. January 1989;45(1):34-40. |
39 |
24 |
| 1990 |
Skerry TM, Suswillo R, El Haj AJ, Ali NN, Dodds RA, Lanyon LE. Load-induced proteoglycan orientation in bone tissuein vivo and in vitro. Calcif Tiss Int. May 1990;46(5):318-326. |
21 |
16 |
| 1993 |
Lanyon LE. Osteocytes, strain detection, bone modeling and remodeling. Calcif Tiss Int. February 1993;53(suppl 1):S102-S107. |
97 |
94 |
| 1993 |
Rawlinson SCF, Mohan S, Baylink DJ, Lanyon LE. Exogenous prostacyclin, but not prostaglandin E₂, produces similar responses in both G6PD activity and RNA production as mechanical loading, and increases IGF-II release, in adult cancellous bone in culture. Calcif Tiss Int. November 1993;53(5):324-329. |
21 |
14 |
| 1994 |
Torrance AG, Mosley JR, Suswillo RFL, Lanyon LE. Noninvasive loading of the rat ulna in vivo induces a strain-related modeling response uncomplicated by trauma or periostal pressure. Calcif Tiss Int. March 1994;54(3):241-247. |
104 |
95 |
| 1992 |
Evans GP, Behiri JC, Vaughan LC, Bonfield W. The response of equine cortical bone to loading at strain rates experienced in vivo by the galloping horse. Equine Vet J. March 1992;24(2):125-128. |
16 |
16 |
| 2006 |
Weller R, Pfau T, May SA, Wilson AM. Variation in conformation in a cohort of National Hunt racehorses. Equine Vet J. November 2006;38(7):616-621. |
3 |
3 |
| 1995 |
Pitsillides AA, Rawlinson SCF, Suswillo RFL, Bourrin S, Zaman G, Lanyon LE. Mechanical strain‐induced NO production by bone cells: a possible role in adaptive bone (re)modeling? FASEB J. December 1995;9(15):1614-1622. |
54 |
49 |
| 2015 |
Salmon PL, Ohlsson C, Shefelbine SJ, Doube M. Structure model index does not measure rods and plates in trabecular bone. Front Endocrinol (Lausanne). 2015;6:162. |
19 |
18 |
| 1984 |
Lanyon LE, Rubin CT. Static vs dynamic loads as an influence on bone remodelling. J Biomech. 1984;17(12):897-905. |
166 |
143 |
| 1987 |
Lanyon LE. Functional strain in bone tissue as an objective, and controlling stimulus for adaptive bone remodelling. J Biomech. 1987;20(11-12):1083-1093. |
72 |
62 |
| 2007 |
Lichtwark GA, Bougoulias K, Wilson AM. Muscle fascicle and series elastic element length changes along the length of the human gastrocnemius during walking and running. J Biomech. 2007;40(1):157-164. |
19 |
17 |
| 2008 |
Zioupos P, Cook RB, Hutchinson JR. Some basic relationships between density values in cancellous and cortical bone. J Biomech. 2008;41(9):1961-1968. |
26 |
24 |
| 2010 |
Sztefek P, Vanleene M, Olsson R, Collinson R, Pitsillides AA, Shefelbine S. Using digital image correlation to determine bone surface strains during loading and after adaptation of the mouse tibia. J Biomech. March 3, 2010;43(4):599-605. |
28 |
25 |
| 1988 |
Pead MJ, Skerry TM, Lanyon LE. Direct transformation from quiescence to bone formation in the adult periosteum following a single brief period of bone loading. J Bone Miner Res. December 1988;3(6):647-656. |
58 |
43 |
| 1989 |
Skerry TM, Bitensky L, Chayen J, Lanyon LE. Early strain‐related changes in enzyme activity in osteocytes following bone loading in vivo. J Bone Miner Res. October 1989;4(5):783-788. |
84 |
66 |
| 1990 |
El Haj AJ, Minter SL, Rawlinson SCF, Suswillo R, Lanyon LE. Cellular responses to mechanical loading in vitro. J Bone Miner Res. September 1990;5(9):923-932. |
49 |
37 |
| 1991 |
Rawlinson SCF, El‐Haj AJ, Minter SL, Tavares IA, Bennett A, Lanyon LE. Loading‐related increases in prostaglandin production in cores of adult canine cancellous bone in vitro: a role for prostacyclin in adaptive bone remodeling? J Bone Miner Res. December 1991;6(12):1345-1351. |
37 |
25 |
| 1992 |
Lanyon LE. Control of bone architecture by functional load bearing. J Bone Miner Res. December 1992;7(suppl 2):S369-S375. |
25 |
23 |
| 1993 |
