Articular cartilage chondrons:​ form, function and failure

Poole, C. Anthony

Year	Entry
2005	Alexopoulos LG, Setton LA, Guilak F. The biomechanical role of the chondrocyte pericellular matrix in articular cartilage. Acta Biomater. May 2005;1(3):317-325.
2006	Guilak F, Alexopoulos LG, Upton ML, Youn I, Choi JB, Cao L, Setton LA, Haider MA. The pericellular matrix as a transducer of biomechanical and biochemical signals in articular cartilage. Annals NY Acad Sci. April 2006;1068(1):498-512.
2002	Mow VC, Guo XE. Mechano-electrochemical properties of articular cartilage: their inhomogeneities and anisotropies. Annu Rev Biomed Eng. 2002;4:175-209.
2005	Alexopoulos LG, Williams GM, Upton ML, Setton LA, Guilak F. Osteoarthritic changes in the biphasic mechanical properties of the chondrocyte pericellular matrix in articular cartilage. J Biomech. March 2005;38(3):509-517.
2007	Choi JB, Youn I, Cao L, Leddy HA, Gilchrist CL, Setton LA, Guilak F. Zonal changes in the three-dimensional morphology of the chondron under compression: the relationship among cellular, pericellular, and extracellular deformation in articular cartilage. J Biomech. 2007;40(12):2596-2603.
2003	Alexopoulos LG, Haider MA, Vail TP, Guilak F. Alterations in the mechanical properties of the human chondrocyte pericellular matrix with osteoarthritis. J Biomech Eng. June 2003;125(3):323-333.
1998	Quinn TM, Grodzinsky AJ, Hunziker EB, Sandy JD. Effects of injurious compression on matrix turnover around individual cells in calf articular cartilage explants. J Orthop Res. July 1998;16(4):490-499.
2022	Franklin M, Sperry MM, Phillips E, Granquist EJ, Marcolongo M, Winkelstein BA. Painful temporomandibular joint overloading induces structural remodeling in the pericellular matrix of that joint's chondrocytes. J Orthop Res. February 2022;40(2):348-358.
2024	Moo EK, Sibole SC, Federico S, Korhonen RK, Herzog W. Microscale investigation of the anisotropic swelling of cartilage tissue and cells in response to hypo-osmotic challenges. J Orthop Res. January 2024;42(1):54-65.
2002	Hunziker EB, Quinn TM, Häuselmann H-J. Quantitative structural organization of normal adult human articular cartilage. Osteoarthritis Cartilage. July 2002;10(7):564-572.
2004	Park S, Hung CT, Ateshian GA. Mechanical response of bovine articular cartilage under dynamic unconfined compression loading at physiological stress levels. Osteoarthritis Cartilage. January 2004;12(1):65-73.
2006	Pritzker KPH, Gay S, Jimenez SA, Ostergaard K, Pelletier J-P, Revell PA, Salter D, van den Berg WB. Osteoarthritis cartilage histopathology: grading and staging. Osteoarthritis Cartilage. January 2006;14(1):13-29.
2006	Youn I, Choi JB, Cao L, Setton LA, Guilak F. Zonal variations in the three-dimensional morphology of the chondron measured in situ using confocal microscopy. Osteoarthritis Cartilage. September 2006;14(9):889-897.
2008	Ofek G, Revell CM, Hu JC, Allison DD, Grande-Allen KJ, Athanasiou KA. Matrix development in self-assembly of articular cartilage. PLoS One. July 2008;3(7):e2795.
2003	Mauck RL, Nicoll SB, Seyhan SL, Ateshian GA, Hung CT. Synergistic action of growth factors and dynamic loading for articular cartilage tissue engineering. Tissue Eng. August 2003;9(4):597-611.
2013	Wu Y. Integrating Biomechanics and Cell Physiology to Understanding IVD Nutrition and Cell Homeostasis [PhD thesis]. Clemson, SC: Clemson University; May 2013.
2003	Mauck RL. Functional Tissue Engineering of Articular Cartilage: The Effect of Physical Forces on the in Vitro Growth of Engineered Constructs [PhD thesis]. Columbia University; 2003.
2005	Park S. Interstitial Fluid Flow-Dependent and Flow-Independent Mechanical and Tribological Response of Articular Cartilage [PhD thesis]. Columbia University; 2005.
2006	Kelly T-AN. Functional Tissue Engineering of Articular Cartilage: Characterization and Optimization of Chondrocyte-Seeded Agarose Hydrogels [PhD thesis]. Columbia University; 2006.
