Cerebral concussion in the monkey:​ an experimental model

Ommaya, Ayub K.; Hirsch, A. E.; Flamm, E. S.; Mahone, R. H.

Affiliations

¹Branch of Surgical Neurology, National Institute of Neurological Diseases and Blindness, Bethesda, Maryland

²David Taylor Model Basin, Carderock, Maryland

³National Institute of Neurological Diseases and Blindness

Abstract

A statistically significant experimental model has been developed for reproducing head injury by impact in the monkey. Results with 80 monkeys subjected to occipital impact under specified conditions (duration of phenomena, 1 to 10 milliseconds) enable the construction of curves relating the production of experimental cerebral concussion in 10, 50, and 90 percent of the monkeys to the average impulse of the blow in pounds-seconds, as well as to the average linear acceleration of the head. These curves are proposed as a baseline from which blows to various parts of the head, as well as nonimpacting impulsive loads, can be studied under various conditions of protection and according to various time regimes.

Links

DOI: 10.1126/science.153.3732.211

PubMed: 4957321

WoS: A19667934600051

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Cited By (39)

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2022	Wynn GF. Repeatability of a Novel Prototype Surrogate Neck Model Developed for Omni-Directional Head Impacts [Master's thesis]. Edmonton, AB: University of Alberta; 2022.
2014	Patton DA. The Biomechanical Determinants of Sports-Related Concussion: Finite Element Simulations of Unhelmeted Head Impacts to Evaluate Kinematic and Tissue-Level Predictors of Injury and Investigate the Design Implications for Soft-Shell Headgear [PhD thesis]. University of New South Wales; March 2014.
2014	Rousseau P. Analysis of Concussion Metrics of Real-World Concussive and Non-Injurious Elbow and Shoulder to Head Collisions in Ice Hockey [PhD thesis]. University of Ottawa; 2014.
2014	Chen Y. Astrocyte Signaling in Traumatic Brain Injury [PhD thesis]. Philadelphia, PA: University of Pennsylvania; 2014.
2014	Daniel RW II. Evaluation of Football Safety Techniques Utilizing Biomechanical Measurements [PhD thesis]. Virginia Polytechnic Institute and State University; June 3, 2014.
1994	Ruan JS. Impact Biomechanics of Head Injury by Mathematical Modeling [PhD thesis]. Detroit, MI: Wayne State University; 1994.
1995	Zhou C. Finite Element Modeling of Impact Response of an Inhomogeneous Brain [PhD thesis]. Detroit, MI: Wayne State University; 1995.
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2018	Arora T. Development of a Subhuman Primate Brain Finite Element Model to Investigate Brain Injury Thresholds Induced by Head Rotation [Master's thesis]. Detroit, MI: Wayne State University; August 2018.
2020	Zhou R. Development of Rat Head Finite Element Model and Tissue Level Biomechanical Threshold for Traumatic Axonal Injury [PhD thesis]. Detroit, MI: Wayne State University; May 2020.
2023	Lyu D. Investigation of Biomechanical Thresholds of Mild to Severe Brain Injury Using an Anisotropic Visco-Hyperelastic Finite Element Head Model: Model Development and Simulation of Impact Injury and Blast Injury [PhD thesis]. Detroit, MI: Wayne State University; August 2023.