Dallas SL, Zaman G, Pead MJ, Lanyon LE. Early strain-related changes in cultured embryonic chick tibiotarsi parallel those associated with adaptive modeling in vivo. J Bone Miner Res. March 1993;8(3):251-259. |
24 |
15 |
| 1993 |
Dodds RA, Ali N, Pead MJ, Lanyon LE. Early loading-related changes in the activity of glucose 6-phosphate dehydrogenase and alkaline phosphatase in osteocytes and periosteal osteoblasts in rat fibulae in vivo. J Bone Miner Res. March 1993;8(3):261-267. |
19 |
15 |
| 1995 |
Rawlinson SCF, Mosley JR, Suswillo RFL, Pitsillides AA, Lanyon LE. Calvarial and limb bone cells in organ and monolayer culture do not show the same early responses to dynamic mechanical strain. J Bone Miner Res. 1995;10(8):1225-1232. |
29 |
25 |
| 1999 |
Zaman G, Pitsillides AA, Rawlinson SCF, Suswillo RFL, Mosley JR, Cheng MZ, Platts LAM, Hukkanen M, Polak JM, Lanyon LE. Mechanical strain stimulates nitric oxide production by rapid activation of endothelial nitric oxide synthase in osteocytes. J Bone Miner Res. July 1999;14(7):1123-1131. |
39 |
37 |
| 2001 |
Lanyon L, Skerry T. Postmenopausal osteoporosis as a failure of bone's adaptation to functional loading: a hypothesis. J Bone Miner Res. November 2001;16(11):1937-1947. |
26 |
23 |
| 2023 |
Sharma A, Michels LV, Pitsillides AA, Greeves J, Plotkin LI, Cardo V, Sims NA, Clarkin CE. Sexing bones: improving transparency of sex reporting to address bias within preclinical studies. J Bone Miner Res. January 2023;38(1):5-13. |
1 |
1 |
| 1987 |
Rubin CT, Lanyon LE. Osteoregulatory nature of mechanical stimuli: function as a determinant for adaptive remodeling in bone. J Orthop Res. 1987;5(2):300-310. |
112 |
95 |
| 1988 |
Skerry TM, Bitensky L, Chayen J, Lanyon LE. Loading-related reorientation of bone proteoglycan in vivo: strain memory in bone tissue? J Orthop Res. July 1988;6(4):547-551. |
23 |
13 |
| 2020 |
Khan MR, Smith RK, David F, Lam R, Hughes G, Godoy RD, Carr AJ, Goodship AE, Dudhia J. Evaluation of the effects of synovial multipotent cells on deep digital flexor tendon repair in a large animal model of intra‐synovial tendinopathy. J Orthop Res. January 2020;38(1):128-138. |
0 |
0 |
| 2023 |
Hopkinson M, Jones G, Evans L, Gohin S, Magnusdottir R, Salmon P, Chenu C, Meeson R, Javaheri B, Pitsillides AA. A new method for segmentation and analysis of bone callus in rodent fracture models using micro-CT. J Orthop Res. August 2023;41(8):1717-1728. |
0 |
0 |
| 2000 |
Noble BS, Reeve J. Osteocyte function, osteocyte death and bone fracture resistance. Mol Cell Endocrinol. January 25, 2000;159(1-2):7-13. |
28 |
26 |
| 2020 |
Madi K, Staines KA, Bay BK, Javaheri B, Geng H, Bodey AJ, Cartmell S, Pitsillides AA, Lee PD. In situ characterization of nanoscale strains in loaded whole joints via synchrotron X-ray tomography. Nat Biomed Eng. March 2020;4(3):343-354. |
6 |
5 |
| 2003 |
Lee K, Jessop H, Suswillo R, Zaman G, Lanyon L. Bone adaptation requires oestrogen receptor-α. Nature. July 24, 2003;424(6947):389. |
42 |
40 |
| 2002 |
Ehrlich PJ, Lanyon LE. Mechanical strain and bone cell function: a review. Osteoporos Int. September 2002;13(9):688-700. |
41 |
40 |
| 2012 |
Moustafa A, Sugiyama T, Prasad J, Zaman G, Gross TS, Lanyon LE, Price JS. Mechanical loading-related changes in osteocyte sclerostin expression in mice are more closely associated with the subsequent osteogenic response than the peak strains engendered. Osteoporos Int. April 2012;23(4):1225-1234. |
35 |
31 |
| 2011 |
Doube M, Kłosowski MM, Wiktorowicz-Conroy AM, Hutchinson JR, Shefelbine SJ. Trabecular bone scales allometrically in mammals and birds. Proc R Soc B. October 22, 2011;278(1721):3067-3073. |
17 |
15 |
| 2021 |
Felder AA, Monzem S, De Souza R, Javaheri B, Mills D, Boyde A, Doube M. The plate-to-rod transition in trabecular bone loss is elusive. R Soc Open Sci. June 9, 2021;8(5):201401. |
1 |
1 |