2014	Sampat SR. Optimization of Culture Conditions for Cartilage Tissue Engineering Using Synovium-Derived Stem Cells [PhD thesis]. Columbia University; 2014.
2019	Franklin ME. Structural Characterization and Introduction of Biomimetic Proteoglycans in Temporomandibular Joint Pain [Master's thesis]. Drexel University; June 2019.
2019	Phillips ER. Cartilage Molecular Engineering Using Biomimetic Proteoglycans [PhD thesis]. Drexel University; March 2019.
2001	Erickson GR. Articular Chondrocyte Response to Osmotic Stress: The Involvement of Calcium and the Cytoskeleton in Cellular Volume Adaptation and Regulation [PhD thesis]. Duke University; 2001.
2004	Alexopoulos LG. The Biomechanical Role of the Chondrocyte Pericellular Matrix in Articular Cartilage [PhD thesis]. Duke University; 2004.
2007	Leddy HA. Diffusional Properties of Articular Cartilage [PhD thesis]. Duke University; 2007.
2009	Christensen SE. The Role of Collagen VI in the Structure and Properties of the Knee Joint [PhD thesis]. Duke University; 2009.
2013	Wilusz RE. Micromechanical Properties of the Extracellular and Pericellular Matrices of Articular Cartilage [PhD thesis]. Duke University; 2013.
2005	Ng LJ. Probing Nanomechanics of Aggrecan and the Aggrecan-Rich Pericellular Matrix of Chondrocytes in Cartilage [PhD thesis]. Cambridge, MA: Massachusetts Institute of Technology; September 2005.
2006	Stevens AL. Mechanical Injury and Inflammatory Cytokines Affect Cartilage Integrity and Tissue Homeostasis: A Mass Spectrometric Analysis of Proteins With Relevance to Arthritis [PhD thesis]. Cambridge, MA: Massachusetts Institute of Technology; September 2006.
2009	Lee B. Time-Dependent Mechanical Behavior of Newly Developing Matrix of Bovine Primary Chondrocytes and Bone Marrow Stromal Cells Using Atomic Force Microscopy [PhD thesis]. Cambridge, MA: Massachusetts Institute of Technology; September 2009.
2017	Ibañez JR. Use of Synthetic Solid Scaffolds to Mechanically Support a Chondrocyte-Seeded Peptide Hydrogel for Articular Cartilage Repair [Master's thesis]. Cambridge, MA: Massachusetts Institute of Technology; June 2017.
2014	Steward AJ. The Mechanotransduction of Hydrostatic Pressure by Mesenchymal Stem Cells [PhD thesis]. University of Notre Dame; April 2014.
2010	Bahney CS. Cartilage Engineering: Designing an Improved System for Effecting Repair of Articular Cartilage Defects [PhD thesis]. Portland, OR: Oregon Health & Science University; August 2010.
2011	Changoor A. Electromechanical and Polarization Microscopy Evaluation of Cartilage Repair and Degeneration [PhD thesis]. École polytechnique de Montréal; January 2011.
2012	Devlin SM. Computer Assisted Mosaic Arthroplasy: A Pilot Study and Animal Trial [Master's thesis]. Queen's University; November 2012.
2012	Kaupp JA. Simulated Joint Loading Enhances the Expression of of Superficial Zone Markers in Tissue Engineered Cartilage Constructs [PhD thesis]. Queen's University; February 2012.
2011	Jeon JE. Development of Zonal Cartilage Constructs: Effects of Chondrocyte Subpopulation, Compressive Stimulation, and Culture Models [PhD thesis]. Queensland University of Technology; 2011.
2016	Levett PA. Photocrosslinkable Hydrogels for Cartilage Tissue Engineering [PhD thesis]. Queensland University of Technology; 2016.
2018	Arabshahi Z. New Mechanical Indentation Framework for Functional Assessment of Articular Cartilage [PhD thesis]. Queensland University of Technology; 2018.
2005	Hu J. Chondrocyte Self -Assembly and Culture in Bioreactors [PhD thesis]. Houston, TX: Rice University; April 2005.
2007	Koay EJ. Chondrocyte Biomechanics and Chondrogenesis [PhD thesis]. Houston, TX: Rice University; December 2007.
2009	Ofek G. Biomechanics of the Single Chondrocyte and Its Developing Extracellular Matrix [PhD thesis]. Houston, TX: Rice University; May 2009.
