Jacobs, Christopher Rae [1965

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AcademicTree: 346827

Academic genealogy

Affiliations (4)

Name	Count	Oldest	Newest
Pennsylvania State University	7	1997	2003
Columbia University	4	2010	2022
Duke University Medical Center	1	2011	2011
Stanford University	11	1994	2008

Papers (21)

Year	Article	Times Cited	Times Cited (no self-citations)
2001	Donahue SW, Jacobs CR, Donahue HJ. Flow-induced calcium oscillations in rat osteoblasts are age, loading frequency, and shear stress dependent. Am J Physiol Cell Physiol. November 2001;281(5):C1635-C1641.	33	27
2010	Jacobs CR, Temiyasathit S, Castillo AB. Osteocyte mechanobiology and pericellular mechanics. Annu Rev Biomed Eng. 2010;12:369-400.	28	27
2011	Hoey DA, Kelly DJ, Jacobs CR. A role for the primary cilium in paracrine signaling between mechanically stimulated osteocytes and mesenchymal stem cells. Biochem Biophys Res Commun. August 19, 2011;412(1):182-187.	21	15
2003	Reilly GC, Haut TR, Yellowley CE, Donahue HJ, Jacobs CR. Fluid flow induced PGE₂ release by bone cells is reduced by glycocalyx degradation whereas calcium signals are not. Biorheology. 2003;40(6):591-603.	38	28
2008	You L, Temiyasathit S, Lee P, Kim CH, Tummala P, Yao W, Kingery W, Malone AM, Kwon RY, Jacobs CR. Osteocytes as mechanosensors in the inhibition of bone resorption due to mechanical loading. Bone. January 2008;42(1):172-179.	47	38
2010	Litzenberger JB, Kim J-B, Tummala P, Jacobs CR. Β₁ integrins mediate mechanosensitive signaling pathways in osteocytes. Calcif Tiss Int. April 2010;86(4):325-332.	18	17
2006	Rubin J, Rubin C, Jacobs CR. Molecular pathways mediating mechanical signaling in bone. Gene. February 15, 2006;367:1-16.	41	34
2001	You J, Reilly GC, Zhen X, Yellowley CE, Chen Q, Donahue HJ, Jacobs CR. Osteopontin gene regulation by oscillatory fluid flow via intracellular calcium mobilization and activation of mitogen-activated protein kinase in MC3T3–E1 osteoblasts. J Biol Chem. April 20, 2001;276(16):13365-13371.	56	36
1997	Jacobs CR, Simo JC, Beaupré GS, Carter DR. Adaptive bone remodeling incorporating simultaneous density and anisotropy considerations. J Biomech. June 1997;30(6):603-613.	30	27
1998	Jacobs CR, Yellowley CE, Davis BR, Zhou Z, Cimbala JM, Donahue HJ. Differential effect of steady versus oscillating flow on bone cells. J Biomech. November 1998;31(11):969-976.	94	73
1999	Jacobs CR, Davis BR, Rieger CJ, Francis JJ, Saad M, Fyhrie DP. The impact of boundary conditions and mesh size on the accuracy of cancellous bone tissue modulus determination using large-scale finite-element modeling. J Biomech. November 1999;32(11):1159-1164.	42	37
2003	Haut Donahue TL, Hull ML, Rashid MM, Jacobs CR. How the stiffness of meniscal attachments and meniscal material properties affect tibio-femoral contact pressure computed using a validated finite element model of the human knee joint. J Biomech. January 2003;36(1):19-34.	31	27
2003	Donahue SW, Donahue HJ, Jacobs CR. Osteoblastic cells have refractory periods for fluid-flow-induced intracellular calcium oscillations for short bouts of flow and display multiple low-magnitude oscillations during long-term flow. J Biomech. January 2003;36(1):35-43.	27	24
2003	Haut Donahue TL, Haut TR, Yellowley CE, Donahue HJ, Jacobs CR. Mechanosensitivity of bone cells to oscillating fluid flow induced shear stress may be modulated by chemotransport. J Biomech. September 2003;36(9):1363-1371.	18	15
2005	Batra NN, Li YJ, Yellowley CE, You L, Malone AM, Kim CH, Jacobs CR. Effects of short-term recovery periods on fluid-induced signaling in osteoblastic cells. J Biomech. September 2005;38(9):1909-1917.	19	14
2011	Guilak F, Jacobs CR. The H-index: use and overuse. J Biomech. November 4, 2011;44(1):208-209.	0	0
2000	You J, Yellowley CE, Donahue HJ, Zhang Y, Chen Q, Jacobs CR. Substrate deformation levels associated with routine physical activity are less stimulatory to bone cells relative to loading-induced oscillatory fluid flow. J Biomech Eng. August 2000;122(4):387-393.	80	67
2000	Yellowley CE, Li Z, Zhou Z, Jacobs CR, Donahue HJ. Functional gap junctions between osteocytic and osteoblastic cells. J Bone Miner Res. February 2000;15(2):209-217.	46	33
2022	Spasic M, Duffy MP, Jacobs CR. Fenoldopam sensitizes primary cilia-mediated mechanosensing to promote osteogenic intercellular signaling and whole bone adaptation. J Bone Miner Res. May 2022;37(5):972-982.	0	0
2004	Li YJ, Batra NN, You L, Meier SC, Coe IA, Yellowley CE, Jacobs CR. Oscillatory fluid flow affects human marrow stromal cell proliferation and differentiation. J Orthop Res. November 2004;22(6):1283-1289.	32	27
2007	Malone AMD, Anderson CT, Tummala P, Kwon RY, Johnston TR, Stearns T, Jacobs CR. Primary cilia mediate mechanosensing in bone cells by a calcium-independent mechanism. Proc Natl Acad Sci USA. August 14, 2007;104(33):13325-13330.	68	57