2013	Nishimuta JF. Degradation of Cartilage and Meniscus Tissues: An in Vitro Investigation in Osteoarthritis Development [PhD thesis]. Stanford University; March 2013.
2016	Vazão de Almeida HM. Cartilage Extracellular Matrix-Derived Scaffolds for Joint Regeneration [PhD thesis]. Trinity College Dublin; January 2016.
2017	Critchley SE. Towards 3D Bioprinting of Anatomically Accurate, Mechanically Reinforced Cartilage Templates for Biological Joint Resurfacing [PhD thesis]. Trinity College Dublin; 2017.
2010	Tapper JE. Dynamic in Vivo Kinematics in an Ovine Stifle Joint Model of Osteoarthritis [PhD thesis]. Calgary, AB: University of Calgary; March 2010.
2013	Madden RMJ. In Situ Chondrocyte Mechanics and Mechanobiology [Master's thesis]. Calgary, AB: University of Calgary; August 2013.
2014	Jablonski CL. Integrin Α1β1 Participates in Chondrocyte Transduction of Osmotic Stress [Master's thesis]. Calgary, AB: University of Calgary; May 2014.
2005	Albrecht DR. Microscale Organization of Cells Within 3-D Hydrogels by Dielectrophoresis: Applications to Cartilage Biology [PhD thesis]. San Diego (UCSD), University of California; 2005.
2009	Hsieh-Bonassera ND. Cartilage Tissue Engineering With Human Chondrocytes from Osteoarthritic Knees and a Semi-Permeable Membrane [PhD thesis]. San Diego (UCSD), University of California; 2009.
2012	Statman LY. Mechanosensitive Β-Catenin Signaling Modulates Mesenchymal Stem Cell Chondrogenesis [PhD thesis]. San Francisco, University of California; 2012.
2022	Ojanen S. Multiscale Imaging and Biomechanics of Articular Cartilage in an Animal Model of Osteoarthritis [PhD thesis]. University of Eastern Finland; 2022.
2013	Deneweth JM. Mapping the Biomechanical Properties of Human Knee Cartilage [PhD thesis]. University of Michigan; 2013.
2022	St. Amant J. Interplay Between Integrin Alpha 1 Beta 1 and Transforming Growth Factor Beta Receptor II in the Development of Spontaneous Osteoarthritis in the Mouse Knee [Master's thesis]. University of Guelph; September 2022.
2021	Dicks A. Human IPSC Tissue-Engineered Cartilage for Disease Modeling of Skeletal Dysplasia-Causing TRPV4 Mutations [PhD thesis]. St. Louis, MO: Washington University in St. Louis; August 2021.

Year	Entry
1979	Meachim G, Stockwell RA. The matrix. In: Freeman MAR, ed. Adult Articular Cartilage. 2nd ed. Kent, England: Pitman Medical; 1979:1-67.
1980	Broom ND, Myers DB. A study of the structural response of wet hyaline cartilage to various loading situations. Connect Tissue Res. 1980;7(4):227-237.
1995	Muir H. The chondrocyte, architect of cartilage: biomechanics, structure, function and molecular biology of cartilage matrix macromolecules. BioEssays. December 1995;17(12):1039-1048.
1995	Guilak F, Ratcliffe A, Mow VC. Chondrocyte deformation and local tissue strain in articular cartilage: a confocal microscopy study. J Orthop Res. May 1995;13(3):410-421.
1995	Hollander AP, Pidoux I, Reiner A, Rorabeck C, Bourne R, Poole AR. Damage to type II collagen in aging and osteoarthritis starts at the articular surface, originates around chondrocytes, and extends into the cartilage with progressive degeneration. J Clin Invest. December 1995;96(6):2859-2869.
1995	Bonassar LJ, Frank EH, Murray JC, Paguio CG, Moore VL, Lark MW, Sandy JD, Wu J-J, Eyre DR, Grodzinsky AJ. Changes in cartilage composition and physical properties due to stromelysin degradation. Arthritis Rheum. February 1995;38(2):173-183.
1987	Poole CA, Flint MH, Beaumont BW. Chondrons in cartilage: ultrastructural analysis of the pericellular microenvironment in adult human articular cartilages. J Orthop Res. 1987;5(4):509-522.
1988	Poole CA, Ayad S, Schofield JR. Chondrons from articular cartilage, I: immunolocalization of type VI collagen in the pericellular capsule of isolated canine tibial chondrons. J Cell Sci. August 1988;90(4):635-643.