Theses (1)

Year	Article	Times Cited	Times Cited (no self-citations)
1994	Jacobs CR. Numerical Simulation of Bone Adaptation to Mechanical Loading [PhD thesis]. Stanford University; June 1994.	15	11

Student Theses (11)

Year	Article	Times Cited
2009	Temiyasathit S. Investigating the Role of Primary Cilia in Mechanotransduction in Bone [PhD thesis]. Stanford University; September 2009.	0
2009	Litzenberger JB. The Role of Integrin Signaling in Bone Mechanotransduction [PhD thesis]. Stanford University; 2009.	1
2009	Alwood JS. Radiation and Mechanical Unloading Effects on Mouse Vertebral Bone: Ground-Based Models of the Spaceflight Environment [PhD thesis]. Stanford University; September 2009.	0
2008	Kwon RY. Mechanical Behavior and Early Molecular Signaling During Mechanotransduction of Fluid Flow in Bone Cells [PhD thesis]. Stanford University; August 2008.	0
2008	Arnsdorf EJ. Guiding Osteogenic Lineage Commitment: The Role of Mesenchymal Stem Cell Biology and the Mechanical Microenvironment [PhD thesis]. Stanford University; September 2008.	0
2007	Malone AMD. Mechanotransduction Mechanisms in Bone Cells [PhD thesis]. Stanford University; August 2007.	1
2021	Duffy MP. The Osteocyte Primary Cilium is a Mechanoresponsive Organelle That Regulates Cytoskeletal Adaptation and Coordinates Mechanotransduction With Adenylyl Cyclases [PhD thesis]. Columbia University; 2021.	0
2018	Spasic M. Targeting Primary Cilia-Mediated Mechanotransduction to Promote Whole Bone Formation [PhD thesis]. Columbia University; 2018.	0
2018	Moore ER. The Primary Cilium Encourages Osteogenic Behavior in Periosteal Osteochondroprogenitors and Osteocytes During Juvenile Skeletal Development and Adult Bone Adaptation [PhD thesis]. Columbia University; 2018.	0
2015	Nguyen AM. Multiscale Mechanobiology of Primary Cilia [PhD thesis]. Columbia University; 2015.	0
2014	Lee KL. A Mechanism of Mechanotransduction Mediated by the Primary Cilium [PhD thesis]. Columbia University; 2014.	0

Collaborators (17)

Name	Count	Oldest	Newest
Fyhrie, David P.	1	1999	1999
Beaupré, Gary S.	1	1997	1997
You, Lidan	3	2004	2008
Rubin, Janet	1	2006	2006
Yao, Wei	1	2008	2008
Rubin, Clinton T.	1	2006	2006
Kwon, Ronald Young	2	2007	2008
Donahue, Henry J.	8	1998	2003
Kim, Chi Hyun	2	2005	2008
Haut Donahue, Tammy L.	2	2003	2003
Carter, Dennis R.	1	1997	1997
Kelly, Daniel J.	1	2011	2011
Reilly, Gwendolen C.	2	2001	2003
Yellowley, Clare E.	8	1998	2005
Guilak, Farshid	1	2011	2011
Donahue, Seth W.	2	2001	2003
Hull, Maury Lane	1	2003	2003